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显示 1-30 #N/A 86 条结果 关于 "F203" 范围 论文
E Fayard et al.
Current opinion in lipidology, 12(2), 113-120 (2001-03-27)
Cholesterol and bile acid metabolism is tightly controlled by nuclear receptors. The liver X receptor, an oxysterol-activated nuclear receptor, limits cholesterol accumulation in the body both by stimulating reverse cholesterol transport and by inhibiting intestinal cholesterol absorption. The liver X
Wenqiang Chang et al.
PloS one, 7(7), e41624-e41624 (2012-08-01)
Candida albicans, the most prevalent fungal pathogen, undergoes yeast-to-hyphal switch which has long been identified as a key fungal virulence factor. We showed here that the lichen-derived small molecule retigeric acid B (RAB) acted as an inhibitor that significantly inhibited
Quorum sensing in dimorphic fungi: farnesol and beyond.
Kenneth W Nickerson et al.
Applied and environmental microbiology, 72(6), 3805-3813 (2006-06-06)
Dirk Wartenberg et al.
Journal of proteomics, 75(13), 4038-4049 (2012-05-29)
The isoprenoid alcohol farnesol represents a quorum-sensing molecule in pathogenic yeasts, but was also shown to inhibit the growth of many filamentous fungi. In order to gain a deeper insight into the antifungal activity of farnesol, we performed 2D-differential gel
Rina Neeman et al.
Digestive diseases and sciences, 59(10), 2462-2469 (2014-06-20)
Hepatic stellate cells (HSCs) have a key role in the formation of hepatic fibrosis. The active form of vitamin D, 1,25(OH)2D3, has been found to have antiproliferative and antifibrotic effects in various tissues including liver. Farnesylthiosalicylic acid (FTS), a novel
Austin B Mogen et al.
PloS one, 10(7), e0133886-e0133886 (2015-07-30)
Streptococcus mutans is the primary causative agent of dental caries, one of the most prevalent diseases in the United States. Previously published studies have shown that Pluronic-based tooth-binding micelles carrying hydrophobic antimicrobials are extremely effective at inhibiting S. mutans biofilm
Sangkyu Park et al.
PloS one, 9(10), e109453-e109453 (2014-10-07)
Sesquiterpenoid capsidiol, exhibiting antifungal activity against pathogenic fungus, is accumulated in infected ripe pepper fruits. In this study, we found a negative relation between the capsidiol level and lesion size in fruits infected with Colletotrichum gloeosporioides, depending on the stage
Seval Erkaya et al.
Journal of basic microbiology, 60(8), 669-678 (2020-05-26)
This study focused on investigating the effect of exogenously applied two quorum sensing molecules (tyrosol and farnesol) on the synthesis of bioactive metabolites (pigments, lactic acid, ethanol, and citric acid) in Monascus purpureus ATCC16365. None of the tested concentrations (62.5
Sarah Gilpin et al.
Cutaneous and ocular toxicology, 29(4), 278-287 (2010-09-23)
The fragrance material farnesol is cited as an infrequent but important cause of allergic contact dermatitis (ACD). It is included in the fragrance mix II patch series and requires labeling in the European Union if it is used in a
Andrea E DeBarber et al.
Biochimica et biophysica acta, 1682(1-3), 18-27 (2004-05-26)
Studies have shown that mammalian cytochromes p450 participate in the metabolism of terpenes, yet their role in the biotransformation of farnesol, an endogenous 15-carbon isoprenol, is unknown. In this report, [(14)C]-farnesol was transformed to more polar metabolites by NADPH-supplemented mammalian
Tristan Rossignol et al.
Antimicrobial agents and chemotherapy, 51(7), 2304-2312 (2007-08-09)
In Candida albicans, the quorum-sensing molecule farnesol inhibits the transition from yeast to hyphae but has no effect on cellular growth. We show that the addition of exogenous farnesol to cultures of Candida parapsilosis causes the cells to arrest, but
Delma S Childers et al.
PloS one, 10(3), e0122775-e0122775 (2015-03-27)
Candida albicans is the most frequently isolated human fungal pathogen and can cause a range of mucosal and systemic infections in immunocompromised individuals. Morphogenesis, the ability to undergo a reversible transition from budding yeast to elongated filaments, is an essential
Martin F Strube-Bloss et al.
PloS one, 10(9), e0137413-e0137413 (2015-09-05)
To trigger innate behavior, sensory neural networks are pre-tuned to extract biologically relevant stimuli. Many male-female or insect-plant interactions depend on this phenomenon. Especially communication among individuals within social groups depends on innate behaviors. One example is the efficient recruitment
Xiaolan Zhang et al.
Therapeutic delivery, 5(1), 53-68 (2013-12-18)
Clinical application of anticancer drugs is limited by problems such as low water solubility, lack of tissue-specificity and toxicity. Formulation development represents an important approach to these problems. Among the many delivery systems studied, polymeric micelles have gained considerable attention
Fan Xie et al.
Biochemical and biophysical research communications, 467(4), 664-669 (2015-10-27)
Aberrant activation of oncoproteins such as members of the Ras family is common in human lung cancers. The proper function of Ras largely depends on a post-translational modification termed prenylation. Bisphosphonates have been shown to inhibit prenylation in cancer cells.
