D33454

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Suppression of pro-inflammatory and proliferative pathways by diferuloylmethane (curcumin) and its analogues dibenzoylmethane, dibenzoylpropane, and dibenzylideneacetone: role of Michael acceptors and Michael donors.

Preetha Anand et al.

Biochemical pharmacology, 82(12), 1901-1909 (2011-09-20)

Curcumin, a diferuloylmethane, has been shown to exhibit anti-inflammatory and anti-proliferative activities. Whereas curcumin has both a Michael acceptor and a Michael donor units, its analogues dibenzoylmethane (DBM, a component of licorice) and dibenzoylpropane (DBP) have a Michael donor but

A glimpse of the inner workings of the templated site.

Christopher J Allender et al.

Chemical communications (Cambridge, England), (2)(2), 165-167 (2008-12-23)

This is the first direct experimental probe, using EXAFS, of the active site within molecularly imprinted polymers and paves the way to a more detailed understanding of the inner workings of molecular imprinting.

Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse.

Guoxiang Shen et al.

Cancer research, 67(20), 9937-9944 (2007-10-19)

Cancer chemopreventive agent sulforaphane (SFN) and dibenzoylmethane (DBM) showed antitumorigenesis effects in several rodent carcinogenesis models. In this study, we investigated the cancer chemopreventive effects and the underlying molecular mechanisms of dietary administration of SFN and DBM alone or in

Exploring polylactide/poly(butylene adipate-co-terephthalate)/rare earth complexes biodegradable light conversion agricultural films.

Yinlei Yu et al.

International journal of biological macromolecules, 127, 210-221 (2019-01-15)

In this work, rare earth europium was combined with different organic ligands to obtain two kinds of rare earth conversion agents, Eu(DBM)4CPC and Eu(TTA)3(TPPO)2. Two kinds of conversion films were successfully prepared by combining them with polylactide and poly(butylene adipate-co-terephthalate).

N3-Ligated nickel(ii) diketonate complexes: synthesis, characterization and evaluation of O2 reactivity.

Josiah G D Elsberg et al.

Dalton transactions (Cambridge, England : 2003), 49(22), 7564-7575 (2020-05-28)

Interest in O2-dependent aliphatic carbon-carbon (C-C) bond cleavage reactions of first row divalent metal diketonate complexes stems from the desire to further understand the reaction pathways of enzymes such as DKE1 and to extract information to develop applications in organic

Mechanisms of apoptotic effects induced by resveratrol, dibenzoylmethane, and their analogues on human lung carcinoma cells.

Chia-Jui Weng et al.

Journal of agricultural and food chemistry, 57(12), 5235-5243 (2009-05-16)

While lung cancer accounts for approximately 20% of cancer diagnoses, it is the leading cause of tumor-related deaths. The apoptotic effects of 3,5,4'-trihydroxystilbene (resveratrol), dibenzoylmethane (DBM), and their analogues on human lung cancer cells are generally unclear. The aims of

Ornithine decarboxylase prevents dibenzoylmethane-induced apoptosis through repressing reactive oxygen species generation.

Chih-Lung Wu et al.

Journal of biochemical and molecular toxicology, 25(5), 312-319 (2011-04-28)

Dibenzoylmethane (DBM) belongs to the flavonoid family and is a minor constituent of the root extract of licorice and the β-diketone analogue of curcumin. It exhibits antimutagenic, anticancer, and chemopreventive effects. Ornithine decarboxylase (ODC), the rate-limiting enzyme of the polyamine

Dietary feeding of dibenzoylmethane inhibits prostate cancer in transgenic adenocarcinoma of the mouse prostate model.

Tin Oo Khor et al.

Cancer research, 69(17), 7096-7102 (2009-08-27)

Dibenzoylmethane (DBM), a minor beta-diketone constituent of licorice, has been shown to exhibit antineoplastic effects in prostate cancer cell lines by induction of cell cycle arrest and regulation of androgen receptor expression. In the present study, we investigated the in

Cytotoxic Half-Sandwich Rh(III) and Ir(III) β-Diketonates.

