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Daniele Tomassoni et al.
Neural regeneration research, 13(4), 692-698 (2018-05-04)
Peripheral neuropathies are chronic painful syndromes characterized by allodynia, hyperalgesia and altered nerve functionality. Nerve tissue degeneration represents the microanatomical correlate of peripheral neuropathies. Aimed to improve the therapeutic possibilities, this study investigated the hypersensitivity and the neuromorphological alterations related
Hossein Farahani et al.
Scientific reports, 7(1), 13467-13467 (2017-10-19)
Characterization and quantification of tumour clonal populations over time via longitudinal sampling are essential components in understanding and predicting the response to therapeutic interventions. Computational methods for inferring tumour clonal composition from deep-targeted sequencing data are ubiquitous, however due to
Jeyce K F Andrade et al.
Pharmacological reports : PR, 68(5), 1046-1053 (2016-08-10)
Nitrofurantoin is a nitroderivative antibiotic that has bactericidal activity against pathogens causing urinary tract infection. A few studies have reported that nitrofurantoin has cytotoxic activity against cancer cells; however, nitrofurans remain a poorly explored class of compounds with respect to
Daniel Wibberg et al.
BMC genomics, 17, 245-245 (2016-03-19)
Sugar beet (Beta vulgaris) is a crop cultivated for its high content in sugar, but it is vulnerable to many soil-borne pathogens. One of them is the basidiomycete Rhizoctonia solani. This fungal species has a compatibility system regulating hyphal fusions
Daniele Tomassoni et al.
International journal of molecular sciences, 14(3), 4580-4595 (2013-02-28)
Oxidative stress is an imbalance between the production of free radicals and antioxidant defense mechanisms, potentially leading to tissue damage. Oxidative stress has a key role in the development of cerebrovascular and/or neurodegenerative diseases. This phenomenon is mainly mediated by
S A Li et al.
Health promotion and chronic disease prevention in Canada : research, policy and practice, 35(8-9), 160-167 (2015-11-26)
Little is known about health care and social service professionals' perspective on the acceptability of long-term home-visit programs serving low-income, first-time mothers. This study describes the experiences and perspectives of these community care providers involved with program referrals or service
Camille Fonouni-Farde et al.
Plant physiology, 175(4), 1795-1806 (2017-10-20)
In legume plants, low-nitrogen soils promote symbiotic interactions with rhizobial bacteria, leading to the formation of nitrogen-fixing root nodules. Among critical signals regulating this developmental process are bacterial Nod Factors (NFs) and several plant hormones, including cytokinins (CKs) and gibberellins
Inga-Marie Schaefer et al.
The American journal of surgical pathology, 39(9), 1234-1241 (2015-05-02)
Diffuse-type neurofibroma, an uncommon variant of neurofibroma, is associated with neurofibromatosis type 1 in ∼60% of cases. Typically presenting in young adults as ill-defined plaque-like dermal/subcutaneous thickening, most cases are located on the trunk or the head and neck region.
Uncompetitive inhibitors of alcohol dehydrogenases.
B V Plapp et al.
Advances in experimental medicine and biology, 463, 295-303 (1999-06-03)
Ashraf Abdelkhaliq et al.
Particle and fibre toxicology, 17(1), 11-11 (2020-03-12)
Silver nanoparticles (AgNPs) are used extensively in various consumer products because of their antimicrobial potential. This requires insight in their potential hazards and risks including adverse effects during pregnancy on the developing fetus. Using a combination of the BeWo b30
Susan M Jack et al.
BMC health services research, 12, 50-50 (2012-03-02)
Despite an increase in knowledge about the epidemiology of intimate partner violence (IPV), much less is known about interventions to reduce IPV and its associated impairment. One program that holds promise in preventing IPV and improving outcomes for women exposed
Elise C Omaki et al.
Maternal and child health journal, 22(7), 1025-1032 (2018-02-09)
Objectives To demonstrate the feasibility of partnering fire department personnel and home visiting nurses to increase the number of low-income homes protected by smoke alarms. Methods During a regularly scheduled home visit, nurses at the Nurse-Family Partnership of Maricopa County
Mohamed B Abou-Donia et al.
Brain sciences, 11(2) (2021-01-28)
Veterans from the 1991 Gulf War (GW) have suffered from Gulf War illness (GWI) for nearly 30 years. This illness encompasses multiple body systems, including the central nervous system (CNS). Diagnosis and treatment of GWI is difficult because there has
Rik Huisman et al.
Molecular plant-microbe interactions : MPMI, 28(12), 1271-1280 (2015-08-28)
In biotrophic plant-microbe interactions, microbes infect living plant cells, in which they are hosted in a novel membrane compartment, the host-microbe interface. To create a host-microbe interface, arbuscular mycorrhizal (AM) fungi and rhizobia make use of the same endosymbiotic program.
S Ramaswamy et al.
Biochemistry, 36(12), 3522-3527 (1997-03-25)
Amides are analogs of aldehydes and potent inhibitors of liver alcohol dehydrogenases. They can be used for structural studies and for inhibiting the metabolism of alcohols that form toxic products. We studied N-alkyl amides that bind to the enzyme-NADH complex
Mohamed Bahie Abou-Donia et al.
