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E3889
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Xuanmao Chen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(1), 339-351 (2015-01-09)
The type 1 adenylyl cyclase (AC1) is an activity-dependent, calcium-stimulated adenylyl cyclase expressed in the nervous system that is implicated in memory formation. We examined the locomotor activity, and impulsive and social behaviors of AC1+ mice, a transgenic mouse strain
Rahul R Deshmukh et al.
Breast cancer research and treatment, 153(1), 79-88 (2015-08-01)
The purpose of present study is to examine the mechanism of the 5'-AMP-activated protein kinase (AMPK) activation induced by proteasome inhibitors. AMPK activation and ubiquitin proteasome system (UPS) inhibition have gained great attention as therapeutic strategies for the treatment of
Thong Hua-Huy et al.
Journal of breath research, 9(3), 036007-036007 (2015-06-17)
Exhaled nitric oxide (NO) is increased as a result of lung inflammation, which in turn causes subsequent interstitial lung disease in patients with systemic sclerosis (SSc). However, the exact time course of inflammatory and fibrotic changes in the SSc lung
Shankar P Das et al.
Genome research, 25(12), 1886-1892 (2015-09-12)
Replication timing is a crucial aspect of genome regulation that is strongly correlated with chromatin structure, gene expression, DNA repair, and genome evolution. Replication timing is determined by the timing of replication origin firing, which involves activation of MCM helicase
Grazia Graziani et al.
Biochemical pharmacology, 95(1), 16-27 (2015-03-22)
Recovery of mitogen activated protein kinase (MAPK) or activation of alternative pathways, such as the PI3K/AKT/mTOR, are involved in acquired resistance to BRAF inhibitors which represent the first-line treatment of BRAF-mutated metastatic melanoma. We recently demonstrated that 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (NBDHEX) and
Roman Krestinin et al.
Biomedicines, 8(10) (2020-10-24)
Mitochondria are key organelles of the cell because their main function is the capture of energy-rich substrates from the cytoplasm and oxidative cleavage with the generation of carbon dioxide and water, processes that are coupled with the synthesis of ATP.
Romina Bertinat et al.
Journal of cellular physiology, 230(10), 2437-2446 (2015-03-03)
Diabetic nephropathy (DN) is characterized by interstitial inflammation and fibrosis, which is the result of chronic accumulation of extracellular matrix produced by activated fibroblasts in the renal tubulointerstitium. Renal proximal tubular epithelial cells (PTECs), through the process of epithelial-to-mesenchymal transition
Elie Simard et al.
PloS one, 10(8), e0128881-e0128881 (2015-08-08)
Increased blood glucose concentrations promote reactions between glucose and proteins to form advanced glycation end-products (AGE). Circulating AGE in the blood plasma can activate the receptor for advanced end-products (RAGE), which is present on both endothelial and vascular smooth muscle
Seong-Hoon Kim et al.
The Journal of pharmacology and experimental therapeutics, 352(1), 175-184 (2014-11-06)
To date, many anticancer drugs have been developed by directly or indirectly targeting microtubules, which are involved in cell division. Although this approach has yielded many anticancer drugs, these drugs produce undesirable side effects. An alternative strategy is needed, and
Sudhish Sharma et al.
Stem cells (Dayton, Ohio), 33(4), 1213-1229 (2015-03-11)
We have demonstrated that human neonatal cardiosphere-derived cells (CDCs) derived from the young are more regenerative due to their robust secretome. However, it is unclear how the decompensated pediatric heart impacts the functional activity of their CDCs. Our aim was
A Humenick et al.
The Journal of physiology, 593(16), 3693-3709 (2015-05-27)
A major class of mechano-nociceptors to the intestine have mechanotransduction sites on extramural and intramural arteries and arterioles ('vascular afferents'). These sensory neurons can be activated by compression or axial stretch of vessels. Using isolated preparations we showed that increasing
Janne Hakkarainen et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(9), 3806-3816 (2015-05-29)
Hydroxysteroid (17β)-dehydrogenase type 1 (HSD17B1) catalyzes the conversion of low active 17-ketosteroids, androstenedione (A-dione) and estrone (E1) to highly active 17-hydroxysteroids, testosterone (T) and E2, respectively. In this study, the importance of HSD17B1 in ovarian estrogen production was determined using
Nadia Efimova et al.
Journal of cell science, 127(Pt 24), 5179-5188 (2014-10-26)
The kinesin KIF1C is known to regulate podosomes, actin-rich adhesion structures that remodel the extracellular matrix during physiological processes. Here, we show that KIF1C is a player in the podosome-inducing signaling cascade. Upon induction of podosome formation by protein kinase
Yu Liu et al.
European journal of pharmacology, 735, 193-201 (2014-04-23)
Hesperetin (HSP, one of the most common flavonoids in Citrus) has been reported to possess many benificial effects and is indicated for many diseases both as a therapeutic drug and as a supplement. Although its vascular effects have been extensively
Goran Mucic et al.
Behavioural brain research, 280, 45-50 (2014-12-03)
Although protein kinases and phosphatases have been reported to be involved in fear memory, information about these signalling molecules in the individual phases of contextual fear conditioning (cFC) is limited. C57BL/6J mice were tested in cFC, sacrificed and hippocampi were
Peter M Hwang et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(40), 14412-14417 (2014-09-24)
The cardiac isoform of troponin I (cTnI) has a unique 31-residue N-terminal region that binds cardiac troponin C (cTnC) to increase the calcium sensitivity of the sarcomere. The interaction can be abolished by cTnI phosphorylation at Ser22 and Ser23, an
André Rey-Cibati et al.