Agnese Petrini et al.

Inorganic chemistry, 56(21), 13600-13612 (2017-10-21)

A series of half-sandwich pentamethylcyclopentadienyl rhodium(III) and iridium(III) complexes [Cp*M(DBM/HDB/AVB)Cl] and [Cp*M(DBM/HDB/AVB)(PTA)][SO

Imaging of hypoxia-inducible factor 1α and septin 9 interaction by bimolecular fluorescence complementation in live cancer cells.

Maya Golan et al.

Oncotarget, 8(19), 31830-31841 (2017-04-06)

Hypoxia-inducible factor 1 (HIF-1) is a major mediator of the hypoxic response involved in tumor progression. We had earlier described the interaction between septin 9 isoform 1 (SEPT9_i1) protein and the oxygen-regulated subunit, HIF-1α. SEPT9_i1 is a member of the

One-pot synthesis of highly conjugated benzofuran derivatives based on electrochemical oxidation of benzenediols in the presence of dibenzoylmethane.

Mohammad Rafiee et al.

Chemical & pharmaceutical bulletin, 55(6), 915-917 (2007-06-02)

Electrochemical oxidation of benzenediols (1--4) has been studied in the presence of dibenzoylmethane (5) as a nucleophile using cyclic voltammetry and controlled-potential coulometry. The results indicate that the electrochemically generated quinones participate in Michael addition reaction with 5 via various

Synthesis and properties of a new red luminescence europium complex containing a 2-(benzimidazol-2-yl)-8-octyloxyquinoline as the second ligand.

Shanji Li

Luminescence : the journal of biological and chemical luminescence, 27(3), 242-245 (2011-09-08)

A new Eu(III) complex, Eu(III)(DBM)(3) BIOQ, has been synthesized with dibenzoylmethane (DBM) as the first ligand and 2-(benzimidazol-2-yl)-8-octyloxyquinoline (BIOQ) as the second ligand. The stability of the complex was analysed by DSC-TG. The results show that the Eu(III) complex has

Dibenzoylmethane, a Component of Licorice, Suppresses Monocyte-to-Macrophage Differentiation and Inflammatory Responses in Human Monocytes and Mouse Macrophages.

Bobin Kang et al.

Biological & pharmaceutical bulletin, 41(8), 1228-1236 (2018-08-03)

The objective of this study was to investigate the effect of dibenzoylmethane (DBM) on monocyte-to-macrophage differentiation, the inflammatory response, and the resulting signaling in human monocytes and murine macrophage. DBM effectively inhibited the monocyte-to-macrophage differentiation induced by phorbol 12-myristate 13-acetate

Optical properties and spectroscope parameters of Sm(DBM)(3)Phen-doped poly(methyl methacrylate).

Zhaogang Nie et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 72(3), 554-560 (2008-12-17)

Rare-earth complex Sm(DBM)(3)Phen-doped poly(methyl methacrylate) was synthesized and its absorption and luminescence spectra were studied. The relationship between the coordinate environment of rare-earth ions and the Judd-Ofelt intensity parameter Omega(2) was analyzed and the spectroscopic quality factor, Omega(4)/Omega(6), for this

Luminescence properties of the Ln-EDTA complexes covalently linked to the chitosan biopolymers containing β-diketonate as antenna ligands.

Israel F Costa et al.

Luminescence : the journal of biological and chemical luminescence, 35(3), 365-372 (2020-01-18)

This paper reports on the preparation, characterization, and photoluminescence properties of novel hybrid materials, in which the EDTA-Ln-L complexes (where L: H2 O, acac, bzac, dbm, and tta ligands, and Ln: Eu, Gd, and Tb) were covalently linked to the

Suppression of androgen receptor expression by dibenzoylmethane as a therapeutic objective in advanced prostate cancer.