Toxicology and industrial health, 34(1), 44-53 (2017-10-27)
A number of studies have linked exposures to industrial and household chemicals and biological toxins to increased risk of autoimmunity in general and elevated levels of autoantibodies to neural antigens specifically. Elevated neural autoantibodies are biomarkers for many diseases such
Takahiro Ono et al.
Neurologia medico-chirurgica, 60(11), 543-552 (2020-10-20)
Pleomorphic xanthoastrocytoma (PXA) is a rare glial tumor, however, its histological differentiation from high-grade gliomas is often difficult. Molecular characteristics may contribute to a better diagnostic discrimination. Prognostic factors of PXA are also important but few relevant reports have been
Rachel Polcyn et al.
Neurochemistry international, 139, 104788-104788 (2020-07-11)
Enolase inhibition is a potential therapeutic strategy currently being investigated for treatment of spinal cord injury (SCI) as it reduces pro-inflammatory cytokines and chemokines, alters metabolic factors, and reduces gliosis in acute SCI. Herein, the role of enolase in SCI
Tal Teitz et al.
PloS one, 6(4), e19133-e19133 (2011-05-12)
Preclinical models of pediatric cancers are essential for testing new chemotherapeutic combinations for clinical trials. The most widely used genetic model for preclinical testing of neuroblastoma is the TH-MYCN mouse. This neuroblastoma-prone mouse recapitulates many of the features of human
Soledad Traubenik et al.
The Plant cell, 32(2), 352-373 (2019-11-22)
Translational control is a widespread mechanism that allows the cell to rapidly modulate gene expression in order to provide flexibility and adaptability to eukaryotic organisms. We applied translating ribosome affinity purification combined with RNA sequencing to characterize translational regulation of
Soo Jung Shin et al.
Free radical biology & medicine, 164, 233-248 (2021-01-11)
Biological aging provokes morbidity and several functional declines, causing older adults more susceptible to a variety of diseases than younger adults. In particular, aging is a major risk factor contributing to non-communicable diseases, such as neurodegenerative disorders. Alzheimer's disease (AD)
Mohamed B Abou-Donia et al.
Neurotoxicology and teratology, 61, 36-46 (2017-03-14)
Gulf War illness (GWI) is primarily diagnosed by symptom report; objective biomarkers are needed that distinguish those with GWI. Prior chemical exposures during deployment have been associated in epidemiologic studies with altered central nervous system functioning in veterans with GWI.
Sandra Bensmihen et al.
PloS one, 6(11), e26114-e26114 (2011-11-17)
The root nodule nitrogen fixing symbiosis between legume plants and soil bacteria called rhizobia is of great agronomical and ecological interest since it provides the plant with fixed atmospheric nitrogen. The establishment of this symbiosis is mediated by the recognition
Nesreen Zoghoul Alsmadi et al.
Acta biomaterialia, 78, 165-177 (2018-07-31)
The repair of nerve gap injuries longer than 3 cm is limited by the need to sacrifice donor tissue and the morbidity associated with the autograft gold standard, while decellularized grafts and biodegradable conduits are effective only in short nerve defects.
Xiangjun Yang et al.
Journal of neuroinflammation, 17(1), 252-252 (2020-08-30)
Glia-driven neuroinflammation promotes neuron injury in glaucoma that is a chronic neurodegenerative disease of the optic nerve and a leading cause of irreversible blindness. Although therapeutic modulation of neuroinflammation is increasingly viewed as a logical strategy to avoid inflammatory neurotoxicity
Y García-Mesa et al.
Journal of anatomy, 231(6), 978-989 (2017-09-15)
The transformation of mechanical energy into electrical signals is the first step in mechanotransduction in the peripheral sensory nervous system and relies on the presence of mechanically gated ion channels within specialized sensory organs called mechanoreceptors. Piezo2 is a vertebrate
Cora Peterson et al.
Prevention science : the official journal of the Society for Prevention Research, 19(6), 705-715 (2017-07-25)
We assessed the US state-level budget and societal impact of implementing two child abuse and neglect (CAN) primary prevention programs. CAN cost estimates and data from two prevention programs (Child-Parent Centers and Nurse-Family Partnership) were combined with current population, cost
Sungjin Chung et al.
American journal of translational research, 8(11), 4574-4585 (2016-12-03)
Besides its effect on high blood pressure, T-type calcium channel blocker is renoprotective in experimental models of renal fibrosis. However, the exact mechanism of T-type calcium channel blocker on tubulointerstitial fibrosis is unclear. We investigated whether the renoprotective effect of
Patricia A Rodriguez et al.
Molecular plant, 12(6), 804-821 (2019-05-28)
In natural environments, plants are exposed to diverse microbiota that they interact with in complex ways. While plant-pathogen interactions have been intensely studied to understand defense mechanisms in plants, many microbes and microbial communities can have substantial beneficial effects on
Sami Saidi et al.
Environmental science and pollution research international, 23(20), 21070-21085 (2016-08-06)
The enzymatic hydrolysis using Prolyve BS coupled to membrane process (Ultrafiltration (UF) and nanofiltration (NF)) is a means of biotransformation of tuna protein waste to Tuna protein hydrolysate (TPH) with higher added values. This method could be an effective solution
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