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Chul-Kyu Park et al.
Neuron, 82(1), 47-54 (2014-04-05)
Intracellular microRNAs (miRNAs) are key regulators of gene expression. The role of extracellular miRNAs in neuronal activation and sensory behaviors are unknown. Here we report an unconventional role of extracellular miRNAs for rapid excitation of nociceptor neurons via toll-like receptor-7
Mariana Martins Gomes Pinheiro et al.
PloS one, 10(3), e0121063-e0121063 (2015-03-26)
Choisya ternata Kunth (Rutaceae) is native to North America where it is popularly known as "Mexican orange". In this study, the anti-inflammatory effects of the essential oil (EO) obtained from the leaves of C. ternata, one of its minor components
Matthew S Reifenberger et al.
American journal of physiology. Renal physiology, 307(1), F86-F95 (2014-05-16)
Numerous reports have linked cytoskeleton-associated proteins with the regulation of epithelial Na(+) channel (ENaC) activity. The purpose of the present study was to determine the effect of actin cytoskeleton disruption by cytochalasin E on ENaC activity in Xenopus 2F3 cells.
Asuka Yuda et al.
Journal of cellular physiology, 230(1), 150-159 (2014-06-07)
Appropriate mechanical loading during occlusion and mastication play an important role in maintaining the homeostasis of periodontal ligament (PDL) tissue. Connective tissue growth factor (CTGF/CCN2), a matricellular protein, is known to upregulate extracellular matrix production, including collagen in PDL tissue.
Hulda R Jonsdottir et al.
Laboratory investigation; a journal of technical methods and pathology, 95(12), 1418-1428 (2015-09-22)
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with high morbidity and mortality. The cellular source of the fibrotic process is currently under debate with one suggested mechanism being epithelial-to-mesenchymal transition (EMT) in the alveolar region. In this
Xiaoping Wang et al.
Monoclonal antibodies in immunodiagnosis and immunotherapy, 34(4), 233-245 (2015-08-25)
Orf is caused by the orf virus (ORFV) and is a non-systemic, widespread disease afflicting sheep, goats, wild ruminants, and humans. Recent outbreaks in sheep and goats in Jilin and other northern Chinese provinces raise concerns about orf control in
Krista A Mitchnick et al.
The European journal of neuroscience, 41(6), 773-786 (2015-02-03)
Epigenetic mechanisms are increasingly acknowledged as major players in memory formation. Specifically, DNA methylation is necessary for the formation of long-term memory in various brain regions, including the hippocampus (HPC); however, its role in the perirhinal cortex (PRh), a structure
Claudia E Mohn et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 23(2), 241-250 (2015-02-20)
The aim of the present study was to perform a biochemical, histological, and histomorphometrical evaluation of the mechanisms involved in tissue repair in rats subjected to submandibulectomy-induced hyposialia, 24, 48, and 72 hours of post-tooth extraction. We studied the correlation
Jürgen Koscielny et al.
Seminars in thrombosis and hemostasis, 31(4), 464-469 (2005-09-09)
In 1974, Wu and Hoak described a method for determining circulating platelet aggregates. This method was modified by Grotemeyer in 1983. The platelet reactivity index (PR) is based on the ratio of platelet aggregates in blood samples obtained in different
Abdel Nasser Hosein et al.
Laboratory investigation; a journal of technical methods and pathology, 93(6), 701-710 (2013-04-10)
Pathology archives contain vast resources of clinical material in the form of formalin-fixed paraffin-embedded (FFPE) tissue samples. Owing to the methods of tissue fixation and storage, the integrity of DNA and RNA available from FFPE tissue is compromized, which means
Zaida Lentini et al.
Frontiers in plant science, 11, 522-522 (2020-05-28)
Embryo rescue (ER) in cassava breeding has several relevant applications, from the recovery of broad crosses to the recovery of seeds from the standard pollination program. Cassava fruit setting may drop from 100%, during the 1st week after pollination, to
Yung-Chang Su et al.
Journal of virology, 89(3), 1564-1578 (2014-11-21)
Human respiratory syncytial virus (RSV) is a major cause of morbidity and severe lower respiratory tract disease in the elderly and very young, with some infants developing bronchiolitis, recurrent wheezing, and asthma following infection. Previous studies in humans and animal
Katherine Beebe et al.
G3 (Bethesda, Md.), 5(7), 1517-1524 (2015-05-23)
The endocrine system employs peptide hormone signals to translate environmental changes into physiological responses. The diffuse endocrine system embedded in the gastrointestinal barrier epithelium is one of the largest and most diverse endocrine tissues. Furthermore, it is the only endocrine
Milind Javle et al.
Human pathology, 45(4), 701-708 (2014-02-11)
Gallbladder cancer is relatively uncommon, with a high incidence in certain geographic locations, including Latin America, East and South Asia, and Eastern Europe. Molecular characterization of this disease has been limited, and targeted therapy options for advanced disease remain an
Jana Krejčí et al.
Journal of cellular biochemistry, 116(10), 2195-2209 (2015-03-27)
We examined the levels and distribution of post-translationally modified histones and protamines in human sperm. Using western blot immunoassay, immunofluorescence, mass spectrometry (MS), and FLIM-FRET approaches, we analyzed the status of histone modifications and the protamine P2. Among individual samples
Allison Mayer et al.
