搜索范围
d9542
应用筛选条件
关键词:'d9542'
显示 1-30 #N/A 10741 条结果 关于 "d9542" 范围 论文
Markus Mandler et al.
Molecular neurodegeneration, 10, 10-10 (2015-04-18)
Multiple system atrophy (MSA) is a neurodegenerative disease characterized by parkinsonism, ataxia and dysautonomia. Histopathologically, the hallmark of MSA is the abnormal accumulation of alpha-synuclein (α-syn) within oligodendroglial cells, leading to neuroinflammation, demyelination and neuronal death. Currently, there is no
Zhenya Lu et al.
PloS one, 10(8), e0135256-e0135256 (2015-08-08)
Mammalian target of rapamycin (mTOR) regulates cell growth, cell differentiation and protein synthesis. Rapamycin, an inhibitor of mTOR, has been widely used as an immunosuppressant and anti-cancer drug. Recently, mTOR inhibitors have also been reported to be a potential anti-epileptic
Sung Hoon Baik et al.
Cell metabolism, 30(3), 493-507 (2019-07-02)
Reactive microglia are a major pathological feature of Alzheimer's disease (AD). However, the exact role of microglia in AD pathogenesis is still unclear. Here, using metabolic profiling, we found that exposure to amyloid-β triggers acute microglial inflammation accompanied by metabolic
Yugo Sawada et al.
International journal of urology : official journal of the Japanese Urological Association, 22(6), 590-595 (2015-03-18)
To examine the effects of combined treatment with sulfoquinovosylacylpropanediol and X-ray irradiation on the remodeling of the prostate cancer microenvironment, including angiogenic and hypoxic characteristics. Human prostate cancer cells (DU145 and PC3) were implanted subcutaneously into the right hind legs
Kai Chen et al.
Genes, 13(10) (2022-10-28)
There are no reliable biomarkers for early diagnosis or prognosis evaluation in pancreatic ductal adenocarcinoma (PDAC). Multiple scRNA-seq datasets for PDAC were retrieved from online databases and combined with scRNA-seq results from our previous study. The malignant ductal cells were
Sharon M Louie et al.
Cell reports, 39(2), 110662-110662 (2022-04-14)
Lung progenitor cells are crucial for regeneration following injury, yet it is unclear whether lung progenitor cells can be functionally engrafted after transplantation. We transplanted organoid cells derived from alveolar type II (AT2) cells enriched by SCA1-negative status (SNO) or
Susanne Kohl et al.
Nature genetics, 47(7), 757-765 (2015-06-02)
Achromatopsia (ACHM) is an autosomal recessive disorder characterized by color blindness, photophobia, nystagmus and severely reduced visual acuity. Using homozygosity mapping and whole-exome and candidate gene sequencing, we identified ten families carrying six homozygous and two compound-heterozygous mutations in the
H S Baik et al.
Oral diseases, 20(6), 574-581 (2013-10-12)
To test the potential stimulatory effect of local application of periodontal ligament (PDL) stromal cells on soft tissue regeneration. Fluorescently labeled PDL cells outgrown from extracted human premolars or phosphate-buffered saline were locally injected to the cutaneous wounds created on
Jian Yan et al.
Digestive diseases and sciences, 60(5), 1315-1324 (2015-01-09)
Hepatitis B virus core promoter (CP) mutations can increase risk of hepatocellular carcinoma. The CP region overlaps with the HBV X (HBx) gene, which has been associated with hepatocarcinogenesis. The cyclin kinase inhibitor P53 is an important regulator of cell
David Gagnon et al.
Journal of virology, 89(12), 6227-6239 (2015-04-03)
The E1 helicase from anogenital human papillomavirus (HPV) types interacts with the cellular WD repeat-containing protein UAF1 in complex with the deubiquitinating enzyme USP1, USP12, or USP46. This interaction stimulates viral DNA replication and is required for maintenance of the
Liang Zhu et al.
Biochemical and biophysical research communications, 464(2), 526-533 (2015-07-15)
Aging of neural stem cell, which can affect brain homeostasis, may be caused by many cellular mechanisms. Autophagy dysfunction was found in aged and neurodegenerative brains. However, little is known about the relationship between autophagy and human neural stem cell
Joëlle Gregoire-Gauthier et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 21(5), 821-828 (2015-01-18)
Although clinical studies have yet to demonstrate clearly the use of intravenous immunoglobulin (IVIG) for prevention of graft-versus-host disease (GVHD), their effective use in a xenogeneic mouse model has been demonstrated. We aimed to determine the mechanism of action by
Kakoli Das et al.
Cancer letters, 353(2), 167-175 (2014-08-03)
Gastric cancer (GC) is a major cause of global cancer mortality. Previous genomic studies have reported that several RTK-RAS pathway components are amplified in GC, with individual tumours often amplifying one component and not others ("mutual exclusivity"). Here, we sought
Amit Kumar et al.
Bioconjugate chemistry, 26(4), 782-789 (2015-03-12)
We report a click-chemistry based modular strategy for antibody labeling with (64)Cu (t1/2 = 12.7 h; β(+) 0.656 MeV, 17.4%; β(-) 0.573 MeV, 39%; EC 43%) under ambient condition utilizing a cross-bridged tetraazamacrocyclic (CB-TE2A) analogue, which otherwise requires harsh conditions
Kirankumar Katta et al.
The Journal of biological chemistry, 290(21), 13168-13177 (2015-04-02)
Heparan sulfate proteoglycans are ubiquitously located on cell surfaces and in the extracellular matrices. The negatively charged heparan sulfate chains interact with a multitude of different proteins, thereby influencing a variety of cellular and developmental processes, for example cell adhesion
Rian Q Landers-Ramos et al.
