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Ian Gibbs-Seymour et al.
Aging cell, 14(2), 162-169 (2015-02-04)
Lamins A/C have been implicated in DNA damage response pathways. We show that the DNA repair protein 53BP1 is a lamin A/C binding protein. In undamaged human dermal fibroblasts (HDF), 53BP1 is a nucleoskeleton protein. 53BP1 binds to lamins A/C
Peter C Soema et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 94, 427-435 (2015-07-07)
In this study, the effect of liposomal lipid composition on the physicochemical characteristics and adjuvanticity of liposomes was investigated. Using a design of experiments (DoE) approach, peptide-containing liposomes containing various lipids (EPC, DOPE, DOTAP and DC-Chol) and peptide concentrations were
Chenxiang Tang et al.
The Journal of biological chemistry, 290(44), 26352-26359 (2015-08-22)
SAMHD1 is a cellular protein that plays key roles in HIV-1 restriction and regulation of cellular dNTP levels. Mutations in SAMHD1 are also implicated in the pathogenesis of chronic lymphocytic leukemia and Aicardi-Goutières syndrome. The anti-HIV-1 activity of SAMHD1 is
Tsz Yan Wong et al.
Chemico-biological interactions, 221, 70-76 (2014-08-12)
Licorice is derived from the rhizomes of Glycyrrhiza glabra. It has been used for confectioneries or culinary purposes. The rhizomes contain many flavonoidal compounds that have been shown to be biologically active. In the present study, effect of the licorice
Jan Laczó et al.
Neurobiology of aging, 36(6), 2024-2033 (2015-04-12)
The very long (VL) poly-T variant at rs10524523 ("523") of the TOMM40 gene may hasten the onset of late-onset Alzheimer's disease (LOAD) and induce more profound cognitive impairment compared with the short (S) poly-T variant. We examined the influence of
Venkataramanan Subramanian et al.
Journal of proteome research, 13(12), 5431-5451 (2014-10-22)
Chlamydomonas reinhardtii is well adapted to survive under different environmental conditions due to the unique flexibility of its metabolism. Here we report metabolic pathways that are active during acclimation to anoxia, but were previously not thoroughly studied under dark, anoxic
Min Zhang et al.
Oncology letters, 10(3), 1841-1847 (2015-12-02)
Peroxiredoxin 1 (Prx1) has a significant role in several malignant types of tumor. However, the role of Prx1 in oral leukoplakia (OLK) has remained to be elucidated. OLK is a common precancerous lesion of the oral mucosa that has a
Nirav M Amin et al.
Developmental biology, 405(2), 291-303 (2015-07-15)
The large size and rapid development of amphibian embryos has facilitated ground-breaking discoveries in developmental biology. Here, we describe the embryogenesis of the Budgett's frog (Lepidobatrachus laevis), an unusual species with eggs that are over twice the diameter of laboratory
Oscar Cerda et al.
Pflugers Archiv : European journal of physiology, 467(8), 1723-1732 (2014-09-19)
Transient receptor potential melastatin-like 4 (TRPM4) is a Ca(2+)-activated non-selective cation channel expressed in a wide range of human tissues. TRPM4 participates in a variety of physiological processes such as T cell activation, myogenic vasoconstriction, and allergic reactions. TRPM4 Ca(2+)
Diego Bernal-Bernal et al.
PloS one, 10(3), e0121322-e0121322 (2015-03-27)
Two prototypes of the large CarD_CdnL_TRCF family of bacterial RNA polymerase (RNAP)-binding proteins, Myxococcus xanthus CarD and CdnL, have distinct functions whose molecular basis remain elusive. CarD, a global regulator linked to the action of several extracytoplasmic function (ECF) σ-factors
S Meshaal et al.
Allergologia et immunopathologia, 43(3), 279-285 (2015-03-23)
Chronic granulomatous disease (CGD) is an inherited disease that results from a defect in the phagocytic cells of the immune system. It is caused by defects in one of the major subunits of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase
James D Chalmers et al.
The Lancet. Respiratory medicine, 1(3), 224-232 (2014-01-17)
Mannose-binding lectin (MBL) is a key component of innate immunity. MBL deficiency is common (10-30% of the general population depending on the definition used) and has been associated with disease progression in cystic fibrosis. We aimed to assess the effect
Christopher A Dieni et al.
PeerJ, 2, e558-e558 (2014-09-12)
The wood frog, Rana sylvatica, survives whole-body freezing and thawing each winter. The extensive adaptations required at the biochemical level are facilitated by alterations to signaling pathways, including the insulin/Akt and AMPK pathways. Past studies investigating changing tissue-specific patterns of
Michael Murphy et al.
The Journal of biological chemistry, 290(31), 19218-19232 (2015-06-18)
Endotoxin tolerance reprograms Toll-like receptor (TLR) 4-mediated macrophage responses by attenuating induction of proinflammatory cytokines while retaining expression of anti-inflammatory and antimicrobial mediators. We previously demonstrated deficient TLR4-induced activation of IL-1 receptor-associated kinase (IRAK) 4, IRAK1, and TANK-binding kinase (TBK)
Yabin Lu et al.
Brain research bulletin, 118, 17-24 (2015-09-01)
Culture of human oligodendrocyte precursor cells (OPCs) can help understand the regulatory mechanism of differentiation and myelination of oligodendrocytes. However, existing culture methods have limitations, particularly the lack of a source of human donor tissue and high cost. We sorted
Susan Yung et al.
