搜索范围
H0887
应用筛选条件
关键词:'H0887'
显示 1-30 #N/A 365 条结果 关于 "H0887" 范围 论文
Activation of AMP-activated protein kinase (AMPK) through inhibiting interaction with prohibitins.
Kanagaki, et al.
iScience, 26, 106293-106293 (2023)
Hanae Sato et al.
Bio-protocol, 10(17) (2020-10-13)
Dynamic histone changes occur as a central part of chromatin regulation. Deposition of histone variants and post-translational modifications of histones are strongly associated with properties of chromatin status. Characterizing the kinetics of histone variants allows important insights into transcription regulation
André Rey-Cibati et al.
Bio-protocol, 10(18), e3766-e3766 (2021-03-05)
Ca2+ is an essential signaling messenger in all eukariotic cells, playing a pivotal role in many cellular functions as cell growth control (differentiation, fertilization and apoptosis), secretion, gene expression, enzyme regulation, among many others. This basic premise includes trypanosomatids as
Wen-Yih Jeng et al.
Acta crystallographica. Section D, Biological crystallography, 68(Pt 7), 829-838 (2012-07-04)
NkBgl, a β-glucosidase from Neotermes koshunensis, is a β-retaining glycosyl hydrolase family 1 enzyme that cleaves β-glucosidic linkages in disaccharide or glucose-substituted molecules. β-Glucosidases have been widely used in several applications. For example, mutagenesis of the attacking nucleophile in β-glucosidase
George J N Tetley et al.
The Journal of biological chemistry, 295(9), 2866-2884 (2020-01-22)
Aberrant Ras signaling drives 30% of cancers, and inhibition of the Rho family small GTPase signaling has been shown to combat Ras-driven cancers. Here, we present the discovery of a 16-mer cyclic peptide that binds to Cdc42 with nanomolar affinity.
Komal Qureshi-Baig et al.
Autophagy, 16(8), 1436-1452 (2019-11-30)
In solid tumors, cancer stem cells (CSCs) or tumor-initiating cells (TICs) are often found in hypoxic niches. Nevertheless, the influence of hypoxia on TICs is poorly understood. Using previously established, TIC-enrichedpatient-derived colorectal cancer (CRC) cultures, we show that hypoxia increases
Alexander A Wurm et al.
Cell reports. Medicine, 4(10), 101200-101200 (2023-09-22)
Targeted therapies are effective in treating cancer, but success depends on identifying cancer vulnerabilities. In our study, we utilize small RNA sequencing to examine the impact of pathway activation on microRNA (miRNA) expression patterns. Interestingly, we discover that miRNAs capable
Bruce A Pfeffer et al.
Experimental eye research, 161, 17-29 (2017-06-03)
A duplex fluorescence assay to assess the viability of cells cultured in multi-well plates is described, which can be carried out in the original culture plate using a plate reader, without exchanges of culture or assay medium, or transfer of
Enrique J Arenas et al.
Nature communications, 12(1), 1237-1237 (2021-02-25)
Immunotherapy has raised high expectations in the treatment of virtually every cancer. Many current efforts are focused on ensuring the efficient delivery of active cytotoxic cells to tumors. It is assumed that, once these active cytotoxic cells are correctly engaged
Edward A Gonzalez et al.
Proceedings of the National Academy of Sciences of the United States of America, 120(37), e2221405120-e2221405120 (2023-09-05)
DNA methylation functions as a repressive epigenetic mark that can be reversed by the Ten-eleven translocation (TET) family of DNA dioxygenases that sequentially oxidize 5-methylcytosine into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). Both 5fC and 5caC can be excised
James R W Conway et al.
Proceedings of the National Academy of Sciences of the United States of America, 120(43), e2304288120-e2304288120 (2023-10-16)
Integrin-dependent adhesion to the extracellular matrix (ECM) mediates mechanosensing and signaling in response to altered microenvironmental conditions. In order to provide tissue- and organ-specific cues, the ECM is composed of many different proteins that temper the mechanical properties and provide
Ji-Hoon Jang et al.
Oncology letters, 16(2), 2030-2038 (2018-07-17)
Renal cell carcinoma (RCC) is one of the most common types of cancer in adults. Previous studies have reported that the survival rate was significantly lower for renal cancer patients with diabetes than for those without diabetes. Metformin is a
Vincent B Luscombe et al.
European journal of pharmacology, 956, 175960-175960 (2023-08-06)
GPR84 is an orphan G-protein coupled receptor (GPCR) linked to inflammation. Strategies targeting GPR84 to prevent excessive inflammation in disease are hampered by a lack of understanding of its precise functional role. We have developed heterologous cell lines with low
Nina Bertaux-Skeirik et al.
Methods in molecular biology (Clifton, N.J.), 1576, 205-213 (2016-08-20)
The culture of organoids has represented a significant advancement in the gastrointestinal research field. Previous research studies have described the oncogenic transformation of human intestinal and mouse gastric organoids. Here we detail the protocol for the oncogenic transformation and orthotopic
Xiangkun Elvis Cao et al.
