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Sara Przetocka et al.
Molecular cell, 72(3), 568-582 (2018-10-23)
Protecting stalled DNA replication forks from degradation by promiscuous nucleases is essential to prevent genomic instability, a major driving force of tumorigenesis. Several proteins commonly associated with the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) have been
Youg R Thaker et al.
The Journal of biological chemistry, 292(15), 6281-6290 (2017-02-12)
The adaptor protein Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) plays a crucial role in T cell activation by linking antigen receptor (T cell receptor, TCR) signals to downstream pathways. At its N terminus, SLP-76 has three
Vincent Muczynski et al.
Blood, 129(17), 2443-2454 (2017-02-19)
Recently, we have identified scavenger receptor class A member I (SR-AI) as a receptor for coagulation factor X (FX), mediating the formation of an FX reservoir at the macrophage surface. Here, we demonstrate that the FX/SR-AI-complex comprises a third protein
Y Zhang et al.
Cell death & disease, 3, e308-e308 (2012-05-11)
Biomaterials that can drive stem cells to an appropriate differentiation level and decrease apoptosis of transplanted cells are needed in regenerative medicine. Nanomaterials are promising novel materials for such applications. Here we reported that carboxylated multiwalled carbon nanotube (MWCNT 1)
Mahmoud Bahari et al.
Journal of dentistry (Tehran, Iran), 11(3), 248-255 (2015-01-30)
To evaluate the effect of different light intensities on the degree of conversion (DC) of dual-cured resin cement at different depths of translucent fiber posts. Thirty translucent fiber posts were randomly assigned into three (n=10) groups. They were cemented in
Harriet E Sandison et al.
Journal of clinical pathology, 66(9), 764-767 (2013-06-13)
Ying Yang 1 (YY1) is a transcription factor involved in both proliferation and apoptosis. It is prognostic in follicular lymphoma (FL), increased protein levels being associated with favourable outcome. PLK1 is a critical regulator of mitosis, playing a role in
Hui Yao et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 107, 1712-1719 (2018-09-28)
The hyper-activation of PI3K/AKT signaling is common in many kinds of malignant tumors and promotes cell growth. Moreover, FBXL5 is reported to play an important role in the progression of gastric cancer and cervical cancer. In this view, this study
Adarsh Dharan et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(50), E10707-E10716 (2017-11-29)
Numerous viruses, including HIV-1, exploit the microtubule network to traffic toward the nucleus during infection. Although numerous studies have observed a role for the minus-end microtubule motor dynein in HIV-1 infection, the mechanism by which the viral core containing the
Angela Bononi et al.
Nature, 546(7659), 549-553 (2017-06-15)
BRCA1-associated protein 1 (BAP1) is a potent tumour suppressor gene that modulates environmental carcinogenesis. All carriers of inherited heterozygous germline BAP1-inactivating mutations (BAP1+/-) developed one and often several BAP1-/- malignancies in their lifetime, mostly malignant mesothelioma, uveal melanoma, and so
Zijian Tang et al.
Methods in molecular biology (Clifton, N.J.), 1487, 195-201 (2016-12-08)
RAS/MAPK signaling responds to diverse extracellular cues and regulates a wide array of cellular processes. Given its biological importance, abnormalities in RAS/MAPK signaling cascade have been intimately implicated in numerous human diseases, including cancer. Herein, we describe a novel methodology
Bojun Zhang et al.
American journal of physiology. Heart and circulatory physiology, 314(2), H359-H369 (2017-11-05)
Endothelial dysfunction in chronic hypoxia (CH)-induced pulmonary hypertension is characterized by reduced store-operated Ca2+ entry (SOCE) and diminished Ca2+-dependent production of endothelium-derived vasodilators. We recently reported that SOCE in pulmonary arterial endothelial cells (PAECs) is tightly regulated by membrane cholesterol
Helena Johansson et al.
PloS one, 5(10), e13678-e13678 (2010-11-05)
Reprogramming of somatic cells for derivation of either embryonic stem (ES) cells, by somatic cell nuclear transfer (SCNT), or ES-like cells, by induced pluripotent stem (iPS) cell procedure, provides potential routes toward non-immunogenic cell replacement therapies. Nucleolar proteins serve as
Yongxin Yu et al.
Molecular cell, 46(1), 7-17 (2012-03-06)
Histone modifications play important roles in regulating DNA-based biological processes. Of the modified sites, histone H3 lysine 56 (H3K56) is unique in that it lies within the globular core domain near the entry-exit sites of the nucleosomal DNA superhelix and
Aleksandra R Dukic et al.
Cellular signalling, 32, 1-11 (2017-01-13)
Communication between adjacent cells can occur via gap junctions (GJ) composed of connexin (Cx) hexamers that allow passage of small molecules. One of the most widely and highly expressed Cxs in human tissues is Cx43, shown to be regulated through
Franziska Wetzel et al.
Cellular and molecular life sciences : CMLS, 74(2), 373-392 (2016-09-09)
The zonula occludens (ZO)-2 protein links tight junctional transmembrane proteins to the actin cytoskeleton and associates with splicing and transcription factors in the nucleus. Multiple posttranslational modifications control the intracellular distribution of ZO-2. Here, we report that ZO-2 is a
Veronica Ceccarelli et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, fj201800245R-fj201800245R (2018-05-15)
In cancer cells, global genomic hypomethylation is found together with localized hypermethylation of CpG islands within the promoters and regulatory regions of silenced tumor suppressor genes. Demethylating agents may reverse hypermethylation, thus promoting gene re-expression. Unfortunately, demethylating strategies are not
Patricia Santofimia-Castaño et al.
