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Kamila A L Wakabayashi et al.
Chemistry & biodiversity, 12(7), 1105-1114 (2015-07-15)
Foeniculum vulgare Mill. (Apiaceae), known as fennel, is a widespread aromatic herbaceous plant, and its essential oil is used as additive in the food, pharmaceutical, cosmetic, and perfume industries. The in vitro antischistosomal activity and cytotoxic effects against V79 cells
Chloe Martin et al.
International journal of pharmaceutics, 481(1-2), 1-8 (2015-01-17)
The field of therapeutics is evolving to include a greater proportion of higher molecular weight, hydrophilic biological compounds. To cater for this new era in healthcare the concomitant development of appropriate drug delivery systems is essential to aid cellular permeation.
Hossein Bannazadeh Baghi et al.
Comparative immunology, microbiology and infectious diseases, 37(5-6), 321-329 (2014-12-03)
The mucosal surfaces are important sites of entry for a majority of pathogens, and viruses in particular. The migration of antigen presenting cells (APCs) from the apical side of the mucosal epithelium to the lymph node is a key event
Jian-wei Zhang et al.
Biochemical pharmacology, 90(3), 265-275 (2014-05-27)
Recently, several studies indicated that senescent tumor cells are resistant to apoptosis in chemotherapy. They may return to cell cycle, thus act as stumbling blocks in anticancer treatments. In the present study, we found that, in human colorectal cancer cells
Sindy Cole et al.
Scientific reports, 5, 16143-16143 (2015-11-06)
The orexin/hypocretin system is important for reward-seeking behaviors, however less is known about its function in non-homeostatic feeding. Environmental influences, particularly cues for food can stimulate feeding in the absence of hunger and lead to maladaptive overeating behavior. The key
Meng Lu et al.
Die Pharmazie, 70(6), 388-393 (2015-07-21)
Ampelopsin (AMP), a novel flavonoid, has been shown to effectively inhibit the proliferation and induce apoptosis of some prostate cancer and breast cancer cell lines. Whether AMP has chemopreventive effects on the cell growth and apoptosis of human osteosarcoma MG-63
Han Qiao et al.
Acta pharmacologica Sinica, 36(9), 1085-1098 (2015-08-04)
Zoledronic acid (ZA), a bisphosphonate, is currently used in combination with chemotherapeutic agents to suppress breast cancer cell proliferation or breast cancer-induced osteolysis. The aim of this study was to investigate the effects of ZA combined with a natural anticancer
Thomas Simon et al.
Neuromolecular medicine, 16(4), 752-771 (2014-08-13)
Bevacizumab is a humanized monoclonal antibody directed against the pro-angiogenic factor vascular and endothelial growth factor-A (VEGF-A) used in the treatment of glioblastomas. Although most patients respond initially to this treatment, studies have shown that glioblastomas eventually recur. Several non-mutually
Chiranjit Dutta et al.
ACS applied materials & interfaces, 7(33), 18397-18405 (2015-08-05)
Designing an effective peptide based molecular transporter for the intracellular delivery of hydrophilic therapeutic biomacromolecules remains a considerable challenge. Highly basic oligoarginine and lipidated arginine rich cell penetrating peptides have been reported in the literature as molecular transporters, which were
Wei Hu et al.
Cancer research, 74(12), 3282-3293 (2014-04-20)
The Notch pathway plays an important role in the growth of high-grade serous ovarian (HGS-OvCa) and other cancers, but its clinical and biologic mechanisms are not well understood. Here, we found that the Notch pathway alterations are prevalent and significantly
Marquiza Sablón-Carrazana et al.
PloS one, 10(9), e0135292-e0135292 (2015-09-04)
The increasing prevalence of conformational diseases, including Alzheimer's disease, type 2 Diabetes Mellitus and Cancer, poses a global challenge at many different levels. It has devastating effects on the sufferers as well as a tremendous economic impact on families and
Harriët Schellekens et al.
ACS chemical neuroscience, 6(7), 1186-1197 (2015-03-03)
Understanding the intricate pathways that modulate appetite and subsequent food intake is of particular importance considering the rise in the incidence of obesity across the globe. The serotonergic system, specifically the 5-HT2C receptor, has been shown to be of critical
Magnus Hole et al.
Biochimica et biophysica acta, 1854(9), 1078-1089 (2015-05-12)
Pharmacological chaperones are small compounds that correct the folding of mutant proteins, and represent a promising therapeutic strategy for misfolding diseases. We have performed a screening of 10,000 compounds searching for pharmacological chaperones of tyrosine hydroxylase (TH), the tetrahydrobiopterin (BH4)-dependent
Hu-Chen Lu et al.
Molecular medicine reports, 12(5), 6642-6648 (2015-09-10)
At present, one of the most life threatening types of adult brain tumor is glioblastoma multiforme (GBM). The molecular mechanism underlying the progression of GBM remains to be fully elucidated. The modern method of clinical treatment has only improved the
Matthias Schröder et al.
Biological chemistry, 396(6-7), 795-802 (2015-02-27)
FTY720 (Fingolimod; Gilenya®) is an immune-modulatory prodrug which, after intracellular phosphorylation by sphingosine kinase 2 (SphK2) and export, mimics effects of the endogenous lipid mediator sphingosine-1-phosphate. Fingolimod has been introduced to treat relapsing-remitting multiple sclerosis. However, little has been published
Zhifa Wang et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(6), 1204-1216 (2014-10-21)
To analyze the effects of platelet-rich fibrin (PRF) on mesenchymal stem cells (MSCs) in vitro and investigate in vivo bone formation by MSC sheets with PRF. Cell proliferation and expression of osteogenesis-related genes within MSC sheets were assessed upon exposure
Lu Ren et al.