EBioMedicine, 76, 103867-103867 (2022-02-13)
Early and accurate determination of bacterial infections as a potential cause for a patient's systemic inflammatory response is required for timely administration of appropriate treatment and antibiotic stewardship. Procalcitonin (PCT) and C-reactive protein (CRP) have both been used as biomarkers
Lukas Vacek et al.
Frontiers in endocrinology, 13, 663625-663625 (2022-04-02)
Obstructive sleep apnea syndrome, characterized by repetitive episodes of tissue hypoxia, is associated with several metabolic impairments. Role of fatty acids and lipids attracts attention in its pathogenesis for their metabolic effects. Parallelly, hypoxia-induced activation of reverse tricarboxylic acid cycle
Arjen Weller et al.
Frontiers in bioengineering and biotechnology, 10, 965200-965200 (2022-09-27)
Unsuccessful clinical translation of orally delivered biological drugs remains a challenge in pharmaceutical development and has been linked to insufficient mechanistic understanding of intestinal drug transport. Live cell imaging could provide such mechanistic insights by directly tracking drug transport across
Szimonetta Xénia Tamás et al.
Nature communications, 14(1), 4610-4610 (2023-08-02)
Leukotriene B4 (LTB4) is a potent lipid chemoattractant driving inflammatory responses during host defense, allergy, autoimmune and metabolic diseases. Gradients of LTB4 orchestrate leukocyte recruitment and swarming to sites of tissue damage and infection. How LTB4 gradients form and spread
Frauke Pedersen et al.
Respiratory medicine, 107(4), 587-595 (2013-01-15)
Induced sputum is a non-invasive sampling technique for the analysis of airway inflammation in various lung diseases and comprises valuable potential for the identification of biomarkers and therapeutic targets by molecular methods. In the context of biobanking with preservation of
Junbo Li et al.
Dalton transactions (Cambridge, England : 2003), 41(13), 3623-3626 (2012-02-24)
We developed a novel method for Cu(2+) detection based on the ion promoted oxidation reaction. Chemodosimeter L (weak fluorescence) can be oxidized into 3-benzothiazoly-7-N,N-diethylaminocoumarin (strong green fluorescence, coumarin 6) by Cu(2+) with high selectivity and sensitivity in HEPES (10 mM
Eng Kuan Moo et al.
Biophysical journal, 105(7), 1590-1600 (2013-10-08)
Impact loading of articular cartilage causes extensive chondrocyte death. Cell membranes have a limited elastic range of 3-4% strain but are protected from direct stretch during physiological loading by their membrane reservoir, an intricate pattern of membrane folds. Using a
Hydrogen ion buffers for biological research.
N E Good et al.
Biochemistry, 5(2), 467-477 (1966-02-01)
Maria-Kyriaki Drekolia et al.
Redox biology, 69, 103014-103014 (2024-01-04)
Protein persulfidation is a significant post-translational modification that involves addition of a sulfur atom to the cysteine thiol group and is facilitated by sulfide species. Persulfidation targets reactive cysteine residues within proteins, influencing their structure and/or function across various biological
Comprehensive isolation of extracellular vesicles and nanoparticles.
Zhang, et al.
Nature Protocols, 18, 1462-1487 (2023)
Joachim Hanna et al.
Nature communications, 13(1), 4075-4075 (2022-07-15)
Th17 cells are key drivers of autoimmune disease. However, the signaling pathways regulating Th17 polarization are poorly understood. Hedgehog signaling regulates cell fate decisions during embryogenesis and adult tissue patterning. Here we find that cell-autonomous Hedgehog signaling, independent of exogenous
Hildegard Herman et al.
Polymers, 16(9) (2024-05-11)
Smart polymeric micelles (PMs) are of great interest in drug delivery owing to their low critical micellar concentration and sizes. In the present study, two different pH-sensitive poly(2-vinyl pyridine)-b-poly(ethylene oxide) (P2VP-b-PEO) copolymer samples were used for the encapsulation of paclitaxel
Janna Eilts et al.
Neurophotonics, 10(4), 044412-044412 (2023-10-27)
Understanding the organization of biomolecules into complexes and their dynamics is crucial for comprehending cellular functions and dysfunctions, particularly in neuronal networks connected by synapses. In the last two decades, various powerful super-resolution (SR) microscopy techniques have been developed that
A Akhlaghi et al.
Poultry science, 92(4), 874-881 (2013-03-09)
A hypothesis was tested that the in ovo injection of biological buffers may reinforce the buffering capacity of albumen, thereby withstanding the increase in albumen pH during storage and improving hatchability and chick quality in long-term stored eggs. Hatching eggs
Barney Viengkhou et al.
Immunity, 57(7), 1696-1709 (2024-06-16)
Aicardi-Goutières syndrome (AGS) is an autoinflammatory disease characterized by aberrant interferon (IFN)-α production. The major cause of morbidity in AGS is brain disease, yet the primary source and target of neurotoxic IFN-α remain unclear. Here, we demonstrated that the brain
Roger Clark et al.
Journal of immunological methods, 473, 112636-112636 (2019-08-02)
Macrophages are a diverse population of cells originating from the myeloid lineage, which form an important component of the innate immune system, helping to regulate immune response through secretion of pro/anti-inflammatory cytokines. However they also have an important homeostatic role
1/13