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Ashish Kumar Sharma et al.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 15(4), 410-418 (2013-02-12)
The objective of this article is to investigate the combination of telmisartan with vildagliptin therapy versus monotherapy of vildagliptin and telmisartan on diabetic nephropathy in type 2 diabetes mellitus rats. In adult rats streptozotocin (65 mg/kg) and nicotinamide (110 mg/kg)
Amanda Leung et al.
Epilepsy research, 109, 114-118 (2014-12-20)
Temporal lobe epilepsy (TLE) has been modeled in mice using pilocarpine induction, with variable results depending on specific strains. To allow efficient xenotransplantation for the purpose of optimizing potential cell-based therapy of human TLE, we have determined the optimal dosing
Natalie Cortes et al.
Life sciences, 122, 42-50 (2014-12-23)
Amaryllidaceae alkaloids exhibit a wide range of physiological effects, of which the acetylcholinesterase (AChE) inhibitory activity is the most relevant. However, scientific evidence related to their neuroprotective effectiveness against glutamate-induced toxicity has been lacking. Thus, the purpose of this study
Marc Zuckermann et al.
Nature communications, 6, 7391-7391 (2015-06-13)
In vivo functional investigation of oncogenes using somatic gene transfer has been successfully exploited to validate their role in tumorigenesis. For tumour suppressor genes this has proven more challenging due to technical aspects. To provide a flexible and effective method
Kohei Miyata et al.
Cancer medicine, 3(5), 1159-1169 (2014-07-26)
Ovarian clear cell carcinoma (OCCC) is a worst histological subtype than other ovarian malignant tumor. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a promising target for ovarian cancer therapy. The aims of this study were to validate the efficacy
X Zhu et al.
Breast cancer research and treatment, 150(3), 479-486 (2015-03-19)
Paraffin sections from 239 cases of surgical resected mammary gland carcinomas were assessed to determine the role of BRCA1 gene methylation in sporadic triple-negative breast cancer and to evaluate the relationship between BRCA1 gene methylation and clinicopathologic features of triple-negative
Larisa Pereboeva et al.
Cancer immunology, immunotherapy : CII, 64(5), 551-562 (2015-02-14)
The standard treatment of high-grade glioma presents a combination of radiotherapy, chemotherapy and surgery. Immunotherapy is proposed as a potential adjunct to standard cytotoxic regimens to target remaining microscopic disease following resection. We have shown ex vivo expanded/activated γδ T
Ingrid R Cordeiro et al.
Biology open, 4(9), 1180-1193 (2015-09-01)
Human adipose-derived stromal cells (hADSC) are a heterogeneous cell population that contains adult multipotent stem cells. Although it is well established that hADSC have skeletal potential in vivo in adult organisms, in vitro assays suggest further differentiation capacity, such as
Daisong Wang et al.
Cell, 180(6), 1198-1211 (2020-03-24)
It has generally proven challenging to produce functional β cells in vitro. Here, we describe a previously unidentified protein C receptor positive (Procr+) cell population in adult mouse pancreas through single-cell RNA sequencing (scRNA-seq). The cells reside in islets, do not
Min-Shu Hsieh et al.
Virchows Archiv : an international journal of pathology, 467(2), 145-153 (2015-05-16)
Mammary analogue secretory carcinoma (MASC) has a specific ETV6-NTRK3 translocation and morphologically overlaps with acinic cell carcinoma (AciCC). Before the recognition of MASC, in AciCC, four histologic patterns were identified including microcystic, solid, papillary-cystic, and follicular. The aim of this
Etienne van Bracht et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 94, 141-151 (2015-05-09)
Lyophilisomes are a novel class of proteinaceous biodegradable nano/microparticle capsules developed for tumor drug delivery. The in vivo characteristics of lyophilisomes are unknown and, therefore, the time course of biodistribution of sized albumin-based lyophilisomes in CD1 mice after intravenous administration
Luciana Meli et al.
Stem cell research, 13(1), 36-47 (2014-05-13)
We developed a three-dimensional (3D) cellular microarray platform for the high-throughput (HT) analysis of human neural stem cell (hNSC) growth and differentiation. The growth of an immortalized hNSC line, ReNcell VM, was evaluated on a miniaturized cell culture chip consisting
Han-Jin Park et al.
PloS one, 10(7), e0132992-e0132992 (2015-07-16)
Human pluripotent stem cell-derived hepatocytes have the potential to provide in vitro model systems for drug discovery and hepatotoxicity testing. However, these cells are currently unsuitable for drug toxicity and efficacy testing because of their limited expression of genes encoding
Inhibition of transcription by dactinomycin reveals a new characteristic of immunogenic cell stress.
Juliette Humeau et al.
EMBO molecular medicine, 12(5), e11622-e11622 (2020-04-24)
Chemotherapy still constitutes the standard of care for the treatment of most neoplastic diseases. Certain chemotherapeutics from the oncological armamentarium are able to trigger pre-mortem stress signals that lead to immunogenic cell death (ICD), thus inducing an antitumor immune response
Xukui Zhang et al.
Oncology reports, 34(1), 302-310 (2015-05-23)
Irradiation has been reported to increase radioresistance and epithelial-mesenchymal transition (EMT) in gastric cancer (GC) cells. The Notch pathway is critically implicated in cancer EMT and radioresistance. In the present study, we investigated the use of a Notch-1 inhibiting compound
Christian Ostalecki et al.
