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Michael Prater et al.
Methods in molecular biology (Clifton, N.J.), 946, 395-409 (2012-11-28)
Evidence is emerging that the mouse mammary epithelium is arranged as a hierarchy that spans from stem cells to lineage-restricted progenitor cells to differentiated luminal and myoepithelial cells. The use of fluorescence-activated cell sorting (FACS) in combination with quantitative functional
L Gabriel Sanchez-Partida et al.
PloS one, 6(6), e21597-e21597 (2011-07-09)
Oocyte cryopreservation is extremely beneficial for assisted reproductive technologies, the treatment of infertility and biotechnology and offers a viable alternative to embryo freezing and ovarian grafting approaches for the generation of embryonic stem cells and live offspring. It also offers
Waleed F A Marei et al.
Molecular human reproduction, 19(9), 590-599 (2013-04-30)
Biological functions of hyaluronan (HA) depend on its molecular size. Small size HAs are known to regulate cell proliferation; however, the expression of HA synthases (HASs) and hyaluronidase-2 (HYAL2) and their role during early embryo development have not been previously
Jean-Philippe Hugnot
Methods in molecular biology (Clifton, N.J.), 1059, 53-63 (2013-08-13)
Whereas neural stem cells and their niches have been extensively studied in the brain, little is known on these cells, their environment and their function in the adult spinal cord. Adult spinal cord neural stem cells are located in a
R N Tsepilov et al.
Zhurnal mikrobiologii, epidemiologii, i immunobiologii, (2)(2), 12-20 (2013-06-29)
Selection of high-mucoid morphotype of Streptococcus equi subsp. zooepidemicus (Streptococcus zooepidemicus) and study of its morphological, physiological, biochemical and technological characteristics for providing increased secretion of hyaluronic acid (HA). Submerged cultivation was performed in 100 ml glass flasks without baffles
Lei Yan et al.
Cell biochemistry and function, 38(3), 257-265 (2019-11-22)
The aim of this study was to investigate the regulatory mechanism of cancer-associated fibroblasts (CAFs) exosome in bladder cancer (BC) cell proliferation and invasion. CAFs and normal fibroblasts (NFs) were isolated from tumor tissues and adjacent normal tissues of BC
Tyl H Taylor et al.
Fertility and sterility, 85(5), 1544-1546 (2006-05-02)
The objective of the present study was to compare a traditionally used bovine-derived hyaluronidase (Hyase) with the newly developed recombinant human-derived enzyme product (Cumulase) in intracytoplasmic sperm injection (ICSI) procedures using a sibling oocyte model in a prospective randomized design.
Biswajit Chowdhury et al.
The Journal of biological chemistry, 288(1), 520-528 (2012-11-23)
Hyaluronidase (HYAL) 2 is a membrane-anchored protein that is proposed to hydrolyze hyaluronan (HA) to smaller fragments that are internalized for breakdown. Initial studies of a Hyal2 knock-out (KO) mouse revealed a mild phenotype with high serum HA, supporting a
Tianyang Lan et al.
International journal of molecular sciences, 23(15) (2022-08-13)
Oocyte vitrification has been widely used in the treatment of infertility and fertility preservation. However, vitrification-induced mitochondrial damage adversely affects oocyte development. Several studies have reported that mitochondrial calcium uptake protein 1 (MICU1) regulates the uptake of mitochondrial calcium by
Systemic Delivery of mPEG-Masked Trispecific T-Cell Nanoengagers in Synergy with STING Agonists Overcomes Immunotherapy Resistance in TNBC and Generates a Vaccination Effect.
Shen, et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 9, e2203523-e2203523 (2022)
Lucia von Mengden et al.
Journal of assisted reproduction and genetics, 39(6), 1277-1295 (2022-04-27)
To study whether the cumulus cell antioxidant system varies accordingly to patients clinical characteristics' as age, infertility diagnosis, BMI, and stimulation protocol applied and if the antioxidant profile of cumulus cells could be used as a predictor of embryo development.
Emanuel Rognoni et al.
eLife, 10 (2021-12-24)
Solar ultraviolet radiation (UVR) is a major source of skin damage, resulting in inflammation, premature ageing, and cancer. While several UVR-induced changes, including extracellular matrix reorganisation and epidermal DNA damage, have been documented, the role of different fibroblast lineages and
Guruprasad Nayak et al.
Journal of assisted reproduction and genetics, 37(5), 1227-1238 (2020-04-27)
Metformin is the most commonly prescribed drug in the management of metabolic disorders such as polycystic ovarian syndrome (PCOS) and gestational diabetes in women of reproductive age. Insulin-sensitizing effect of metformin helps in improving from PCOS features such as hyperandrogenism
Liesl Jacobs et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 28(4), 1068-1077 (2020-02-27)
Checkpoint-inhibiting antibodies elicit impressive clinical responses, but still face several issues. The current study evaluated whether DNA-based delivery can broaden the application of checkpoint inhibitors, specifically by pursuing cost-efficient in vivo production, facilitating combination therapies, and exploring administration routes that lower
Marco Ragusa et al.
RNA biology, 16(9), 1237-1248 (2019-05-29)
Circular RNAs (circRNAs) have a critical role in the control of gene expression. Their function in spermatozoa (SPZ) is unknown to date. Twenty-eight genes, involved in SPZ/testicular and epididymal physiology, were given in circBase database to find which of them
Steven H Bailey et al.