Autoimmunity, 48(7), 471-487 (2015-06-24)
Progression to chronic renal failure varies between patients with lupus nephritis. We compared the effects of mycophenolate mofetil (MMF) and cyclophosphamide (CTX), on renal histology and cellular pathways of fibrosis in murine lupus nephritis. Female NZBWF1/J mice were randomized to
Annamária Fejes-Szabó et al.
Journal of neural transmission (Vienna, Austria : 1996), 121(7), 725-738 (2014-01-05)
The systemic administration of nitroglycerine induces attacks in migraineurs and is able to activate and sensitize the trigeminal system in animals involving glutamate and α7-nicotinic acetylcholine receptors, among others. Kynurenic acid is one of the endogenous glutamate receptor antagonists, and
Clémence Henry et al.
Plant physiology, 169(2), 1072-1089 (2015-08-14)
Little is known about how salt impacts primary metabolic pathways of C4 plants, particularly related to kernel development and seed set. Osmotic stress was applied to maize (Zea mays) B73 by irrigation with increasing concentrations of NaCl from the initiation
Tomonaga Ichikawa et al.
Cellular signalling, 27(10), 2087-2098 (2015-07-26)
N-myc downstream-regulated gene 2 (NDRG2) is one of the important stress-inducible genes and plays a critical role in negatively regulating PI3K/AKT signaling during hypoxia and inflammation. Through recruitment of PP2A phosphatase, NDRG2 maintains the dephosphorylated status of PTEN to suppress
Diana M Tacelosky et al.
Behavioral neuroscience, 129(6), 744-755 (2015-10-27)
Drug overdose now exceeds car accidents as the leading cause of accidental death in the United States. Of those drug overdoses, a large percentage of the deaths are due to heroin and/or pharmaceutical overdose, specifically misuse of prescription opioid analgesics.
Rajagopal Sudarsan et al.
Parasitology international, 64(1), 43-49 (2014-10-05)
In the malarial parasite Plasmodium falciparum, the conserved ribosomal stalk protein P2 (PfP2) exhibits extra-ribosomal stage-specific oligomerization and trafficking to the host red cell membrane. Antibodies directed against PfP2 arrested cell division. We sought to examine whether P2 from a
Thati Madhusudhan et al.
Nature communications, 6, 6496-6496 (2015-03-11)
Endoplasmic reticulum (ER) stress is associated with diabetic nephropathy (DN), but its pathophysiological relevance and the mechanisms that compromise adaptive ER signalling in podocytes remain unknown. Here we show that nuclear translocation of the transcription factor spliced X-box binding protein-1
Yuelong Ji et al.
Nutrients, 6(12), 5900-5914 (2014-12-23)
Plasma homocysteine (Hcy) is a modifiable, independent risk factor for cardiovascular disease (CVD) and is affected by both environmental and genetic factors. This study aimed to describe the gender- and age-specific distribution of Hcy concentration for 1117 subjects aged 10-66
Jung-Sun Cho et al.
Experimental biology and medicine (Maywood, N.J.), 240(2), 185-193 (2014-10-09)
Mesenchymal stem cells (MSCs) are multipotent progenitor cells in adult tissues. This study aimed to investigate nasal polyp (NP) tissues as a potential new source of multipotent MSCs that maintain their stemness and differentiation potential following multiple rounds of passaging.
[73-year-old man with refractory idiopathic thrombocytopenia purpura].
T Austein et al.
Deutsche medizinische Wochenschrift (1946), 138(46), 2357-2358 (2013-11-07)
Takashi Nojiri et al.
Pulmonary pharmacology & therapeutics, 29(1), 24-30 (2014-01-28)
We recently reported that administration of atrial natriuretic peptide during the perioperative period has prophylactic effects with respect to not only cardiovascular but also respiratory complications following pulmonary resection. However, its mechanisms are not well understood. The objective of the
Takuro Mizukami et al.
International journal of oncology, 47(2), 499-505 (2015-06-18)
Since the prognosis of unresectable advanced gastric cancer remains poor, novel therapeutic strategies are needed. Somatic MEK1 gene mutations have been reported as oncogenic activating mutations in gastric cancer, and MEK inhibitors can be effective against such gastric cancers. In
Kyung-No Son et al.
Journal of virology, 89(18), 9383-9392 (2015-07-03)
Early biochemical studies of viral replication suggested that most viruses produce double-stranded RNA (dsRNA), which is essential for the induction of the host immune response. However, it was reported in 2006 that dsRNA could be detected by immunofluorescence antibody staining
Jane Atesoh Awuh et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(31), E4272-E4280 (2015-07-22)
Several mechanisms are involved in controlling intracellular survival of pathogenic mycobacteria in host macrophages, but how these mechanisms are regulated remains poorly understood. We report a role for Kelch-like ECH-associated protein 1 (Keap1), an oxidative stress sensor, in regulating inflammation
Meltem Avci-Adali et al.
Nucleic acid therapeutics, 24(4), 250-257 (2014-07-24)
Hitherto, several aptamers have been selected against cell surface molecules. The use of these aptamers for in vivo applications requires the prior in-depth in vitro evaluation of cell specific binding. Here, we demonstrate the in vitro tests, which are imperatively
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