Phillip A Lichtor et al.
Nature chemistry, 4(12), 990-995 (2012-11-24)
Selectivity in the catalytic functionalization of complex molecules is a major challenge in chemical synthesis. The problem is magnified when there are several possible stereochemical outcomes and when similar functional groups occur repeatedly within the same molecule. Selective polyene oxidation
Megan L Falsetta et al.
Antimicrobial agents and chemotherapy, 56(12), 6201-6211 (2012-09-19)
Fluoride is the mainstay of dental caries prevention, and yet current applications offer incomplete protection and may not effectively address the infectious character of the disease. Therefore, we evaluated the effectiveness of a novel combination therapy (CT; 2 mM myricetin
Nobuwa Aoki et al.
Journal of natural products, 71(7), 1308-1310 (2008-06-19)
An ethyl acetate-soluble fraction of a methanol extract from the stems of Angelica keiskei was subjected to chromatographic separation to give three new chalcones, designated as xanthokeismins A-C (1-3), in addition to a known chalcone, xanthoangelol B (4). The structures
Nuno Cerca et al.
The Journal of antibiotics, 66(5), 255-258 (2013-04-04)
Antibiotic resistance is a serious problem in Staphylococcus epidermidis infections as many clinical isolates of this organism are resistant to up to eight different antibiotics. The increased resistance to conventional antibiotic therapy has lead to the search for new antimicrobial
Marc M Schumacher et al.
eLife, 4 (2015-03-06)
Schnyder corneal dystrophy (SCD) is an autosomal dominant disorder in humans characterized by abnormal accumulation of cholesterol in the cornea. SCD-associated mutations have been identified in the gene encoding UBIAD1, a prenyltransferase that synthesizes vitamin K2. Here, we show that
Kit Kennedy et al.
PLoS biology, 17(7), e3000376-e3000376 (2019-07-19)
Apicomplexan parasites possess a plastid organelle called the apicoplast. Inhibitors that selectively target apicoplast housekeeping functions, including DNA replication and protein translation, are lethal for the parasite, and several (doxycycline, clindamycin, and azithromycin) are in clinical use as antimalarials. A
Louise A Knight et al.
BMC cancer, 9, 38-38 (2009-01-30)
Previous data suggest that lipophilic statins such as fluvastatin and N-bisphosphonates such as zoledronic acid, both inhibitors of the mevalonate metabolic pathway, have anti-cancer effects in vitro and in patients. We have examined the effect of fluvastatin alone and in
Melanie L Langford et al.
Eukaryotic cell, 12(9), 1281-1292 (2013-07-23)
Quorum sensing by farnesol in Candida albicans inhibits filamentation and may be directly related to its ability to cause both mucosal and systemic diseases. The Ras1-cyclic AMP signaling pathway is a target for farnesol inhibition. However, a clear understanding of
Ke-Feng Wang et al.
Scientific reports, 8(1), 15213-15213 (2018-10-14)
As the first fungal quorum sensing molecule, farnesol-induced morphological transition is usually studied in dimorphic fungi, but in basidiomycetes the morphological changes regulated by farnesol are rarely investigated. In this study, we found that farnesol made the basidiomycete Coriolus versicolor
A Berrocal et al.
Journal of applied microbiology, 113(1), 126-134 (2012-04-24)
For Ophiostoma (Ceratocystis) ulmi, the ability to undergo morphological change is a crucial factor for its virulence. To gain an understanding of quorum-sensing activity in O. ulmi as it relates to yeast-mycelium dimorphism control, this study examines the effects of
Thomas L Horn et al.
Chemico-biological interactions, 152(2-3), 79-99 (2005-04-21)
Farnesol demonstrates antitumor activity in several animal models for human cancer and was being considered for development as a cancer chemopreventive agent. This study was performed to characterize the effects of minimally toxic doses of farnesol on the activity of
Alexandre Yukio Saito et al.
Journal of pharmaceutical and biomedical analysis, 111, 100-103 (2015-04-17)
Nerolidol is a naturally occurring sesquiterpene found in the essential oils of many types of flowers and plants. It is frequently used in cosmetics, as a food flavoring agent, and in cleaning products. In addition, nerolidol is used as a
Novel salvage pathway utilizing farnesol and geranylgeraniol for protein isoprenylation.
D C Crick et al.
Biochemical and biophysical research communications, 237(3), 483-487 (1997-08-28)
K Hanley et al.
Journal of lipid research, 42(3), 390-398 (2001-03-20)
Lipids that are synthesized de novo in the epidermis, including fatty acids, oxysterols, 1,25-dihydroxyvitamin D(3), and farnesol, can regulate the differentiation of normal human keratinocytes (NHK). Cholesterol sulfate (CS), an epidermal lipid that is produced in the upper nucleated layers
Xiaoyun Wang et al.
Mycologia, 106(5), 881-888 (2014-06-05)
Farnesol (FOH) is known to induce apoptosis in some fungi and mammalian cells. We treated Aspergillus flavus, one of the leading causes of human invasive aspergillosis and a key producer of the most potent naturally occurring hepatocarcinogenic compounds, with FOH
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