GF96220065

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Common defects of mitochondria and iron in neurodegeneration and diabetes (MIND): a paradigm worth exploring.

Matthew Stroh et al.

Biochemical pharmacology, 88(4), 573-583 (2013-12-24)

A popular, if not centric, approach to the study of an event is to first consider that of the simplest cause. When dissecting the underlying mechanisms governing idiopathic diseases, this generally takes the form of an ab initio genetic approach.

Ocean chemistry: Fingerprints of a trace nutrient.

Joseph A Resing et al.

Nature, 511(7508), 164-165 (2014-07-11)

Microcytic anemia.

Shraga Aviner et al.

The New England journal of medicine, 371(26), 2536-2536 (2014-12-30)

High-nutrition biscuits to increase animal protein in diets of HIV-infected Kenyan women and their children: a study in progress.

Judith Ernst et al.

Food and nutrition bulletin, 35(4 Suppl), S198-S204 (2015-02-03)

Preliminary evidence suggests that improved nutrition early in HIV infection may delay progression to AIDS and delay the initiation or improve the effectiveness of antiretroviral drug therapy. There are few studies that evaluate food-based interventions in drug-naïve, HIV-infected women and

Ocean Science. Microbial proteins and oceanic nutrient cycles.

C Mark Moore

Science (New York, N.Y.), 345(6201), 1120-1121 (2014-09-06)

Conventional and novel peripheral blood iron markers compared against bone marrow in Malawian children.

Femkje A M Jonker et al.

Journal of clinical pathology, 67(8), 717-723 (2014-06-12)

Iron deficiency is an important child health problem. Its diagnosis in areas of high infection exposure remains complicated as inflammation may interfere with the accuracy of peripheral iron markers. With this study, we aimed to validate the conventional iron markers

Hypoferremia of infection: a double-edged sword?

Kristen L Lokken et al.

Nature medicine, 20(4), 335-337 (2014-04-09)

Speciation of phosphorus in the sediments of Lake Bini (Ngaoundere-Cameroon).

Joseph Marie Sieliechi et al.

Environmental technology, 35(13-16), 1831-1839 (2014-06-25)

In this study, spatial and seasonal variations of phosphorus fractions in Lake Bini sediments were evaluated using a sequential extraction method. The sampling of water and sediments (surface and coring) was carried out at seven sites around the lake during

Inverse agonist of estrogen-related receptor γ controls Salmonella typhimurium infection by modulating host iron homeostasis.

Don-Kyu Kim et al.

Nature medicine, 20(4), 419-424 (2014-03-25)

In response to microbial infection, expression of the defensin-like peptide hepcidin (encoded by Hamp) is induced in hepatocytes to decrease iron release from macrophages. To elucidate the mechanism by which Salmonella enterica var. Typhimurium (S. typhimurium), an intramacrophage bacterium, alters

Toxic effects of IV iron preparations in CKD patients.

Nosratola D Vaziri

Nephrology news & issues, 28(2), 4-5 (2014-03-22)

Loss of blood associated with hemodialysis procedures and laboratory testing, together with impaired iron absorption due to elevation of hepcidin, invariably cause iron deficiency in end-stage renal disease patients. For this reason, nearly all ESRD patients require intravenous iron to

Self-limiting growth of metal fluoride thin films by oxidation reactions employing molecular precursors

Qiu et al.

Physical review letters, 85(7), 1492-1495 (2000-09-06)

FeF (2) films are grown by the reaction of XeF (2) and SeF (6) with iron foil. The growth initially follows the Mott-Cabrera parabolic rate law, indicating that the process is diffusion limited. At a certain film thickness, however, the

The molecular biology of human iron metabolism.

William E Winter et al.

Laboratory medicine, 45(2), 92-102 (2014-05-30)

Iron is one of the most important nonorganic substances that make life possible. Iron plays major roles in oxygen transport (eg, hemoglobin; -67% of total body iron [TBI]), short-term oxygen storage (eg, myoglobin; -3.5% of TBI), and energy generation (eg

Oral iron supplementation after blood donation: a randomized clinical trial.

Joseph E Kiss et al.

JAMA, 313(6), 575-583 (2015-02-11)

Although blood donation is allowed every 8 weeks in the United States, recovery of hemoglobin to the currently accepted standard (12.5 g/dL) is frequently delayed, and some donors become anemic. To determine the effect of oral iron supplementation on hemoglobin

The iron-sensing fur regulator controls expression timing and levels of salmonella pathogenicity island 2 genes in the course of environmental acidification.

Eunna Choi et al.

Infection and immunity, 82(6), 2203-2210 (2014-03-20)

In order to survive inside macrophages, Salmonella produces a series of proteins encoded by genes within Salmonella pathogenicity island 2 (SPI-2). In the present study, we report that Fur, a central regulator of iron utilization, negatively controls the expression of

Biotechnology: Against the grain.

Michael Eisenstein

Nature, 514(7524), S55-S57 (2014-11-05)

Synthesis and characterization of new derivatives of alginic acid and evaluation of their iron(III)-crosslinked beads as potential controlled release matrices.

Samer R Abulateefeh et al.

Pharmaceutical development and technology, 19(7), 856-867 (2013-09-17)

The excellent gelling and safety profiles of alginic acid combined, however, with drawbacks of its ionotropically crosslinked beads (i.e. their quick release of loaded drugs) prompted us to chemically modify alginic acid. Alginic acid was chemically conjugated with four amines

Lipocalin 2 imparts selective pressure on bacterial growth in the bladder and is elevated in women with urinary tract infection.

Magnus Steigedal et al.

