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Heather N Lavezzi et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(3), 676-687 (2014-08-29)
The rostromedial tegmental nucleus (RMTg) is a strong inhibitor of dopamine neurons in the ventral tegmental area (VTA) reported to influence neurobiological and behavioral responses to reward omission, aversive and fear-eliciting stimuli, and certain drugs of abuse. Insofar as previous
Mohammed Z Ariffin et al.
Frontiers in neuroanatomy, 11, 79-79 (2017-10-03)
Cholinergic mechanisms in supramammillary nucleus (SuM), especially the lateral SuM (lSuM) modulates septo-hippocampal neural activity. The lSuM, as compared to the contiguous medial SuM (mSuM) has relatively dense projections to hippocampus and cingulate cortex (Cg). In the present study, we
Suriya Subramanian et al.
Brain structure & function, 223(6), 2907-2924 (2018-04-28)
The lateral preoptic area (LPO) and ventral pallidum (VP) are structurally and functionally distinct territories in the subcommissural basal forebrain. It was recently shown that unilateral infusion of the GABAA receptor antagonist, bicuculline, into the LPO strongly invigorates exploratory locomotion
Lin Zhong et al.
Nature neuroscience, 22(6), 963-973 (2019-05-01)
The posterior parietal cortex (PPC) has been implicated in perceptual decision-making and categorization, but whether its activity plays a causal role remains controversial. Here we examined the population dynamics of PPC activity during an auditory-guided decision task in mice. We
Andrew Miri et al.
Neuron, 95(3), 683-696 (2017-07-25)
Blocking motor cortical output with lesions or pharmacological inactivation has identified movements that require motor cortex. Yet, when and how motor cortex influences muscle activity during movement execution remains unresolved. We addressed this ambiguity using measurement and perturbation of motor
Jiwei Yao et al.
Nature neuroscience, 21(11), 1541-1550 (2018-10-27)
Urination (also called micturition) is thought to be regulated by a neural network that is distributed in both subcortical and cortical regions. Previously, urination-related neurons have been identified in subcortical structures such as the pontine micturition center (also known as
Tiago Marques et al.
Current biology : CB, 28(11), 1703-1713 (2018-05-22)
Visual motion is an ethologically important stimulus throughout the animal kingdom. In primates, motion perception relies on specific higher-order cortical regions. Although mouse primary visual cortex (V1) and higher-order visual areas show direction-selective (DS) responses, their role in motion perception
Milad Mohammadi et al.
Behavioural brain research, 272, 40-45 (2014-07-06)
Aversive events induce aversive memories (fear learning) and can also establish appetitive memories. This is the case for cues associated with the cessation of an aversive event (relief learning) or occurring in an explicitly unpaired fashion (safety learning). However, the
Bilal A Bari et al.
Neuron, 103(5), 922-933 (2019-07-10)
Decisions occur in dynamic environments. In the framework of reinforcement learning, the probability of performing an action is influenced by decision variables. Discrepancies between predicted and obtained rewards (reward prediction errors) update these variables, but they are otherwise stable between
Fiona D Zeeb et al.
Psychopharmacology, 232(24), 4481-4491 (2015-09-22)
Studies employing the Iowa Gambling Task (IGT) demonstrated that areas of the frontal cortex, including the ventromedial prefrontal cortex, orbitofrontal cortex (OFC), dorsolateral prefrontal cortex, and anterior cingulate cortex (ACC), are involved in the decision-making process. However, the precise role
Pan Cheng et al.
Cell research, 31(7), 758-772 (2021-01-21)
Ca2+ channels are essential to cell birth, life, and death. They can be externally activated by optogenetic tools, but this requires robust introduction of exogenous optogenetic genes for expression of photosensitive proteins in biological systems. Here we present femtoSOC, a
Elina A K Jacobs et al.
Current biology : CB, 30(24), 4944-4955 (2020-10-24)
In many behavioral tasks, cortex enters a desynchronized state where low-frequency fluctuations in population activity are suppressed. The precise behavioral correlates of desynchronization and its global organization are unclear. One hypothesis holds that desynchronization enhances stimulus coding in the relevant
Seokheon Hong et al.
Cell death & disease, 10(12), 943-943 (2019-12-11)
In the current study we present evidence suggesting that PARP-1 regulates neurogenesis and its deficiency may result in schizophrenia-like behavioral deficits in mice. PARP-1 knockout neural stem cells exhibited a marked upregulation of embryonic stem cell phosphatase that can suppress
Laurie L Wellman et al.
Neurobiology of learning and memory, 137, 27-35 (2016-11-08)
Fear conditioning associated with inescapable shock training (ST) and fearful context re-exposure (CR) alone can produce significant behavioral fear, a stress response and alterations in subsequent REM sleep. These alterations may vary among animals and are mediated by the basolateral
Benjamin A Rowland et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(21), 7198-7202 (2014-05-23)
Detecting and locating environmental events are markedly enhanced by the midbrain's ability to integrate visual and auditory cues. Its capacity for multisensory integration develops in cats 1-4 months after birth but only after acquiring extensive visual-auditory experience. However, briefly deactivating
Yu Song et al.
