Merck
CN
高级检索
Chemical Structure Search
Search Within

G1251

应用筛选条件
关键词:'G1251'
显示 1-30 共 394 条结果 关于 "G1251" 范围 论文
Helen N Saada et al.
International journal of radiation biology, 90(12), 1179-1183 (2014-06-18)
To evaluate the modulator role of fish oil (FO) on some biochemical changes in the brain of gamma-irradiated rats (RAD). Male albino rats Sprague Dawley were divided into four groups (n = 10). (i) received vehicle via gavages during 28
D Rating et al.
Journal of neurology, 230(4), 217-225 (1983-01-01)
In 14 children with epilepsy, 51 with febrile convulsions and 22 with meningitis gamma-aminobutyric acid (GABA) concentrations in lumbar CSF were determined. While the mean for CSF GABA concentrations for all epileptic children was unchanged [144 (range: 73-285) pmol/ml; controls:
Juliane C Campos et al.
Autophagy, 13(8), 1304-1317 (2017-06-10)
We previously reported that facilitating the clearance of damaged mitochondria through macroautophagy/autophagy protects against acute myocardial infarction. Here we characterize the impact of exercise, a safe strategy against cardiovascular disease, on cardiac autophagy and its contribution to mitochondrial quality control
Ryan E Tooker et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(49), 19176-19193 (2013-12-07)
Coding a wide range of light intensities in natural scenes poses a challenge for the retina: adaptation to bright light should not compromise sensitivity to dim light. Here we report a novel form of activity-dependent synaptic plasticity, specifically, a "weighted
Hanna Österman et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 309(10), R1204-R1214 (2015-10-02)
Fetal growth restriction programs an increased risk of cardiovascular disease in adulthood, but the actual mechanisms of this developmental programming are not fully understood. Previous studies in mammalian models suggest that hearts of growth-restricted fetuses have reduced cardiomyocyte number due
Jasdeep Saini et al.
Journal of clinical medicine, 9(10) (2020-10-15)
In many neurodegenerative and muscular disorders, and loss of innervation in sarcopenia, improper reinnervation of muscle and dysfunction of the motor unit (MU) are key pathogenic features. In vivo studies of MUs are constrained due to difficulties isolating and extracting
Christoph B Messner et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(28), 7403-7407 (2017-06-28)
The evolutionary origins of metabolism, in particular the emergence of the sugar phosphates that constitute glycolysis, the pentose phosphate pathway, and the RNA and DNA backbone, are largely unknown. In cells, a major source of glucose and the large sugar
Beatrice Bocca et al.
Annali dell'Istituto superiore di sanita, 41(2), 197-203 (2005-10-26)
The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were compared. In patients, the following significant (p <
Kyungtae Kang et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(3), E241-E248 (2015-01-08)
The posttranslational modification of neural cell-adhesion molecule (NCAM) with polysialic acid (PSA) and the spatiotemporal distribution of PSA-NCAM play an important role in the neuronal development. In this work, we developed a tissue-based strategy for metabolically incorporating an unnatural monosaccharide
Yuanyuan Chen et al.
Molecular pharmacology, 86(2), 231-242 (2014-06-11)
Aspartyl aminopeptidase (DNPEP) has been implicated in the control of angiotensin signaling and endosome trafficking, but its precise biologic roles remain incompletely defined. We performed a high-throughput screen of ∼25,000 small molecules to identify inhibitors of DNPEP for use as
Anna Grygoruk et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(20), 6924-6937 (2014-05-16)
Monoamine neurotransmitters are stored in both synaptic vesicles (SVs), which are required for release at the synapse, and large dense-core vesicles (LDCVs), which mediate extrasynaptic release. The contributions of each type of vesicular release to specific behaviors are not known.
Tamara Perez-Rosello et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(22), 9259-9272 (2013-05-31)
Although it is well established that many glutamatergic neurons sequester Zn(2+) within their synaptic vesicles, the physiological significance of synaptic Zn(2+) remains poorly understood. In experiments performed in a Zn(2+)-enriched auditory brainstem nucleus--the dorsal cochlear nucleus--we discovered that synaptic Zn(2+)
Reşit Çakmak et al.
Bioorganic & medicinal chemistry letters, 21(18), 5398-5402 (2011-07-29)
Discovery of GR inhibitors has become very popular recently due to antimalarial and anticancer activities. In this study, the synthesis and GR inhibitory capacities of novel nitroaromatic compounds (NCs) (1-3) were reported. Some commercially available molecules were also tested for
Alyssa N Coyne et al.
Neuron, 107(6), 1124-1140 (2020-07-17)
Through mechanisms that remain poorly defined, defects in nucleocytoplasmic transport and accumulations of specific nuclear-pore-complex-associated proteins have been reported in multiple neurodegenerative diseases, including C9orf72 Amyotrophic Lateral Sclerosis and Frontotemporal Dementia (ALS/FTD). Using super-resolution structured illumination microscopy, we have explored
Olga Boudker et al.
Nature, 445(7126), 387-393 (2007-01-19)
Secondary transporters are integral membrane proteins that catalyse the movement of substrate molecules across the lipid bilayer by coupling substrate transport to one or more ion gradients, thereby providing a mechanism for the concentrative uptake of substrates. Here we describe
Continued response off treatment after BRAF inhibition in refractory hairy cell leukemia.
