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Steve Arns et al.
Bioorganic & medicinal chemistry, 20(6), 2131-2140 (2012-02-22)
There is an important medical need for effective therapies to redress the general bone loss associated with advanced osteoporosis. Prostaglandin E(2) and related EP4 receptor agonists have been shown to stimulate bone regrowth but their use has been limited by
G Alfredsson et al.
Psychopharmacology, 99(3), 322-327 (1989-01-01)
Twenty-four acutely ill schizophrenic patients (DSM-III-R), 18-42 years old, were treated for 6 weeks with sulpiride. Sulpiride was administered in three different daily dosages (starting with 400, 800 or 1200 mg) according to a double blind randomized administration schedule. The
Richard S Givens et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 11(3), 472-488 (2012-02-22)
Most applications of photoremovable protecting groups have used o-nitrobenzyl compounds and their (often commercially available) derivatives that, however, have several disadvantages. The focus of this review is on applications of the more recently developed title compounds, which are especially well
F Guneral et al.
Clinical chemistry, 40(6), 862-866 (1994-06-01)
Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days to 16 years, subdivided into five age groups. We quantified 69
Shubha Murthy et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(8), 3527-3536 (2015-05-09)
Alternative activation of alveolar macrophages is linked to fibrosis following exposure to asbestos. The scavenger receptor, macrophage receptor with collagenous structure (MARCO), provides innate immune defense against inhaled particles and pathogens; however, a receptor for asbestos has not been identified.
Kamalesh Pal et al.
Spine, 30(3), E68-E72 (2005-02-01)
The present study was carried out to assess the metabolic differences between cerebrospinal fluid samples of patients with spina bifida and age-matched control individuals. To study the metabolite profile of cerebrospinal fluid of patients with spina bifida using proton magnetic
Lihui Fu et al.
Analytical biochemistry, 421(1), 198-202 (2011-11-15)
G-quadruplex ligands can interfere with the telomere structure, telomere elongation/replication, and proliferation of cancer cells. A key element in the development of potent G-quadruplex ligands is the screening of large chemical libraries of potential candidates. Here, we describe a simple
Umeo Takahama et al.
FEBS letters, 518(1-3), 116-118 (2002-05-09)
Human saliva contained 4-hydroxyphenylacetic acid (HPA) (2-10 microM) and nitrite (60-300 microM). HPA was nitrated to 4-hydroxy-3-nitrophenylacetic acid (NO2HPA) when HPA and sodium nitrite were mixed at pH 1.0. NO2HPA was also formed when saliva was incubated under acidic conditions.
Shu-yan Niu et al.
Biosensors & bioelectronics, 24(9), 2943-2946 (2009-03-25)
A novel DNA biosensor based on enzyme-enhanced fluorescence detection on etched optical fibers was developed. The hybridization complex of DNA probe and biotinylated target was formed on the etched optical fiber, and was then bound with streptavidin labeled horseradish peroxidase
Isla M Twigg et al.
Oecologia, 193(3), 583-591 (2020-06-20)
Benthic primary producers in coastal ecosystems provide important habitat for marine organisms through the provision of complex 3D habitat. Primary producers produce organic matter, while simultaneously producing reactive oxygen species, including hydrogen peroxide (H2O2), a driver of oxidative stress. Through
Wolfram Gronwald et al.
Kidney international, 79(11), 1244-1253 (2011-03-11)
Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of kidney failure; however, urinary biomarkers for the disease are lacking. In a step towards identifying such markers, we used multidimensional-multinuclear nuclear magnetic resonance (NMR) spectroscopy with support vector machine-based
Rohan A Davis et al.
Journal of medicinal chemistry, 54(6), 1682-1692 (2011-02-22)
In order to discover novel probes that may help in the investigation and control of infectious diseases through a new mechanism of action, we have evaluated a library of phenol-based natural products (NPs) for enzyme inhibition against four recently characterized
Catalina Carrasco-Pozo et al.
Antioxidants (Basel, Switzerland), 9(11) (2020-11-15)
Meat consumption plays a critical role in the development of several types of cancer. Hemin, a metabolite of myoglobin produced after meat intake, has been demonstrated to be involved in the cancer initiation phase. Macrophages are key components of the
Nantidaporn Ruangchan et al.
The Journal of biological chemistry, 286(1), 223-233 (2010-10-30)
p-Hydroxyphenylacetate (HPA) 3-hydroxylase (HPAH) catalyzes the hydroxylation of HPA at the ortho-position to yield 3,4-dihydroxyphenylacetate. The enzyme is a flavin-dependent two-component monooxygenase that consists of a reductase component and an oxygenase component (C(2)). C(2) catalyzes the hydroxylation of HPA using
G M Tyce et al.
Clinical pharmacology and therapeutics, 34(3), 390-398 (1983-09-01)
Two patients in hepatic coma were treated with L-dopa. The first patient showed clear clinical improvement, but the second patient did not. Analyses of urinary metabolites indicated that L-dopa was not absorbed by the second patient. There was evidence that
Olivier Boulat et al.
