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Second generation DNA-encoded dynamic combinatorial chemical libraries.
Reddavide F V, et al.
Chemical Communications (Cambridge, England), 55, 3753-3756 (2019)
Christopher W Murray et al.
Trends in pharmacological sciences, 33(5), 224-232 (2012-03-31)
Fragment-based drug discovery (FBDD) has become established in both industry and academia as an alternative approach to high-throughput screening for the generation of chemical leads for drug targets. In FBDD, specialised detection methods are used to identify small chemical compounds
Francesco V Reddavide et al.
Angewandte Chemie (International ed. in English), 54(27), 7924-7928 (2015-05-28)
Dynamic combinatorial chemistry (DCC) explores the thermodynamic equilibrium of reversible reactions. Its application in the discovery of protein binders is largely limited by difficulties in the analysis of complex reaction mixtures. DNA-encoded chemical library (DECL) technology allows the selection of
The 'rule of three' for fragment-based drug discovery: where are we now?
Harren Jhoti et al.
Nature reviews. Drug discovery, 12(8), 644-645 (2013-07-13)
A 'rule of three' for fragment-based lead discovery?
Miles Congreve et al.
Drug discovery today, 8(19), 876-877 (2003-10-14)
Christopher W Murray et al.
Nature chemistry, 1(3), 187-192 (2009-06-01)
The search for new drugs is plagued by high attrition rates at all stages in research and development. Chemists have an opportunity to tackle this problem because attrition can be traced back, in part, to the quality of the chemical
Alexander L Satz
ACS medicinal chemistry letters, 9(5), 408-410 (2018-05-26)
Use of DNA-encoded libraries (DELs) in the pharmaceutical industry has rapidly increased. We discuss what to expect when you run a DEL screen and contemplate guidelines for library design. Additionally, we consider some visionary work and extrapolate to the future.
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