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IDENTIFICATION OF ALLODEOXYCHOLIC ACID AS THE MAJOR COMPONENT OF GALLSTONES INDUCED IN THE RABBIT BY 5-ALPHA-CHOLESTAN-3-BETA-OL.
A F HOFMANN et al.
The Journal of biological chemistry, 239, 2813-2821 (1964-09-01)
Gerd Liebezeit et al.
Bulletin of environmental contamination and toxicology, 85(6), 585-588 (2010-11-17)
To follow faecal pollution steroid compounds have been analysed in 106 sediment samples from the Siak River, E Sumatra, Indonesia. Coprostanol was detected in 40 of these. Contents ranged from 50 to 10,530 ng/g d.w. with a mean of 878
Monika Ostrowska et al.
Neurologia i neurochirurgia polska, 45(6), 600-603 (2012-01-04)
A 34-year-old patient demonstrating pyramidal and cerebellar signs, accompanied by epilepsy, peripheral neuropathy, mental retardation and bilateral cataract was diagnosed with cerebrotendinous xanthomatosis based on the clinical picture, magnetic resonance imaging of the brain and serum sterol analysis. Tendon xanthomas
Claudia Fuentealba et al.
Food chemistry, 232, 664-672 (2017-05-12)
Walnuts (Juglans regia L.) are well known for their flavour, nutritional and health properties. The light colour of walnuts is a quality attribute that leads to consumer preference. The aim of this study was to correlate attributes such as colour
Branko S Jursic et al.
Bioorganic & medicinal chemistry letters, 20(24), 7372-7375 (2010-11-03)
Synthetic modifications of cholesterol and other traditional steroid molecules have become a promising area for the exploration and development of novel antifungal agents, especially with respect to the development of fatty-acid esters of steroids. In addition, 2,3-functionalized steroids are also
Kyrill S Rogacev et al.
Clinical journal of the American Society of Nephrology : CJASN, 7(6), 943-948 (2012-03-31)
Recent clinical trials on cholesterol-lowering in patients with CKD yielded conflicting results, which might have resulted from different treatment strategies. Serum cholesterol levels are determined by endogenous synthesis and intestinal absorption, which are differentially influenced by various classes of cholesterol-lowering
César C Martins et al.
Environmental pollution (Barking, Essex : 1987), 188, 71-80 (2014-02-22)
Babitonga Bay is a South Atlantic estuary with significant ecological function; it is part of the last remaining areas of mangrove communities in the Southern Hemisphere. The aim of this study was to determine the spatial distribution of the faecal
Bruce K Hope et al.
The Science of the total environment, 417-418, 263-272 (2012-01-17)
Oregon's Senate Bill 737, enacted in 2007, required the state's 52 largest municipal wastewater treatment plants (WWTP) and water pollution control facilities (WPCF) to collect effluent samples in 2010 and analyze them for persistent organic pollutants. These facilities are located
Estelle Wolff et al.
The Journal of nutrition, 141(10), 1791-1798 (2011-08-26)
LDL-cholesterol (LDL-C) reduction may be achieved by various types of prudent diets, but their effects on surrogate markers of cholesterol absorption and synthesis have not been well studied in humans. We aimed to assess whether the extent of cholesterol absorption
Matthew G K Benesch et al.
Chemistry and physics of lipids, 164(1), 62-69 (2010-11-09)
It is commonly believed that all membrane sterols are rigid all-trans ring systems with a fully extended alkyl side-chain and that they similarly influence phospholipid bilayer physical properties. Here, we report the sterol concentration-dependent, thermotropic phase behaviour of binary dipalmitoylphosphatidylcholine
Benjamin L Stottrup et al.
Biophysical journal, 90(9), 3176-3183 (2006-02-08)
We investigate the miscibility phase behavior of lipid monolayers containing a wide variety of sterols. Six of the sterols satisfy a definition from an earlier study of "membrane-active sterols" in bilayers (cholesterol, epicholesterol, lathosterol, dihydrocholesterol, ergosterol, and desmosterol), and six
Anetta Kuczyńska et al.
Plant physiology and biochemistry : PPB, 141, 215-224 (2019-06-11)
Plants are usually exposed to several types of abiotic stress in regular field conditions. The lipid profile of barley homozygous lines exposed to drought, heat, salinity, and their combinations, was investigated in the present study. Free fatty acids, free sterols
Kimiyasu Isobe et al.
Journal of bioscience and bioengineering, 95(3), 257-263 (2005-10-20)
Cholesterol oxidase (CHO) with high stability in detergents was found from an isolated strain, Y-134, belonging to the gamma-subclass of Proteobacteria. CHO production reached its maximum by incubation at 30 degrees C for 12 d. It was purified from cell-free
J Giacometti
The Analyst, 126(4), 472-475 (2001-05-09)
In general, analyses for aliphatic alcohols, sterols and tocopherols in vegetable oils are performed separately. A simple and reliable procedure is presented for the quantification of the alkanols, squalene, alpha-tocopherol and sterols in olive oils by a direct method involving
M Derrien et al.
Water research, 46(13), 4009-4016 (2012-06-08)
Improving the microbiological quality of coastal and river waters relies on the development of reliable markers that are capable of determining sources of fecal pollution. Recently, a principal component analysis (PCA) method based on six stanol compounds (i.e. 5β-cholestan-3β-ol (coprostanol)
G Lupattelli et al.
