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关键词:'G0639'
显示 31-60 共 124 条结果 关于 "G0639" 范围 论文
Xingchu Gong et al.
International journal of pharmaceutics, 493(1-2), 208-213 (2015-08-01)
An analysis of data collected from 25 sets of diverse pharmaceutical powders has identified that an exponential growth function satisfactorily describes the relationship between tablet brittleness and tablet porosity while a power law function well describes the relationship between tablet
D Saw et al.
Digestive diseases and sciences, 41(2), 322-325 (1996-02-01)
A wide variety of diseases and injuries can cause granulomatous hepatitis, and drug-induced granulomatous hepatitis is a well-described entity. Sulfonylurea derivatives, which are commonly used oral hypoglycemic agents in the treatment of non-insulin-dependent diabetes mellitus, have been implicated in liver
Sarah E Tulk et al.
Journal of cellular biochemistry, 116(5), 711-720 (2015-02-03)
Vitamin D3 has emerged as an important regulator of the immune system. With metabolic enzymes for vitamin D3 activation and vitamin D receptors (VDR) now identified in a variety of immune cells, the active vitamin D3 metabolite 1,25(OH)2D3, is thought
Bradley K Schniers et al.
The Biochemical journal, 478(20), 3757-3774 (2021-09-28)
PEPT1 is a proton-coupled peptide transporter that is up-regulated in PDAC cell lines and PDXs, with little expression in the normal pancreas. However, the relevance of this up-regulation to cancer progression and the mechanism of up-regulation have not been investigated.
Huifang Lian et al.
Frontiers in medicine, 9, 845129-845129 (2022-04-26)
Fungal keratitis is a sight-threatening corneal infection caused by fungal pathogens, and the pathogenic mechanisms have not been fully elucidated. The aim of this study was to determine whether NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome-mediated pyroptosis contributes
Hiroe Honda et al.
Journal of leukocyte biology, 96(6), 1087-1100 (2014-09-12)
Inflammasome activation initiates the development of many inflammatory diseases, including obesity and type 2 diabetes. Therefore, agents that target discrete activation steps could represent very important drugs. We reported previously that ILG, a chalcone from Glycyrrhiza uralensis, inhibits LPS-induced NF-κB
J F Caro
The American journal of medicine, 89(2A), 17S-25S (1990-08-20)
Increased hepatic glucose production is responsible for fasting hyperglycemia in type II diabetes. Insulin resistance is the key in this process because of the inability of insulin to suppress hepatic glucose production, thereby allowing an unopposed glucagon effect. Glyburide, one
Vijay Ramani et al.
Journal of leukocyte biology, 98(6), 1037-1048 (2015-08-09)
Inflammation is induced because of interplay among multiple signaling pathways and molecules during infectious and noninfectious tissue injuries. Crosstalk between Toll-like receptor-4 signaling and the neuronal apoptosis inhibitor protein, major histocompatibility class 2 transcription activator, incompatibility locus protein from Podospora
Ayesha Rashid et al.
Pakistan journal of pharmaceutical sciences, 27(1), 153-159 (2014-01-01)
The study was aimed to evaluate various pharmacokinetic parameters of a commercially available fixed dose combination of oral antidiabetics (Metformin/Glibenclamide 500/5mg tablets) in plasma sample of normal healthy adult male volunteers by applying an accurate, selective, and reproducible HPLC-UV analytical
J A Kim et al.
Biochemical and biophysical research communications, 261(3), 682-688 (1999-08-12)
Glibenclamide, an inhibitor of cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channels, induced apoptosis in a dose- and time-dependent manner in HepG2 human hepatoblastoma cells. Glibenclamide increased intracellular Ca(2+) concentration, which was significantly inhibited by Ca(2+) release blockers dantrolene and
Sammy W M Shiu et al.
Clinical science (London, England : 1979), 126(2), 175-181 (2013-08-03)
LDL (low-density lipoprotein) is subjected to pro-atherogenic modifications in the circulation. A novel uraemia-independent mechanism of carbamylation of lipoproteins mediated by MPO (myeloperoxidase) has recently been reported. We have investigated whether carbamylation of LDL was increased in patients with Type
Maryam Sharifi-Sanjani et al.
American journal of physiology. Heart and circulatory physiology, 304(10), H1294-H1301 (2013-03-26)
Myocardial metabolites such as adenosine mediate reactive hyperemia, in part, by activating ATP-dependent K(+) (K(ATP)) channels in coronary smooth muscle. In this study, we investigated the role of adenosine A(2A) and A(2B) receptors and their signaling mechanisms in reactive hyperemia.
Zhiwei Cai et al.
American journal of physiology. Cell physiology, 305(8), C817-C828 (2013-06-21)
The chemical structures of the thyroid hormones triiodothyronine (T3) and thyroxine (T4) resemble those of small-molecules that inhibit the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel. We therefore tested the acute effects of T3, T4 and reverse T3 (rT3)
Eva Bernhart et al.
Biochemical pharmacology, 96(2), 119-130 (2015-05-24)
Glioblastoma is the most common malignant brain tumor, which, despite combined radio- and chemotherapy, recurs and is invariably fatal for affected patients. Members of the sphingolipid (SL) family are potent effectors of glioma cell proliferation. In particular sphingosine-1-phosphate (S1P) and
Eduardo Hernandez-Cuellar et al.
