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Larisa Pereboeva et al.
Cancer immunology, immunotherapy : CII, 64(5), 551-562 (2015-02-14)
The standard treatment of high-grade glioma presents a combination of radiotherapy, chemotherapy and surgery. Immunotherapy is proposed as a potential adjunct to standard cytotoxic regimens to target remaining microscopic disease following resection. We have shown ex vivo expanded/activated γδ T
Association of- 330 interleukin-2 gene polymorphism with oral cancer
Singh PK, et al.
The Indian Journal of Medical Research, 146(6), 730-730 (2017)
Shihong Zhang et al.
Journal of virology, 89(16), 8304-8317 (2015-06-05)
T cell responses play a critical role in controlling or clearing viruses. Therefore, strategies to prevent or treat infections include boosting T cell responses. T cells specific for various pathogens have been reported in unexposed individuals and an influence of
Association of Interleukin-2-330T/G and Interleukin-10-1082A/G Genetic Polymorphisms with B-Cell Non-Hodgkin Lymphoma in a Cohort of Egyptians
Rahman HAA, et al.
Turkish journal of haematology : official journal of Turkish Society of Haematology, 35(2), 99-99 (2018)
Mariana Borsa et al.
Virology journal, 12, 77-77 (2015-05-16)
The unfolded protein response (UPR) is one of the pathways triggered to ensure quality control of the proteins assembled in the endoplasmic reticulum (ER) when cell homeostasis is compromised. This mechanism is primarily composed of three transmembrane proteins serving as
Michael L Freeman et al.
Journal of virology, 88(14), 7862-7869 (2014-05-03)
CD8 and CD4 T cells are each critically important for immune control of murine gammaherpesvirus 68 (γHV68) infection. In immunocompetent mice, acute γHV68 infection results in lifelong latency, but in the absence of CD4 T cell help, mice succumb to
N-glycan engineering of a plant-produced anti-CD20-hIL-2 immunocytokine significantly enhances its effector functions
Marusic C, et al,
Biotechnology and Bioengineering, 115(3), 565-576 (2018)
J Pega et al.
Journal of virology, 89(18), 9581-9590 (2015-07-15)
Foot-and-mouth disease (FMD) is a highly contagious viral disease affecting biungulate species. Commercial vaccines, formulated with inactivated FMD virus (FMDV), are regularly used worldwide to control the disease. Here, we studied the generation of antibody responses in local lymphoid tissues
Cecilie Brekke Rygh et al.
PloS one, 9(9), e108414-e108414 (2014-10-01)
There are currently no established radiological parameters that predict response to immunotherapy. We hypothesised that multiparametric, longitudinal magnetic resonance imaging (MRI) of physiological parameters and pharmacokinetic models might detect early biological responses to immunotherapy for glioblastoma targeting NG2/CSPG4 with mAb9.2.27
Ping Niu et al.
Oncotarget, 6(20), 17938-17957 (2015-08-11)
Inflammation is a double-edged sword with both detrimental and beneficial consequences. Understanding of the mechanisms of crosstalk between the inflammatory milieu and human adult mesenchymal stem cells is an important basis for clinical efforts. Here, we investigate changes in the
M Taniguchi et al.
Cell death & disease, 6, e1717-e1717 (2015-04-10)
We previously reported that IL-2 deprivation induced acid sphingomyelinase-mediated (ASM-mediated) ceramide elevation and apoptosis in an NK/T lymphoma cell line KHYG-1. However, the molecular mechanism of ASM-ceramide-mediated apoptosis during IL-2 deprivation is poorly understood. Here, we showed that IL-2 deprivation
Alan D Guerrero et al.
Immunology, 143(4), 640-650 (2014-06-24)
We have previously shown that interleukin-2 (IL-2) inhibits dendritic cell (DC) development from mouse bone marrow (BM) precursors stimulated with the ligand for FMS-like tyrosine kinase 3 receptor (Flt3L), and have provided evidence that this inhibition occurs at the monocyte
Interleukin 2, 37-37 (2012)
Rosa Molfetta et al.
European journal of immunology, 44(9), 2761-2770 (2014-05-23)
The NKG2D activating receptor on human NK cells mediates "altered self" recognition, as its ligands (NKG2DLs) are upregulated on target cells in a variety of stress conditions. Evidence collected in the past years shows that, even though expression of NKG2DLs
Daniela Fenoglio et al.
Human vaccines & immunotherapeutics, 11(4), 838-850 (2015-02-26)
Peptide540-548, peptide611-626, peptide672-686 and peptide766-780, which are derived from human telomerase, constitute the immunogenic component of the GX301 cancer vaccine. The relative immunogenicity of these peptides is unknown, thus it is unsure whether their combined use offers real advantages over
Julia Roider et al.
Immunology, 143(2), 193-201 (2014-04-15)
Methods for identifying physiologically relevant CD8 T-cell epitopes are critically important not only for the development of T-cell-based vaccines but also for understanding host-pathogen interactions. As experimentally mapping an optimal CD8 T-cell epitope is a tedious procedure, many bioinformatic tools
Riki Okita et al.
