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Jie Li et al.
Oncotarget, 5(4), 882-893 (2014-03-25)
Glioblastoma remains one of the deadliest of human cancers, with most patients succumbing to the disease within two years of diagnosis. The available data suggest that simultaneous inactivation of critical nodes within the glioblastoma molecular circuitry will be required for
H Uys
African journal of psychiatry, 16(1), 23-28 (2013-02-19)
Literature on the prevalence and clinical presentation of South African psychiatric HIV positive patients as well as their management is lacking. This study was performed to investigate these parameters. A prospective study to investigate the prevalence and clinical presentation of
Hanna Iderberg et al.
Neuropharmacology, 95, 121-129 (2015-03-10)
Metabotropic glutamate receptor 4 (mGlu4) negatively modulates GABA and glutamate release in the 'indirect pathway' of the basal ganglia, and has thus been proposed as a potential target to treat motor symptoms in Parkinson's disease. Here, we present an extensive
Erica H Z Wang et al.
Neurocritical care, 16(1), 170-183 (2011-11-01)
Delirium is the most common mental disturbance in critically-ill patients and results in significant morbidity and mortality. Haloperidol is a preferred agent for the treatment of delirium in this population because of its rapid onset of action and lack of
Andrés Ciudad-Roberts et al.
British journal of pharmacology, 172(20), 4970-4984 (2015-08-01)
The psychostimulant mephedrone is often consumed in combination with alcohol (EtOH). This kind of drug consumption during adolescence is a matter of concern. We studied, in adolescent CD-1 mice, whether EtOH could enhance the psychostimulant (locomotor acivity) and rewarding [conditioned
Chao Deng et al.
Psychiatry research, 225(3), 347-354 (2015-01-13)
Neuregulin-1 (NRG1) and ErbB4 genes have been identified as candidate genes for schizophrenia. Post-mortem studies indicated that NRG1-ErbB4 signalling is impaired in schizophrenia subjects. This study investigated whether short- or long-term antipsychotic treatment has different effects on the expression of
G Telegdy et al.
Behavioural brain research, 270, 326-329 (2014-05-13)
Urocortin 3 (Ucn 3) was found to impair passive avoidance learning in male and female mice. The possible involvement of transmitters in the action, the animals were pretreated with the following receptor antagonists in doses which alone could not influence
Cristina Sempio et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 970, 1-7 (2014-09-15)
The aim of the study was to develop and validate a simple, sensitive and specific method for the detection and quantitative determination of 88 substances among psychoactive drugs and their metabolites in whole blood, and to apply the procedure to
Keiko Tsuchie et al.
Asian journal of psychiatry, 6(2), 119-123 (2013-03-08)
There have been reports of a positive relationship between schizophrenia and hyperbilirubinemia. Patients with schizophrenia show a significantly higher frequency of hyperbilirubinemia than patients suffering from other psychiatric disorders and when compared to the general population. Previously we observed that
Auxiliadora Mena et al.
Behavioural brain research, 252, 188-194 (2013-06-13)
When a neutral stimulus is repeatedly paired with a drug, an association is established between them that can induce two different responses: either an opponent response that counteracts the effect of the drug, or a response that is similar to
Yeast sphingolipids do not need to contain very long chain fatty acids
Cerantola V, et al.
The Biochemical Journal, 401(1), 205-216 (2007)
Influence of antipsychotic drugs on human endogenous retrovirus (HERV) transcription in brain cells.
Olivia Diem et al.
PloS one, 7(1), e30054-e30054 (2012-01-19)
Human endogenous retroviruses (HERVs) have been associated with various neurological and neuropsychiatric disorders. Transcripts and proteins of at least three HERV groups, HERV-W, ERV9 and HERV-K(HML-2) have been detected repeatedly in brain samples or cerebrospinal fluid of patients with schizophrenia
In-Seon Lee et al.
Scientific reports, 5, 17140-17140 (2015-11-26)
We suggest a new placebo analgesia animal model and investigated the role of the dopamine and opioid systems in placebo analgesia. Before and after the conditioning, we conducted a conditioned place preference (CPP) test to measure preferences for the cues
Homeira Ebrahimzadeh et al.
International journal of pharmaceutics, 453(2), 601-609 (2013-06-08)
In this study an extraction procedure using molecular imprinted polymer nanoparticles for the determination of haloperidol in biological samples is proposed. The haloperidol imprinted polymer nanoparticles were synthesized successfully by precipitation polymerization in a flask containing haloperidol as a template
Ikuo Masuho et al.
Cell, 183(2), 503-521 (2020-10-03)
The control over the extent and timing of G protein signaling is provided by the regulator of G protein signaling (RGS) proteins that deactivate G protein α subunits (Gα). Mammalian genomes encode 20 canonical RGS and 16 Gα genes with
Davide Amato et al.
Neuropharmacology, 95, 243-251 (2015-04-07)
Presentation of non-aversive light stimuli for several seconds was found to reliably induce locomotor activation and exploratory-like activity. Light-induced locomotor activity (LIA) can be considered a convenient simple model to study sensory-motor activation. LIA was previously shown to coincide with
Anwar Anwar-Mohamed et al.
