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A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury.
Feng Qian et al.
The EMBO journal, 28(19), 2896-2907 (2009-08-22)
There are at least 11 mitogen-activated protein kinase (MAPK) phosphatases (MKPs) and only 3 major groups of MAPKs, raising the question of whether these phosphatases have non-redundant functions in vivo. Using a modified mouse model of local Shwartzman reaction, we
Suhas G Kallapur et al.
American journal of respiratory and critical care medicine, 179(10), 955-961 (2009-02-24)
Chorioamnionitis frequently associates with preterm delivery and increased amniotic fluid IL-1, and causes fetal lung and systemic inflammation. However, chorioamnionitis is also associated with a paradoxical reduction in the incidence of surfactant deficiency-related respiratory distress syndrome in preterm infants. To
Ryusuke Yoshimi et al.
Journal of immunology (Baltimore, Md. : 1950), 182(12), 7527-7538 (2009-06-06)
The tripartite motif (TRIM) family member, TRIM21, is an E3 ubiquitin ligase for IFN regulatory factor (IRF)3 and IRF8 that functions in both innate and acquired immunity. It is also an autoantigen known as Ro52/SS-A. The function of TRIM21 in
Chengcong Yin et al.
Mucosal immunology, 13(6), 892-907 (2020-07-29)
Acute respiratory distress syndrome (ARDS) is a kind of comprehensive disease with excessive inflammation and high clinical mortality. Multiple immune cells are involved in the ARDS process. Amongst these populations, lung-resident alveolar macrophages (AMs) are known to participate in the
Siddhartha Jaiswal et al.
Cell, 138(2), 271-285 (2009-07-28)
Macrophages clear pathogens and damaged or aged cells from the blood stream via phagocytosis. Cell-surface CD47 interacts with its receptor on macrophages, SIRPalpha, to inhibit phagocytosis of normal, healthy cells. We find that mobilizing cytokines and inflammatory stimuli cause CD47
Sebastian E Winter et al.
Infection and immunity, 77(5), 1904-1916 (2009-02-25)
Salmonella enterica serotype Typhimurium causes acute inflammatory diarrhea in humans. Flagella contribute to intestinal inflammation, but the mechanism remains unclear since most mutations abrogating pattern recognition of flagellin also prevent motility and reduce bacterial invasion. To determine the contribution of
Patty Zwollo et al.
Developmental and comparative immunology, 32(12), 1482-1496 (2008-07-12)
To date, the trout B-cell is poorly defined, as many essential molecular markers are not yet available for this species. In mammalian systems, the transcription factor Pax5, expressed from pre-B through plasmablast stages, provides an important marker for B-cell differentiation.
Yan Su et al.
Frontiers in microbiology, 2, 154-154 (2011-08-04)
Genetically modified B cells are excellent tolerogenic antigen-presenting cells (APCs) in multiple models of autoimmunity. However, the mechanisms of action are still not completely understood. In our models, we generate antigen-specific tolerogenic B cells by transducing naïve or primed B
Bin Li et al.
International journal of molecular sciences, 15(1), 1143-1161 (2014-01-21)
Innate immunity is the first line of defense in human beings against pathogen infection; monocytes/macrophages are the primary cells of the innate immune system. Recently, macrophages/monocytes have been discovered to participate in LPS clearance, and the clearance efficiency determines the
J L Hayworth et al.
Clinical and experimental immunology, 157(1), 60-70 (2009-08-08)
Staphylococcal enterotoxin B (SEB) is a pyrogenic exotoxin and a potent superantigen which causes massive T cell activation and cytokine secretion, leading to profound immunosuppression and morbidity. The inhibition of SEB-induced responses is thus considered a goal in the management
Gillian D Pullinger et al.
Infection and immunity, 76(11), 5310-5321 (2008-09-17)
Salmonella enterica serovar Dublin is a host-restricted serovar associated with typhoidal disease in cattle. In contrast, the fowl-associated serovar S. enterica serovar Gallinarum is avirulent in calves, yet it invades ileal mucosa and induces enteritis at levels comparable to those
Baomei Shao et al.
Innate immunity, 18(6), 825-833 (2012-03-24)
Much evidence indicates that bacterial LPS (endotoxin) is removed from the bloodstream mainly by the liver, yet the hepatic uptake mechanisms remain uncertain and controversial. In plasma, LPS can be either 'free' (as aggregates, bacterial membrane fragments or loosely bound
Lina E Tze et al.
The Journal of experimental medicine, 208(1), 149-165 (2011-01-12)
Effective vaccine adjuvants must induce expression of major histocompatibility (MHC) class II proteins and the costimulatory molecule CD86 on dendritic cells (DCs). However, some adjuvants elicit production of cytokines resulting in adverse inflammatory consequences. Development of agents that selectively increase
Sylvain Losdat et al.
PloS one, 6(7), e22221-e22221 (2011-07-19)
Mounting an immune response against pathogens incurs costs to organisms by its effects on important life-history traits, such as reproductive investment and survival. As shown recently, immune activation produces large amounts of reactive species and is suggested to induce oxidative
Ignacio M Larrayoz et al.
Journal of hypertension, 27(12), 2365-2376 (2009-09-05)
Inhibition of angiotensin II receptor type 1 (AT1) reduces chronic inflammation associated with hypertension. We asked whether AT1 receptor inhibition would reduce the innate inflammatory response induced by bacterial lipopolysaccharide (LPS). We used unstimulated human circulating monocytes obtained from healthy
Tatyana Y Postnikova et al.