American journal of otolaryngology, 36(3), 324-329 (2015-01-30)
To determine the feasibility of a rapid method of processing mandible bone margins for intraoperative histopathologic examination and to assess the relative value of fine, coarse, and core specimens in assessing bone margins. Prospective histologic controlled study. A tertiary level
Zhenhua Hu et al.
Nature cell biology, 22(2), 175-186 (2020-01-15)
Mouse embryonic stem cells (ESCs) sporadically transit into an early embryonic-like state characterized by the expression of 2-cell (2C) stage-restricted transcripts. Here, we identify a maternal factor-negative elongation factor A (NELFA)-whose heterogeneous expression in mouse ESCs is coupled to 2C
Jisang Park et al.
Veterinary microbiology, 177(1-2), 142-153 (2015-03-31)
Actinobacillus pleuropneumoniae is the causative agent of porcine pleuropneumonia and severe economic loss in the swine industry has been caused by the infection. Therefore, the development of an effective vaccine against the bacteria is necessary. ApxII toxin, among several virulence
Bianca Schulze et al.
European journal of immunology, 44(12), 3596-3604 (2014-09-05)
The opportunistic fungal pathogen Cryptococcus neoformans causes lung inflammation and fatal meningitis in immunocompromised patients. Regulatory T (Treg) cells play an important role in controlling immunity and homeostasis. However, their functional role during fungal infection is largely unknown. In this
Carolin Hartmann et al.
Immunology letters, 164(1), 44-52 (2015-01-13)
Colonization with Streptococcus pneumoniae (S. pneumoniae) is associated with an increased risk for recurrent wheeze and asthma. Killed S. pneumoniae showed some potential as an effective immunomodulatory therapy in a murine model of asthma. Murine studies demonstrated protection against allergic
Christopher R Cogle et al.
Leukemia, 28(10), 1978-1987 (2014-03-19)
Vascular endothelial cells are a critical component of the hematopoietic microenvironment that regulates blood cell production. Recent studies suggest the existence of functional cross-talk between hematologic malignancies and vascular endothelium. Here we show that human acute myeloid leukemia (AML) localizes
Jiabo Xu et al.
Annals of clinical and laboratory science, 45(3), 292-300 (2015-06-28)
To examine the effects and possible mechanism of the immunosuppressant agent cyclophosphamide (CP) combined with bone marrow mesenchymal stromal cells (BM-MSCs) on bleomycin induced lung fibrosis in mice. BM-MSCs labeled with red fluorescence protein (RFP) from male Friend virus B-type(FVB)
Chi-Hsien Liu et al.
Chemical & pharmaceutical bulletin, 63(2), 59-67 (2015-03-10)
Lutein is a macular pigment that contributes to maintaining eye health. The development of lutein-laden nanocarriers for ocular delivery would have the advantages of user friendliness and cost-effectiveness. Nano-scaled vehicles such as cyclodextrin (CD) and nanoemulsion could overcome the barriers
Jonathan DeGeer et al.
The Journal of cell biology, 210(5), 817-832 (2015-09-02)
During development, netrin-1 is both an attractive and repulsive axon guidance cue and mediates its attractive function through the receptor Deleted in Colorectal Cancer (DCC). The activation of Rho guanosine triphosphatases within the extending growth cone facilitates the dynamic reorganization
Michael Thiele et al.
Journal of immunology (Baltimore, Md. : 1950), 195(5), 2343-2352 (2015-07-26)
Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine and counterregulator of glucocorticoids, is a potential therapeutic target. MIF is markedly different from other cytokines because it is constitutively expressed, stored in the cytoplasm, and present in the circulation of healthy
Patrícia Canteri de Souza et al.
Journal of microbiological methods, 118, 182-186 (2015-10-11)
Models of host–pathogen interactions are crucial for the analysis of microbial pathogenesis. In this context, invertebrate hosts, including Drosophila melanogaster (fruit fly), Caenorhabditis elegans (nematode) and Galleria mellonella (moth), have been used to study the pathogenesis of fungi and bacteria.
Lalita Wattanachanya et al.
Experimental cell research, 333(2), 289-302 (2015-02-24)
G protein-coupled receptor (GPCR) signaling in osteoblasts (OBs) is an important regulator of bone formation. We previously described a mouse model expressing Rs1, an engineered constitutively active Gs-coupled GPCR, under the control of the 2.3 kb Col I promoter. These
Aiko Sueta et al.
International journal of oncology, 46(5), 2143-2153 (2015-03-05)
The newly identified gene, metastasis‑associated in colon cancer 1 (MACC1), is suggested to be a transcriptional regulator of c‑Met, leading to cancer progression in colorectal cancer. To date however, little is known of the role of MACC1 in breast cancer.
Lorraine B Ferreira et al.
Journal of biomaterials applications, 29(7), 965-976 (2014-09-12)
Statins are hypolipemiant drugs with osteoinductive effect. We evaluated the potential of simvastatin loaded into poly(lactic-co-glycolic acid) (PLGA) microspheres to heal critical size defects in rat calvaria. PLGA scaffolds (50:50 ratio) were synthesized as pure membranes or as microspheres loaded
Franca Raucci et al.
Theriogenology, 84(5), 732-742 (2015-06-04)
Primordial germ cells (PGCs) are the precursors of differentiated germ cells. Located in the epiblast of a stage X (EG&K) embryo, the PGCs translocate anteriorly to the germinal crescent and migrate, within 48 to 56 hours of development, through the
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