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Niku Oksala et al.
Atherosclerosis, 242(1), 145-154 (2015-07-21)
Kindlins (FERMT) are cytoplasmic proteins required for integrin (ITG) activation, leukocyte transmigration, platelet aggregation and thrombosis. Characterization of kindlins and their association with atherosclerotic plaques in human(s) is lacking. Exploratory microarray (MA) was first performed followed by selective quantitative validation
Yingmeng Ni et al.
International journal of molecular sciences, 16(11), 27956-27966 (2015-11-28)
IL-33 is a new member of the IL-1 family cytokines, which is expressed by different types of immune cells and non-immune cells. IL-33 is constitutively expressed in the nucleus, where it can act as a transcriptional regulator. So far, no
M Shahidullah et al.
Experimental eye research, 140, 85-93 (2015-09-01)
The bulk of the lens consists of tightly packed fiber cells. Because mature lens fibers lack mitochondria and other organelles, lens homeostasis relies on a monolayer of epithelial cells at the anterior surface. The detection of various signaling pathways in
C Hochfellner et al.
Journal of applied microbiology, 118(4), 864-872 (2015-01-22)
The interaction of quinolone and indoloquinazoline alkaloids concerning their antimycobacterial activity was studied. The antimycobacterial and modulating activity of evodiamine (1), rutaecarpine (2) and evocarpine (3) was tested on mycobacteria including three multidrug-resistant (MDR) clinical isolates of Mycobacterium tuberculosis. Antagonistic
J Reifenrath et al.
Biomedical materials (Bristol, England), 10(4), 045021-045021 (2015-08-13)
For the evaluation of new magnesium-based alloys, many different in vitro and in vivo methods are used. It was the aim of the current study to perform in vitro and in vivo corrosion studies of the new alloy Mg-La-Nd-Zr for
Yu Si et al.
Scientific reports, 5, 16683-16683 (2015-12-08)
Acquired cholesteatoma is a chronic inflammatory disease characterized by both hyperkeratinized squamous epithelial overgrowth and bone destruction. Toll-like receptor (TLR) activation and subsequent inflammatory cytokine production are closely associated with inflammatory bone disease. However, the expression and function of TLRs
Marietta Müller et al.
Scientific reports, 5, 12523-12523 (2015-08-04)
E5 proteins are amongst the least understood of the Human Papillomavirus (HPV) encoded gene products. They are small, membrane-integrated proteins known to modulate a number of critical host pathways associated with pathogenesis including growth factor receptor signaling and immune evasion.
Xin Zhou et al.
RNA (New York, N.Y.), 21(11), 1885-1897 (2015-09-02)
PIWI proteins and piRNA pathways are essential for transposon silencing and some aspects of gene regulation during animal germline development. In contrast to most animal species, some flatworms also express PIWIs and piRNAs in somatic stem cells, where they are
Youseung Kim et al.
Bioorganic & medicinal chemistry, 23(15), 4980-4988 (2015-06-06)
PABA/NO [O(2)-{2,4-dinitro-5-[4-(N-methylamino)benzoyloxy]phenyl} 1-(N,N-dimethylamino) diazen-1-ium-1,2-diolate] is a nitric oxide (NO)-releasing arylating agent designed to be selectively activated by reaction with glutathione (GSH) on catalysis by glutathione S-transferase P1 (GSTP1), an enzyme frequently overexpressed in cancer cells. PABA/NO has proven active in
Emilie Bédard et al.
FEMS microbiology letters, 356(2), 226-234 (2014-06-05)
This study investigated how quickly cells of the opportunistic pathogen Pseudomonas aeruginosa recover culturability after exposure to two of the most common environmental stressors present in drinking water, free chlorine and copper ions. Viable but nonculturable (VBNC) P. aeruginosa undetected by
Mauro Siragusa et al.
Science signaling, 8(390), ra81-ra81 (2015-08-20)
Endothelial nitric oxide synthase (eNOS) catalyzes the conversion of l-arginine and molecular oxygen into l-citrulline and nitric oxide (NO), a gaseous second messenger that influences cardiovascular physiology and disease. Several mechanisms regulate eNOS activity and function, including phosphorylation at Ser
Ayse Nur Polat et al.
Journal of proteome research, 14(9), 4087-4098 (2015-08-14)
Cytokinesis is the last step of the cell cycle that requires coordinated activities of the microtubule cytoskeleton, actin cytoskeleton, and membrane compartments. Aurora B kinase is one of the master regulatory kinases that orchestrate multiple events during cytokinesis. To reveal
Hamada AbdElgawad et al.
The New phytologist, 208(2), 354-369 (2015-06-04)
Proline (Pro) is a versatile metabolite playing a role in the protection of plants against environmental stresses. To gain a deeper understanding of the regulation of Pro metabolism under predicted future climate conditions, including drought stress, elevated temperature and CO2
Graham J Hickman et al.
Advanced healthcare materials, 4(4), 593-601 (2014-11-14)
Developing materials that can preferentially select defined cancer cell populations for biological characterization will greatly enhance our understanding of cancer cell growth, differentiation, and invasion. The transitional events between epithelial and mesenchymal phenotypes are particularly crucial, as primary tumors and
William G Herrick et al.
Cellular and molecular bioengineering, 8(3), 333-348 (2015-10-27)
Smooth muscle cell (SMC) invasion into plaques and subsequent proliferation is a major factor in the progression of atherosclerosis. During disease progression, SMCs experience major changes in their microenvironment, such as what integrin-binding sites are exposed, the portfolio of soluble
Enzo Medico et al.
