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Iu N Perlamutrov et al.
Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury, (3)(3), 45-51 (2013-07-04)
The prevalence of cytomegalovirus infection (CMVI) dictates the necessity of its in-depth investigation in the patients presenting with the signs of chronic inflammatory diseases of sexual organs. The objective of the present study was to estimate the effectiveness of combined
Steve Ramirez et al.
Science (New York, N.Y.), 341(6144), 387-391 (2013-07-28)
Memories can be unreliable. We created a false memory in mice by optogenetically manipulating memory engram-bearing cells in the hippocampus. Dentate gyrus (DG) or CA1 neurons activated by exposure to a particular context were labeled with channelrhodopsin-2. These neurons were
Nobuaki Takahashi et al.
Molecular cell, 80(5), 828-844 (2020-11-01)
Cancer-associated mutations that stabilize NRF2, an oxidant defense transcription factor, are predicted to promote tumor development. Here, utilizing 3D cancer spheroid models coupled with CRISPR-Cas9 screens, we investigate the molecular pathogenesis mediated by NRF2 hyperactivation. NRF2 hyperactivation was necessary for
He Li et al.
Investigative ophthalmology & visual science, 54(7), 4675-4682 (2013-06-15)
Trachoma is a conjunctival scarring disease, which is the leading infectious cause of blindness worldwide. Elimination of blinding trachoma is being held back by the high rate of trichiasis recurrence following surgery. There is currently no treatment available to suppress
Yannick Bongrand et al.
The Canadian veterinary journal = La revue veterinaire canadienne, 53(10), 1109-1113 (2013-04-02)
An atypical case of Mycoplasma pneumonia with an unusual radiographic and computed tomographic pattern was diagnosed in a Siamese kitten. The cat showed no response to broad-spectrum antibiotic therapy including enrofloxacin. The administration of doxycycline led to a dramatic clinical
Eryn E Dixon et al.
Journal of cell science, 133(14) (2020-06-10)
Cystogenesis is a morphological consequence of numerous genetic diseases of the epithelium. In the kidney, the pathogenic mechanisms underlying the program of altered cell and tubule morphology are obscured by secondary effects of cyst expansion. Here, we developed a new
Lucile Delespaul et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(3), 857-867 (2016-08-17)
Despite various differences, nontranslocation-related sarcomas (e.g., comprising undifferentiated pleomorphic sarcoma, leiomyosarcoma, myxofibrosarcoma) are unified by their complex genetics. Extensive analysis of the tumor genome using molecular cytogenetic approaches showed many chromosomal gains, losses, and translocations per cell. Genomic quantitative alterations
Colin W Garvie et al.
Nature communications, 12(1), 4375-4375 (2021-07-18)
DNMDP and related compounds, or velcrins, induce complex formation between the phosphodiesterase PDE3A and the SLFN12 protein, leading to a cytotoxic response in cancer cells that express elevated levels of both proteins. The mechanisms by which velcrins induce complex formation
Gal Mazor et al.
Aging, 13(11), 14843-14861 (2021-06-12)
Aging is a factor associated with poor prognosis in glioblastoma (GBM). It is therefore important to understand the molecular features of aging contributing to GBM morbidity. TP73-AS1 is a long noncoding RNA (lncRNA) over expressed in GBM tumors shown to
J Delaloye et al.
Revue medicale suisse, 9(383), 879-884 (2013-05-24)
Q fever is a zoonosis caused by an intracellular Gram-negative bacteria, Coxiella burnetii. Animals are the main reservoir and transmission to men generally is occurring by inhalation of contaminated aerosols. Acute Q fever generally is benign and usually resolves spontaneously.
Nathan Robertson et al.
The Journal of biological chemistry, 295(52), 18436-18448 (2020-11-01)
Reliable, specific polyclonal and monoclonal antibodies are important tools in research and medicine. However, the discovery of antibodies against their targets in their native forms is difficult. Here, we present a novel method for discovery of antibodies against membrane proteins
Zihan Zhang et al.
International journal of molecular sciences, 22(22) (2021-11-28)
Immortalized cell lines have been used in a wide range of applications in research on immune disorders and cellular metabolic regulation due to the stability and uniformity of their cellular characteristics. At present, the investigation into molecular functions and signaling
Phu N Tran et al.
PloS one, 15(11), e0241362-e0241362 (2020-11-07)
Buprenorphine is a μ-opioid receptor (MOR) partial agonist used to manage pain and addiction. QTC prolongation that crosses the 10 msec threshold of regulatory concern was observed at a supratherapeutic dose in two thorough QT studies for the transdermal buprenorphine
Stuart L Johnson et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(21), 8720-8725 (2013-05-08)
The development of neural circuits relies on spontaneous electrical activity that occurs during immature stages of development. In the developing mammalian auditory system, spontaneous calcium action potentials are generated by inner hair cells (IHCs), which form the primary sensory synapse.
Maximilian W Popp et al.
Nature communications, 6, 6632-6632 (2015-03-27)
Nonsense-mediated mRNA decay (NMD) limits the production of aberrant mRNAs containing a premature termination codon and also controls the levels of endogenous transcripts. Here we show that when human cells are treated with clinically used chemotherapeutic compounds, NMD activity declines
Sean K Ryan et al.