Kimberly M Jackson et al.

Anticancer research, 27(3B), 1483-1488 (2007-06-29)

The androgen receptor (AR) plays an important role in the development and progression of prostate cancer. Functional AR expression persists in most cases of hormone-refractory prostate cancer and may play a role clinically in the progression from hormone-responsive to hormone-refractory

A novel PVC-membrane optical sensor for highly sensitive and selective determination of UO2(2+) ion based on a recently synthesized benzo-substituted macrocyclic diamide and dibenzoylmethane.

Mojtaba Shamsipur et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 77(1), 319-323 (2010-07-17)

A highly sensitive ion-selective bulk optode membrane for sensing UO2(2+) ion based on plasticized poly(vinyl chloride) containing 6,7,9,10,12,13,15,16,23,24,25,26-dodecahydrodibenzo[n,v][1,4,7,10,13,17,20]pentaoxa-diazacyclotricosine-22,27-dione as ionophore, dibenzodylmethane as chromoionophore and sodium tetraphenylborate as an ionic additive was prepared. In addition to its high stability, reproducibility and

Differential in vivo mechanism of chemoprevention of tumor formation in azoxymethane/dextran sodium sulfate mice by PEITC and DBM.

Ka Lung Cheung et al.

Carcinogenesis, 31(5), 880-885 (2009-12-05)

Previously, phenethyl isothiocyanate (PEITC) and dibenzoylmethane (DBM) had been shown to inhibit intestinal carcinogenesis in Apc(Min/+) mice. In this study, we investigated the chemopreventive efficacy of PEITC and DBM in the azoxymethane (AOM)-initiated and dextran sodium sulfate (DSS)-promoted colon cancer

Dibenzoylmethane activates Nrf2-dependent detoxification pathway and inhibits benzo(a)pyrene induced DNA adducts in lungs.

R K Thimmulappa et al.

Medicinal chemistry (Shariqah (United Arab Emirates)), 4(5), 473-481 (2008-09-11)

Cigarette smoke derived carcinogens have been identified as the main agents implicated in lung carcinogenesis. Epidemiological as well as animal studies have indicated that certain phytochemicals can block the carcinogenic process by enhancing the detoxification of environmental and or dietary

Pharmacokinetics of dietary cancer chemopreventive compound dibenzoylmethane in rats and the impact of nanoemulsion and genetic knockout of Nrf2 on its disposition.

Wen Lin et al.

Biopharmaceutics & drug disposition, 32(2), 65-75 (2011-02-23)

The pharmacokinetic disposition of a dietary cancer chemopreventive compound dibenzoylmethane (DBM) was studied in male Sprague-Dawley rats after intravenous (i.v.) and oral (p.o.) administrations. Following a single i.v. bolus dose, the mean plasma clearance (CL) of DBM was low compared

Dietary phytochemicals induce p53- and caspase-independent cell death in human neuroblastoma cells.

Sangeetha Sukumari-Ramesh et al.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 29(7), 701-710 (2011-06-28)

Neuroblastoma (NB) is the most prevalent pediatric solid tumor and a leading cause of cancer-related death in children. In the present study, a novel cytotoxic role for the dietary compounds, curcumin, andrographolide, wedelolactone, dibenzoylmethane, and tanshinone IIA was identified in

Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of new potent hormone sensitive lipase inhibitors.

Mutasem O Taha et al.

Journal of medicinal chemistry, 51(20), 6478-6494 (2008-09-24)

Hormone sensitive lipase (HSL) has been recently implicated in diabetes and obesity, prompting attempts to discover new HSL inhibitors. Toward this end, we explored the pharmacophoric space of HSL inhibitors using four diverse sets of compounds. Subsequently, genetic algorithm and

Transient enol isomers of dibenzoylmethane and avobenzone as efficient hydrogen donors toward a nitroxide pre-fluorescent probe.

Alexis Aspée et al.