Bio-protocol, 10(18), e3766-e3766 (2021-03-05)
Ca2+ is an essential signaling messenger in all eukariotic cells, playing a pivotal role in many cellular functions as cell growth control (differentiation, fertilization and apoptosis), secretion, gene expression, enzyme regulation, among many others. This basic premise includes trypanosomatids as
Xiaoli Zhang et al.
Reproductive biomedicine online, 30(5), 514-521 (2015-03-17)
We previously reported that bone morphogenetic protein 4/drosophila mothers against decapentaplegic protein (BMP4/Smad) signalling pathway initiated primordial follicle growth and prevented oocyte apoptosis via up-regulation of Sohlh2 and receptor for kit ligand (c-kit). The mechanism underlying this process was not
Adam J Watkins et al.
Reproduction (Cambridge, England), 149(6), 563-575 (2015-03-11)
Mammalian placentation is dependent upon the action of trophoblast cells at the time of implantation. Appropriate fetal growth, regulated by maternal nutrition and nutrient transport across the placenta, is a critical factor for adult offspring long-term health. We have demonstrated
Laurel A Cooley et al.
Methods in molecular biology (Clifton, N.J.), 995, 133-145 (2013-03-16)
Fluorescent ion sensors are quite valuable in experimental biology. The development of new sensor molecules requires determination of spectral properties (absorption bands, fluorescence excitation, and emission maxima) in order to characterize the type of optical response to the target ion.
Zhilun Zhao et al.
Nature communications, 12(1), 1305-1305 (2021-02-28)
Imaging the spatial distribution of biomolecules is at the core of modern biology. The development of fluorescence techniques has enabled researchers to investigate subcellular structures with nanometer precision. However, multiplexed imaging, i.e. observing complex biological networks and interactions, is mainly
Isadora Maria Villas Boas et al.
PloS one, 10(3), e0118615-e0118615 (2015-03-12)
The caterpillar of the moth Premolis semirufa, commonly named pararama, is found in the Brazilian Amazon region. Accidental contact with the caterpillar bristles causes an intense itching sensation, followed by symptoms of an acute inflammation, which last for three to
Colin J Stoneking et al.
Pflugers Archiv : European journal of physiology, 466(8), 1529-1539 (2013-11-07)
The activity of many ion channels is modulated by ions other than the ones they primarily conduct, with important consequences for cell signalling. In this study, we demonstrate that Mg(2+) inhibits the intermediate conductance calcium-activated potassium channel (KCa3.1) in human
Madeleen Bosma et al.
Biochimica et biophysica acta, 1841(12), 1648-1655 (2014-09-25)
We used human cardiomyocyte-derived cells to create an in vitro model to study lipid metabolism and explored the effects of PPARγ; ACSL1 and ATGL on fatty acid-induced ER stress. Compared to oleate, palmitate treatment resulted in less intracellular accumulation of
Byoungduck Park et al.
Molecular medicine reports, 12(5), 7577-7581 (2015-10-16)
Akt, or protein kinase B, is a key serine-threonine kinase, which exerts anti-apoptotic effects and promotes cell proliferation in response to various stimuli. Recently, however, it was demonstrated that Akt exhibits a proapoptotic role in certain contexts. During etoposide‑induced apoptosis
Parker C Wilson et al.
Molecular endocrinology (Baltimore, Md.), 29(6), 896-908 (2015-04-15)
Angiotensin II (AngII) plays a critical role in the regulation of vascular tone and blood pressure mainly via regulation of Ca(2+) mobilization. Several reports have implicated sphingosine kinase 1 (SK1)/sphingosine 1-phosphate (S1P) in the mobilization of intracellular Ca(2+) through a
Emily Hill et al.
STAR protocols, 1(3), 100139-100139 (2020-12-31)
This protocol provides two independent methods to functionally detect the neuronal expression of CO2-sensitive hemichannels. These hemichannels (consisting of connexins 26 or 30) are directly gated by CO2, independent of pH changes and until recently were thought to be only
Ashwini K Devkota et al.
Chembiochem : a European journal of chemical biology, 15(16), 2435-2442 (2014-09-17)
eEF-2K is a potential target for treating cancer. However, potent specific inhibitors for this enzyme are lacking. Previously, we identified 2,6-diamino-4-(2-fluorophenyl)-4H-thiopyran-3,5-dicarbonitrile (DFTD) as an inhibitor of eEF-2K. Here we describe its mechanism of action against eEF-2K, on the basis of
Shiladitya Chattopadhyay et al.
PloS one, 8(2), e56655-e56655 (2013-02-26)
Rotavirus (RV) being the major diarrhoegenic virus causes around 527000 children death (<5 years age) worldwide. In cellular environment, viruses constantly adapt and modulate to survive and replicate while the host cell also responds to combat the situation and this
Y Sun et al.
Oncogene, 34(19), 2527-2537 (2014-06-24)
Eyes absent 1 (Eya1) is a conserved critical regulator of organ-specific stem cells. Ectopic Eya1 activities, however, promote transformation of mammary epithelial cells. Signals that instigate Eya1 oncogenic activities remain to be determined. Here, we show that Akt1 kinase physically
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