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C Salis et al.
Neurochemistry international, 61(5), 798-806 (2012-07-11)
The differentiation of myelin-forming Schwann cells (SC) is completed with the appearance of myelin proteins MBP and P(0) and a concomitant downregulation of markers GFAP and p75NTR, which are expressed by immature and adult non-myelin-forming SC. We have previously demonstrated
Hui Wang et al.
Molecular cell, 78(1), 31-41 (2020-03-04)
Cellular iron homeostasis is dominated by FBXL5-mediated degradation of iron regulatory protein 2 (IRP2), which is dependent on both iron and oxygen. However, how the physical interaction between FBXL5 and IRP2 is regulated remains elusive. Here, we show that the
Peng Jia et al.
Zhonghua yi xue za zhi, 92(31), 2214-2218 (2012-11-20)
To explore the effects of ferric ion on the differentiation from both RAW264.7 and bone marrow macrophages to osteoclast in vitro and bone resorption in vivo. In the presence of 50 ng/ml receptor activator of nuclear factor kappa-B ligand (RANKL)
Yulia Pollak et al.
Journal of neural transmission (Vienna, Austria : 1996), 120(1), 37-48 (2012-03-27)
Iron accumulation and iron-related oxidative stress are involved in several pathological conditions and provide a rationale for the development of iron chelators as novel promising therapeutic strategies. Thus, we have recently synthesized multifunctional non-toxic, brain permeable iron chelating compounds, M30
Harsh Vardhan et al.
Cell biology international, 35(8), 793-798 (2011-03-19)
Chlamydia trachomatis is the leading cause of sexually transmitted infection worldwide, in which disease outcome is determined by the balance between pro- and anti-inflammatory host immune responses. Iron plays important roles in regulation and enhancement of various pro- and anti-inflammatory
Jiadong Wu et al.
Bone, 121, 16-28 (2019-01-06)
Iron accumulation is an independent risk factor for type I osteoporosis, but the molecular mechanisms of the phenomenon are not well defined, and effective therapy has not been reported. Here, we found that the level of mTOR was increased both
Sunggyu Yoon et al.
Molecules and cells, 40(12), 976-985 (2017-12-15)
Iron is an essential divalent ion for aerobic life. Life has evolved to maintain iron homeostasis for normal cellular and physiological functions and therefore imbalances in iron levels exert a wide range of consequences. Responses to iron dysregulation in blood
Ryan M Mitchell et al.
Neurobiology of aging, 32(6), 1114-1123 (2009-06-30)
HFE gene variants are relatively common genetic variants in Caucasians. The H63D HFE genetic variant has been repeatedly associated with a number of neurodegenerative diseases. We developed neuroblastoma cell lines expressing different HFE polymorphisms to explore the mechanisms behind these
Peter E Burby et al.
Bio-protocol, 7(8) (2017-07-15)
A fundamental procedure for most modern biologists is the genetic manipulation of the organism under study. Although many different methods for editing bacterial genomes have been used in laboratories for decades, the adaptation of CRISPR/Cas9 technology to bacterial genetics has
Marc Y Fink et al.
Current protocols in microbiology, 57(1), e102-e102 (2020-06-10)
Giardia lamblia is a protozoan parasite that is found ubiquitously throughout the world and is a major contributor to diarrheal disease. Giardia exhibits a biphasic lifestyle existing as either a dormant cyst or a vegetative trophozoite. Infections are typically initiated
T Takahara et al.
Nihon rinsho. Japanese journal of clinical medicine, 56(11), 2865-2869 (1998-12-16)
The high signal intensity from the intestinal fluid usually deteriorates the projection images of MR cholangiopancreatography (MRCP) because it superimposes on the biliary tract. FerriSeltz (Otsuka pharmaceutical, Tokushima, Japan; a ferric ammonium citrate-based positive oral contrast agent) solution in a
Iron excess limits HHIPL-2 gene expression and decreases osteoblastic activity in human MG-63 cells.
M Doyard et al.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 23(10), 2435-2445 (2012-01-13)
In order to understand mechanisms involved in osteoporosis observed during iron overload diseases, we analyzed the impact of iron on a human osteoblast-like cell line. Iron exposure decreases osteoblast phenotype. HHIPL-2 is an iron-modulated gene which could contribute to these
David J Lemler et al.
Breast cancer research : BCR, 19(1), 25-25 (2017-03-09)
Duodenal cytochrome b (DCYTB) is a ferrireductase that functions together with divalent metal transporter 1 (DMT1) to mediate dietary iron reduction and uptake in the duodenum. DCYTB is also a member of a 16-gene iron regulatory gene signature (IRGS) that
Nootchanat Mairuae et al.
Neuroscience letters, 500(1), 36-40 (2011-06-21)
Activation of microglia could be beneficial and yet simultaneously harmful depending upon nature of pathological milieu. Regardless of disease-specific etiology, iron accumulation, particularly in activated microglia, is a notable feature associated with a series of neuropathologies, including Alzheimer's diseases. Although
Fumiya Ito et al.
Redox biology, 47, 102174-102174 (2021-10-27)
Asbestos-associated diseases remain a social burden worldwide. Our previous studies identified asbestos-induced iron-rich milieu for mesothelial cells with ceaseless macrophage ferroptosis. However, molecular mechanisms how this mutagenic milieu influences mesothelial cells have not been elucidated yet. Here, we propose a
Michelle Riegman et al.
