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Marta Siernicka et al.
Immunology, 146(1), 173-183 (2015-06-23)
Natural killer (NK) cells are considered critical components of the innate and adaptive immune responses. Deficiencies in NK cell activity are common, such as those that occur in cancer patients, and they can be responsible for dysfunctional immune surveillance. Persistent
Jason M God et al.
Immunology, 142(3), 492-505 (2014-03-19)
While Burkitt lymphoma (BL) has a well-known defect in HLA class I-mediated antigen presentation, the exact role of BL-associated HLA class II in generating a poor CD4(+) T-cell response remains unresolved. Here, we found that BL cells are deficient in
Erik Ames et al.
Oncoimmunology, 4(9), e1036212-e1036212 (2015-09-26)
Natural killer (NK) cells are innate lymphocytes postulated to mediate resistance against primary haematopoietic but not solid tumor malignancies. Cancer stem cells (CSCs) are a small subset of malignant cells with stem-like properties which are resistant to chemo- and radiotherapies
Larisa Kizima et al.
PloS one, 9(4), e94547-e94547 (2014-04-18)
Prevalent infection with human herpes simplex 2 (HSV-2) or human papillomavirus (HPV) is associated with increased human immunodeficiency virus (HIV) acquisition. Microbicides that target HIV as well as these sexually transmitted infections (STIs) may more effectively limit HIV incidence. Previously
Ling Wu et al.
Journal of immunology (Baltimore, Md. : 1950), 193(4), 1590-1599 (2014-07-16)
IL-17 is a proinflammatory cytokine implicated in the pathogenesis of autoimmune diseases including psoriasis. ACT1 is an essential adaptor molecule in the IL-17 signaling pathway. A missense single nucleotide polymorphism (rs33980500; SNP-D10N) that resulted in the substitution of an asparagine
Kyung-Rok Yu et al.
PloS one, 9(8), e102426-e102426 (2014-08-05)
Because human mesenchymal stem cells (hMSC) have profound immunomodulatory effects, many attempts have been made to use hMSCs in preclinical and clinical trials. For hMSCs to be used in therapy, a large population of hMSCs must be generated by in
Francesca Pretto et al.
Cancer immunology, immunotherapy : CII, 63(9), 901-910 (2014-06-05)
Antibody-cytokine fusion proteins ("immunocytokines") represent a promising class of armed antibody products, which allow the selective delivery of potent pro-inflammatory payloads at the tumor site. The antibody-based selective delivery of interleukin-2 (IL2) is particularly attractive for the treatment of metastatic
Roberta Martinelli et al.
Journal of cell science, 127(Pt 17), 3720-3734 (2014-07-09)
Immune cell trafficking requires the frequent breaching of the endothelial barrier either directly through individual cells ('transcellular' route) or through the inter-endothelial junctions ('paracellular' route). What determines the loci or route of breaching events is an open question with important
Functional incompatibility between the generic NF-? motif and a subtype-specific Sp1III element drives the formation of HIV-1 subtype C viral promoter
Verma A, et al.
Journal of Virology, JVI-00308 (2016)
Anthony Meager et al.
Expert review of clinical immunology, 10(8), 1029-1047 (2014-06-06)
Cytokines regulate many aspects of cell growth and differentiation and play pivotal roles in the orchestration of immune defence against invading pathogens. Though 'self' proteins, they are potentially immunogenic and can give rise to anti-cytokine autoantibodies (aCA). The main foci
Joseph Y Kim et al.
PloS one, 10(8), e0136235-e0136235 (2015-08-20)
Immune prophylaxis and treatment of transplanted tissue rejection act indiscriminately, risking serious infections and malignancies. Although animal data suggest that cellular immune responses causing rejection may be rather narrow and predictable based on genetic background, there are only limited data
Min Ruan et al.
International journal of oncology, 44(6), 2103-2110 (2014-03-29)
Increasing evidence suggests that communication between tumor and immune cells can alter the tumor microenvironment in ways that promote tumor development. The purpose of this study was to characterize the immune response elicited by TLR-9-activated OSCC cells, to identify the
Kristin Lampe et al.
European journal of immunology, 45(7), 2072-2083 (2015-05-02)
Absence of MHC class I expression is an important mechanism by which NK cells recognize a variety of target cells, yet the pathways underlying "missing-self" recognition, including the involvement of activating receptors, remain poorly understood. Using ethyl-N-nitrosourea mutagenesis in mice
Qing Tong et al.
