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关键词:'E3876'
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Adam P Gunn et al.
Journal of neurochemistry, 156(6), 979-987 (2020-07-03)
Glutaminyl cyclases (QC) catalyze the formation of neurotoxic pGlu-modified amyloid-β peptides found in the brains of people with Alzheimer's disease (AD). Reports of several-fold increases in soluble QC (sQC) expression in the brain and peripheral circulation of AD individuals has
Ana Tufegdžić Vidaković et al.
Cell, 180(6), 1245-1261 (2020-03-07)
In response to transcription-blocking DNA damage, cells orchestrate a multi-pronged reaction, involving transcription-coupled DNA repair, degradation of RNA polymerase II (RNAPII), and genome-wide transcription shutdown. Here, we provide insight into how these responses are connected by the finding that ubiquitylation
Kuntian Luo et al.
Nucleic acids research, 43(11), 5465-5475 (2015-05-08)
There are the two major pathways responsible for the repair of DNA double-strand breaks (DSBs): non-homologous end-joining (NHEJ) and homologous recombination (HR). NHEJ operates throughout the cell-cycle, while HR is primarily active in the S/G2 phases suggesting that there are
Stephen R Fuhs et al.
The Journal of biological chemistry, 286(17), 14830-14841 (2011-03-03)
Caveolin (Cav) proteins in the plasma membrane have numerous binding partners, but the determinants of these interactions are poorly understood. We show here that Cav-3 has a small ubiquitin-like modifier (SUMO) consensus motif (ΨKX(D/E, where Ψ is a hydrophobic residue))
María Guadalupe Lozano-Rosas et al.
Cancer biology & therapy, 21(1), 81-94 (2019-09-26)
S-adenosylmethionine (SAM), biosynthesis from methionine and ATP, is markedly decreased in hepatocellularular carcinoma (HCC) for a diminution in ATP levels, and the down regulation of the liver specific MAT1a enzyme. Its metabolic activity is very important in the transmethylation reactions
Shohei Shinozaki et al.
Science signaling, 7(351), ra106-ra106 (2014-11-13)
Inflammation increases the abundance of inducible nitric oxide synthase (iNOS), leading to enhanced production of nitric oxide (NO), which can modify proteins by S-nitrosylation. Enhanced NO production increases the activities of the transcription factors p53 and nuclear factor κB (NF-κB)
Sudip Datta Banik et al.
Ecology of food and nutrition, 54(6), 644-662 (2015-11-01)
Early menarche (EM) (i.e., age at menarche [AAM] <12 years of age) is related to short height and higher body fatness. In a mixed-longitudinal study done in Merida, Yucatan, height, body mass index (BMI), and percentage of body fat (BF%)
James Shue-Min Yeh et al.
PloS one, 10(7), e0129681-e0129681 (2015-07-15)
Microbubbles conjugated with targeting ligands are used as contrast agents for ultrasound molecular imaging. However, they often contain immunogenic (strept)avidin, which impedes application in humans. Although targeting bubbles not employing the biotin-(strept)avidin conjugation chemistry have been explored, only a few
María Elena Sánchez-Mendoza et al.
Molecules (Basel, Switzerland), 25(9) (2020-05-14)
Peptic ulcer disease, the most common gastrointestinal disorder, is currently treated with several types of drugs, but all have severe side effects. The aim of the present study was to evaluate the gastroprotective activity of juanislamin, isolated from Calea urticifolia
Wen Zhang et al.
FEBS letters, 595(2), 169-182 (2020-10-28)
BRCA1/BRCA2-containing complex subunit 3 (BRCC3) is a lysine 63-specific deubiquitinase involved in multiple biological processes, such as DNA repair and immune responses. However, the regulation mechanism for BRCC3 protein stability is still unknown. Here, we demonstrate that BRCC3 is mainly
Karin K M Chia et al.
American journal of physiology. Cell physiology, 309(4), C239-C250 (2015-06-19)
Protein kinase C can activate NADPH oxidase and induce glutathionylation of the β1-Na(+)-K(+) pump subunit, inhibiting activity of the catalytic α-subunit. To examine if signaling of nitric oxide-induced soluble guanylyl cyclase (sGC)/cGMP/protein kinase G can cause Na(+)-K(+) pump stimulation by
Rab40C is a novel Varp-binding protein that promotes proteasomal degradation of Varp in melanocytes.
Ayaka Yatsu et al.
Biology open, 4(3), 267-275 (2015-02-11)
Varp (VPS9-ankyrin repeat protein) was originally identified as an activator of small GTPase Rab21 through its VPS9 domain, but it has subsequently been shown to function as a Rab32/38 effector through its first ANKR1 domain. Although these functions of Varp
Ashok K Dilly et al.
Orphanet journal of rare diseases, 15(1), 211-211 (2020-08-20)
Mucinous colon cancers (MCC) are characterized by abundant production of mucin 2 (MUC2) protein and are less sensitive to standard systemic chemotherapy. We postulated that severe/persistent endoplasmic reticulum stress (ERS) aggravation in MCC would overwhelm compensatory cytoprotective pathways and induce
Joydeep Roy et al.
Molecular biology of the cell, 26(9), 1583-1600 (2015-03-06)
Hsp70 aids in protein folding and directs misfolded proteins to the cellular degradation machinery. We describe discrete roles of Hsp70,SSA1 as an important quality-control machinery that switches functions to ameliorate the cellular environment. SSA1 facilitates folding/maturation of newly synthesized protein
Yin Shi et al.
