CN
Search Within
D9542
应用筛选条件
关键词:'D9542'
显示 31-60 共 10693 条结果 关于 "D9542" 范围 论文
Anna Raynor et al.
Lipids in health and disease, 14, 69-69 (2015-07-15)
Metastasis is the leading cause of mortality in malignant diseases. Patients with metastasis often show reduced Lysophosphatidylcholine (LysoPC) plasma levels and treatment of metastatic tumour cells with saturated LysoPC species reduced their metastatic potential in vivo in mouse experiments. To
Koji Takeda et al.
Biochemical and biophysical research communications, 454(1), 119-124 (2014-12-03)
The clinical success of cell-based therapeutic angiogenesis has been limited in diabetic patients with critical limb ischemia. We previously reported that an injectable cell scaffold (ICS), which is a nano-scaled hydroxyapatite (HAp)-coated polymer microsphere, enhances therapeutic angiogenesis. Subsequently, we developed
Andrea Olmos-Ortiz et al.
The Journal of steroid biochemistry and molecular biology, 148, 187-193 (2014-08-05)
IL-10 and calcitriol help to achieve a successful pregnancy by suppressing active maternal immunity; however, these factors exert opposite effects upon microbial infections. In the skin and immune cells, IL-10 downregulates β-defensins while calcitriol induces cathelicidin gene expression in various
Trina Das et al.
The Journal of general virology, 96(Pt 2), 294-310 (2014-10-30)
Chikungunya virus (CHIKV) has recently affected millions of people in the Indian Ocean, with rare cases of encephalopathy and encephalitis occurring in neonates. In the study described herein, the capacity of mouse brain cells to control infection through innate immune
Isaac Canals et al.
Scientific reports, 5, 13654-13654 (2015-09-09)
Sanfilippo syndrome is a rare lysosomal storage disorder caused by an impaired degradation of heparan sulfate (HS). It presents severe and progressive neurodegeneration and currently there is no effective treatment. Substrate reduction therapy (SRT) may be a useful option for
Tae Chul Moon et al.
PloS one, 9(9), e108595-e108595 (2014-10-01)
PGD₂ has long been implicated in allergic diseases. Recent cloning of a second PGD₂ receptor, DP2 (also known as CRTh2), led to a greater understanding of the physiological and pathophysiological implications of PGD₂. PGD₂ signaling through DP1 and DP2 mediates
Jack R Jerome et al.
International journal of molecular sciences, 24(3) (2023-02-12)
Vision loss in diabetic retinopathy features damage to the blood-retinal barrier and neovascularization, with hypertension and the renin-angiotensin system (RAS) having causal roles. We evaluated if finerenone, a non-steroidal mineralocorticoid receptor (MR) antagonist, reduced vascular pathology and inflammation in diabetic
Yajun Li et al.
Cell death and differentiation, 28(7), 2112-2125 (2021-02-12)
The ubiquitin-proteasome system regulates many distinct biological processes. Its dysregulation causes various diseases, including but not limited to cancer. In this study, based on the analysis of gene expression in several colorectal cancer (CRC) datasets, we show that FBXL6, a
Wonhwa Lee et al.
Inflammation, 38(1), 110-125 (2014-09-25)
Here, three structurally related polyphenols found in the Chinese herb Huang Qui, namely baicalin, baicalein, and wogonin, were examined for its effects on inflammatory responses by monitoring the effects of baicalin, baicalein, and wogonin on lipopolysaccharide (LPS)-mediated vascular inflammatory responses.
Chieh-Yang Cheng et al.
Oncogenesis, 9(3), 38-38 (2020-03-25)
Aberrant neuroendocrine signaling is frequent yet poorly understood feature of prostate cancers. Membrane metalloendopeptidase (MME) is responsible for the catalytic inactivation of neuropeptide substrates, and is downregulated in nearly 50% of prostate cancers. However its role in prostate carcinogenesis, including
Daisuke Tokuhara et al.
Digestive diseases and sciences, 59(11), 2682-2692 (2014-05-20)
Peyer's patches (PPs), which are covered by specialized follicle-associated epithelium (FAE) including M cells, play a central role in immune induction in the gastrointestinal tract. This study is to investigate a new molecule to characterize PPs. We generated a monoclonal
Wooyoung Jeong et al.
Biochemical and biophysical research communications, 463(4), 575-581 (2015-06-06)
Successful development of the conceptus and implantation requires an intimate trophic connection between maternal uterus and conceptus mediated by local regulators including growth factors. Platelet-derived growth factor (PDGF) acts as a chemotactic factor for a variety of cell types. Current
Kyoung Un Park et al.
Clinical chemistry and laboratory medicine, 52(7), 1033-1040 (2014-03-29)
This study aimed to investigate the significance of circulating HER2 and MYC gene fragments quantification in the diagnosis of gastric cancer. Levels of HER2 and MYC genes were evaluated by fluorescence in situ hybridization and real-time PCR in 81 gastric
Hong Lei et al.
Basic research in cardiology, 110(4), 35-35 (2015-05-13)
C1q/tumor necrosis factor-related protein-6 (CTRP6) is a newly identified adiponectin paralog with modulation effects on metabolism and inflammation. However, the cardiovascular function of CTRP6 remains unknown. This study aimed to determine its role in cardiac fibrosis and explore the possible
Jie Chen et al.