Toxicology letters, 230(3), 382-392 (2014-08-17)
Acquired cardiac long QT syndrome (LQTS) is a frequent drug-induced toxic event that is often caused through blocking of the human ether-á-go-go-related (hERG) K(+) ion channel. This has led to the removal of several major drugs post-approval and is a
Zheyuan Qian et al.
Journal of pharmaceutical and biomedical analysis, 102, 299-304 (2014-12-03)
A highly sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and fully validated for quantification of arotinolol enantiomers in rat plasma using haloperidol as the internal standard. After solid phase extraction of 50.0 μL rat plasma in
C Leucht et al.
The Cochrane database of systematic reviews, (1)(1), CD004278-CD004278 (2008-02-07)
Chlorpromazine and haloperidol are benchmark antipsychotic drugs. Both are said to be equally effective when used at equivalent doses, but have different side-effect profiles. To compare the effects of haloperidol and chlorpromazine for people with schizophrenia and schizophrenia-like psychoses. We
Jesu C Ferreira-Júnior et al.
Archives of pharmacal research, 38(6), 950-956 (2014-08-21)
The antinociceptive activity of icariside E4, a dihydrobenzofuran-type lignan isolated from Tabebuia roseo-alba (Ridley) Sandwith (Bignoniaceae) bark, was evaluated in mice by using chemical and thermal models of nociception. Intraperitoneal (i.p.) administration of crude T. roseo-alba bark extract and its
Céline Devroye et al.
Neuropharmacology, 97, 329-337 (2015-06-28)
The central serotonin2B receptor (5-HT2BR) is currently considered as an interesting pharmacological target for improved treatment of drug addiction. In the present study, we assessed the effect of two selective 5-HT2BR antagonists, RS 127445 and LY 266097, on cocaine-induced hyperlocomotion
Jami L Hickey et al.
The American journal of emergency medicine, 31(6), 1003-1003 (2013-04-16)
Cannabinoid hyperemesis syndrome (CHS) is a condition characterized by cyclical vomiting without other identifiable cause in patients with chronic cannabis use. Patients with CHS report that compulsive bathing and hot showers are the only reliable treatments to improve symptoms. Cannabinoid
William A Schmalhofer et al.
Assay and drug development technologies, 8(6), 714-726 (2010-12-17)
The voltage-gated potassium channel, human Ether-à-go-go related gene (hERG), represents the molecular component of IKr, one of the potassium currents involved in cardiac action potential repolarization. Inhibition of IKr increases the duration of the ventricular action potential, reflected as a
J M Goikolea et al.
Journal of affective disorders, 144(3), 191-198 (2012-10-24)
Treatment of acute mania with second-generation antipsychotics has been claimed to involve a lower risk of switch to depression than haloperidol. However, clinical guidelines clearly state that this is not a proven fact. Meta-analysis of double-blind randomized controlled trials in
Kathrin Arnhard et al.
Analytical and bioanalytical chemistry, 407(2), 405-414 (2014-11-05)
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become an indispensable analytical technique in clinical and forensic toxicology for detection and identification of potentially toxic or harmful compounds. Particularly, non-target LC-MS/MS assays enable extensive and universal screening requested in systematic toxicological analysis.
Karolina Pytka et al.
PloS one, 10(11), e0142499-e0142499 (2015-11-12)
The aim of this study was to further characterize pharmacological properties of two phenylpiperazine derivatives: 1-{2-[2-(2,6-dimethlphenoxy)ethoxy]ethyl}-4-(2-methoxyphenyl)piperazynine hydrochloride (HBK-14) and 2-[2-(2-chloro-6-methylphenoxy)ethoxy]ethyl-4-(2- methoxyphenyl)piperazynine dihydrochloride (HBK-15) in radioligand binding and functional in vitro assays as well as in vivo models. Antidepressant-like properties were
Maintenance treatment with long-acting injectable antipsychotics: comparing old with new.
Donald C Goff
JAMA, 311(19), 1973-1974 (2014-05-23)
Donard S Dwyer et al.
Neuropharmacology, 92, 56-62 (2015-01-13)
Here, we define a protophenotype as an endophenotype that has been conserved during evolution. Social feeding in Caenorhabditis elegans may be an example of a protophenotype related to asociality in schizophrenia. It is regulated by the highly conserved neuropeptide Y
Priscilla B Pail et al.
Neurotoxicology, 50, 71-80 (2015-08-10)
Mephedrone and methedrone are cathinone-related compounds, which act as non-selective substrates for monoamine transporters, facilitating a neurotransmitter release. We compared the acute pharmacological effects of mephedrone and methedrone, attempting to further evaluate the action mechanisms of methedrone by responsibly and
A Angelini et al.
Journal of biological regulators and homeostatic agents, 29(2), 357-365 (2015-07-01)
Multidrug resistance (MDR) mediated by P-glycoprotein (Pgp) remains one of the major obstacles to effective cancer chemotherapy. Several chemosensitizers have been used in vivo and in vitro to reverse MDR but have exhibited several unwanted side effects. Antipsychotics are often
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