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Jun Zeng et al.
Journal of cellular and molecular medicine, 25(16), 7809-7824 (2021-06-29)
Intracerebral hemorrhage (ICH) can induce intensively oxidative stress, neuroinflammation, and brain cell apoptosis. However, currently, there is no highly effective treatment available. Puerarin (PUE) possesses excellent neuroprotective effects by suppressing the NF-κB pathway and activating the PI3K/Akt signal, but its
Caterina Peraldo-Neia et al.
BMC cancer, 14, 918-918 (2014-12-07)
Standard chemotherapy in unresectable biliary tract carcinoma (BTC) patients is based on gemcitabine combined with platinum derivatives. However, primary or acquired resistance is inevitable and no second-line chemotherapy is demonstrated to be effective. Thus, there is an urgent need to
Geng Jia et al.
OncoTargets and therapy, 8, 303-311 (2015-02-13)
Tubeimoside-1 (TBMS1) is a natural compound isolated from tubeimoside, which has been widely used as a traditional Chinese herbal medicine. The purpose of the present study is to investigate the anti-tumor effect and the underling mechanism of TBMS1 on glioma
Sixian Liang et al.
Oncotarget, 6(2), 1020-1030 (2014-12-30)
Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer for which there is no effective treatment. Previously, we and others demonstrated that CXCR4 surface expression is an independent prognostic factor for disease relapse and survival in breast cancer.
M A Javidi et al.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 123(10), 632-636 (2015-07-17)
One of the major obstacles needed to be overcome before using cell therapy for clinical purposes is the high probability of tumor formation in patients who receive the transplants, as undifferentiated stem cells (SCs) have the potential to form teratomas/teratocarcinoma
Simone Di Franco et al.
STAR protocols, 2(4), 100880-100880 (2021-10-30)
Cancer stem cells (CSCs) play a key role in tumor initiation and progression. A real-time tool to evaluate the activation of CSC-specific signaling pathways is crucial for the study of this cancer cell subset. Here, we present a protocol to monitor
Molly Dore et al.
Cancer management and research, 13, 7871-7884 (2021-10-28)
Endometrial cancer (EC) is the most common gynaecologic malignancy in the developed world, and incidence is increasing in premenopausal women. The levonorgestrel intrauterine system (LNG-IUS) is gaining traction as an alternative treatment for hyperplasia and early-stage EC for women who
Xiao-Lan Li et al.
Oncotarget, 6(34), 36689-36699 (2015-10-10)
PRIMA-1met (APR-246) is a methylated derivative and structural analog of PRIMA-1 (p53 re-activation and induction of massive apoptosis). PRIMA-1met has been reported to restore both the wild type (wt) structure and function of mutant p53. Here, we show that PRIMA-1met
Terézia Kisková et al.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 23(6), 506-513 (2014-09-26)
Resveratrol and celecoxib were used as chemopreventive agents in animal models of carcinogenesis, and exert antiproliferative and proapoptotic effects on cancer cells. Therefore, the aim of this study was to evaluate whether combining resveratrol with celecoxib may exert more potent
Rohit Shetty et al.
Investigative ophthalmology & visual science, 56(2), 738-750 (2015-02-05)
The present study was designed to understand the role of inflammatory cytokines secreted by corneal epithelial cells in keratoconus (KC) and the response to treatment with cyclosporine A (CyA). The study involved 129 Indian KC patients clinically graded according to
Debasis Nayak et al.
Materials science & engineering. C, Materials for biological applications, 58, 44-52 (2015-10-20)
In the current investigation we report the biosynthesis potentials of bark extracts of Ficus benghalensis and Azadirachta indica for production of silver nanoparticle without use of any external reducing or capping agent. The appearance of dark brown color indicated the
Camelia Ungureanu et al.
Bioelectrochemistry (Amsterdam, Netherlands), 107, 14-24 (2015-09-29)
Implant-associated infections are a major cause of morbidity and mortality. This study was performed using titanium samples coated by anodization with a titanium dioxide (TiO2) shielded nanotube layer. TiO2/Ti surface was modified by simple immersion in torularhodin solution and by
Birendra Behera et al.
Environmental toxicology and pharmacology, 38(1), 288-296 (2014-07-08)
Anticancer and immunostimulatory properties of tryptic digest peptides of Abrus precatorius agglutinin protein (10kDAGP) have already been reported. Here attempt has been made to further validate anticancer properties of 10kDAGP peptides in Ehrlich's ascites carcinoma (EAC) and B16 melanoma (B16M)
Dave J Koss et al.
Cellular and molecular life sciences : CMLS, 72(23), 4613-4632 (2015-06-14)
Patients suffering from tauopathies including frontotemporal dementia (FTD) and Alzheimer's disease (AD) present with intra-neuronal aggregation of microtubule-associated protein Tau. During the disease process, Tau undergoes excessive phosphorylation, dissociates from microtubules and aggregates into insoluble neurofibrillary tangles (NFTs), accumulating in
Ulrike Klenke et al.
