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Andrew S Weyrich et al.
Trends in cardiovascular medicine, 16(3), 75-80 (2006-03-21)
Interactions between platelets and leukocytes link critical thrombotic and inflammatory events that control an array of cardiovascular syndromes. In atherosclerosis alone, inducible gene expression in platelets and leukocytes modulates the initiation and development of vulnerable plaques that increase a patient's
Christopher B Pattillo et al.
Annals of the New York Academy of Sciences, 1207, 83-88 (2010-10-20)
Chronic and intermittent ischemic vascular disorders represent a burgeoning clinical challenge. Previous studies have focused on the idea that therapeutic angiogenesis strategies could alleviate tissue ischemia; however, it is now appreciated that vascular disease is not simply limited to vascular
Scott J Hughes et al.
Cellular signalling, 27(5), 1008-1018 (2015-03-01)
Equilibrative nucleoside transporter subtype 1 (ENT1) is critical for the regulation of the biological activities of endogenous nucleosides such as adenosine, and for the cellular uptake of chemotherapeutic nucleoside analogs. Previous studies have implicated protein kinase C (PKC) in the
C Arimany-Nardi et al.
British journal of pharmacology, 171(16), 3868-3880 (2014-05-02)
Inhibitors of DNA methyltransferases (DNMTs), such as azacytidine, decitabine and zebularine, are used for the epigenetic treatment of cancer. Their action may depend upon their translocation across the plasma membrane. The aim of this study was to identify transporter proteins
Xiying Wang et al.
American journal of ophthalmology, 158(4), 738-744 (2014-06-29)
To evaluate serum and plasma vascular endothelial growth factor (VEGF) concentrations in neovascular age-related macular degeneration patients treated bimonthly with an intravitreal injection of aflibercept or ranibizumab. Prospective, interventional case series. This study includes 17 eyes of 17 patients treated
D B J Bone et al.
Microvascular research, 98, 16-22 (2014-12-03)
Adenosine is an endogenous regulator of vascular tone. This activity of adenosine is terminated by its uptake and metabolism by microvascular endothelial cells (MVEC). The predominant transporter involved is ENT1 (equilibrative nucleoside transporter subtype 1). MVEC also express the nucleobase
John S Morrison et al.
Journal of pharmaceutical sciences, 103(10), 3022-3032 (2014-07-30)
A unique opportunity exists at the drug discovery stage to overcome inherently poor solubility by selecting drug candidates with superior supersaturation propensity. Existing supersaturation assays compare either precipitation-resistant or precipitation-inhibiting excipients, or higher-energy polymorphic forms, but not multiple compounds or
R P W Rouhl et al.
Expert review of neurotherapeutics, 8(11), 1661-1665 (2008-11-07)
Transient ischemic attack (TIA) or a (minor) ischemic stroke increases the risk of a recurrent stroke or death. Antiplatelet therapy with aspirin or clopidogrel is, in the absence of a potential cardiac embolic source, common practice to lower this risk.
Yi-Ling Hsieh et al.
Journal of pharmaceutical sciences, 103(9), 2724-2735 (2014-02-08)
The aim of this study was to investigate the pH-induced precipitation behavior of four ionizable compounds (papaverine, dipyridamole, glyburide, and warfarin) in the absence and presence of polymers. Polymers selected included nonionic, anionic, and cationic polymers. Precipitates were analyzed immediately
Pitchai Balakumar et al.
Pharmacological research, 90, 36-47 (2014-09-30)
Low-doses of fenofibrate and dipyridamole have pleiotropic renoprotective actions in diabetic rats. This study investigated their combined effect relative to their individual treatments and lisinopril in rats with diabetic nephropathy. Streptozotocin (55mg/kg, i.p., once)-administered diabetic rats were allowed for 10
Enxi Quan et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(4), 433-443 (2015-01-18)
Active transport of glucuronide out of cells is a critical process in elimination of drugs via the glucuronidation pathway. Here, HeLa cells were stably transfected with UGT1A1 and the contributions of BCRP and MRP family transporters to the cellular efflux
Azza Ramadan et al.
Purinergic signalling, 10(2), 305-312 (2013-10-29)
The adenosine transporter 1 (ENT1) transports nucleosides, such as adenosine, and cytotoxic nucleoside analog drugs. ENT1 is well established to play a role in adenosinergic signaling in the cardiovascular system by modulating adenosine levels. Moderate ethanol consumption is cardioprotective and
Natalie Crown et al.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 67(9), 728-733 (2010-04-23)
The safety of fixed-dose combination aspirin-extended-release (ER) dipyridamole for stroke prevention in patients with ischemic heart disease is reviewed. Randomized controlled trials have established the superiority of aspirinER dipyridamole over aspirin alone for secondary stroke prevention. One limitation of this
Vijaya L Damaraju et al.
Molecular cancer therapeutics, 14(1), 236-245 (2014-12-19)
Multitargeted tyrosine kinase inhibitors (TKI) axitinib, pazopanib, and sunitinib are used to treat many solid tumors. Combination trials of TKIs with gemcitabine, a nucleoside anticancer drug, in pancreas, renal, lung, ovarian, and other malignancies resulted in little benefit to patients.
Alessia Melani et al.
