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显示 1-30 共 435 条结果 关于 "G0923" 范围 论文
Yu Shi et al.
Journal of affective disorders, 249, 35-44 (2019-02-12)
Depression after stroke (DAS) is a serious complication of stroke that significantly restricts rehabilitation. Brain imaging technology is an important method for studying the emotional network of DAS. However, few studies have focused on dynamic interactions within the network. The
Jan Baumann et al.
Molecular biology of the cell, 29(1), 42-52 (2017-11-10)
The secretory pathway is a major determinant of cellular homoeostasis. While research into secretory stress signaling has so far mostly focused on the endoplasmic reticulum (ER), emerging data suggest that the Golgi itself serves as an important signaling hub capable
Bryn Flinders et al.
Analytical chemistry, 90(20), 11835-11846 (2018-09-21)
The liver is the primary organ involved in handling of bile salts, a class of amphipathic molecules with signaling activities as well as desired and detrimental detergent actions. To allow in-depth investigation of functions of bile salts in healthy and
Haipeng Zhu et al.
International journal of molecular medicine, 36(2), 595-601 (2015-06-18)
The present study aimed to reveal the association between insulin-like growth factor binding protein-2 (IGFBP-2) and the sensitivity of bladder cancer cells to cisplatin, and determine the underlying mechanism involving maspin. A total of 32 bladder cancer tissue samples were
Marcus A Price et al.
Biotechnology and bioengineering, 117(6), 1805-1816 (2020-02-23)
The CRISPR-Cas9 system has become increasingly popular for genome engineering across all fields of biological research, including in the Gram-positive model organism Bacillus subtilis. A major drawback for the commercial use of Cas9 is the IP landscape requiring a license
A Maciejewski-Duval et al.
Journal of autoimmunity, 94, 99-109 (2018-08-01)
Mammalian target of rapamycin complex 1 (mTORC 1) drives the proinflammatory expansion of T helper (TH) type 1, TH17 cells and controls fibroblast proliferation, typical features of large vessel vasculitis (LVV) pathogenesis. Molecular pathways involved in arterial lesions of LVV are
Luca Roscini et al.
Microorganisms, 8(8) (2020-08-23)
Yeast taxonomy was introduced based on the idea that physiological properties would help discriminate species, thus assuming a strong link between physiology and taxonomy. However, the instability of physiological characteristics within species configured them as not ideal markers for species
Mi-Ok Sim et al.
Nutrition research and practice, 9(4), 364-369 (2015-08-06)
Inflammation is associated with various types of acute and chronic alcohol liver diseases. In this study, we examined whether umbelliferone (7-hydroxycoumarin, UF) ameliorates chronic alcohol-induced liver damage by modulating inflammatory response and the antioxidant system. Rats were fed a Liber-Decarli
Christian R Werner et al.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 131(2), 299-317 (2017-10-31)
Genomic prediction using the Brassica 60 k genotyping array is efficient in oilseed rape hybrids. Prediction accuracy is more dependent on trait complexity than on the prediction model. In oilseed rape breeding programs, performance prediction of parental combinations is of fundamental
Romel Rosales Ramirez et al.
Journal of virology, 93(4) (2018-11-23)
Dengue virus (DENV) is a mosquito-borne virus of the family Flaviviridae The RNA viral genome encodes three structural and seven nonstructural proteins. Nonstructural protein 1 (NS1) is a multifunctional protein actively secreted in vertebrate and mosquito cells during infection. In
David Rotter et al.
EMBO reports, 19(12) (2018-11-06)
Increasing non-shivering thermogenesis (NST), which expends calories as heat rather than storing them as fat, is championed as an effective way to combat obesity and metabolic disease. Innate mechanisms constraining the capacity for NST present a fundamental limitation to this
Antony T Vincent et al.
PLoS neglected tropical diseases, 13(5), e0007270-e0007270 (2019-05-24)
The causative agents of leptospirosis are responsible for an emerging zoonotic disease worldwide. One of the major routes of transmission for leptospirosis is the natural environment contaminated with the urine of a wide range of reservoir animals. Soils and surface
Huda H Al-Khalaf et al.
Molecular and cellular biology, 40(9) (2020-02-06)
During aging, cellular plasticity and senescence play important roles in tissue regeneration and the pathogenesis of different diseases, including cancer. We have recently shown that senescent breast luminal cells can activate their adjacent stromal fibroblasts. In the present report, we
Haoyu Xue et al.
Journal of ethnopharmacology, 269, 113706-113706 (2020-12-22)
Chronic cholestasis is a usual clinical pathological process in hepatopathy and has few treatment options; it is classified under the category of jaundice in Chinese medicine. Da-Huang-Xiao-Shi decoction (DHXSD) is a classic Chinese prescription which is used to treat jaundice.
Danelle K Seymour et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(46), E7317-E7326 (2016-11-03)
The ubiquity of nonparental hybrid phenotypes, such as hybrid vigor and hybrid inferiority, has interested biologists for over a century and is of considerable agricultural importance. Although examples of both phenomena have been subject to intense investigation, no general model
Erik D Enbody et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(4) (2021-01-23)
The relative role of genetic adaptation and phenotypic plasticity is of fundamental importance in evolutionary ecology [M. J. West-Eberhard, Proc. Natl. Acad. Sci. U.S.A. 102 (suppl. 1), 6543-6549 (2005)]. European eels have a complex life cycle, including transitions between life
Christine Nyaga et al.
