H3780

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Enhanced chiral recognition by β-cyclodextrin at liquid/liquid interfaces as revealed by chromatographic and interfacial tension measurements.

Yusuke Iimura et al.

Journal of colloid and interface science, 508, 469-475 (2017-09-02)

The chiral selectivity of β-cyclodextrin (β-CD) in the water/hexane (3.0% THF) two-phase system is studied with chromatography and interfacial tension measurements. Chromatography using silica gel impregnated with aqueous β-CDas the stationary phase reveals that the chiral selectivity of this system

Point mutation of cytochrome P450 2A6 (a polymorphic variant CYP2A6.25) confers new substrate specificity towards flavonoids.

Tomohide Uno et al.

Biopharmaceutics & drug disposition, 36(8), 552-563 (2015-07-30)

CYP2A6 is a major hepatic member of the cytochrome P450 family in humans. Much variation in CYP2A6 levels and activity can be attributed to genetic polymorphisms of this gene. CYP2A6*25 comprises an amino acid substitution, F118L. To clarify the effect

Ordered mesoporous silica functionalized with β-cyclodextrin derivative for stereoisomer separation of flavanones and flavanone glycosides by nano-liquid chromatography and capillary electrochromatography.

Mariana Silva et al.

Journal of chromatography. A, 1490, 166-176 (2017-02-17)

In this paper a chiral stationary phase (CSP) was prepared by the immobilization of a β-CD derivative (3,5-dimethylphenylcarbamoylated β-CD) onto the surface of amino-functionalized spherical ordered mesoporous silica (denoted as SM) via a urea linkage using the Staudinger reaction. The

2'-Hydroxyflavanone prevents LPS-induced inflammatory response and cytotoxicity in murine macrophages.

Himangshu Sonowal et al.

Toxicology in vitro : an international journal published in association with BIBRA, 69, 104966-104966 (2020-08-18)

2'-Hydroxyflavanone (2-HF) is a natural flavonoid isolated from citrus fruits. Multiple studies have demonstrated that 2-HF with its anti-proliferative and pro-apoptotic effects prevent the growth of various cancers. Although 2-HF is a well known anti-oxidative and chemopreventive agent, its role

Hydroxyflavanone inhibits gastric carcinoma MGC-803 cell proliferation.

Haiyan Zhang et al.

International journal of clinical and experimental medicine, 8(9), 16955-16959 (2015-12-03)

Gastric carcinoma (GC) is the most common primary malignancy of the digestive tract, with increasing incidence in many countries. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to assess inhibition of HepG2 cell proliferation by 2'-hydroxyflavanone. The STAT3 pathway was performed. 2'-hydroxyflavanone

Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach.

Hui Cao et al.

Food chemistry, 270, 257-263 (2018-09-04)

Herein, the protein binding rates of structurally different flavonoids to human serum albumin (HSA) were elucidated by applying the high performance affinity chromatography (HPAC). The flavonoids with hydroxyl groups on ring A showed a higher protein binding rate compared with

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