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关键词:'EPI003'
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Long Jin et al.
Theriogenology, 87, 298-305 (2016-10-16)
Cloning remains as an important technique to enhance the reconstitution and distribution of animal population with high-genetic merit. One of the major detrimental factors of this technique is the abnormal epigenetic modifications. MGCD0103 is known as a histone deacetylase inhibitor.
Christina Stache et al.
Neurosurgical focus, 41(6), E14-E14 (2016-12-03)
OBJECTIVE In this study, the authors investigated the underlying mechanisms responsible for high tumor recurrence rates of adamantinomatous craniopharyngioma (ACP) after radiotherapy and developed new targeted treatment protocols to minimize recurrence. ACPs are characterized by the activation of the receptor
Prashanth Thevkar Nagesh et al.
Journal of virology, 90(9), 4614-4625 (2016-02-26)
Viruses dysregulate the host factors that inhibit virus infection. Here, we demonstrate that human enzyme, histone deacetylase 1 (HDAC1) is a new class of host factor that inhibits influenza A virus (IAV) infection, and IAV dysregulates HDAC1 to efficiently replicate
Targeting histone deacetylase activity to arrest cell growth and promote neural differentiation in Ewing sarcoma.
Souza B K, et al.
Molecular Neurobiology, 1-17 (2018)
The biology of HDAC in cancer: the nuclear and epigenetic components.
Handbook of Experimental Pharmacology, 206, 13-37 (2011)
Covalent modifications of histones during development and disease pathogenesis.
Bhaumik S R, et al.
Nature Structural and Molecular Biology, 14(11), 1008-1008 (2007)
Elżbieta Fiedor et al.
Cancer genomics & proteomics, 15(4), 329-336 (2018-07-07)
A common finding in cancer cells is the overexpression of histone deacetylases (HDACs), leading to altered expression and activity of numerous proteins involved in carcinogenesis. Considering that leptin can modulate the levels of HDACs, we hypothesised that leptin receptor antagonists
Qing-Shan Gao et al.
Zygote (Cambridge, England), 24(2), 236-244 (2015-05-01)
We investigated the effect of human induced pluripotent stem cell (hiPS) medium on porcine somatic cell nuclear transfer and bovine in vitro fertilized early blastocysts, in comparison with North Carolina State University (NCSU)-37 medium and in vitro culture (IVC)-II medium.
Jun-Xue Jin et al.
Biochemical and biophysical research communications, 456(1), 156-161 (2014-12-03)
In this study, we investigated the effects of the histone deacetylase inhibitor PXD101 (belinostat) on the preimplantation development of porcine somatic cell nuclear transfer (SCNT) embryos and their expression of the epigenetic markers histone H3 acetylated at lysine 9 (AcH3K9).
Controlling the double helix.
Felsenfeld G and Groudine M
Nature, 421(6921), 448-448 (2003)
Influenza A virus dysregulates host histone deacetylase 1 that inhibits viral infection in lung epithelial cells.
Nagesh P T and Husain M
Journal of Virology (2016)
Cierra J Walker et al.
Nature biomedical engineering, 5(12), 1485-1499 (2021-04-21)
Fibrotic disease is caused by the continuous deposition of extracellular matrix by persistently activated fibroblasts (also known as myofibroblasts), even after the resolution of the injury. Using fibroblasts from porcine aortic valves cultured on hydrogels that can be softened via
Chun-Han Chen et al.
Oncotarget, 6(34), 35991-36002 (2015-10-16)
Upregulation of class I histone deacetylases (HDAC) correlates with poor prognosis in colorectal cancer (CRC) patients. Previous study revealed that (E)-N-hydroxy-3-(1-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl)acrylamide (Compound 11) is a potent and selective class I HDAC inhibitor, exhibited significant anti-proliferative activity in various human cancer
High mobility group box 1 release from hepatocytes during ischemia and reperfusion injury is mediated by decreased histone deacetylase activity.
Evankovich J, et al.
The Journal of Biological Chemistry (2010)
The persistent organochlorine pesticide endosulfan modulates multiple epigenetic regulators with oncogenic potential in MCF-7 cells.
Ghosh K, et al.
The Science of the Total Environment, 624, 1612-1622 (2018)
Long Jin et al.
Biotechnology letters, 38(9), 1433-1441 (2016-06-09)
To examine the effect of PCI-24781 (abexinostat) on the blastocyst formation rate in pig somatic cell nuclear transferred (SCNT) embryos and acetylation levels of the histone H3 lysine 9 and histone H4 lysine 12. Treatment with 0.5 nM PCI-24781 for 6 h
Bárbara Kunzler Souza et al.
Molecular neurobiology, 55(9), 7242-7258 (2018-02-06)
There is an urgent need for advances in the treatment of Ewing sarcoma (EWS), an aggressive childhood tumor with possible neuroectodermal origin. Inhibition of histone deacetylases (HDAC) can revert aberrant epigenetic states and reduce growth in different experimental cancer types.
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