Nature communications, 6, 7002-7002 (2015-05-01)
The development of molecularly targeted anticancer agents relies on large panels of tumour-specific preclinical models closely recapitulating the molecular heterogeneity observed in patients. Here we describe the mutational and gene expression analyses of 151 colorectal cancer (CRC) cell lines. We
Shen-An Hwang et al.
International journal of immunopathology and pharmacology, 28(4), 452-468 (2015-09-01)
Lactoferrin (LF), an iron binding protein with immune modulatory activities, has adjuvant activity to enhance vaccine efficacy. Tuberculosis (TB) is a pulmonary disease caused by the pathogen Mycobacterium tuberculosis (MTB). Progressive TB disease is clinically defined by damaging pulmonary pathology
Vi Khanh Truong et al.
Applied microbiology and biotechnology, 99(16), 6831-6840 (2015-04-22)
The surface nanotopography and architecture of medical implant devices are important factors that can control the extent of bacterial attachment. The ability to prevent bacterial attachment substantially reduces the possibility of a patient receiving an implant contracting an implant-borne infection.
Simon A Ramsbottom et al.
PLoS genetics, 10(12), e1004871-e1004871 (2014-12-19)
Planar cell polarity (PCP) is the mechanism by which cells orient themselves in the plane of an epithelium or during directed cell migration, and is regulated by a highly conserved signalling pathway. Mutations in the PCP gene Vangl2, as well
Tip W Loo et al.
The Journal of biological chemistry, 290(27), 16954-16963 (2015-05-20)
P-glycoprotein (P-gp; ABCB1) is an ABC drug pump that protects us from toxic compounds. It is clinically important because it confers multidrug resistance. The homologous halves of P-gp each contain a transmembrane (TM) domain (TMD) with 6 TM segments followed
Hiroyuki Takeda et al.
Scientific reports, 5, 11333-11333 (2015-06-11)
G-protein-coupled receptors (GPCRs) are one of the most important drug targets, and anti-GPCR monoclonal antibody (mAb) is an essential tool for functional analysis of GPCRs. However, it is very difficult to develop GPCR-specific mAbs due to difficulties in production of
Virginia Carvalhais et al.
Molecular immunology, 65(2), 429-435 (2015-03-10)
Virulence of Staphylococcus epidermidis is mainly attributed to surface colonization and biofilm formation in indwelling medical devices. Physiological heterogeneity of biofilms may influence host immune response and sensitivity to antibiotics. Dormant cells, among others, contribute to biofilm heterogeneity. The aim
Paulami Rudra et al.
Nucleic acids research, 43(12), 5855-5867 (2015-05-23)
We propose a novel mechanism of gene regulation in Mycobacterium tuberculosis where the protein Rv1222 inhibits transcription by anchoring RNA polymerase (RNAP) onto DNA. In contrast to our existing knowledge that transcriptional repressors function either by binding to DNA at
Heide De Haene et al.
Clinical chemistry and laboratory medicine, 44(2), 220-222 (2006-02-16)
In plasma, triglycerides (TG) are transported in lipoprotein particles (mainly chylomicrons, very low-density and low-density lipoprotein). Turbidimetry (bichromatically at 660 and 700 nm) allows measurement of the lipemic (L) index. We explored the use of this index, in combination with
Takanobu Nagata et al.
PloS one, 10(5), e0127942-e0127942 (2015-05-27)
Myocardial ischemia reperfusion injury (IRI) adversely affects cardiac performance and the prognosis of patients with acute myocardial infarction. Although myocardial signal transducer and activator of transcription (STAT) 3 is potently cardioprotective during IRI, the inhibitory mechanism responsible for its activation
Katharina Flach et al.
Biochimica et biophysica acta, 1842(9), 1527-1538 (2014-06-07)
Tau is the major microtubule-associated protein in neurons involved in microtubule stabilization in the axonal compartment. Changes in tau gene expression, alternative splicing and posttranslational modification regulate tau function and in tauopathies can result in tau mislocalization and dysfunction, causing
Mahnaz Jebreili et al.
Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine, 10(7), 362-365 (2015-08-08)
The main purpose of this study was to investigate the calming effects of breastmilk odor and vanilla odor on preterm infants during and after venipuncture. One hundred thirty-five preterm infants were randomly selected and divided into three groups: control, vanilla
G Blomqvist et al.
American journal of physiology. Endocrinology and metabolism, 283(1), E20-E28 (2002-06-18)
Using R-beta-[1-(11)C]hydroxybutyrate and positron emission tomography, we studied the effect of acute hyperketonemia (range 0.7-1.7 micromol/ml) on cerebral ketone body utilization in six nondiabetic subjects and six insulin-dependent diabetes mellitus (IDDM) patients with average metabolic control (HbA(1c) = 8.1 +/-
Joanna L Richens et al.
International immunopharmacology, 24(2), 166-168 (2014-12-17)
Components of the plasma proteome, particularly serum albumin, have been shown to compromise the accuracy of protein microarray technologies through non-specific binding interactions. Optimisation of array conditions is imperative to help address these problems. Here we demonstrate how modifications to
Gina L Razidlo et al.
Cancer research, 75(14), 2907-2915 (2015-05-16)
Pancreatic cancer, one of the most lethal forms of human cancer, is largely resistant to many conventional chemotherapeutic agents. Although many therapeutic approaches focus on tumor growth, metastasis is a primary factor contributing to lethality. Therefore, novel therapies to target
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