G5294

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关键词:'G5294'

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Geranylgeranyl pyrophosphate synthase facilitates the organization of cardiomyocytes during mid-gestation through modulating protein geranylgeranylation in mouse heart

Chen Z, et al.

Cardiovascular Research, 114(7), 965-978 (2018)

Simvastatin modulates cellular components in influenza A virus-infected cells.

Parvaneh Mehrbod et al.

International journal of molecular medicine, 34(1), 61-73 (2014-05-03)

Influenza A virus is one of the most important health risks that lead to significant respiratory infections. Continuous antigenic changes and lack of promising vaccines are the reasons for the unsuccessful treatment of influenza. Statins are pleiotropic drugs that have

Geranylgeranyl transferase regulates CXC chemokine formation in alveolar macrophages and neutrophil recruitment in septic lung injury

Hasan Z, et al.

American Journal of Physiology. Lung Cellular and Molecular Physiology, 304(4), L221-L229 (2012)

Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth

Falsetti SC, et al.

Molecular and cellular biology, 27(22), 8003-8014 (2007)

Discovery of Geranylgeranyltransferase-I Inhibitors with Novel Scaffolds by the Means of Quantitative Structure-Activity Relationship Modeling, Virtual Screening, and Experimental Validation

Peterson YK, et al.

Journal of medicinal chemistry, 52(14), 4210-4220 (2009)

Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis.

Vera Mugoni et al.

Cell, 152(3), 504-518 (2013-02-05)

Protection against oxidative damage caused by excessive reactive oxygen species (ROS) by an antioxidant network is essential for the health of tissues, especially in the cardiovascular system. Here, we identified a gene with important antioxidant features by analyzing a null

Statins Decrease Programmed Death-Ligand 1 (PD-L1) by Inhibiting AKT and β-Catenin Signaling.

Woo-Jin Lim et al.

Cells, 10(9) (2021-09-29)

Retrospective observational studies have reported that statins improve clinical outcomes in patients previously treated with programmed cell death protein 1 (PD-1)-targeting monoclonal antibodies for malignant pleural mesothelioma (MPM) and advanced non-small cell lung cancer (NSCLC). In multiple mouse cancer models

Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway.

Hong-Li Jiao et al.

Cell death & disease, 11(7), 571-571 (2020-07-28)

Oxysterol-binding protein like protein 3 (OSBPL3) has been shown involving in the development of several human cancers. However, the relationship between OSBPL3 and colorectal cancer (CRC), particularly the role of OSBPL3 in the proliferation, invasion and metastasis of CRC remains

Inhibition of Rho and Rac geranylgeranylation by atorvastatin is critical for preservation of endothelial junction integrity.

Hongbing Xiao et al.

PloS one, 8(3), e59233-e59233 (2013-04-05)

Small GTPases (guanosine triphosphate, GTP) are involved in many critical cellular processes, including inflammation, proliferation, and migration. GTP loading and isoprenylation are two important post-translational modifications of small GTPases, and are critical for their normal function. In this study, we

Prenylation of Axonally Translated Rac1 Controls NGF-Dependent Axon Growth.

Emily Scott-Solomon et al.

Developmental cell, 53(6), 691-705 (2020-06-14)

Compartmentalized signaling is critical for cellular organization and specificity of functional outcomes in neurons. Here, we report that post-translational lipidation of newly synthesized proteins in axonal compartments allows for short-term and autonomous responses to extrinsic cues. Using conditional mutant mice

Statin-mediated inhibition of cholesterol synthesis induces cytoprotective autophagy in human leukemic cells.

Urosh Vilimanovich et al.

European journal of pharmacology, 765, 415-428 (2015-09-12)

Statins exhibit anti-leukemic properties due to suppression of the mevalonate pathway by the inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase, and subsequent depletion of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate. We investigated the role of autophagy, a controlled intracellular self-digestion, in the anti-leukemic

Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma.

Staci L Haney et al.

Oncogene, 38(26), 5308-5320 (2019-03-29)

Rab proteins play an essential role in regulating intracellular membrane trafficking processes. Rab activity is dependent upon geranylgeranylation, a post-translational modification that involves the addition of 20-carbon isoprenoid chains via the enzyme geranylgeranyl transferase (GGTase) II. We have focused on

Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways.

Craig S Clements et al.

Biogerontology, 20(3), 337-358 (2019-05-02)

Hutchinson-Gilford progeria syndrome (HGPS) is a rare, premature ageing syndrome in children. HGPS is normally caused by a mutation in the LMNA gene, encoding nuclear lamin A. The classical mutation in HGPS leads to the production of a toxic truncated

P53-and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance

Hashimoto A, et al.

The Journal of Cell Biology, 213(1), 81-95 (2016)

The polyphenols (-)-epigallocatechin-3-gallate and luteolin synergistically inhibit TGF-β-induced myofibroblast phenotypes through RhoA and ERK inhibition.

Alana L Gray et al.

PloS one, 9(10), e109208-e109208 (2014-10-02)

The presence of reactive stroma, predominantly composed of myofibroblasts, is directly associated with and drives prostate cancer progression. We have previously shown that (-)-Epigallocatechin-3-gallate (EGCG), in the form of Polyphenon E, significantly decreases serum levels of HGF and VEGF in

Inhibition of prenyltransferase activity by statins in both liver and muscle cell lines is not causative of cytotoxicity.

Rowena H Gee et al.

Toxicology, 329, 40-48 (2015-01-13)

As inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase, statins are an important first-line treatment for hypercholesterolemia. However, a recognized side-effect of statin therapy is myopathy, which in severe cases can present as potentially fatal rhabdomyolysis. This represents an important impediment to successful statin

Modulation of sterol biosynthesis regulates viral replication and cytokine production in influenza A virus infected human alveolar epithelial cells.

Kenrie P Y Hui et al.

Antiviral research, 119, 1-7 (2015-04-18)

Highly pathogenic H5N1 viruses continue to transmit zoonotically, with mortality higher than 60%, and pose a pandemic threat. Antivirals remain the primary choice for treating H5N1 diseases and have their limitations. Encouraging findings highlight the beneficial effects of combined treatment

Farnesyltransferase inhibitor and rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson-Gilford progeria syndrome fibroblasts.

Mehmet U Bikkul et al.

Biogerontology, 19(6), 579-602 (2018-06-17)

Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal premature ageing disease in children. HGPS is one of several progeroid syndromes caused by mutations in the LMNA gene encoding the nuclear structural proteins lamins A and C. In classic HGPS

Inhibition of Rab prenylation by statins induces cellular glycosphingolipid remodeling.

Beth Binnington et al.

Glycobiology, 26(2), 166-180 (2015-09-26)

Statins, which specifically inhibit HMG Co-A reductase, the rate-limiting step of cholesterol biosynthesis, are widely prescribed to reduce serum cholesterol and cardiac risk, but many other effects are seen. We now show an effect of these drugs to induce profound

Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification.

Takuya Kitamura et al.

The Biochemical journal, 465(1), 79-87 (2014-10-07)

Aldehyde dehydrogenases (ALDHs) catalyse the conversion of toxic aldehydes into non-toxic carboxylic acids. Of the 21 ALDHs in mice, it is the ALDH3 family members (ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2 and ALDH3B3) that are responsible for the removal of lipid-derived aldehydes.

Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells.

Omar F Ali et al.

Respiratory research, 12, 137-137 (2011-10-18)

Recent clinical data suggest statins have transient but significant effects in patients with pulmonary arterial hypertension. In this study we explored the molecular effects of statins on distal human pulmonary artery smooth muscle cells (PASMCs) and their relevance to proliferation

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