Plastic and reconstructive surgery, 133(2), 127e-132e (2014-01-29)
Soft-tissue augmentation has become an increasingly popular option for facial rejuvenation. Hyaluronic acid fillers are part of the most rapidly expanding segment of this market, largely because of their safe drug profile and temporary nature. Despite their good safety profile
Mauro Pavan et al.
Carbohydrate polymers, 97(2), 321-326 (2013-08-06)
Five amide derivatives of Hyaluronic Acid (HA) were synthesized with C8, C12, C15, C16 and C18 linear alkyl-amines. These polymers (Hyadd) were tested against thermal, oxidative and hyaluronidase degradation by means of rheological experiments and SEC analysis and compared to
Martin Leeb et al.
Current protocols in mouse biology, 5(2), 155-185 (2015-06-13)
Haploid genetics has facilitated new insights into mammalian pathways and disease mechanisms. Most animal cells are diploid, and mammalian haploid cell cultures have remained elusive for a long time. Recent methodological progress has enabled the routine derivation of haploid stem
Luciana Azôr Dib et al.
Reproductive sciences (Thousand Oaks, Calif.), 21(8), 984-992 (2014-01-17)
Considering the scarcity of literature data about the predictive capacity of polarization microscopy (PM) in identifying meiotic normality in human in vivo-matured oocytes, the main objective of the present study was to determine whether qualitative analysis of the spindle through
Ang Li et al.
International journal of molecular sciences, 22(14) (2021-07-25)
Mitoflashes are spontaneous transients of the biosensor mt-cpYFP. In cardiomyocytes, mitoflashes are associated with the cyclophilin D (CypD) mediated opening of mitochondrial permeability transition pore (mPTP), while in skeletal muscle they are considered hallmarks of mitochondrial respiration burst under physiological
M Ruiz-Estevez et al.
Stem cell research & therapy, 12(1), 292-292 (2021-05-21)
There are over 17,000 patients in the US waiting to receive liver transplants, and these numbers are increasing dramatically. Significant effort is being made to obtain functional hepatocytes and liver tissue that can for therapeutic use in patients. Blastocyst complementation
Michele G Da Broi et al.
Molecular reproduction and development, 85(2), 128-136 (2017-12-17)
Early endometriosis is associated with infertility, and oxidative stress may play a role in the pathogenesis of disease-related infertility. This prospective case-control study aimed to compare the presence of oxidative stress markers in the follicular microenvironment and systemic circulation of
Federico Ferreres et al.
Marine drugs, 10(12), 2766-2781 (2012-12-12)
Purified phlorotannin extracts from four brown seaweeds (Cystoseira nodicaulis (Withering) M. Roberts, Cystoseira tamariscifolia (Hudson) Papenfuss, Cystoseira usneoides (Linnaeus) M. Roberts and Fucus spiralis Linnaeus), were characterized by HPLC-DAD-ESI-MSn. Fucophloroethol, fucodiphloroethol, fucotriphloroethol, 7-phloroeckol, phlorofucofuroeckol and bieckol/dieckol were identified. The antioxidant
Sofía Masuelli et al.
International journal of molecular sciences, 24(13) (2023-07-14)
Breast cancer is a complex and heterogeneous disease that displays diverse molecular subtypes and clinical outcomes. Although it is known that the location of tumors can affect their biological behavior, the underlying mechanisms are not fully understood. In our previous
Meagan R Rollins et al.
Nature communications, 14(1), 528-528 (2023-02-02)
T cell receptor (TCR) transgenic mice represent an invaluable tool to study antigen-specific immune responses. In the pre-existing models, a monoclonal TCR is driven by a non-physiologic promoter and randomly integrated into the genome. Here, we create a highly efficient
Hiwa Karimi et al.
Reproductive toxicology (Elmsford, N.Y.), 69, 196-203 (2017-03-13)
A study using a mouse IVF model was conducted to examine the hypothesis that in vitro fertilization (IVF) treatment may lead to immune system alteration in the offspring. Phagocytic activity and lymphocyte proliferative responses to mitogen, alloantigen, and purified protein
Yanjiao Shao et al.
Nature protocols, 9(10), 2493-2512 (2014-09-26)
Conventional embryonic stem cell (ESC)-based gene targeting, zinc-finger nuclease (ZFN) and transcription activator-like effector nuclease (TALEN) technologies are powerful strategies for the generation of genetically modified animals. Recently, the CRISPR/Cas system has emerged as an efficient and convenient alternative to
Rong-xin Zhang et al.
Tumori, 99(1), 108-112 (2013-04-04)
In a previous study, we found a hyaluronidase 3 (HYAL3) gene mutation in exon 2 at position 188 by genome sequencing in a lung squamous cell carcinoma patient. The mutation results in substitution of serine for alanine. The aim of
Runhong Lei et al.
International journal of molecular sciences, 19(3) (2018-03-02)
The excellent biocompatibility and biological effects of fullerenol and its derivatives make their biomedical application promising. The potential effects of fullerenol in mammals have been extensively studied, but little is known about its effects on female reproduction. Using canonical oocyte-granulosa
Morgan Oatley et al.
Nature communications, 11(1), 586-586 (2020-01-31)
The endothelial to haematopoietic transition (EHT) is the process whereby haemogenic endothelium differentiates into haematopoietic stem and progenitor cells (HSPCs). The intermediary steps of this process are unclear, in particular the identity of endothelial cells that give rise to HSPCs
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