Pharmaceuticals (Basel, Switzerland), 13(3) (2020-03-22)
Infectious diseases in early postnatal ontogenesis often result in cognitive impairments, particularly learning and memory. The essential foundation of learning and memory is long-term synaptic plasticity, which depends on N-methyl-D-aspartate (NMDA) receptors. In the present study, bacterial infection was modeled
Sarah K Meadows et al.
PloS one, 3(4), e1912-e1912 (2008-04-03)
Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures. We have sought to determine the impact of several variables on the PB gene expression profile of an environmental
Shereen Shoma et al.
Infection and immunity, 76(4), 1547-1557 (2008-01-16)
Pneumolysin is a pore-forming cytolysin known as a major virulence determinant of Streptococcus pneumoniae. This protein toxin has also been shown to activate the Toll-like receptor 4 (TLR4) signaling pathway. In this study, a mutant S. pneumoniae strain deficient in
Sophie Van Linthout et al.
Journal of molecular medicine (Berlin, Germany), 89(2), 151-160 (2010-10-26)
The protective effects of high-density lipoprotein (HDL) under lipopolysaccharide (LPS) conditions have been well documented. Here, we investigated whether an effect of HDL on Toll-like receptor 4 (TLR4) expression and signalling may contribute to its endothelial-protective effects and to improved
Wen-Chi Wei et al.
Journal of biomedical science, 18, 94-94 (2011-12-23)
Skin is the largest organ in the body, and is directly exposed to extrinsic assaults. As such, the skin plays a central role in host defense and the cutaneous immune system is able to elicit specific local inflammatory and systemic
Yang Yu et al.
Scientific reports, 6, 20845-20845 (2016-02-10)
Phospholipid transfer protein (PLTP) participates in high density lipoprotein (HDL) metabolism. Increased plasma PLTP activity was observed in lipopolysaccharide (LPS) triggered acute inflammatory diseases. This study aimed to determine the exact role of PLTP in LPS induced inflammation. HDL pool
James A Listman et al.
Molecular immunology, 45(9), 2667-2677 (2008-03-01)
The immediate early (IE) proteins of human cytomegalovirus (hCMV) have diverse roles in directing viral and host cell transcription. Among these is the ability of IE2 to induce transcription of the IL1B gene that codes for IL-1beta in monocytes. This
Mitchell A Psotka et al.
Infection and immunity, 77(3), 959-969 (2009-01-07)
Hemolytic-uremic syndrome (HUS) caused by Shiga toxin-producing Escherichia coli infection is a leading cause of pediatric acute renal failure. Bacterial toxins produced in the gut enter the circulation and cause a systemic toxemia and targeted cell damage. It had been
Constance Schmelzer et al.
Mediators of inflammation, 2009, 415437-415437 (2009-04-25)
MicroRNAs (miRs) are involved in key biological processes via suppression of gene expression at posttranscriptional levels. According to their superior functions, subtle modulation of miR expression by certain compounds or nutrients is desirable under particular conditions. Bacterial lipopolysaccharide (LPS) induces
G Tumurkhuu et al.
Clinical and experimental immunology, 152(1), 182-191 (2008-03-01)
The mechanism underlying acute lung injury in lethal endotoxic shock induced by administration of lipopolysaccharide (LPS) into alpha-galactosylceramide (alpha-GalCer)-sensitized mice was studied. Sensitization with alpha-GalCer resulted in the increase of natural killer T (NK T) cells and the production of
Elena Topchiy et al.
PloS one, 11(5), e0155030-e0155030 (2016-05-14)
Sepsis is the leading cause of death in critically ill patients. While decreased Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) function improves clinical outcomes in murine and human sepsis, the mechanisms involved have not been fully elucidated. We tested the hypothesis
Jiejie Sun et al.
Journal of immunology (Baltimore, Md. : 1950), 205(9), 2402-2413 (2020-09-30)
The long-term evolutionary interaction between the host and symbiotic microbes determines their cooperative relationship. It is well known that the symbiotic microbes have evolved various mechanisms to either benefit or exploit the mammalian host immune system to maintain homeostasis. However
Hung Q Doan et al.
Anticancer research, 29(7), 2473-2478 (2009-07-15)
Toll-like receptors (TLRs) are involved in innate immunity. Overexpression of TLRs has been implicated in various types of cancer including colorectal cancer (CRC). The phosphatidylinositol-3'-kinase (PI3K)/Akt signaling pathway is involved in CRC growth and progression. In this study, we determined
Xiao Su et al.
Journal of immunology (Baltimore, Md. : 1950), 180(10), 6947-6953 (2008-05-06)
CD47 modulates neutrophil transmigration toward the sites of infection or injury. Mice lacking CD47 are susceptible to Escherichia coli (E. coli) peritonitis. However, less is known concerning the role of CD47 in the development of acute lung inflammation and injury.
Elias Leiva-Salcedo et al.
Mediators of inflammation, 2011, 152625-152625 (2011-09-24)
The purinergic P2X7 receptor (P2X7R) plays an important role during the immune response, participating in several events such as cytokine release, apoptosis, and necrosis. The bacterial endotoxin lipopolysaccharide (LPS) is one of the strongest stimuli of the immune response, and
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