Experimental and molecular pathology, 95(1), 1-6 (2013-04-16)
Novel approaches of individualized medicine require rapid analyses of comprehensive multi-gene expression patterns both at the RNA and protein levels. Optimally these analyses are achieved with minimal amounts of tissues, which are derived from routine procedures of clinical diagnostics. We
Caroline M Mitchell et al.
The Journal of infectious diseases, 210(4), 651-655 (2014-03-22)
Depot medroxyprogesterone acetate (DMPA) has been linked to human immunodeficiency virus type 1 (HIV-1) acquisition. Vaginal microbiota of women using DMPA for up to 2 years were cultured. Mucosal immune cell populations were measured by immunohistological staining. Over 12 months
Vinesh Anandarajan et al.
Current genetics, 66(3), 593-605 (2020-02-09)
Formaldehyde is a common environmental pollutant and is associated with adverse health effects. Formaldehyde is also considered to be a carcinogen because it can form DNA adducts, leading to genomic instability. How these adducts are prevented and removed is not
M Sato et al.
Oral diseases, 21(1), e86-e97 (2014-03-13)
Mesiodentes are usually found in the central position of the upper or lower jaw as supernumerary teeth. Here, we obtained 10 mesiodentes and three permanent teeth (PT) and separated the dental pulp (DP) from these into crown and root portions.
Daniel P Morris et al.
PloS one, 10(8), e0134442-e0134442 (2015-08-06)
In mammals, increasing evidence supports mechanisms of co-transcriptional gene regulation and the generality of genetic control subsequent to RNA polymerase II (Pol II) recruitment. In this report, we use Pol II Chromatin Immunoprecipitation to investigate relationships between the mechanistic events
Paul J Toren et al.
Molecular cancer therapeutics, 14(1), 59-69 (2014-10-30)
VT-464 is a novel, nonsteroidal, small-molecule CYP17A1 inhibitor with 17,20-lyase selectivity. This study evaluates the anticancer activity of VT-464 compared with abiraterone (ABI) in castrate-resistant prostate cancer cell lines and xenograft models that are enzalutamide (ENZ)-responsive (C4-2) or ENZ-resistant (MR49C
Minjeong Jung et al.
PloS one, 10(1), e0116972-e0116972 (2015-01-28)
Autophagy is a lysosomal degradative pathway that plays an important role in maintaining cellular homeostasis. We previously showed that the inhibition of autophagy causes pancreatic β-cell apoptosis, suggesting that autophagy is a protective mechanism for the survival of pancreatic β-cells.
Feng Chen et al.
Journal of interventional cardiology, 28(3), 257-263 (2015-05-21)
We investigated whether the combination coating of a novel "prohealing coating" hyaluronan-chitosan (HC) and anti-CD34 antibody applied on an SES (HCASES) can reduce neointimal formation while promoting endothelialization compared to either agent alone. Drug-eluting stents have considerably reduced the incidence
Catherine A Mayer et al.
Pediatric research, 78(2), 145-151 (2015-05-08)
Continuous positive airway pressure (CPAP) is a primary form of respiratory support used in the intensive care of preterm infants, but its long-term effects on airway (AW) function are unknown. We developed a neonatal mouse model of CPAP treatment to
Qingyuan Meng et al.
International journal of nanomedicine, 10, 2313-2323 (2015-04-08)
Cell culture systems have proven to be crucial for the in vitro maintenance of primary hepatocytes and the preservation of hepatic functional expression at a high level. A poly-(N-p-vinylbenzyl-4-O-β-D-galactopyranosyl-D-gluconamide) matrix can recognize cells and promote liver function in a spheroid
Maximilian W Schenk et al.
Nature communications, 12(1), 6652-6652 (2021-11-19)
Small cell lung cancer (SCLC) has a 5-year survival rate of <7%. Rapid emergence of acquired resistance to standard platinum-etoposide chemotherapy is common and improved therapies are required for this recalcitrant tumour. We exploit six paired pre-treatment and post-chemotherapy circulating
Ina Rosenberger et al.
Journal of controlled release : official journal of the Controlled Release Society, 194, 130-137 (2014-09-01)
Iron oxide-containing magnetic nanoparticles (MNPs) have certain advantages over currently used contrast agents for tumor imaging by magnetic resonance imaging (MRI) as they offer the possibility of functionalization with ligands and tracers. Functionalized MNPs also may be used for targeted
Aya D Pusic et al.
Experimental neurology, 264, 43-54 (2014-12-17)
Multiple sclerosis and migraine with aura are clinically correlated and both show imaging changes suggestive of myelin disruption. Furthermore, cortical myelin loss in the cuprizone animal model of multiple sclerosis enhances susceptibility to spreading depression, the likely underlying cause of
Sean M Hartig et al.
Molecular endocrinology (Baltimore, Md.), 29(9), 1320-1333 (2015-07-21)
Insulin resistance and type 2 diabetes mellitus (T2DM) result from an inability to efficiently store and catabolize surplus energy in adipose tissue. Subcutaneous adipocytes protect against insulin resistance and T2DM by coupling differentiation with the induction of brown fat gene
Rob J W Arts et al.
Journal of leukocyte biology, 98(1), 129-136 (2015-05-03)
Epidemiologic studies suggest that VAS has long-lasting immunomodulatory effects. We hypothesized that ATRA inhibits inflammatory cytokines in a model of trained immunity in monocytes by inducing epigenetic reprogramming through histone modifications. We used an previously described in vitro model of
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