E5391

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关键词:'E5391'

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Analyzing the developmental expression of sigma factors with S1-nuclease mapping.

J Kormanec

Methods in molecular biology (Clifton, N.J.), 160, 481-494 (2001-03-27)

Accurate and live peroxisome biogenesis evaluation achieved by lentiviral expression of a green fluorescent protein fused to a peroxisome targeting signal 1.

Tanguy Demaret et al.

Histochemistry and cell biology, 153(5), 295-306 (2020-03-04)

Peroxisomes are ubiquitous organelles formed by peroxisome biogenesis (PB). During PB, peroxisomal matrix proteins harboring a peroxisome targeting signal (PTS) are imported inside peroxisomes by peroxins, encoded by PEX genes. Genetic alterations in PEX genes lead to a spectrum of

Buccal micronucleus cytome assay.

Philip Thomas et al.

Nature protocols, 4(6), 825-837 (2009-05-16)

The Buccal Micronucleus Cytome (BMCyt) assay is a minimally invasive method for studying DNA damage, chromosomal instability, cell death and the regenerative potential of human buccal mucosal tissue. This method is increasingly used in molecular epidemiological studies for investigating the

The frequencies of micronuclei, nucleoplasmic bridges and nuclear buds as biomarkers of genomic instability in patients with urothelial cell carcinoma.

Arjeta Podrimaj-Bytyqi et al.

Scientific reports, 8(1), 17873-17873 (2018-12-16)

Bladder urothelial cell carcinoma (UCC) is an increasingly prevalent cancer worldwide, and thus, gaining a better understanding of its identifiable risk factors is a global priority. This study addressed this public health need with the understanding that cancer-initiating events, such

Chemical pulldown combined with mass spectrometry to identify the molecular targets of antimalarials in cell-free lysates.

Robert J Smith et al.

STAR protocols, 4(1), 102002-102002 (2023-01-08)

Here, we provide a protocol using chemical pulldown combined with mass spectrometry (LC-MS/MS) to identify drug targets in Plasmodium falciparum. This approach works upon the principle that a resin-bound inhibitor selectively binds its molecular target(s) in cell-free lysates. We describe

Treatment of glioma by cisplatin-loaded nanogels conjugated with monoclonal antibodies against Cx43 and BSAT1.

Vladimir P Baklaushev et al.

Drug delivery, 22(3), 276-285 (2014-01-21)

Targeted drug delivery for brain tumor treatment is one of the important objectives in nanomedicine. Human glioblastoma is the most frequent and aggressive type of brain tumors. The preferential expression of membrane protein connexin 43 (Cx43) and brain-specific anion transporter

Comparative Anatomy of the Mammalian Corneal Subbasal Nerve Plexus.

Carl Marfurt et al.

Investigative ophthalmology & visual science, 60(15), 4972-4984 (2019-12-04)

The subbasal nerve plexus (SNP) is the densest and most recognizable component of the mammalian corneal innervation; however, the anatomical configuration of the SNP in most animal models remains incompletely described. The purpose of the current study is to describe

Inactivation of Retinoblastoma Protein (Rb1) in the Oocyte: Evidence That Dysregulated Follicle Growth Drives Ovarian Teratoma Formation in Mice.

Qi-En Yang et al.

PLoS genetics, 11(7), e1005355-e1005355 (2015-07-16)

The origin of most ovarian tumors is undefined. Here, we report development of a novel mouse model in which conditional inactivation of the tumor suppressor gene Rb1 in oocytes leads to the formation of ovarian teratomas (OTs). While parthenogenetically activated

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