Molecular therapy oncolytics, 23, 311-329 (2021-11-18)
Drug resistance has become one of the largest challenges for cancer chemotherapies. Under certain conditions, cancer cells hijack autophagy to cope with therapeutic stress, which largely undermines the chemo-therapeutic efficacy. Currently, biomarkers indicative of autophagy-derived drug resistance remain largely inclusive.
Arpan Manna et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 15(14), 3067-3077 (2014-07-30)
Rate constants and derived activation parameters of organic reactions in aqueous media, in particular Diels-Alder reactions, are sensitive to the presence of cosolvents in water. To enhance the solubility window of water, we introduced ionic liquids as cosolvents in the
Eun Hyeon Song et al.
Journal of cell science, 128(5), 913-922 (2015-01-16)
Net1 isoform A (Net1A) is a RhoA GEF that is required for cell motility and invasion in multiple cancers. Nuclear localization of Net1A negatively regulates its activity, and we have recently shown that Rac1 stimulates Net1A relocalization to the plasma
F Nuritova et al.
Neuroscience, 222, 159-172 (2012-07-31)
Excitatory synaptic transmission in area CA1 of the mammalian hippocampus is rapidly depressed during hypoxia. The depression is largely attributable to an increase in extracellular adenosine and activation of inhibitory adenosine A(1) receptors on presynaptic glutamatergic terminals. However, sequential exposure
The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains.
Carlos Gomez-Diaz et al.
iScience, 24(11), 103241-103241 (2021-11-11)
The Linear Ubiquitin Chain Assembly Complex (LUBAC), composed of HOIP, HOIL-1L, and SHARPIN, promotes tumor necrosis factor (TNF)-dependent NF-κB signaling in diverse cell types. HOIL-1L contains an Npl4 Zinc Finger (NZF) domain that specifically recognizes linear ubiquitin chains, but its
Aitor Carretero et al.
Analytical and bioanalytical chemistry, 406(22), 5465-5476 (2014-06-28)
Multiple analytical methods are required to comprehensively assess oxidative homeostasis and specific damage to macromolecules. Our aim was to develop a straightforward strategy for the fast assessment of global oxidative status and specific damage to DNA, proteins, and lipids. To
Linda Sasset et al.
The Journal of biological chemistry, 290(47), 28175-28188 (2015-10-16)
Endoplasmic reticulum-associated degradation (ERAD) is an essential quality control mechanism of the folding state of proteins in the secretory pathway that targets unfolded/misfolded polypeptides for proteasomal degradation. The cytosolic p97/valosin-containing protein is an essential ATPase for degradation of ERAD substrates.
Elizabeth M Bafaro et al.
Metallomics : integrated biometal science, 7(9), 1319-1330 (2015-04-18)
The human (h) ZIP4 transporter is a plasma membrane protein which functions to increase the cytosolic concentration of zinc. hZIP4 transports zinc into intestinal cells and therefore has a central role in the absorption of dietary zinc. hZIP4 has eight
Mauricio Berriel Diaz et al.
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 208, 219-242 (2016-12-03)
Multiple epidemiological studies demonstrated that overweight and obesity significantly increase the risk of several types of cancer. As the prevalence of obesity is dramatically rising, it is expected that it will represent one of the major lifestyle-associated risk factors for
Dinesh Kumar Verma et al.
eNeuro, 7(5) (2020-09-06)
Small ubiquitin-like modifier (SUMO) is a widespread regulatory mechanism of post-translational modification (PTM) that induces rapid and reversible changes in protein function and stability. Using SUMO conjugase Ubc9-overexpressing or knock-down cells in Parkinson's disease (PD) models, we demonstrate that SUMOylation
Francisca Díaz-Pérez et al.
Journal of cardiovascular pharmacology, 60(5), 439-449 (2012-11-13)
Nitric oxide (NO) is an endogenous vasodilator molecule synthetized from L-arginine by a family of nitric oxide synthases. In differentiated human endothelial cells, it is well known that L-arginine uptake via cationic amino acid transporters (y(+)/CAT) or system y(+)L is
Snežana D Marković et al.
General physiology and biophysics, 33(4), 393-401 (2014-08-26)
The effects of nitroglycerin (glyceryl trinitrate - GTN) are mediated by liberated nitric oxide (NO) and formed reactive nitrogen species, which induces oxidative stress during biotransformation in red blood cells (RBCs). The aim of this study was to evaluate effects
Carlos M Guardia et al.
Cell reports, 31(13), 107837-107837 (2020-07-02)
Autophagy is a catabolic process involving capture of cytoplasmic materials into double-membraned autophagosomes that subsequently fuse with lysosomes for degradation of the materials by lysosomal hydrolases. One of the least understood components of the autophagy machinery is the transmembrane protein
Jong Ho Park et al.
Nature communications, 5, 5483-5483 (2014-11-19)
DBC1 is a major inhibitor of SIRT1, which plays critical roles in the control of diverse cellular processes, including stress response and energy metabolism. Therefore, the DBC1-SIRT1 interaction should finely be regulated. Here we report that DBC1 modification by Small
Comparative mechanisms of protein transduction mediated by cell-penetrating peptides in prokaryotes.
Betty Revon Liu et al.
The Journal of membrane biology, 248(2), 355-368 (2015-02-07)
Bacterial and archaeal cell envelopes are complex multilayered barriers that serve to protect these microorganisms from their extremely harsh and often hostile environments. Import of exogenous proteins and nanoparticles into cells is important for biotechnological applications in prokaryotes. In this
Young-Nam Lee et al.
Biochemical and biophysical research communications, 420(4), 851-856 (2012-04-03)
Clusterin is a disulfide-linked heterodimeric glycoprotein that has been implicated in a variety of biological processes. Its expression has been shown to be elevated during cellular senescence and normal aging, but it is uncertain whether clusterin protects against aging or
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