Journal of cellular physiology, 229(11), 1647-1659 (2014-03-13)
Hertwig's epithelial root sheath (HERS) cells participate in cementum formation through epithelial-mesenchymal transition (EMT). Previous studies have shown that transforming growth factor beta 1 (TGF-β1) and fibroblast growth factor 2 (FGF2) are involved in inducing EMT. However, their involvement in
Jonathan D Windster et al.
EMBO reports, 24(4), e55789-e55789 (2023-03-01)
Efficient isolation of neurons and glia from the human enteric nervous system (ENS) is challenging because of their rare and fragile nature. Here, we describe a staining panel to enrich ENS cells from the human intestine by fluorescence-activated cell sorting
Ze Wang et al.
The international journal of neuropsychopharmacology, 25(11), 951-967 (2022-09-17)
Cooperative defect is 1 of the earliest manifestations of disease patients with Alzheimer disease (AD) exhibit, but the underlying mechanism remains unclear. We evaluated the cooperative function of APP/PS1 transgenic AD model mice at ages 2, 5, and 8 months
Lukas F Mager et al.
The Journal of clinical investigation, 125(7), 2579-2591 (2015-05-27)
Myeloproliferative neoplasms (MPNs) are characterized by the clonal expansion of one or more myeloid cell lineage. In most cases, proliferation of the malignant clone is ascribed to defined genetic alterations. MPNs are also associated with aberrant expression and activity of
Charmaine J Green et al.
Human reproduction (Oxford, England), 30(2), 284-298 (2014-11-30)
Does insulin-like growth factor 1 (IGF1) increase adhesion competency of blastocysts to increase attachment to uterine epithelial cells in vitro? IGF1 increases apical fibronectin on blastocysts to increase attachment and invasion in an in vitro model of implantation. Fibronectin integrin
Ching-Yan Chloé Yeung et al.
PloS one, 9(9), e107036-e107036 (2014-09-12)
The small GTPase RhoA is a major regulator of actin reorganization during the formation of stress fibers; thus identifying molecules that regulate Rho activity is necessary for a complete understanding of the mechanisms that determine cell contractility. Here, we have
Fabian Alexander Grimm et al.
Assay and drug development technologies, 13(9), 529-546 (2015-11-06)
Cell-based high-content screening (HCS) assays have become an increasingly attractive alternative to traditional in vitro and in vivo testing in pharmaceutical drug development and toxicological safety assessment. The time- and cost-effectiveness of HCS assays, combined with the organotypic nature of
High folate receptor expression in gliomas can be detected in vivo using folate-based positron emission tomography with high tumor-to-brain uptake ratio divulging potential future targeting possibilities.
Miner, et al.
Frontiers in Immunology, 14, 1145473-1145473 (2023)
Xiaoyang Li et al.
Cancer control : journal of the Moffitt Cancer Center, 28, 10732748211045274-10732748211045274 (2021-11-13)
The dedifferentiated variant of chondrosarcoma is highly aggressive and carries an especially grim prognosis. While chemotherapeutics has failed to benefit patients with dedifferentiated chondrosarcoma significantly, preclinical chemosensitivity studies have been limited by a scarcity of available cell lines. There is
Teresa Vanessa Fiorentino et al.
The American journal of pathology, 185(1), 139-150 (2014-12-03)
In this study, we aimed to evaluate the effects of exenatide (EXE) treatment on exocrine pancreas of nonhuman primates. To this end, 52 baboons (Papio hamadryas) underwent partial pancreatectomy, followed by continuous infusion of EXE or saline (SAL) for 14
Aisha Fasih et al.
Radiation research, 182(1), 50-59 (2014-06-10)
Pancreatic cancer is relatively radioresistant, however, radiotherapy has been shown to provide efficacy in the treatment of local disease. To increase the effectiveness of radiotherapy in pancreatic cancer, radiosensitizing drugs are under development. In this study, we investigated the radiosensitizing
Yan Zhang et al.
Molecular cancer research : MCR, 12(8), 1181-1191 (2014-05-14)
The relationship between tumor-associated macrophages (TAM) and epithelial-to-mesenchymal transition (EMT) during the initiation and progression of metastasis is still unclear. Here, a role for the vitamin D receptor (VDR) in metastasis was identified, as well as a role in the
Dandan Yu et al.
PloS one, 9(6), e99859-e99859 (2014-06-20)
Interleukin-7 (IL7) is a pleiotropic cytokine that is actively involved in the immune system. The Chinese tree shrew (Tupaia belangeri chinensis) has been proposed as an alternative experimental animal to primates in biomedical research. However, there is a lack of
Mariano Sánchez-Siles et al.
International journal of dermatology, 53(12), 1454-1459 (2014-06-06)
A study is made of DNA damage and apoptosis in a group of patients with oral leukoplakia (OL) with mild dysplasia. The study comprised 30 patients with a clinicopathological diagnosis of OL with mild dysplasia and 30 controls. Both samples
Sarah Escuin et al.
Journal of cell science, 128(14), 2468-2481 (2015-06-05)
The cytoskeleton is widely considered essential for neurulation, yet the mouse spinal neural tube can close despite genetic and non-genetic disruption of the cytoskeleton. To investigate this apparent contradiction, we applied cytoskeletal inhibitors to mouse embryos in culture. Preventing actomyosin
Chang-an Wang et al.
Experimental and molecular pathology, 98(2), 254-259 (2015-01-27)
Triple negative breast cancer (TNBC) is a heterogeneous disease with higher rates of relapse and decreased overall survival in metastatic tumors. Due to its poor prognosis, it is necessary to identify effective biomarkers that are associated with tumor growth and
2/357