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显示 31-60 共 9174 条结果 关于 "E6758" 范围 论文
Roomina Jahroomishirazi et al.
Cells, tissues, organs, 200(2), 141-152 (2015-05-23)
Mesenchymal stem cells (MSCs) have great promise in the field of regenerative medicine due to their differentiation potential into several lineages. Besides the bone marrow, MSCs can be obtained from the dermis, which represents a large stem cell reservoir in
Theresia Estomih Nkya et al.
Parasites & vectors, 7, 480-480 (2014-10-17)
Resistance of mosquitoes to insecticides is mainly attributed to their adaptation to vector control interventions. Although pesticides used in agriculture have been frequently mentioned as an additional force driving the selection of resistance, only a few studies were dedicated to
Yusuke Sakota et al.
Biological & pharmaceutical bulletin, 37(6), 1014-1020 (2014-06-03)
Collagen gel contraction assay is a method for evaluating contraction of cells embedded in collagen gel matrices through measuring the gel size. In the present study, we established a protocol for collagen gel contraction assay using human bronchial smooth muscle
Ousseynou Sarr et al.
PloS one, 9(6), e98433-e98433 (2014-06-14)
Uteroplacental insufficiency (UPI)-induced intrauterine growth restriction (IUGR) predisposes individuals to adult visceral obesity. We postulated that low birth weight (LBW) offspring, from UPI-induced IUGR pregnancies, would display a visceral adipose lipogenic molecular signature involving altered gene expression, phosphorylation status of
Seth S Martin et al.
Atherosclerosis, 239(1), 67-72 (2015-01-13)
Higher serum leptin levels have been associated with a modestly higher incidence of cardiovascular disease in studies involving mostly Caucasian men. We aimed to assess the hypothesis that higher baseline levels of serum leptin are associated with higher risk of
Reeta Tiwari et al.
Cancer investigation, 32(8), 402-408 (2014-07-16)
Betulinic acid (BA) has been shown to cause apoptosis in neuroblastoma and melanoma cell lines. We evaluated the cytotoxicity of BA in two breast cancer cell lines MCF-7 and T47D differing in their p53 status. Treatment with BA resulted in
Christian Krug et al.
Cancer immunology, immunotherapy : CII, 63(10), 999-1008 (2014-06-19)
Chimeric antigen receptors (CARs), which combine an antibody-derived binding domain (single chain fragment variable) with T-cell-activating signaling domains, have become a promising tool in the adoptive cellular therapy of cancer. Retro- and lenti-viral transductions are currently the standard methods to
Hagen Frickmann et al.
Infectious diseases (London, England), 47(7), 491-498 (2015-03-13)
Molecular methods, in particular PCR, are increasingly used for the diagnosis of enteric pathogens in stool samples. In high-endemicity settings, however, asymptomatic carriage or residual DNA from previous infections will hamper the interpretation of positive test results. We assessed the
Ana C Mestre-Citrinovitz et al.
PloS one, 10(4), e0124756-e0124756 (2015-04-22)
Progesterone receptor and estrogen receptor participate in growth and differentiation of the different rat decidual regions. Steroid hormone receptor antagonists were used to study steroid regulation of decidualization. Here we describe a suppressive interaction between progesterone receptor (onapristone) and estrogen
Sylvain Lefort et al.
Autophagy, 10(12), 2122-2142 (2014-11-27)
The triple-negative breast cancer (TN BC) subtype is the most aggressive form of invasive BC. Despite intensive efforts to improve BC treatments, patients with TN BC continue to exhibit poor survival, with half developing resistance to chemotherapy. Here we identify
Chaitali Mukherjee et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(23), 8701-8717 (2015-06-13)
The cerebellum is crucial for sensorimotor coordination. The cerebellar architecture not only requires proper development but also long-term integrity to ensure accurate functioning. Developmental defects such as impaired neuronal migration or neurodegeneration are thus detrimental to the cerebellum and can
Kathy Saraiva-Pava et al.
World journal of gastroenterology, 21(21), 6526-6542 (2015-06-16)
To establish a cellular model correctly mimicking the gastric epithelium to overcome the limitation in the study of Helicobacter pylori (H. pylori) infection. Aiming to overcome this limitation, clones of the heterogenic cancer-derived NCI-N87 cell line were isolated, by stably-transducing
Michael Schaller-Schönitz et al.
PloS one, 9(5), e97243-e97243 (2014-05-20)
Signal transducers and activators of transcription (STATs) are latent cytoplasmic transcription factors linking extracellular signals to target gene transcription. Hematopoietic cells express two highly conserved STAT5-isoforms (STAT5A/STAT5B), and STAT5 is directly activated by JAK2 downstream of several cytokine receptors and
Yunhe Xu et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 253(7), 1085-1096 (2015-02-15)
Microglia contribute to immune homeostasis of the retina, and thus act as a potential regulator determining successful repair or retinal stem cell transplantation. We investigated the interaction between human microglia and retinal progenitor cells in cell co-culture to further our
S K Hegazy et al.
Transplant infectious disease : an official journal of the Transplantation Society, 17(3), 350-360 (2015-02-24)
Infections downregulate cytochrome-P activities and thus may alter drug disposition, especially for drugs with a narrow therapeutic index. Cyclosporine (CyA), still used for the prevention of allograft rejection in renal transplant recipients in Egypt, seems to be affected by these
Helen P Kourea et al.