Oncology reports, 34(6), 2864-2870 (2015-10-28)
EGFR/HER2 are frequently expressed in MPM tissues, however, no studies have shown the clinical benefit of using EGFR/HER2-targeting drugs in patients with malignant pleural mesothelioma (MPM). It was reported that the tyrosine kinase inhibitor (TKI) lapatinib enhanced trastuzumab-mediated antibody-dependent cellular
Steven D Scoville et al.
Scientific reports, 5, 12490-12490 (2015-08-01)
We have developed a rapid negative selection method to enrich rare mononuclear cells from human tissues. Unwanted and antibody-tethered cells are selectively depleted during a Ficoll separation step, and there is no need for magnetic-based reagents and equipment. The new
Sandra A Jacobs et al.
Cell transplantation, 23(9), 1099-1110 (2013-04-09)
Human multipotent adult progenitor cells (hMAPCs) are isolated from bone marrow with a more extensive expansion capacity compared to human mesenchymal stem cells (hMSCs) and with the ability to differentiate into endothelium. Like hMSCs, hMAPCs inhibit T-cell proliferation induced by
Sol A Ban et al.
Journal of clinical immunology, 34(8), 941-953 (2014-09-11)
Idiopathic CD4 lymphopenia constitutes a heterogeneous group of immunodeficiencies with characteristically low CD4+ T-cell counts with largely unknown genetic etiology. We here sought to determine the underlying molecular cause in an index family with two patients suffering from combined immunodeficiency
Carla Marusic et al.
Plant biotechnology journal, 14(1), 240-251 (2015-04-17)
Anti-CD20 murine or chimeric antibodies (Abs) have been used to treat non-Hodgkin lymphomas (NHLs) and other diseases characterized by overactive or dysfunctional B cells. Anti-CD20 Abs demonstrated to be effective in inducing regression of B-cell lymphomas, although in many cases
Ambra Sarracino et al.
mBio, 9(6) (2018-11-15)
Posttranscriptional regulation of HIV-1 replication is finely controlled by viral and host factors. Among the former, Rev controls the export of partially spliced and unspliced viral RNAs from the nucleus and their translation in the cytoplasm or incorporation into new
Elisabetta Volpe et al.
The Journal of allergy and clinical immunology, 134(2), 373-381 (2014-06-10)
Thymic stromal lymphopoietin (TSLP) is a major proallergic cytokine that promotes TH2 responses through dendritic cell (DC) activation. Whether it also plays a role in human autoimmune inflammation and associated pathways is not known. In this study we investigated the
Daniela Wojta-Stremayr et al.
PloS one, 10(5), e0126034-e0126034 (2015-05-07)
A variety of adjuvants fostering humoral immunity are known as of today. However, there is a lack of adjuvants or adjuvant strategies, which directly target T cellular effector functions and memory. We here determined whether systemically toxic cytokines such as
Diana Seidel et al.
Cancer immunology, immunotherapy : CII, 64(5), 621-634 (2015-02-26)
The disialoganglioside GD2 is a well-established target antigen for passive immunotherapy in neuroblastoma (NB). Despite the recent success of passive immunotherapy with the anti-GD2 antibody ch14.18 and cytokines, treatment of high-risk NB remains challenging. We expanded the approach of GD2-specific
Peter D Kurktschiev et al.
The Journal of experimental medicine, 211(10), 2047-2059 (2014-09-17)
The transcription factor T-bet regulates the production of interferon-γ and cytotoxic molecules in effector CD8 T cells, and its expression correlates with improved control of chronic viral infections. However, the role of T-bet in infections with differential outcome remains poorly
Katharina Kreymborg et al.
Cancer immunology research, 3(8), 849-854 (2015-07-01)
The costimulatory molecules B7-H3 and B7-H4 are overexpressed in a variety of human tumors and have been hypothesized as possible biomarkers and immunotherapeutic targets. Despite this potential, the predominating uncertainty about their functional implication in tumor-host interaction hampers their evaluation
Sandra García-Gallego et al.
European journal of medicinal chemistry, 98, 139-148 (2015-05-26)
The development of novel strategies to prevent HIV-1 infection is of outstanding relevance. Metal complexes of Cu(2+), Ni(2+), Co(2+) and Zn(2+) derived from sulfonated and carboxylated poly(propylene imine) dendrimers with ethylenediamine core were evaluated as tunable antiviral agents against HIV-1.
Yan Shen et al.
Annals of hematology, 93(12), 2019-2028 (2014-07-18)
Cytokine-induced killer (CIK) cells, one of the feasible and effective methods of adoptive immunotherapy, have shown anti-leukemia activity in vivo and in vitro. But the strategy exhibits limited cytotoxic activity in clinical studies. In this study, CIK cells were transfected
Masateru Hiyoshi et al.
Retrovirology, 12, 73-73 (2015-08-21)
Adult T-cell leukemia (ATL) is caused by human T-cell leukemia virus type 1 (HTLV-1) infection. However, there are no therapies to prevent ATL development in high-risk asymptomatic carriers. To develop a therapy targeting HTLV-1-infected cells that are known to express
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