Annals of the New York Academy of Sciences, 1207, 89-96 (2010-10-20)
Pharmacological therapy able to improve the cognitive performances of patients with chronic vascular pathologies currently remains unavailable. Many studies of chronic cerebral hypotension in rodents have revealed alterations in reference memory and learning. Dipyridamole was introduced into clinical medicine in
Seemant Chaturvedi
Clinical therapeutics, 30(7), 1196-1205 (2008-08-12)
Approximately 25% of strokes are recurrent. Antiplatelet therapy is indicated for the prevention of recurrent stroke in patients with a history of noncardioembolic minor stroke or transient ischemic attack (TIA). Although clinicians may choose acetylsalicylic acid (ASA) as first-line therapy
A Mitra et al.
Molecular pharmaceutics, 11(8), 2835-2844 (2014-07-16)
The purpose of this study was to investigate the influence of gastric emptying patterns, surfactants, and dosage form on the supersaturation of a poorly soluble weakly basic drug, dipyridamole, using an in vitro model mimicking the dynamic environment of the
Harry Karmouty-Quintana et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(1), 50-60 (2014-10-17)
Idiopathic pulmonary fibrosis (IPF) is a lethal, fibroproliferative disease. Pulmonary hypertension (PH) can develop secondary to IPF and increase mortality. Alternatively, activated macrophages (AAMs) contribute to the pathogenesis of both IPF and PH. Here we hypothesized that adenosine signaling through
Elizabeth K Joseph et al.
The journal of pain : official journal of the American Pain Society, 15(7), 771-777 (2014-05-06)
Endothelin-1 (ET-1) acts on endothelial cells to enhance mechanical stimulation-induced release of adenosine triphosphate (ATP), which in turn can act on sensory neurons innervating blood vessels to contribute to vascular pain, a phenomenon we have referred to as stimulus-dependent hyperalgesia
B M Al-Ali et al.
Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 67(1), 11-18 (2015-02-11)
Aim of the study was to analyze the relationship between erectile function and cardiovascular risk factors by assessing arterial stiffness and myocardial scintigraphy and carotid artery intima-media thickness. Fifty-nine consecutive asymptomatic men aged 30-86 years, were included. Myocardial scintigraphy, Doppler
Simon Nicolussi et al.
Biochemical pharmacology, 92(4), 669-689 (2014-10-07)
Besides the suggested role of a putative endocannabinoid membrane transporter mediating the cellular uptake of the endocannabinoid anandamide (AEA), this process is intrinsically coupled to AEA degradation by the fatty acid amide hydrolase (FAAH). Differential blockage of each mechanism is
Jignesh Bhavsar et al.
Clinical hemorheology and microcirculation, 44(3), 193-205 (2010-04-07)
Reperfusion injury and no-reflow phenomenon are known entities that contribute to persistent impairment in myocardial perfusion and regional myocardial dysfunction following restoration of epicardial coronary blood flow after a myocardial infarction. Following prolonged ischemia, oxidative stress and inflammation-mediated alterations in
Justyna Kusek et al.
Molecular pharmacology, 87(1), 39-51 (2014-10-31)
Cell-permeable orthosteric ligands can assist folding of G protein-coupled receptors in the endoplasmic reticulum (ER); this pharmacochaperoning translates into increased cell surface levels of receptors. Here we used a folding-defective mutant of human A1-adenosine receptor as a sensor to explore
Wolfgang G Eisert
Advances in cardiology, 47, 78-86 (2012-08-22)
The antithrombotic activity of dipyridamole was initially discovered in an in vivo experiment about half a century ago. At that time science had not appreciated the complexity of the regulation of local thrombus formation. Inhibition of platelets has been the
C D d'Esterre et al.
Annals of the New York Academy of Sciences, 1207, 71-75 (2010-10-20)
Currently, many stroke-prone individuals take antithrombotic drugs, which have known antiplatelet properties, to decrease stroke incidence. There is now evidence that this regimen could also reduce stroke severity through neuroprotective, nonplatelet mechanisms that include anti-inflammatory processes. Inflammation was found to
Ya Hui Tang et al.
Experimental neurology, 261, 417-423 (2014-07-25)
While transient ischemic attack (TIA) is a well-known harbinger of ischemic stroke, the mechanisms that link TIA to subsequent strokes remain poorly understood. The overall aim of this study was to determine whether: 1) brief periods of transient cerebral ischemia
Dipyridamole with aspirin is better than aspirin alone in preventing vascular events after ischaemic stroke or TIA.
Cathie Sudlow
BMJ (Clinical research ed.), 334(7599), 901-901 (2007-04-28)
E L L M De Schryver et al.
The Cochrane database of systematic reviews, (3)(3), CD001820-CD001820 (2007-07-20)
Patients with limited cerebral ischaemia of arterial origin are at risk of serious vascular events (4% to 11% annually). Aspirin reduces that risk by 13%. In one trial, adding dipyridamole to aspirin was associated with a 22% risk reduction compared
Sarah Dewilde et al.
Journal of clinical epidemiology, 65(8), 835-845 (2012-06-26)
To identify confounding factors that may explain the incoherence between direct and indirect evidence in a published analysis comparing extended-release dipyridamole (ERDP) plus aspirin to clopidogrel for the reduction of stroke. An existing analysis was updated with new studies from
Anna Maria Siebel et al.
Zebrafish, 12(2), 127-136 (2015-01-07)
Adenosine is a well-known endogenous modulator of neuronal excitability with anticonvulsant properties. Thus, the modulation exerted by adenosine might be an effective tool to control seizures. In this study, we investigated the effects of drugs that are able to modulate
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