Psychoneuroendocrinology, 117, 104690-104690 (2020-05-18)
Ample evidence suggests that early life stress (ELS) is a high-risk factor for the development of visceral pain disorders, whereas the mechanism underlying neuronal circuit remains elusive. Herein, we employed neonatal colorectal distension (CRD) to induce visceral hypersensitivity in rats.
Yugen Shi et al.
Acta physiologica (Oxford, England), 227(2), e13315-e13315 (2019-05-23)
Overactivation of the sympathetic nerve may lead to severe ventricular arrhythmias (VAs) after myocardial infarction (MI). Thus, targeting sympathetic nerve activity is an effective strategy to prevent VAs clinically. The superior cervical ganglion (SCG), the extracardiac sympathetic ganglion innervating cardiac
Han Qin et al.
Neuron, 99(1), 47-55 (2018-06-19)
The ability to remember and to navigate to safe places is necessary for survival. Place navigation is known to involve medial entorhinal cortex (MEC)-hippocampal connections. However, learning-dependent changes in neuronal activity in the distinct circuits remain unknown. Here, by using
Stephanie E Tanninen et al.
Hippocampus, 25(11), 1456-1464 (2015-04-14)
Anatomical and electrophysiological studies collectively suggest that the entorhinal cortex consists of several subregions, each of which is involved in the processing of different types of information. Consistent with this idea, we previously reported that the dorsolateral portion of the
Yuya Ogawa et al.
Pharmacology, biochemistry, and behavior, 198, 173034-173034 (2020-09-11)
In the spinal cord, γ-aminobutyric acid (GABA) interneurons play an essential role in antinociception. However, not all actions of GABA favor antinociception at the supraspinal level. We previously reported that gabaculine, which increases endogenous GABA in the synaptic clefts, induces
E Zayra Millan et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(11), 2555-2565 (2015-04-16)
Neurobiological mechanisms that influence behavior in the presence of alcohol-associated stimuli involve processes that organize behavior during the presence of these cues, and separately, regulation of behavior in their absence. However, little is known about anatomical structures that might mediate
Sanne Moorman et al.
Current biology : CB, 31(12), 2619-2632 (2021-05-12)
Cortical-basal ganglia (CBG) circuits are critical for motor learning and performance, and are a major site of pathology. In songbirds, a CBG circuit regulates moment-by-moment variability in song and also enables song plasticity. Studies have shown that variable burst firing
Adam G Gordon-Fennell et al.
Frontiers in neuroscience, 13, 1433-1433 (2020-02-06)
The lateral preoptic area (LPO) is a hypothalamic region whose function has been largely unexplored. Its direct and indirect projections to the ventral tegmental area (VTA) suggest that the LPO could modulate the activity of the VTA and the reward-related
Aaron B Bradford et al.
The Journal of pharmacology and experimental therapeutics, 356(1), 2-12 (2015-10-31)
Methylmercury (MeHg) disrupts cerebellar function, especially during development. Cerebellar granule cells (CGC), which are particularly susceptible to MeHg by unknown mechanisms, migrate during this process. Transient changes in intracellular Ca(2+) (Ca(2+) i) are crucial to proper migration, and MeHg is
Hector Vargas-Perez et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(23), 7899-7909 (2014-06-06)
Drug administration to avoid unpleasant drug withdrawal symptoms has been hypothesized to be a crucial factor that leads to compulsive drug-taking behavior. However, the neural relationship between the aversive motivational state produced by drug withdrawal and the development of the
Max F K Happel et al.
PloS one, 12(1), e0169461-e0169461 (2017-01-04)
Robust perception of auditory objects over a large range of sound intensities is a fundamental feature of the auditory system. However, firing characteristics of single neurons across the entire auditory system, like the frequency tuning, can change significantly with stimulus
Craig P Mantanona et al.
Journal of psychopharmacology (Oxford, England), 34(12), 1371-1381 (2020-10-27)
Thalamic subregions mediate various cognitive functions, including attention, inhibitory response control and decision making. Such neuronal activity is modulated by cholinergic thalamic afferents and deterioration of such modulatory signaling has been theorised to contribute to cognitive decline in neurodegenerative disorders.
Si-Ting Huang et al.
Frontiers in pharmacology, 12, 615202-615202 (2021-04-06)
Visceral hypersensitivity as a common clinical manifestation of irritable bowel syndrome (IBS) may contribute to the development of chronic visceral pain. Our prior studies authenticated that the activation of the corticotropin-releasing factor (CRF) neurons in paraventricular nucleus (PVN) contributed to
Daniel H O'Connor et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(5), 1947-1967 (2010-02-05)
Linking activity in specific cell types with perception, cognition, and action, requires quantitative behavioral experiments in genetic model systems such as the mouse. In head-fixed primates, the combination of precise stimulus control, monitoring of motor output, and physiological recordings over
Nandor Ludvig et al.
Behavioural brain research, 286, 293-299 (2015-03-17)
This study investigated the possible influence of the Subdural Pharmacotherapy Device (SPD) on spatial memory in 3 adult, male bonnet macaques (Macaca radiata). The device was implanted in and above the subdural/subarachnoid space and cranium overlaying the right parietal/frontal cortex:
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