Photochemistry and photobiology, 83(3), 481-485 (2006-11-11)

Dibenzoylmethane and avobenzone photochemistry involves the formation of transient enol isomers (Z and E). Conjugation of the OH group with the carbonyl group in these transient isomers reduces the OH bond energy. A fast reduction of the pre-fluorescent probe (C343T)

Influence of substituent on UV absorption and keto-enol tautomerism equilibrium of dibenzoylmethane derivatives.

Jan Zawadiak et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 96, 815-819 (2012-08-29)

UV absorption spectra of dibenzoylmethane and its 23 derivatives with acetamide, tert-butyl, chloride, fluoride, hydroxyl, methyl, methoxy and nitro substituents in aromatic rings were collected. General influence of substituent on absorption maxima and absorption intensity was defined. Hyperchromic effects were

Efficacy of dibenzoylmethane derivatives in protecting against endoplasmic reticulum stress and inhibiting nuclear factor kappa B on dextran sulfate sodium induced colitis in mice.

Rika Murakami et al.

Biological & pharmaceutical bulletin, 33(12), 2029-2032 (2010-12-09)

We recently reported that some dibenzoylmethane (DBM) derivatives have a protective effect against endoplasmic reticulum (ER) stress and inhibit nuclear factor kappa B (NF-κB). The aim of this study was to evaluate the effect of DBM derivatives against dextran sulfate

Development and validation of an HPLC method for the determination of dibenzoylmethane in rat plasma and its application to the pharmacokinetic study.

Guoxiang Shen et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 852(1-2), 56-61 (2007-01-24)

A highly sensitive and simple high-performance liquid chromatographic (HPLC) assay has been developed and validated for the quantification of dibenzoylmethane (DBM) in rat plasma. DBM and internal standard (I.S.) 1-(5-chloro-2-hydroxy-4-methylphenyl)-3-phenyl-1,3-propanedione (CHMPP) were extracted from rat plasma by ethyl acetate/methanol (95:5

Copper(II) as a Platform for Probing the Steric Demand of Bulky β-Diketonates.

Alec T Larson et al.

Inorganic chemistry, 59(1), 423-432 (2019-12-17)

The synthesis and characterization of a series of copper bis(β-diketonate) complexes, functionalized with sterically hindered o-biphenyl and m-terphenyl functional groups, are reported. X-ray structural analysis reveals that the ligands exhibit several modes of flexibility in order to accommodate the steric

Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells.

Miguel López-Lázaro et al.

Journal of natural products, 70(12), 1884-1888 (2007-12-14)

Recent data suggest that curcumin, a phytochemical with cancer chemopreventive potential, might be useful in the treatment of several solid and hematological malignancies. DNA topoisomerases (topos) are the target of several drugs commonly used in cancer chemotherapy. These drugs induce

Reversible modulation in luminescence intensity of a single vesicle composed of diblock azo-copolymer and tris(dibenzoylmethanate)(phenanthroline)europium(III).

Qing Yan et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 71(5), 1644-1647 (2008-07-29)

Tris(dibenzoylmethanate)(phenanthroline)europium(III)[Eu(DBM)(3)Phen]-doped amphiphilic vesicles were obtained by self-assembling of poly(N-isopropylacrylamide)-b-poly[6-[4-(4-methylphenyl-azo) phenoxy] hexylacrylate] (PNIPAM(83)-b-PAzoM(20)) in presence of Eu(DBM)(3)Phen in the mixed solvent of THF/H(2)O (50/50 vol.%). Their optical properties were studied by UV-vis and fluorescence spectroscopies. The UV-vis spectrum showed that the

A strategy to achieve efficient dual-mode luminescence in lanthanide-based magnetic hybrid nanostructure and its demonstration for the detection of latent fingerprints.

Praveen K Shahi et al.

Journal of colloid and interface science, 491, 199-206 (2016-12-28)

We have synthesized a novel inorganic-organic hybrid nanostructure (IOHN) composed of fluoride nanophosphor (NaGd

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