Biochimica et biophysica acta. General subjects, 1862(6), 1283-1295 (2018-03-14)
NUPR1 is a multifunctional intrinsically disordered protein (IDP) involved, among other functions, in chromatin remodelling, and development of pancreatic ductal adenocarcinoma (PDAC). It interacts with several biomolecules through hydrophobic patches around residues Ala33 and Thr68. The drug trifluoperazine (TFP), which
Ahmed M Hashad et al.
Scientific reports, 8(1), 3445-3445 (2018-02-24)
Vascular T-type Ca2+ channels (CaV3.1 and CaV3.2) play a key role in arterial tone development. This study investigated whether this conductance is a regulatory target of angiotensin II (Ang II), a vasoactive peptide that circulates and which is locally produced
Byung-Kwon Choi et al.
Cancer medicine, 1(1), 28-38 (2013-01-24)
Aberrant expression and activation of EGFR and ERBB2 (HER2) have been successfully targeted for cancer therapeutics. Recent evidence from both basic and clinical studies suggests that ERBB3 (HER3) serves as a key activator of downstream signaling through dimerization with other
Komal Ramani et al.
eLife, 11 (2022-10-05)
Trans-differentiation of hepatic stellate cells (HSCs) to activated state potentiates liver fibrosis through release of extracellular matrix (ECM) components, distorting the liver architecture. Since limited antifibrotics are available, pharmacological intervention targeting activated HSCs may be considered for therapy. A-kinase anchoring
Y Jang et al.
Operative dentistry, 42(1), E1-E9 (2016-10-01)
The purpose of this study was to investigate the influence of insufficient light exposure on the polymerization of conventional and self-adhesive dual-cure resin cements under ceramic restorations. Two conventional dual-cure resin cements (Rely-X ARC, Duolink) and two self-adhesive resin cements
Rafael B Junqueira et al.
Journal of prosthodontics : official journal of the American College of Prosthodontists (2018-10-16)
To evaluate the radiopacity of luting cements submitted to different aging procedures. Twenty discs (1 × 4 mm) of each of the following cements were prepared: zinc phosphate, RelyX Luting 2, Variolink 2, AllCem, RelyX U200, Multilink, Panavia F2.0, and
Valerie Le Sage et al.
Virology, 502, 73-83 (2016-12-26)
Stress granules (SGs) are dynamic cytoplasmic aggregates of translationally silenced mRNAs that assemble in response to environmental stress. SGs appear to play an important role in antiviral innate immunity and many viruses have evolved to block or subvert SGs components
Ransom H Poythress et al.
American journal of physiology. Cell physiology, 305(2), C215-C227 (2013-05-25)
Turnover of focal adhesions (FAs) is known to be critical for cell migration and adhesion of proliferative vascular smooth muscle (VSM) cells. However, it is often assumed that FAs in nonmigratory, differentiated VSM (dVSM) cells embedded in the wall of
Dave Boucher et al.
The Journal of experimental medicine, 215(3), 827-840 (2018-02-13)
Host-protective caspase-1 activity must be tightly regulated to prevent pathology, but mechanisms controlling the duration of cellular caspase-1 activity are unknown. Caspase-1 is activated on inflammasomes, signaling platforms that facilitate caspase-1 dimerization and autoprocessing. Previous studies with recombinant protein identified
Olivier Calvayrac et al.
The Journal of pathology (2018-09-13)
The cell cycle inhibitor p27Kip1 is a tumor suppressor via the inhibition of CDK complexes in the nucleus. However, p27 also plays other functions in the cell and may acquire oncogenic roles when located in the cytoplasm. Activation of oncogenic
Shringar Rao et al.
RNA (New York, N.Y.), 24(2), 219-236 (2017-11-12)
The nucleocapsid (NC) is an N-terminal protein derived from the HIV-1 Gag precursor polyprotein, pr55Gag NC possesses key functions at several pivotal stages of viral replication. For example, an interaction between NC and the host double-stranded RNA-binding protein Staufen1 was
Crystal D Rogers
Data in brief, 20, 419-425 (2018-09-04)
This article contains data related to the research article entitled, "A catenin-dependent balance between N-cadherin and E-cadherin controls neuroectodermal cell fate choices" (Rogers et. al., 2018) [1]. The data presented here include (1) proximity ligation assays using antibodies that recognize
João Pitta et al.
The Journal of prosthetic dentistry, 119(5), 833-839 (2017-10-03)
Saliva contamination has been shown to decrease bonding to zirconia. Adopting a less contamination-sensitive cement system may be an alternative to decontamination. The purpose of this in vitro study was to assess the ability of different primer/cement systems to promote a
Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs.
Paul A Parcon et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association, 14(2), 230-242 (2017-09-26)
Alzheimer apolipoprotein E (APOE) ɛ4/ɛ4 carriers have earlier disease onset and more protein aggregates than patients with other APOE genotypes. Autophagy opposes aggregation, and important autophagy genes are coordinately regulated by transcription factor EB (TFEB) binding to "coordinated lysosomal expression
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