GW22461F

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Polymorphic variant at the IL2 region is associated with type 1 diabetes and may affect serum levels of interleukin-2.

Marta Fichna et al.

Molecular biology reports, 40(12), 6957-6963 (2013-10-25)

Polymorphic variants at the interleukin-2 (IL2) locus affect the risk of several autoimmune disorders. Our aim was to evaluate the association of the four IL2 polymorphisms (rs6822844, rs6534349, rs2069762 and rs3136534) with type 1 diabetes (T1D) in the Polish population

Expression and cellular distribution of the interleukin 2 signaling system in cortical lesions from patients with focal cortical dysplasia.

Wei Guo et al.

Journal of neuropathology and experimental neurology, 73(3), 206-222 (2014-02-04)

Focal cortical dysplasia (FCD) is a well-known cause of medically intractable epilepsy. To understand the potential role of the inflammatory cytokine interleukin 2 (IL-2) in the pathogenesis of FCD, we investigated the expression patterns of IL-2 and its receptors (IL-2Rs)

Low-dose interleukin-2 therapy: a driver of an imbalance between immune tolerance and autoimmunity.

Agata Kosmaczewska

International journal of molecular sciences, 15(10), 18574-18592 (2014-10-17)

For many years, the role of interleukin-2 (IL-2) in autoimmune responses was established as a cytokine possessing strong pro-inflammatory activity. Studies of the past few years have changed our knowledge on IL-2 in autoimmune chronic inflammation, suggesting its protective role

Identification of alternatively spliced isoforms of interleukin-2/15 receptor β chain in ducks.

Jipseol Jeong et al.

Veterinary immunology and immunopathology, 162(3-4), 154-161 (2014-12-03)

Interleukin (IL)-2 and IL-15 receptor β (IL-2/15Rβ, CD122) play important roles in signal transduction for biological functions of IL-2 and IL-15. We found that ducks possess three different IL-2/15Rβ transcripts, a conventional form (duIL-2/15Rβ) and two variants. Comparisons between the

Label-Free Biosensing with High Selectivity in Complex Media using Microtoroidal Optical Resonators.

Erol Ozgur et al.

Scientific reports, 5, 13173-13173 (2015-08-15)

Although label-free biosensors comprised of optical microcavities inherently possess the capability of resolving molecular interactions at individual level, this extreme sensitivity restricts their convenience for large scale applications by inducing vulnerability towards non-specific interactions that readily occur within complex media.

Modeling interleukin-2-based immunotherapy in AIDS pathogenesis.

Marcel Joly et al.

Journal of theoretical biology, 335, 57-78 (2013-06-29)

In this paper, we sought to identify the CD4(+) T-cell dynamics in the course of HIV infection in response to continuous and intermittent intravenous courses of interleukin-2 (IL-2), the principal cytokine responsible for progression of CD4(+) T-lymphocytes from the G1

Aerosol interleukin-2 induces natural killer cell proliferation in the lung and combination therapy improves the survival of mice with osteosarcoma lung metastasis.

Sergei R Guma et al.

Pediatric blood & cancer, 61(8), 1362-1368 (2014-03-13)

We have previously shown that aerosol interleukin-2 (IL-2) increased the number of intravenously injected human natural killer (NK) cells in the lungs. In this study we investigated whether this increase was secondary to NK cell proliferation and determined the site

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