Plants (Basel, Switzerland), 9(4) (2020-04-12)
Prior knowledge on heterosis and quantitative genetic parameters on maize lethal necrosis (MLN) can help the breeders to develop numerous resistant or tolerant hybrids with optimum resources. Our objectives were to (1) estimate the quantitative genetic parameters for MLN disease
Michael Mounié et al.
Arthritis care & research, 70(7), 1074-1081 (2017-10-04)
To assess and compare direct costs between giant cell arteritis (GCA) patients and matched controls and to identify incremental cost drivers. We carried out a population-based, retrospective cohort study using the French National Health Insurance System database. Cost analysis was
Robert Creutznacher et al.
Chembiochem : a European journal of chemical biology, 21(7), 1007-1021 (2019-10-24)
Bile acids have been reported as important cofactors promoting human and murine norovirus (NoV) infections in cell culture. The underlying mechanisms are not resolved. Through the use of chemical shift perturbation (CSP) NMR experiments, we identified a low-affinity bile acid
Otmane Lamrabet et al.
Developmental and comparative immunology, 107, 103645-103645 (2020-02-18)
Dictyostelium discoideum is a free-living soil amoeba which feeds upon bacteria. To bind, ingest, and kill bacteria, D. discoideum uses molecular mechanisms analogous to those found in professional phagocytic cells of multicellular organisms. D. discoideum is equipped with a large
Xiao Lin Peng et al.
PloS one, 9(11), e113716-e113716 (2014-11-25)
Vascular endothelial hyperpermeability is one of the manifestations of endothelial dysfunction. Resveratrol (Res) is considered to be beneficial in protecting endothelial function. However, currently, the exact protective effect and involved mechanisms of Res on endothelial dysfunction-hyperpermeability have not been completely
Yibei Zhang et al.
Microbiological research, 235, 126448-126448 (2020-03-03)
Vibrio parahaemolyticus is a common foodborne pathogen in seafood and represents a major threat to human health worldwide. In this study, we identified that PhoR, a histidine kinase, is involved in the regulation of swarming and flagella assembly. RNA sequencing
Juliana Ramos-Pereira et al.
Food microbiology, 84, 103253-103253 (2019-08-20)
Fifteen samples of semi-hard ripened cheeses, both spoiled (10) and unspoiled (5), and obtained from cheese factories located in Northwest of Spain, were analysed by a dilution plating technique and direct sampling. A total of 32 isolates were identified at
Hongxia Zhang et al.
International journal of medical microbiology : IJMM, 310(1), 151356-151356 (2019-10-06)
Bacterial outer membrane vesicles (OMVs) play a vital role in the mechanism of host-pathogen communication, while emerging evidence suggests that OMVs regulate host immune responses through differentially packaged small noncoding RNAs (sncRNAs) to target host mRNA function. Therefore, we identified
Hannah R Shrader et al.
Surgery, 169(3), 617-622 (2020-12-04)
Introduction of gut flora into the biliary system is common owing to biliary stenting in patients with obstructing pancreatic head cancer. We hypothesize that alteration of biliary microbiome modifies bile content that modulates pancreatic cancer cell survival. Human bile samples
J Fornetti et al.
Cell death and differentiation, 23(2), 185-196 (2015-06-27)
After weaning, during mammary gland involution, milk-producing mammary epithelial cells undergo apoptosis. Effective clearance of these dying cells is essential, as persistent apoptotic cells have a negative impact on gland homeostasis, future lactation and cancer susceptibility. In mice, apoptotic cells
Reema Narayan et al.
Carbohydrate polymers, 261, 117893-117893 (2021-03-27)
Glycosylated pH-sensitive mesoporous silica nanoparticles (MSNs) of capecitabine (CAP) were developed for targeting colorectal cancer. The MSNs possessed an average pore diameter of 8.12 ± 0.43 nm, pore volume of 0.73 ± 0.21 cm3/g, and particle size of 245.24 ±
Tanuza Das et al.
Journal of molecular biology, 431(19), 3900-3912 (2019-07-23)
Deubiquitinating enzymes have key roles in diverse cellular processes whose enzymatic activities are regulated by different mechanisms including post-translational modification. Here, we show that USP15 is phosphorylated, and its localization and activity are dependent on the phosphorylation status. Nuclear-cytoplasmic fractionation
Xinxin Tong et al.
PeerJ, 8, e8379-e8379 (2020-01-29)
Ophiocordyceps sinensis is a highly valued fungus that has been used as traditional Asian medicine. This fungus is one of the most important sources of income for the nomadic populations of the Tibetan Plateau. With global warming and excessive collection
Tatsuro Hagi et al.
Applied microbiology and biotechnology, 104(24), 10641-10653 (2020-11-08)
Akkermansia muciniphila is a prominent member of the gut microbiota and the organism gets exposed to bile acids within this niche. Several gut bacteria have bile response genes to metabolize bile acids or an ability to change their membrane structure
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