Endocrinology, 155(5), 1851-1863 (2014-02-26)
Metabolic dysfunctions are often linked to reproductive abnormalities. Adiponectin (ADP), a peripheral hormone secreted by white adipose tissue, is important in energy homeostasis and appetite regulation. GnRH neurons are integral components of the reproductive axis, controlling synthesis, and release of
Aurelie Vivares et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(1), 29-44 (2014-07-30)
1. The quantitative prediction of the pharmacokinetic parameters of a drug from data obtained using human in vitro systems remains a significant challenge i.e. prediction of metabolic clearance in humans and estimation of the relative contribution of enzymes involved in
Tessa Gargett et al.
Cytotherapy, 17(4), 487-495 (2015-01-13)
Chimeric antigen receptor (CAR) T cells are a novel immunotherapy for cancer. To achieve anti-tumor efficacy, these cells must survive, expand, and persist after infusion into patients, functions that are reportedly best achieved by cells with a stem or central-memory
Amitabh Das et al.
Scientific reports, 5, 16932-16932 (2015-11-20)
Persistent macrophage activation is associated with the expression of various pro-inflammatory genes, cytokines and chemokines, which may initiate or amplify inflammatory disorders. A novel synthetic BET inhibitor, JQ1, was proven to exert immunosuppressive activities in macrophages. However, a genome-wide search
Enrica Borsi et al.
Oncotarget, 5(7), 1779-1792 (2014-04-16)
The increasing importance of hypoxia-inducible factor-1α (HIF-1α) in tumorigenesis raises the possibility that agents which specifically inhibit this transcription factor, would provide significant therapeutic benefit. The constitutive expression of HIF-1α in about 35% of Multiple Myeloma (MM) patients suggests HIF-1α
Qingmei Liu et al.
International immunopharmacology, 25(2), 465-473 (2015-03-10)
The prevalence of food allergy has increased in Asian countries. Marine algae have been proposed as the potential resource for anti-allergic therapeutics. The present study was aimed at isolating R-phycocyanin (RPC) from Porphyra haitanensis and determining the anti-allergy potential of
Yuan Lu et al.
Applied biochemistry and biotechnology, 177(5), 1164-1175 (2015-08-19)
Interferon (IFN)-λ, also known as IL-28A, IL-28B, or IL-29, is a new type III IFN, which shares many functional characteristics with type I IFN (α/β). Currently, IFN-α is used in the treatment of certain forms of cancer with severe adverse
Xiaohong Du et al.
PloS one, 9(7), e103016-e103016 (2014-07-23)
Methoxychlor (MXC), an organochlorine pesticide, has adverse effects on male reproduction at toxicological doses. Humans and wild animals are exposed to MXC mostly through contaminated dietary intake. Higher concentrations of MXC have been found in human milk, raising the demand
Ryan L O'Hare Doig et al.
Experimental neurology, 261, 136-146 (2014-06-17)
Secondary degeneration contributes substantially to structural and functional deficits following traumatic injury to the CNS. While it has been proposed that oxidative stress is a feature of secondary degeneration, contributing reactive species and resultant oxidized products have not been clearly
Tilman Läppchen et al.
European journal of medicinal chemistry, 89, 279-295 (2014-12-03)
Calixarene 0118 is a potent anti-angiogenic agent that effectively inhibited tumor growth in preclinical studies, and is currently being evaluated in a phase I clinical trial. We have designed two close mimetics of calixarene 0118 containing a terminal alkynyl-functional group
Akiva N Rappaport et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(47), 15568-15581 (2015-11-27)
Learning of novel information, including novel taste, requires activation of neuromodulatory transmission mediated, for example, by the muscarinic acetylcholine receptors (mAChRs) in relevant brain structures. In addition, drugs enhancing the function of mAChRs are used to treat memory impairment and
Auemphon Mordmuang et al.
Nutrients, 7(10), 8503-8517 (2015-10-27)
Bovine mastitis is one of the most important infectious diseases in dairy herds, and staphylococci are the most important etiologic agents of this disease. Antibiotics and chemical agents used in livestock for prevention and cure of the disease can accumulate
Ana Casadó et al.
Journal of pharmaceutical sciences, 103(10), 3127-3138 (2014-08-06)
The effect of the lipid composition on the physicochemical properties of a liposomal carrier containing irinotecan (CPT-11) and its in vitro antitumoral activity on a colon cancer cell line has been investigated. The paper describes the procurement of a novel
Wu-Chao Wang et al.
Life sciences, 122, 100-107 (2014-12-24)
Phagocytosis plays essential roles during inflammation and immune response. This study aims to explore the underlying mechanism of corticotropin-releasing hormone (CRH) and urocortin (UCN)-promoted phagocytosis of rat macrophages. To induce phagocytosis, rat macrophages were incubated with carboxylated fluorescent microspheres. The
Jakob Schöttle et al.
Oncotarget, 6(36), 38458-38468 (2015-11-06)
Treatment with EGFR kinase inhibitors improves progression-free survival of patients with EGFR-mutant lung cancer. However, all patients with initial response will eventually acquire resistance and die from tumor recurrence. We found that intermittent high-dose treatment with erlotinib induced apoptosis more
Fen Hu et al.
PloS one, 9(9), e107217-e107217 (2014-09-26)
The local concentration of extracellular Ca(2+) ([Ca(2+)]o) in bone microenvironment is accumulated during bone remodeling. In the present study we investigated whether elevating [Ca(2+)]o induced store-operated calcium entry (SOCE) in primary rat calvarial osteoblasts and further examined the contribution of
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