Journal of immunology (Baltimore, Md. : 1950), 193(12), 6081-6089 (2014-11-16)

Competition for iron is a critical component of successful bacterial infections, but the underlying in vivo mechanisms are poorly understood. We have previously demonstrated that lipocalin 2 (LCN2) is an innate immunity protein that binds to bacterial siderophores and starves

Hepatocellular carcinoma in thalassaemia: an update of the Italian Registry.

Caterina Borgna-Pignatti et al.

British journal of haematology, 167(1), 121-126 (2014-07-06)

The risk of developing hepatocellular carcinoma (HCC) in patients with thalassaemia is increased by transfusion-transmitted infections and haemosiderosis. All Italian Thalassaemia Centres use an ad hoc form to report all diagnoses of HCC to the Italian Registry. Since our last

Quantification of dissolved iron sources to the North Atlantic Ocean.

Tim M Conway et al.

Nature, 511(7508), 212-215 (2014-07-11)

Dissolved iron is an essential micronutrient for marine phytoplankton, and its availability controls patterns of primary productivity and carbon cycling throughout the oceans. The relative importance of different sources of iron to the oceans is not well known, however, and

The basic leucine zipper stress response regulator Yap5 senses high-iron conditions by coordination of [2Fe-2S] clusters.

Nicole Rietzschel et al.

Molecular and cellular biology, 35(2), 370-378 (2014-11-05)

Iron is an essential, yet at elevated concentrations toxic trace element. To date, the mechanisms of iron sensing by eukaryotic iron-responsive transcription factors are poorly understood. The Saccharomyces cerevisiae transcription factor Yap5, a member of the Yap family of bZIP

Parenteral iron as a cause of hypophosphataemia.

Francisco J Fernández-Fernández et al.

BMJ (Clinical research ed.), 349, g4616-g4616 (2014-07-17)

Bioavailability of cobalt and iron from citric-acid-adsorbed CoFe2O4 nanoparticles in the terrestrial isopod Porcellio scaber.

Tea Romih et al.

The Science of the total environment, 508, 76-84 (2014-12-02)

The aim of this study was to determine whether citric acid adsorbed onto cobalt ferrite (CoFe2O4) nanoparticles (NPs) influences the bioavailability of their constituents Co and Fe. Dissolution of Co and Fe was assessed by two measures: (i) in aqueous

Exposure to low-dose (56)Fe-ion radiation induces long-term epigenetic alterations in mouse bone marrow hematopoietic progenitor and stem cells.

Isabelle R Miousse et al.

Radiation research, 182(1), 92-101 (2014-06-25)

There is an increasing need to better understand the long-term health effects of high-linear energy transfer (LET) radiation due to exposure during space missions, as well as its increasing use in clinical treatments. Previous studies have indicated that exposure to

Interspecies competition triggers virulence and mutability in Candida albicans-Pseudomonas aeruginosa mixed biofilms.

Abigail Trejo-Hernández et al.

The ISME journal, 8(10), 1974-1988 (2014-04-18)

Inter-kingdom and interspecies interactions are ubiquitous in nature and are important for the survival of species and ecological balance. The investigation of microbe-microbe interactions is essential for understanding the in vivo activities of commensal and pathogenic microorganisms. Candida albicans, a

Multiple nutrient stresses at intersecting Pacific Ocean biomes detected by protein biomarkers.

Mak A Saito et al.

Science (New York, N.Y.), 345(6201), 1173-1177 (2014-09-06)

Marine primary productivity is strongly influenced by the scarcity of required nutrients, yet our understanding of these nutrient limitations is informed by experimental observations with sparse geographical coverage and methodological limitations. We developed a quantitative proteomic method to directly assess

Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: inhibition of constitutive and interleukin 6-induced activation by iron depletion.

Goldie Y L Lui et al.

Molecular pharmacology, 87(3), 543-560 (2015-01-07)

Pharmacologic manipulation of metal pools in tumor cells is a promising strategy for cancer treatment. Here, we reveal how the iron-binding ligands desferrioxamine (DFO), di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), and di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC) inhibit constitutive and interleukin 6-induced activation of signal transducer and

Technical and economic feasibility of polyester dyeing wastewater treatment by coagulation/flocculation and Fenton's oxidation.

Carmen S D Rodrigues et al.

Environmental technology, 35(9-12), 1307-1319 (2014-04-08)

This study aims to investigate the efficiency of individual and integrated processes applied to organic matter abatement and biodegradability improvement of a polyester dyeing wastewater, namely coagulation/flocculation combined with Fenton's reagent (Approach 1), Fenton oxidation alone (Approach 2) and its

Iron in intracellular infection: to provide or to deprive?

Sandro Silva-Gomes et al.

Frontiers in cellular and infection microbiology, 3, 96-96 (2013-12-25)

Due to their chemical versatility, transition metals were incorporated as cofactors for several basic metabolic pathways in living organisms. This same characteristic makes them potentially harmful, since they can be engaged in deleterious reactions like Fenton chemistry. As such, organisms

Effect of anions and humic acid on the performance of nanoscale zero-valent iron particles coated with polyacrylic acid.

Hong-Seok Kim et al.

Chemosphere, 113, 93-100 (2014-07-30)

Effects of anions (NO3(-), HCO3(-), Cl(-), SO4(2-)) and humic acid on the reactivity and core/shell chemistries of polyacrylic acid-coated nanoscale zero-valent iron (PAA-NZVI) and inorganically modified NZVI (INORG-NZVI) particles were investigated. The reactivity tests under various ion concentrations (0.2-30mN) revealed

Microcytic anemia.

Thomas G DeLoughery

The New England journal of medicine, 371(26), 2537-2537 (2014-12-30)

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