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Kristina Desch et al.
Cell reports, 36(8), 109583-109583 (2021-08-26)
Homeostatic synaptic scaling allows for bi-directional adjustment of the strength of synaptic connections in response to changes in their input. Protein phosphorylation modulates many neuronal processes, but it has not been studied on a global scale during synaptic scaling. Here
Sandra A Touati et al.
Cell reports, 29(7), 2105-2119 (2019-11-14)
Temporal control over protein phosphorylation and dephosphorylation is crucial for accurate chromosome segregation and for completion of the cell division cycle during exit from mitosis. In budding yeast, the Cdc14 phosphatase is thought to be a major regulator at this
DONSON facilitates Cdc45 and GINS chromatin association and is essential for DNA replication initiation
Kingsley G, et al.
Nucleic Acids Research, 51(18), 9748?9763-9748?9763 (2023)
Helena Borland et al.
The Journal of biological chemistry, 298(11), 102531-102531 (2022-09-27)
α-synucleinopathy is driven by an imbalance of synthesis and degradation of α-synuclein (αSyn), causing a build up of αSyn aggregates and post-translationally modified species, which not only interfere with normal cellular metabolism but also by their secretion propagates the disease.
M D Miller et al.
Nature structural biology, 1(7), 461-468 (1994-07-01)
The crystal structure of Serratia endonuclease has been solved to 2.1 A by multiple isomorphous replacement. This magnesium-dependent enzyme is equally active against single- and double-stranded DNA, as well as RNA, without any apparent base preference. The Serratia endonuclease fold
Christine E Broster Reix et al.
Microbiology spectrum, 9(2), e0091521-e0091521 (2021-10-28)
Trypanosoma brucei belongs to a genus of protists that cause life-threatening and economically important diseases of human and animal populations in Sub-Saharan Africa. T. brucei cells are covered in surface glycoproteins, some of which are used to escape the host
Yosuke Asano et al.
Scientific reports, 11(1), 8502-8502 (2021-04-21)
Bone is a highly dynamic organ that undergoes remodeling equally regulated by osteoblast-mediated bone formation and osteoclast-mediated bone resorption. To clarify the regulation of osteoblastogenesis, primary murine osteoblasts are required for an in vitro study. Primary osteoblasts are isolated from
Cosmos Yuqi Wang et al.
Science advances, 7(51), eabk1924-eabk1924 (2021-12-18)
Synapses are thought to be organized by interactions of presynaptic neurexins with postsynaptic ligands, particularly with neuroligins and cerebellins. However, when a neuron forms adjacent pre- and postsynaptic specializations, as in dendrodendritic or axo-axonic synapses, nonfunctional cis neurexin/ligand interactions would
An extracellular nuclease from Serratia marcescens. II. Specificity of the enzyme.
M Nestle et al.
The Journal of biological chemistry, 244(19), 5219-5225 (1969-10-10)
Preliminary In Vitro Assessment of Decellularized Porcine Descending Aorta for Clinical Purposes.
Casarin, et al.
Journal of Functional Biomaterials, 14 (2023)
Mayilaadumveettil Nishana et al.
Genome biology, 21(1), 108-108 (2020-05-13)
Ubiquitously expressed CTCF is involved in numerous cellular functions, such as organizing chromatin into TAD structures. In contrast, its paralog, CTCFL, is normally only present in the testis. However, it is also aberrantly expressed in many cancers. While it is
Zhao-Qiu Wu et al.
The Journal of biological chemistry, 283(37), 25503-25513 (2008-07-16)
In a search for Polo-like kinase 1 (Plk1) interaction proteins, we have identified TRF1 (telomeric repeat binding factor 1) as a potential Plk1 target. In this communication we report further characterization of the interaction. We show that Plk1 associates with
Marc Lavigne et al.
Nucleic acids research, 49(13), 7695-7712 (2021-07-08)
The multidomain non-structural protein 3 (Nsp3) is the largest protein encoded by coronavirus (CoV) genomes and several regions of this protein are essential for viral replication. Of note, SARS-CoV Nsp3 contains a SARS-Unique Domain (SUD), which can bind Guanine-rich non-canonical
Xin Wang et al.
Molecular cell, 77(5), 999-1013 (2020-02-06)
U6 snRNA, as an essential component of the catalytic core of the pre-mRNA processing spliceosome, is heavily modified post-transcriptionally, with 2'-O-methylation being most common. The role of these modifications in pre-mRNA splicing as well as their physiological function in mammals
Jonathan K Merritt et al.
Human molecular genetics, 29(15), 2461-2470 (2020-05-30)
Rett syndrome (RTT) is a neurodevelopmental disorder primarily caused by mutations in Methyl-CpG-binding Protein 2 (MECP2). More than 35% of affected individuals have nonsense mutations in MECP2. For these individuals, nonsense suppression has been suggested as a possible therapeutic approach.