Nature cell biology, 22(9), 1042-1048 (2020-09-02)
Ferroptosis is a regulated form of necrotic cell death that is caused by the accumulation of oxidized phospholipids, leading to membrane damage and cell lysis1,2. Although other types of necrotic death such as pyroptosis and necroptosis are mediated by active
Luisa Maria Nieto R et al.
Molecular & cellular proteomics : MCP, 17(9), 1685-1701 (2018-05-31)
Tuberculosis (TB) continues to be an important public health threat worldwide, due in part to drug resistant Mycobacterium tuberculosis (Mtb) strains. The United States recently reported a shortage of isoniazid (INH), which could drive higher INH resistance rates. Changes in
Satoru Morita et al.
Japanese journal of radiology, 28(2), 117-122 (2010-02-26)
The aim of this study was to compare prospectively the image quality of magnetic resonance cholangiopancreatography (MRCP) using manganese chloride tetrahydrate (Bothdel Oral Solution 10) (MCT), a new negative oral contrast agent; ferric ammonium citrate (FerriSeltz powder 20%) (FAC); and
Kyle A Bauckman et al.
Autophagy, 12(5), 850-863 (2016-03-24)
Autophagy is a cellular recycling pathway, which in many cases, protects host cells from infections by degrading pathogens. However, uropathogenic Escherichia coli (UPEC), the predominant cause of urinary tract infections (UTIs), persist within the urinary tract epithelium (urothelium) by forming
Andrew E Armitage et al.
Journal of innate immunity, 8(5), 517-528 (2016-07-18)
Withdrawal of iron from serum (hypoferraemia) is a conserved innate immune antimicrobial strategy that can withhold this critical nutrient from invading pathogens, impairing their growth. Hepcidin (Hamp1) is the master regulator of iron and its expression is induced by inflammation.
Hugh Dickinson et al.
Bio-protocol, 8(16), e2977-e2977 (2018-08-20)
Studies of pollen germination and post-germination development are not only essential for understanding plant reproduction but also are an excellent model system for tip-based growth. Here we describe easy, reproducible methods for germination and growth of pollen from the model
Samuele Marro et al.
Haematologica, 95(8), 1261-1268 (2010-02-25)
Macrophages of the reticuloendothelial system play a key role in recycling iron from hemoglobin of senescent or damaged erythrocytes. Heme oxygenase 1 degrades the heme moiety and releases inorganic iron that is stored in ferritin or exported to the plasma
Hong-Sheng Dai et al.
Journal of virology, 87(20), 11231-11243 (2013-08-09)
Rational design and directed evolution are powerful tools to generate and improve protein function; however, their uses are mostly limited to enzyme and antibody engineering. Here we describe a directed-evolution strategy, named the tandem selection and enrichment system (TSES), and
Yinghui Zhang et al.
Antioxidants & redox signaling, 13(7), 999-1009 (2010-04-22)
Cytosolic ferritins sequester and store iron, consequently protecting cells against iron-mediated free radical damage. However, the mechanisms of iron exit from the ferritin cage and reutilization are largely unknown. In a previous study, we found that mitochondrial ferritin (MtFt) expression
Wenhan Zhu et al.
Cell host & microbe, 27(3), 376-388 (2020-02-23)
During short-lived perturbations, such as inflammation, the gut microbiota exhibits resilience and reverts to its original configuration. Although microbial access to the micronutrient iron is decreased during colitis, pathogens can scavenge iron by using siderophores. How commensal bacteria acquire iron
Abhishek Asthana et al.
Scientific reports, 7(1), 9600-9600 (2017-08-31)
Prion disease-associated retinal degeneration is attributed to PrP-scrapie (PrPSc), a misfolded isoform of prion protein (PrPC) that accumulates in the neuroretina. However, a lack of temporal and spatial correlation between PrPSc and cytotoxicity suggests the contribution of host factors. We
Sant-Rayn Pasricha et al.
Nature communications, 8(1), 403-403 (2017-09-03)
Hepcidin regulates systemic iron homeostasis. Suppression of hepcidin expression occurs physiologically in iron deficiency and increased erythropoiesis but is pathologic in thalassemia and hemochromatosis. Here we show that epigenetic events govern hepcidin expression. Erythropoiesis and iron deficiency suppress hepcidin via
Connie W Y Ha et al.
Cell, 183(3), 666-683 (2020-09-30)
A mysterious feature of Crohn's disease (CD) is the extra-intestinal manifestation of "creeping fat" (CrF), defined as expansion of mesenteric adipose tissue around the inflamed and fibrotic intestine. In the current study, we explore whether microbial translocation in CD serves
Carla V Galmozzi et al.
Bio-protocol, 7(6), e2176-e2176 (2017-03-20)
Isolation of ribosomal particles is an essential step in the study of ribosomal components as well as in the analysis of trans-acting factors that interact with the ribosome to regulate protein synthesis and modulate the expression profile of the cell
Hiroko Nobuta et al.
Cell stem cell, 25(4), 531-541 (2019-10-05)
Pelizaeus-Merzbacher disease (PMD) is an X-linked leukodystrophy caused by mutations in Proteolipid Protein 1 (PLP1), encoding a major myelin protein, resulting in profound developmental delay and early lethality. Previous work showed involvement of unfolded protein response (UPR) and endoplasmic reticulum
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