Carbohydrate research, 406, 19-26 (2015-02-07)
A purified water-soluble fraction (ICP5) of a polysaccharide, isolated from a local Maori mushroom Iliodiction cibarium in New Zealand, was investigated for its structural properties. Size exclusion chromatography and dynamic light scattering showed that ICP5 had a large MW of
Samantha Jardon-Xicotencatl et al.
Toxins, 7(10), 4294-4314 (2015-10-30)
Aflatoxins, a group of extremely toxic mycotoxins produced by Aspergillus flavus, A. parasiticus and A. nomius, can occur as natural contaminants of certain agricultural commodities, particularly maize. These toxins have been shown to be hepatotoxic, carcinogenic, mutagenic and cause severe
Ying Dong et al.
Fish & shellfish immunology, 97, 375-381 (2019-12-25)
Infectious pancreatic necrosis virus (IPNV) is a common pathogen that causes huge economic losses for the salmonid aquaculture industry. Autophagy plays an important regulatory role in the invasion of pathogenic microorganisms. In this study, we explored the relationship between IPNV
Long Hua et al.
International journal of clinical and experimental pathology, 8(3), 3076-3082 (2015-06-06)
long non-coding RNA ANRIL (lncRNA ANRIL) has been demonstrated to play a crucial role in cancer progression. However, its effects in hepatocellular carcinoma (HCC) have not been explored. The aim of this study was to investigate the clinical significance of
Wan Mohd Nuzul Hakimi Wan Salleh et al.
Archives of pharmacal research, 38(4), 485-493 (2014-08-08)
The present study aimed to examine the chemical compositions of the essential oils of Beilschmiedia madang and their antioxidant, antibacterial, antifungal, anticholinesterase and anti-tyrosinase activities. The major constituents of the essential oils of leaf and bark of B. madang were
Yoshinori Ohkura et al.
Journal of cardiovascular pharmacology, 65(5), 500-507 (2015-01-31)
S-equol is known as an estrogenic substance, but its ability to restore vascular endothelial function is unknown. The aim of this study was to investigate the impact of S-equol on endothelial function and intimal thickening under isoflavone- and estrogen-deficient circumstances.
Jonatas Rafael de Oliveira et al.
Archives of oral biology, 59(8), 808-814 (2014-05-28)
To evaluate the antimicrobial activity of Arctium lappa L. extract on Staphylococcus aureus, S. epidermidis, Streptococcus mutans, Candida albicans, C. tropicalis and C. glabrata. In addition, the cytotoxicity of this extract was analyzed on macrophages (RAW 264.7). By broth microdilution
Jianfeng Wei et al.
Journal of chemotherapy (Florence, Italy), 26(6), 348-352 (2014-07-30)
We investigated the effects of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), alone and in combination, on apoptosis and intracellular calcium concentration in hepatocellular carcinoma (HepG2) cells. We used HepG2 cells to test the effects of ATRA and ATO
Dandan Han et al.
Journal of cellular physiology, 235(11), 8839-8851 (2020-04-25)
Ferroptosis, an autophagy-dependent cell death, is characterized by lipid peroxidation and iron accumulation, closely associated with pathogenesis of gestational diabetes mellitus (GDM). Sirtuin 3 (SIRT3) has positive regulation on phosphorylation of activated protein kinase (AMPK), related to maintenance of cellular
Peifang Jiang et al.
European archives of psychiatry and clinical neuroscience, 265(6), 497-509 (2015-02-28)
Hippocampus endogenous neurogenesis has been postulated to play a favorable role in brain restoration after injury. However, the underlying molecular mechanisms have been insufficiently deciphered. Here we investigated the potential regulatory capacity of MAPK/ERK signaling on neurogenesis and the associated
Satyanarayana R Pondugula et al.
Toxicology letters, 232(3), 580-589 (2014-12-30)
Activation of human pregnane X receptor (hPXR)-regulated expression of cytochrome P450 3A4 (CYP3A4) and multidrug resistance protein 1 (MDR1) plays an important role in mediating adverse drug interactions. Given the common use of natural products as part of adjunct human
Florian Käfer et al.
Langmuir : the ACS journal of surfaces and colloids, 31(32), 8940-8946 (2015-07-24)
The change in thermoresponsive behavior from a single phase transition of upper critical solution temperature (UCST)-type of an acrylamide-acrylonitrile copolymer (AAm-co-AN) to a double responsive behavior (LCST-UCST-type (LCST, lower critical solution temperature)) in water by the introduction of a poly(ethylene
Adel Rezaei Moghadam et al.
BMC complementary and alternative medicine, 15, 246-246 (2015-07-23)
Methotrexate (MTX) is an antimetabolite broadly used in treatment of cancer and autoimmune diseases. MTX-induced hepatotoxicity limits its application. We investigated hepatoprotective effects of turmeric in MTX-induced liver toxicity. All experiments were performed on male Wistar albino rats that were
Shunsuke Yuri et al.
PloS one, 10(6), e0129242-e0129242 (2015-06-16)
Knowledge on how to maintain and expand nephron progenitor cells (NPC) in vitro is important to provide a potentially valuable source for kidney replacement therapies. In our present study, we examined the possibility of optimizing NPC maintenance in the "re-aggregate"
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