Stem cell reports, 14(4), 703-716 (2020-03-30)
HIV-associated neurocognitive disorders (HAND) affect over half of HIV-infected individuals, despite antiretroviral therapy (ART). Therapeutically targetable mechanisms underlying HAND remain elusive, partly due to a lack of a representative model. We developed a human-induced pluripotent stem cell (hiPSC)-based model, independently
Adam W Whisnant et al.
Nature communications, 11(1), 2038-2038 (2020-04-29)
The predicted 80 open reading frames (ORFs) of herpes simplex virus 1 (HSV-1) have been intensively studied for decades. Here, we unravel the complete viral transcriptome and translatome during lytic infection with base-pair resolution by computational integration of multi-omics data.
Magdalena Gebert et al.
Cellular and molecular life sciences : CMLS, 78(21-22), 7061-7080 (2021-10-13)
Accumulation of misfolded proteins in ER activates the unfolded protein response (UPR), a multifunctional signaling pathway that is important for cell survival. The UPR is regulated by three ER transmembrane sensors, one of which is inositol-requiring protein 1 (IRE1). IRE1
Jae-Ho Lee et al.
Cancer research, 73(12), 3604-3614 (2013-05-02)
Dysregulated bone morphogenetic proteins (BMP) may contribute to the development and progression of renal cell carcinoma (RCC). Herein, we report that BMP-6 promotes the growth of RCC by interleukin (IL)-10-mediated M2 polarization of tumor-associated macrophages (TAM). BMP-6-mediated IL-10 expression in
Olof Torper et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(17), 7038-7043 (2013-03-27)
Cellular reprogramming is a new and rapidly emerging field in which somatic cells can be turned into pluripotent stem cells or other somatic cell types simply by the expression of specific combinations of genes. By viral expression of neural fate
Ryuta Tobe et al.
The Journal of biological chemistry, 288(21), 14709-14715 (2013-04-17)
Antibiotics target bacteria by interfering with essential processes such as translation, but their effects on translation in mammalian cells are less well characterized. We found that doxycycline, chloramphenicol, and Geneticin (G418) interfered with insertion of selenocysteine (Sec), which is encoded
Sean K Ryan et al.
STAR protocols, 1(3), 100190-100190 (2020-12-31)
This protocol establishes a tri-culture of hiPSC-derived neurons, astrocytes, and microglia for the study of cellular interactions during homeostasis, injury, and disease. This system allows for mechanistic studies that can identify the roles of individual cell types in disease and
Megan P Stogsdill et al.
American journal of respiratory cell and molecular biology, 49(1), 128-134 (2013-03-26)
Receptors for advanced glycation end-products (RAGE) are multiligand surface receptors detected abundantly in pulmonary tissue. Our previous work revealed increased RAGE expression in cells and lungs exposed to tobacco smoke and RAGE-mediated cytokine expression via proinflammatory mechanisms involving NF-κB. RAGE
Rapid desensitization to doxycycline.
Suran L Fernando et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 111(1), 73-74 (2013-06-29)
Valeria Manias et al.
Revista Argentina de microbiologia, 45(1), 50-53 (2013-04-09)
We herein present the case of an adult male patient who consulted for lower extremity edema, a 2- month history of fever and oppressive chest pain radiating to the left arm. He referred neither contact with breeding animals nor consumption
Benedetta Assetta et al.
Journal of visualized experiments : JoVE, (165) (2020-11-24)
In Alzheimer's disease (AD) and other neurodegenerative disorders, oligodendroglial failure is a common early pathological feature, but how it contributes to disease development and progression, particularly in the gray matter of the brain, remains largely unknown. The dysfunction of oligodendrocyte
Tianshu Li et al.
Oncotarget, 6(25), 21428-21442 (2015-05-31)
Krüppel-like factor 8 (KLF8) is a dual transcriptional factor critical for breast cancer progression. Epidermal growth factor receptor (EGFR) is frequently overexpressed in aggressive such as triple-negative breast cancer and associated with poor clinical outcomes. Here we report a novel
Alicia Anderson et al.
MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports, 62(RR-03), 1-30 (2013-03-29)
Q fever, a zoonotic disease caused by the bacterium Coxiella burnetii, can cause acute or chronic illness in humans. Transmission occurs primarily through inhalation of aerosols from contaminated soil or animal waste. No licensed vaccine is available in the United
Evgenia Leikina et al.
Developmental cell, 46(6), 767-780 (2018-09-11)
Classic mechanisms for membrane fusion involve transmembrane proteins that assemble into complexes and dynamically alter their conformation to bend membranes, leading to mixing of membrane lipids (hemifusion) and fusion pore formation. Myomaker and Myomerger govern myoblast fusion and muscle formation
Songlei Liu et al.
Nucleic acids research, 49(10), e58-e58 (2021-03-12)
We present barcoded oligonucleotides ligated on RNA amplified for multiplexed and parallel insitu analyses (BOLORAMIS), a reverse transcription-free method for spatially-resolved, targeted, in situ RNA identification of single or multiple targets. BOLORAMIS was demonstrated on a range of cell types
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