Nutrition, metabolism, and cardiovascular diseases : NMCD, 21(9), 620-627 (2011-08-23)
Investigating cholesterol metabolism, which derives from balancing cholesterol synthesis and absorption, opens new perspectives in the pathogenesis of dyslipidemias and the metabolic syndrome (MS). Cholesterol metabolism is studied by measuring plasma levels of campesterol, sitosterol and cholestanol, that is, plant
Michel R Hoenig et al.
Atherosclerosis, 184(2), 247-254 (2005-10-12)
Statins have been the mainstay of lipid-lowering therapy since their introduction. However, as lower LDL cholesterol targets are sought, adjunct therapies are becoming increasingly important. Few patients reach new targets with statin monotherapy. We propose that the cholestanol:cholesterol ratio can
Apinya Jusakul et al.
Mutation research, 731(1-2), 48-57 (2011-11-03)
Oxysterols are cholesterol oxidation products that are generated by enzymatic reactions through cytochrome P450 family enzymes or by non-enzymatic reactions involving reactive oxygen and nitrogen species. Oxysterols have been identified in bile in the setting of chronic inflammation, suggesting that
Richard J Delle Bovi et al.
Biochimica et biophysica acta. Biomembranes, 1861(4), 819-826 (2019-01-27)
The plasma membrane is a dynamic environment with a complex composition of lipids, proteins, and cholesterol. Areas enriched in cholesterol and sphingolipids are believed to form lipid rafts, domains of highly ordered lipids. The unique physical properties of these domains
Eric J Niesor et al.
Atherosclerosis, 219(2), 761-767 (2011-10-11)
Subjects with high HDL-C show elevated plasma markers of cholesterol absorption and reduced markers of cholesterol synthesis. We evaluated the effect of dalcetrapib, a cholesteryl ester transfer protein modulator, on markers of cholesterol homeostasis in healthy subjects. Dalcetrapib was administered
B Pilo de la Fuente et al.
Neurologia (Barcelona, Spain), 26(7), 397-404 (2011-02-25)
cerebrotendinous xanthomatosis (CTX) is an autosomal recessive disease caused by a deficiency of mitochondrial enzyme sterol 27-hydrolylase. Such a deficiency results in a reduced production of chenodeoxycholic acid and in an increased formation of cholestanol. It is clinically characterized by
Bungo Shirouchi et al.
Cytotechnology, 72(1), 175-187 (2020-01-15)
Nuclear receptors, such as liver X receptors (LXRs) and sterol regulatory element-binding proteins (SREBPs), are key regulators of lipogenic genes, including fatty acid synthase (FASN). It has been reported that several oxycholesterols (OCs) act as LXR ligands; however, it is
Kotaro Nochioka et al.
Circulation journal : official journal of the Japanese Circulation Society, 76(8), 2023-2030 (2012-05-30)
Ezetimibe is an inhibitor of cholesterol absorption in the intestine. We examined whether ezetimibe improves endothelial function, and if so, what mechanisms are involved. Nineteen healthy subjects (male/female 14/5; mean age, 31±3 [SD] years-old) were randomized to receive ezetimibe (10mg/day)
Daniel Balleza et al.
Biophysical journal, 116(3), 503-517 (2019-01-23)
Understanding the lateral organization of biological membranes plays a key role on the road to fully appreciate the physiological functions of this fundamental barrier between the inside and outside regions of a cell. Ternary lipid bilayers composed of a high
S Grasso et al.
Food science and technology international = Ciencia y tecnologia de los alimentos internacional, 22(8), 743-751 (2016-05-12)
Low-fat meat products could be excellent carriers for plant sterols, known for their cholesterol-lowering properties. In this study, we developed a protocol for the manufacture of a deli-style turkey enriched with plant sterols (S) at a level sufficient to deliver
Yousuke Seyama
Journal of medicinal food, 6(3), 217-224 (2003-10-31)
Cholestanol, not cholesterol, is a minor component in the human body and in foods, but an increase in cholestanol concentration in serum induces a pathological condition named cerebrotendinous xanthomatosis (CTX). In our investigation of this disease for more than 25
Claudia Gutterres Vilela et al.
Marine pollution bulletin, 62(10), 2055-2074 (2011-08-30)
Rodrigo de Freitas Lagoon, located in the Rio de Janeiro City, receives several types of polluted discharges. The knowledge of the sediment microfauna correlated with heavy metal and organic matter concentrations could supply important data about the conditions of the
Yajaira Suárez et al.
Biochimica et biophysica acta, 1734(2), 203-213 (2005-05-21)
Cholesterol is a major component of the plasma membrane in mammalian cells, where it acts as a modulator of bulk physical state and integrity. In addition to its structural role, cholesterol is essential for proliferation and other cell processes. The
T Inoue et al.
Journal of clinical pharmacy and therapeutics, 36(1), 103-110 (2011-01-05)
Telmisartan, an angiotensin II type 1 receptor blocker (ARB), acts as a partial agonist for peroxisome proliferator-activated receptor-γ, and thus improves abnormalities of glucose metabolism and hypertriglyceridaemia in addition to its documented blood pressure-lowering effects. Recently, it has been demonstrated
Morgane Derrien et al.
Journal of agricultural and food chemistry, 59(13), 7294-7302 (2011-05-25)
Thirty-five samples of cow feces (cowpat and cow manure) and pig slurries subjected to different treatment processes and different storage times before land spreading were extracted and analyzed by gas chromatography-mass spectrometry to determine their fecal stanol profiles. The fresh
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