American journal of physiology. Heart and circulatory physiology, 309(3), H407-H420 (2015-06-10)
We aimed to determine if chronic endurance-exercise habits affected redox status and paracrine function of CD34(+) and CD34(-)/CD31(+) circulating angiogenic cells (CACs). Subjects were healthy, nonsmoking men and women aged 18-35 yr and categorized by chronic physical activity habits. Blood
Shicai Chen et al.
International journal of clinical and experimental medicine, 8(8), 13203-13210 (2015-11-10)
Emerging evidences suggested an important role of purinergic receptor P2Y4 in nerve system. The present study aims to investigate the localization and possible function of P2Y4 receptor in recurrent laryngeal nerve (RLN) following regeneration. Right RLN of fifty Sprague-Dawley rats
Cristina Martínez-Ramos et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(6), 1249-1257 (2014-10-29)
Cancer research focuses increasingly on cancer stem cell study as those cells are thought to be the root of chemo and radioresistance of the most aggressive cancer types. Nevertheless, two-dimensional (2D) cell culture and even three-dimensional (3D) spheroid models, with
Xiaohong Zhang et al.
Development (Cambridge, England), 141(17), 3352-3362 (2014-08-01)
FGF signaling is essential for mammary gland development, yet the mechanisms by which different members of the FGF family control stem cell function and epithelial morphogenesis in this tissue are not well understood. Here, we have examined the requirement of
Ting He et al.
Molecular and cellular endocrinology, 402, 13-20 (2014-12-30)
Resveratrol (RSV) is reported to have renoprotective activity against diabetic nephropathy, while the mechanisms underlying its function have not been fully elucidated. In this study, we investigate the effect and related mechanism of RSV against high glucose-induced epithelial to mesenchymal
Vera Dugina et al.
Molecules (Basel, Switzerland), 26(8) (2021-05-01)
We have shown previously that two cytoplasmic actin isoforms play different roles in neoplastic cell transformation. Namely, β-cytoplasmic actin acts as a tumor suppressor, whereas γ-cytoplasmic actin enhances malignant features of tumor cells. The distinct participation of each cytoplasmic actin
F Javier Carreras et al.
PloS one, 10(6), e0128516-e0128516 (2015-06-02)
To develop the use of cultured tissue of the prelaminar optic nerve of the pig to explore possible alterations of the astrocyte-axon metabolic pathways in glaucoma, we map the distribution of the glucose transporters GLUT1 and GLUT3 in fresh and
Hongquan Dong et al.
Journal of neuroinflammation, 11, 140-140 (2014-08-15)
Lithium, an effective mood stabilizer for the treatment of bipolar disorders, has been recently suggested to have a role in neuroprotection during neurodegenerative diseases. The pathogenesis of neurological disorders often involves the activation of microglia and associated inflammatory processes. Thus
Mickael Fourrier et al.
The Journal of general virology, 95(Pt 5), 1015-1024 (2014-02-04)
Since the discovery of a non-virulent infectious salmon anaemia virus (ISAV) HPR0 variant, many studies have speculated on the functional role of deletions within the highly polymorphic region (HPR) of genomic segment 6, which codes for the haemagglutinin-esterase (HE) protein.
Jong Shin et al.
Virology, 468-470, 113-125 (2014-08-27)
Progressive Multifocal Leukoencephalopathy (PML) is caused by lytic replication of JC virus (JCV) in specific cells of the central nervous system. Like other polyomaviruses, JCV encodes a large T-antigen helicase needed for replication of the viral DNA. Here, we report
Yufeng Jiang et al.
Molecular and cellular biochemistry, 406(1-2), 255-262 (2015-05-15)
Mitogen-activated protein kinase (MAPK) pathway-dependent linker phosphorylation of Smad2/3 and subsequent formation of Smad2/3/4 complex and its nuclear translocation are crucial for dysregulated transforming growth factor beta (TGF)-β/Smad signaling in liver fibrosis. Abrogation of this critical step of TGF-β/Smad signaling
Lauri Vanharanta et al.
Traffic (Copenhagen, Denmark), 21(5), 386-397 (2020-03-08)
The human Niemann-Pick C1 (NPC1) gene encoding a 1278 amino acid protein is very heterogeneous. While some variants represent benign polymorphisms, NPC disease carriers and patients may possess rare variants, whose functional importance remains unknown. An NPC1 cDNA construct known
Shen-Yi Bruce Howng et al.
PloS one, 10(5), e0126667-e0126667 (2015-05-12)
The Dicer1 allele is used to show that microRNAs (miRNAs) play important roles in astrocyte development and functions. While it is known that astrocytes that lack miRNAs are dysregulated, the in vivo phenotypes of these astrocytes are not well understood.
Mahmood M Alam et al.
Nature communications, 6, 7285-7285 (2015-07-08)
Our understanding of the key phosphorylation-dependent signalling pathways in the human malaria parasite, Plasmodium falciparum, remains rudimentary. Here we address this issue for the essential cGMP-dependent protein kinase, PfPKG. By employing chemical and genetic tools in combination with quantitative global
Guodong Xu et al.
BMC pulmonary medicine, 14, 174-174 (2014-11-09)
Epithelial-mesenchymal transition (EMT) has been believed to be related with chemotherapy resistance in non-small cell lung cancer (NSCLC). Recent studies have suggested eIF5A-2 may function as a proliferation-related oncogene in tumorigenic processes. We used cell viability assays, western blotting, immunofluorescence
1/359