Histology and histopathology, 30(9), 1129-1141 (2015-03-26)
Metronomic taxane administration has putative antiangiogenic properties. Herein, we examined the baseline tumor angiogenic profile of patients with metastatic breast carcinoma (MBC) in a prospective-retrospective translational research study. The interplay between the angiogenic factors expressed in the tumors and their
Jerome Di Giovanni et al.
The EMBO journal, 34(15), 2059-2077 (2015-06-26)
Recycling synaptic vesicles (SVs) transit through early endosomal sorting stations, which raises a fundamental question: are SVs sorted toward endolysosomal pathways? Here, we used snapin mutants as tools to assess how endolysosomal sorting and trafficking impact presynaptic activity in wild-type
Vincent Panneton et al.
The Journal of biological chemistry, 290(34), 20960-20971 (2015-07-15)
Protein kinases carry out important functions in cells both by phosphorylating substrates and by means of regulated non-catalytic activities. Such non-catalytic functions have been ascribed to many kinases, including some members of the Ste20 family. The Drosophila Ste20 kinase Slik
John E Baatz et al.
In vivo (Athens, Greece), 28(4), 411-423 (2014-07-02)
Clinical trials are currently used to test therapeutic efficacies for lung cancer, infections and diseases. Animal models are also used as surrogates for human disease. Both approaches are expensive and time-consuming. The utility of human biospecimens as models is limited
Anna Otte et al.
International journal of oncology, 45(3), 1151-1158 (2014-06-28)
A recently established cellular model for the rare small cell carcinoma of the ovary hypercalcemic type (SCCOHT-1) was characterized in comparison to ovarian adenocarcinoma cells (NIH:OVCAR-3 and SK-OV-3). The different cancer populations exhibited a common sensitivity in acidic pH milieu
Amandine Chatagnon et al.
Nucleic acids research, 43(10), 4833-4854 (2015-04-22)
In mouse embryonic cells, ligand-activated retinoic acid receptors (RARs) play a key role in inhibiting pluripotency-maintaining genes and activating some major actors of cell differentiation. To investigate the mechanism underlying this dual regulation, we performed joint RAR/RXR ChIP-seq and mRNA-seq
Christopher J Pappas et al.
Applied and environmental microbiology, 81(9), 3176-3181 (2015-03-01)
Leptospirosis, an emerging zoonotic disease, remains poorly understood because of a lack of genetic manipulation tools available for pathogenic leptospires. Current genetic manipulation techniques include insertion of DNA by random transposon mutagenesis and homologous recombination via suicide vectors. This study
Wenjing Lei et al.
PloS one, 10(7), e0130421-e0130421 (2015-07-21)
Hyperhomocysteinemia (HHcy) leads to several clinical manifestations including hepatic fibrosis. Excess deposition of extracellular matrix (ECM) components including collagen is the eponymous lesion of liver fibrosis. In this study, we demonstrated that elevated concentration of Hcy induced the expression of
Elena Pérez et al.
International journal of pharmaceutics, 492(1-2), 10-19 (2015-07-15)
Most antitumor drugs usually affect not only rapidly dividing cells, such as those in tumors, but also highly proliferative cells in normal tissues. This nonspecific drawback could be successfully solved by using nanocarriers as controlled drug delivery systems. In this
M Fujiya et al.
Oncogene, 33(40), 4847-4856 (2013-10-30)
It is well known that microRNAs (miRs) are abnormally expressed in various cancers and target the messenger RNAs (mRNAs) of cancer-associated genes. While (miRs) are abnormally expressed in various cancers, whether miRs directly target oncogenic proteins is unknown. The present
Yung-Ting Kuo et al.
PloS one, 10(5), e0125343-e0125343 (2015-05-08)
Neuroblastoma (NB) is a common neural crest-derived extracranial solid cancer in children. Among all childhood cancers, NB causes devastating loss of young lives as it accounts for 15% of childhood cancer mortality. Neuroblastoma, especially high-risk stage 4 NB with MYCN
Raymundo Cruz et al.
Pathology, research and practice, 211(11), 829-838 (2015-08-25)
Animal models have been used to understand the basic biology of osteoarthritis (OA) and have helped to identify new candidate biomarkers for the early diagnosis and treatment of this condition. Small animals cannot sufficiently mimic human diseases; therefore, large animal
Yaíma L Lightfoot et al.
The EMBO journal, 34(7), 881-895 (2015-02-11)
Intestinal immune regulatory signals govern gut homeostasis. Breakdown of such regulatory mechanisms may result in inflammatory bowel disease (IBD). Lactobacillus acidophilus contains unique surface layer proteins (Slps), including SlpA, SlpB, SlpX, and lipoteichoic acid (LTA), which interact with pattern recognition
Karina Fischer et al.
The American journal of clinical nutrition, 101(4), 794-807 (2015-04-04)
Visceral (VAT) and subcutaneous abdominal (SAAT) and trunk (STRAT) adipose tissue (AT) have been suggested to be differentially influenced by diet. We investigated whether and to what extent usual patterns of nutrient intake are associated with VAT, SAAT, and STRAT
Camille Keeler et al.
Biophysical journal, 105(12), 2843-2853 (2013-12-24)
We present an improved and extended version of a recently proposed mathematical approach for modeling isotherms of ligand-to-macromolecule binding from isothermal titration calorimetry. Our approach uses ordinary differential equations, solved implicitly and numerically as initial value problems, to provide a
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