Sascha Dietrich et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(19), e300-e303 (2013-05-22)
Yang-Kai Wang et al.
American journal of physiology. Heart and circulatory physiology, 307(2), H182-H190 (2014-05-20)
The rostral ventrolateral medulla (RVLM) plays a key role in cardiovascular regulation. It has been reported that tonically active glutamatergic input to the RVLM is increased in hypertensive rats, whereas angiotensin-converting enzyme 2 (ACE2) in the brain has been suggested
Joel R Meyerson et al.
Nature, 514(7522), 328-334 (2014-08-15)
Ionotropic glutamate receptors are ligand-gated ion channels that mediate excitatory synaptic transmission in the vertebrate brain. To gain a better understanding of how structural changes gate ion flux across the membrane, we trapped rat AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) and kainate
Martin D Haustein et al.
Neuron, 82(2), 413-429 (2014-04-20)
The spatiotemporal activities of astrocyte Ca²⁺ signaling in mature neuronal circuits remain unclear. We used genetically encoded Ca²⁺ and glutamate indicators as well as pharmacogenetic and electrical control of neurotransmitter release to explore astrocyte activity in the hippocampal mossy fiber
Soner Donmez et al.
Applied biochemistry and biotechnology, 176(5), 1431-1444 (2015-05-08)
An electrochemical nucleic acid biosensor based on label-free DNA detection method was prepared for the first time by using electropolymerized poly(L-glutamic acid)-modified pencil graphite electrode (PGA/PGE) for detection of hepatitis C virus genotype 1a (HCV1a). Inosine-substituted 20-mer probes related to
Ie E Koliesnikova et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(3), 58-64 (2013-08-21)
The results of pharmacological correction of experimental mitochondrial dysfunction in brain stem neurons after single injection of specific respiratory complex I inhibitor rotenone by complex agents mildronate and rhytmocor have been presented. It was shown that 14-days rhytmocor injection promoted
C J L Silwood et al.
Journal of dental research, 81(6), 422-427 (2002-07-05)
We have explored the ability of high-resolution NMR techniques to (1) index salivary biomolecules and (2) provide valuable data regarding intra- and inter-subject variability in the concentrations of a series of components readily determinable by this technique (organic acids and
Nils Muhlert et al.
Journal of neurology, neurosurgery, and psychiatry, 85(8), 833-839 (2014-01-17)
Glutamate is the principal excitatory neurotransmitter and is involved in normal brain function. Cognitive impairment is common in multiple sclerosis (MS), and understanding its mechanisms is crucial for developing effective treatments. We used structural and metabolic brain imaging to test
Margarita V Glazova et al.
Journal of neurochemistry, 132(2), 218-229 (2014-10-30)
It has recently been proposed that extracellular signal-regulated kinases 1 and 2 (ERK1/2) are one of the factors mediating seizure development. We hypothesized that inhibition of ERK1/2 activity could prevent audiogenic seizures by altering GABA and glutamate release mechanisms. Krushinsky-Molodkina
Lu Qi et al.
JAMA, 310(8), 821-828 (2013-08-29)
Diabetes is associated with an elevated risk of coronary heart disease (CHD). Previous studies have suggested that the genetic factors predisposing to excess cardiovascular risk may be different in diabetic and nondiabetic individuals. To identify genetic determinants of CHD that
Daniel R Dempsey et al.
Biochemistry, 53(49), 7777-7793 (2014-11-19)
Arylalkylamine N-acetyltransferase (AANAT) catalyzes the penultimate step in the biosynthesis of melatonin and other N-acetylarylalkylamides from the corresponding arylalkylamine and acetyl-CoA. The N-acetylation of arylalkylamines is a critical step in Drosophila melanogaster for the inactivation of the bioactive amines and
Fabian Istel et al.
Bio-protocol, 5(14) (2015-07-20)
Here, we describe a method enabling the phenotypic profiling of genome-scale deletion collections of fungal mutants to detect phenotypes for various stress conditions. These stress conditions include among many others antifungal drug susceptibility, temperature-induced and osmotic as well as heavy
Ming Li et al.
International journal of molecular sciences, 16(5), 9134-9151 (2015-04-29)
Paroxysmal kinesigenic choreoathetosis (PKC) is an inherited disease of the nervous system. We previously identified PRRT2 as the causative gene of PKC. However, as little is known about the function of PRRT2, elucidating its function will benefit not only PKC
Seok-Min Kang et al.
Clinical biochemistry, 44(4), 293-299 (2010-12-21)
We sought to identify metabolic pathways characterizing human heart failure (HF) using ¹NMR based urinary metabolomic analysis in conjunction with multivariate statistics. Patients with systolic HF of ischemic origin (n=15) and healthy controls (n=20) participated in this study. Patients with
Hao Bin Wu et al.
Nature communications, 6, 6512-6512 (2015-03-12)
Electrochemical water splitting has been considered as a promising approach to produce clean and sustainable hydrogen fuel. However, the lack of high-performance and low-cost electrocatalysts for hydrogen evolution reaction hinders the large-scale application. As a new class of porous materials
1/14