Veterinary record open, 8(1), e20-e20 (2021-10-12)
Actinobacillus pleuropneumoniae (AP) is the causative agent of porcine pleuropneumonia. Apx exotoxins are the most important virulence factors associated with the induction of lesions. ApxI is highly cytotoxic on a wide range of cells. Besides the induction of necrosis and
Marilia Trindade de Santana et al.
Pharmaceutical biology, 51(9), 1144-1149 (2013-06-26)
Citronellal is a monoterpene present in the oil of many species, including Cymbopogon winterianus Jowitt (Poaceae). The present study investigated the effect of citronellal on inflammatory nociception induced by different stimuli and examined the involvement of the NO-cGMP-ATP-sensitive K⁺ channel
Shilpa Raut et al.
Journal of pharmaceutical and biomedical analysis, 109, 121-127 (2015-03-15)
We are reporting a new methodology of using Raman spectroscopy for studying the drug surfactant interactions in self-emulsifying drug delivery systems (SEDDS). The physicochemical properties of surfactants could affect the performance of drugs from lipid delivery systems. Thus the purpose
G Koren
Reproductive toxicology (Elmsford, N.Y.), 15(3), 227-229 (2001-06-08)
Oral hypoglycemics have been avoided in pregnancy due to their potential to cause fetal hyperinsulinemia/hypoglycemia. A recent human study has shown glyburide to minimally cross the placenta, allowing a safe new treatment for gestational diabetes. The mechanisms for the minimal
Glucocorticoids distinctively modulate the CFTR channel with possible implications in lung development and transition into extrauterine life
Laube M, et al.
Testing, 10(4), e0124833-e0124833 (2015)
R C Palheta et al.
Life sciences, 92(10), 569-575 (2013-01-29)
We previously reported that mechanical atrial stretch (AS) by balloon distention increased gastric tonus in anesthetized rats. The present study evaluated the effect of AS on the gastric emptying of a liquid test meal in awake rats and its underlying
A E Boyd et al.
The American journal of medicine, 89(2A), 3S-10S (1990-08-20)
A high-affinity sulfonylurea receptor has been identified on the plasma membrane of the beta cell. The potent second-generation sulfonylureas, glyburide and glipizide, saturate the receptor in the low nM concentration range, whereas first-generation drugs bind to and saturate the receptor
Mariel Núñez et al.
BMC pharmacology & toxicology, 14, 6-6 (2013-01-15)
Glibenclamide (Gli) binds to the sulphonylurea receptor (SUR) that is a regulatory subunit of ATP-sensitive potassium channels (KATP channels). Binding of Gli to SUR produces the closure of KATP channels and the inhibition of their activity. This drug is widely
Ya-Jean Wang et al.
Toxicology letters, 223(2), 139-145 (2013-09-10)
Methamphetamine (MA), a highly abused amphetamine-like psychostimulant, has surged in popularity worldwide in the last decade. Repeated MA exposure has been shown to affect the alternative splice variant expression of large conductance Ca(2+)-activated K(+) (BK) channels. It remains unclear whether
The second generation oral sulfonylureas: glyburide and glipizide.
T Kuhn
American pharmacy, NS28(10), 55-61 (1988-10-01)
Editorial: sulfonylureas differ in effects on ischemic preconditioning--is it time to retire glyburide?
Matthew C Riddle
The Journal of clinical endocrinology and metabolism, 88(2), 528-530 (2003-02-08)
Charles J Glueck et al.
Expert opinion on pharmacotherapy, 3(11), 1557-1568 (2002-11-20)
Gestational diabetes (GD) develops because pregnancy increases requirements for insulin secretion while increasing insulin resistance. Women with GD often have impaired pancreatic beta-cell compensation for insulin resistance. The nature of GD is currently contentious, with debate about its existence, diagnosis
Gary N Fox et al.
Cutis, 76(1), 41-45 (2005-09-08)
Lichenoid reactions to sulfonylurea drugs have been reported, albeit infrequently. To our knowledge, this is the first case of a generalized lichenoid dermatitis likely induced by the third-generation sulfonylurea hypoglycemic drug glyburide.
Eun-Seon Yoo et al.
Cell reports, 37(7), 109997-109997 (2021-11-18)
The anorexigenic effect of serotonergic compounds has largely been attributed to activation of serotonin 2C receptors (Htr2cs). Using mouse genetic models in which Htr2c can be selectively deleted or restored (in Htr2c-null mice), we investigate the role of Htr2c in
Wenli Yang et al.
Journal of pediatric endocrinology & metabolism : JPEM, 26(5-6), 591-594 (2013-05-04)
The ATP-sensitive K+ channel controls insulin secretion from the islet. Mutations in KCNJ11 can cause permanent and transient neonatal diabetes. To date, more than 30 KCNJ11 mutations have been revealed as related to the onset of neonatal diabetes mellitus (NDM)
Jason M York et al.
Translational research : the journal of laboratory and clinical medicine, 164(4), 259-269 (2014-08-26)
Acute pancreatitis (AP), although most often a mild and self-limiting inflammatory disease, worsens to a characteristically necrotic severe acute pancreatitis (SAP) in about 20% of cases. Obesity, affecting more than one-third of American adults, is a risk factor for the
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