Clinical chemistry and laboratory medicine, 41(12), 1642-1658 (2004-01-08)
Organic acid analysis is used for the early detection/ exclusion and for the follow-up of inherited disorders of amino acid and organic acid metabolism. Urinary organic acid concentrations in 417 healthy Caucasian children (1 day to 17 years of age)
Matthew Snelson et al.
Science advances, 7(14) (2021-04-02)
Intake of processed foods has increased markedly over the past decades, coinciding with increased microvascular diseases such as chronic kidney disease (CKD) and diabetes. Here, we show in rodent models that long-term consumption of a processed diet drives intestinal barrier
Jose Luis Muñoz-Muñoz et al.
Acta biochimica Polonica, 58(3), 303-311 (2011-09-03)
Tyrosinase shows kinetic cooperativity in its action on o-diphenols, but not when it acts on monophenols, confirming that the slow step is the hydroxylation of monophenols to o-diphenols. This model can be generalised to a wide range of substrates; for
Sébastien Brier et al.
Biochemistry, 51(34), 6738-6752 (2012-07-28)
Neisserial adhesin A (NadA) is a surface exposed trimeric protein present in most hypervirulent meningococcal strains and involved in epithelial cell adhesion and colonization. The expression of nadA is controlled by Neisserial adhesin regulator (NadR), a member of the MarR
Luca Fagnocchi et al.
Journal of bacteriology, 194(2), 460-474 (2011-11-15)
The Neisseria meningitidis regulator NadR was shown to repress expression of the NadA adhesin and play a major role in NadA phase-variable expression. In this study, we identified through microarray analysis over 30 genes coregulated with nadA in the NadR
Umeo Takahama et al.
European journal of oral sciences, 117(5), 555-562 (2009-09-18)
4-Hydroxyphenylacetic acid (HPA) and nitrite are present in human mixed whole saliva, and HPA can be nitrated by peroxidase/hydrogen peroxide (H(2)O(2))/nitrite systems in the oral cavity. Thus, the objectives of the present study were to estimate the concentrations of HPA
Ferdinand A van Dorsten et al.
Molecular nutrition & food research, 54(7), 897-908 (2009-12-17)
The metabolic impact of polyphenol-rich red wine and grape juice consumption in humans was studied using a metabolomics approach. Fifty-eight men and women participated in a placebo-controlled, double-crossover study in which they consumed during a period of 4 wk, either
I Raw et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 17(3-4), 271-279 (1984-01-01)
The congenital pain insensitivity syndrome is accompanied by: a) the presence of a yellow-brown pigment in the basal layer of the epidermis with the histochemical properties of melanin, b) decrease of urinary and blood concentration of dopamine and norepinephrine, c)
Feelly Ruether et al.
Journal of pharmaceutical sciences, 98(11), 4205-4215 (2009-03-14)
The knowledge of the solubility of pharmaceuticals in pure solvents and solvent mixtures is crucial for designing the crystallization process of drug substances. The first step in finding optimal crystallization conditions is usually a solvent screening. Since experiments are very
Daniele Del Rio et al.
Nutrition (Burbank, Los Angeles County, Calif.), 26(11-12), 1110-1116 (2010-01-19)
The aim of this study was to investigate green tea flavan-3-ol catabolism and plasma pharmacokinetic and urinary excretion by high-performance liquid chromatography with tandem mass spectrometry to evaluate their absolute bioavailability by taking into account all known and some unknown
Low CSF GABA concentration in children with febrile convulsions, untreated epilepsy, and meningitis.
D Rating et al.
Journal of neurology, 230(4), 217-225 (1983-01-01)
In 14 children with epilepsy, 51 with febrile convulsions and 22 with meningitis gamma-aminobutyric acid (GABA) concentrations in lumbar CSF were determined. While the mean for CSF GABA concentrations for all epileptic children was unchanged [144 (range: 73-285) pmol/ml; controls:
Characterization of negative tone photoresist based on acid catalyzed dehydration crosslinking of novolac resins having pendant carboxyl groups
Liu HH, et al.
Journal of Polymer Research, 9, 251-256 (2002)
Journal of the Chemical Society. Perkin Transactions 1, 3005-3005 (1991)
Mark G Jones et al.
Clinica chimica acta; international journal of clinical chemistry, 361(1-2), 150-158 (2005-07-05)
Previous work by others have suggested the occurrence of one or more chemical or metabolic 'markers' for ME/CFS including specific amino acids and organic acids and a number of unidentified compounds (CFSUM1, CFSUM2). We have shown elsewhere that CFSUM1 is
F A Muskiet et al.
Clinical chemistry, 25(7), 1281-1284 (1979-07-01)
We report quantitative data on beta-glucuronidase- and sulfatase-hydrolyzable conjugates of homovanillic acid, 3,4-dihydroxyphenylacetic acid, p-hydroxyphenylacetic acid, and vanillic acid in the urine of 20 apparently normal and healthy control persons and of three patients with neuroblastoma. We used organic solvent
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