Syed Nabeel-Shah et al.
iScience, 25(1), 103562-103562 (2021-12-14)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein is essential for viral replication, making it a promising target for antiviral drug and vaccine development. SARS-CoV-2 infected patients exhibit an uncoordinated immune response; however, the underlying mechanistic details of
S Baba et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 44(5), 701-712 (2014-06-17)
Chronic rhinosinusitis with nasal polyps is generally characterized by local Th2 inflammation and is categorized into two subtypes in Japan: eosinophilic chronic rhinosinusitis (similar to chronic rhinosinusitis with nasal polyps in western countries) and non-eosinophilic chronic rhinosinusitis (characterized by Th1-dominant
Preventing packaging of translatable P5-associated DNA contaminants in recombinant AAV vector preps.
Mark A Brimble et al.
Molecular therapy. Methods & clinical development, 24, 280-291 (2022-02-26)
Recombinant adeno-associated virus (rAAV) vectors are increasingly being used for clinical gene transfer and have shown great potential for the treatment of several monogenic disorders. However, contaminant DNA from producer plasmids can be packaged into rAAV alongside the intended expression
Bridget E Collins et al.
Genes, brain, and behavior, 21(1), e12739-e12739 (2021-05-05)
Rett syndrome is a neurodevelopmental disorder caused predominantly by loss-of-function mutations in MECP2, encoding transcriptional modulator methyl-CpG-binding protein 2 (MeCP2). Although no disease-modifying therapies exist at this time, some proposed therapeutic strategies aim to supplement the mutant allele with a
Ellen F Vieux et al.
SLAS discovery : advancing life sciences R & D, 26(4), 547-559 (2021-03-30)
Recent advances in targeted protein degradation have enabled chemical hijacking of the ubiquitin-proteasome system to treat disease. The catalytic rate of cereblon (CRBN)-dependent bifunctional degradation activating compounds (BiDAC), which recruit CRBN to a chosen target protein, resulting in its ubiquitination
Valentina Dzreyan et al.
Journal of molecular neuroscience : MN, 71(4), 826-835 (2020-09-13)
Neurotrauma is among the main causes of human disability and mortality. Nerve injury impairs not only neurons but also causes death of satellite glial cells remote from the injury site. We studied the dynamics of expression of different proapoptotic proteins
Yiju Wei et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8(24), e2102653-e2102653 (2021-10-31)
The Hippo pathway effector TAZ promotes cellular growth, survival, and stemness through regulating gene transcription. Recent studies suggest that TAZ liquid-liquid phase separation (LLPS) compartmentalizes key cofactors to activate transcription. However, how TAZ LLPS is achieved remains unknown. Here, it
Michael L van de Weijer et al.
Molecular cell, 79(5), 768-781 (2020-08-02)
Misfolded proteins in the endoplasmic reticulum (ER) are degraded by ER-associated degradation (ERAD). Although ERAD components involved in degradation of luminal substrates are well characterized, much less is known about quality control of membrane proteins. Here, we analyzed the degradation
G N Eaves et al.
Journal of bacteriology, 85(2), 273-278 (1963-02-01)
Eaves, George N. (Wayne State University College of Medicine, Detroit, Mich.) and Charles D. Jeffries. Isolation and properties of an exocellular nuclease of Serratia marcescens. J. Bacteriol. 85:273-278. 1963.-The exocellular nuclease of Serratia marcescens, isolated by anion-exchange chromatography on diethylaminoethyl-Sephadex
Giel Vandemoortele et al.
Journal of proteome research, 18(1), 95-106 (2018-12-12)
The CRISPR/Cas9 revolution is profoundly changing the way life sciences technologies are used. Many assays now rely on engineered clonal cell lines to eliminate the overexpression of bait proteins. Control cell lines are typically nonengineered cells or engineered clones, implying
Peter Haahr et al.
Molecular cell, 70(1), 165-174 (2018-03-27)
Deubiquitylating enzymes (DUBs) enhance the dynamics of the versatile ubiquitin (Ub) code by reversing and regulating cellular ubiquitylation processes at multiple levels. Here we discovered that the uncharacterized human protein ZUFSP (zinc finger with UFM1-specific peptidase domain protein/C6orf113/ZUP1), which has
Anna Motnenko et al.
PLoS genetics, 14(10), e1007643-e1007643 (2018-10-20)
The Fanconi Anemia (FA) pathway is important for repairing interstrand crosslinks (ICLs) between the Watson-Crick strands of the DNA double helix. An initial and essential stage in the repair process is the detection of the ICL. Here, we report the
Chong-Hyun Kim et al.
Brain and behavior, 10(12), e01891-e01891 (2020-10-17)
Densin-180 interacts with postsynaptic molecules including calcium/calmodulin-dependent protein kinase IIα (CaMKIIα) but its function in learning and memory process has been unclear. To investigate a role of hippocampal densin-180 in contextual fear conditioning (CFC) learning and memory processes, knockdown (KD)
Ru Gao et al.
Science advances, 6(20), eaaz8411-eaaz8411 (2020-05-20)
Transcriptional status determines the HIV replicative state in infected patients. However, the transcriptional mechanisms for proviral replication control remain unclear. In this study, we show that, apart from its function in HIV integration, LEDGF/p75 differentially regulates HIV transcription in latency
Yongqiang Gao et al.
Genes & development, 36(9-10), 634-646 (2022-06-03)
In response to starvation, endospore-forming bacteria differentiate into stress-resistant spores that can remain dormant for years yet rapidly germinate and resume growth in response to nutrients. The small molecule dipicolinic acid (DPA) plays a central role in both the stress
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