Journal of immunology (Baltimore, Md. : 1950), 192(11), 5012-5022 (2014-04-25)
Acquired aplastic anemia (AA) is a potentially fatal bone marrow (BM) failure syndrome. IFN-γ-producing Th1 CD4(+) T cells mediate the immune destruction of hematopoietic cells, and they are central to the pathogenesis. However, the molecular events that control the development
Lindsey Chudley et al.
Cancer immunology, immunotherapy : CII, 63(11), 1199-1211 (2014-08-20)
Ex vivo ELISPOT and multimer staining are well-established tests for the assessment of antigen-specific T cells. Many laboratories are now using a period of in vitro stimulation (IVS) to enhance detection. Here, we report the findings of a multi-centre panel
Jan Leipe et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(5), 1165-1175 (2014-05-02)
The minor allele of the IL4R gene single-nucleotide polymorphism, rs1805010, confers impaired interleukin-4 (IL-4) signaling and has been associated with an aggressive destructive course of rheumatoid arthritis (RA). IL-4 inhibits the development of Th17 cells, a cell population recently identified
Jenny W Che et al.
Virology, 482, 89-97 (2015-04-04)
Heterologous immunity refers to the phenomenon whereby a history of an immune response against one pathogen can provide a level of immunity to a second unrelated pathogen. Previous investigations have shown that heterologous immunity is not necessarily reciprocal, such as
Hiroyuki Otsuki et al.
Virology, 460-461, 1-10 (2014-07-11)
Several derivatives of human immunodeficiency virus type 1 (HIV-1) that evade macaque restriction factors and establish infection in pig-tailed macaques (PtMs) have been described. These monkey-tropic HIV-1s utilize CXCR4 as a co-receptor that differs from CCR5 used by most currently
David Bending et al.
Journal of immunology (Baltimore, Md. : 1950), 193(6), 2699-2708 (2014-08-06)
The maintenance of FOXP3 expression in CD25(hi) regulatory T cells (Tregs) is crucial to the control of inflammation and essential for successful Treg transfer therapies. Coexpression of CD25 and FOXP3 in combination with a hypomethylated region within the FOXP3 gene
T Fujiyama et al.
Clinical and experimental immunology, 177(1), 110-120 (2014-03-04)
Dermatomyositis (DM) and polymyositis (PM) are collectively termed autoimmune myopathy. To investigate the difference between muscle- and skin-infiltrating T cells and to address their role for myopathy, we characterized T cells that were directly expanded from the tissues. Enrolled into
A Bai et al.
Cell death & disease, 6, e1828-e1828 (2015-07-24)
Acid sphingomyelinase (ASM), a lipid hydrolase enzyme, has the potential to modulate various cellular activation responses via the generation of ceramide and by interaction with cellular receptors. We have hypothesized that ASM modulates CD4(+) T-cell receptor activation and impacts immune
Nicolle H R Litjens et al.
Journal of immunology (Baltimore, Md. : 1950), 194(11), 5282-5293 (2015-04-29)
Expansion of Ag-specific naturally occurring regulatory T cells (nTregs) is required to obtain sufficient numbers of cells for cellular immunotherapy. In this study, different allogeneic stimuli were studied for their capacity to generate functional alloantigen-specific nTregs. A highly enriched nTreg
Carole Sanchez et al.
Human immunology, 76(9), 644-650 (2015-09-27)
Natural killer cells (NK) are pivotal cells of innate immunity. They are potent antileukemic cytotoxic effectors. A defect in their cytotoxicity has been described in some hematopoietic malignancies such as acute myeloid leukemia, multiple myeloma and myelodysplastic syndromes. This defect
Sasmita Mishra et al.
Vaccine, 32(26), 3285-3292 (2014-04-12)
Hepatitis C virus (HCV) is a major cause of liver disease. Spontaneous resolution of infection is associated with broad, MHC class I- (CD8(+)) and class II-restricted (CD4(+)) T cell responses to multiple viral epitopes. Only 20% of patients clear infection
O Traitanon et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 14(6), 1277-1289 (2014-05-21)
The presence of CD28(-) memory CD8 T cells in the peripheral blood of renal transplant patients is a risk factor for graft rejection and resistance to CTLA-4Ig induction therapy. In vitro analyses have indicated poor alloantigen-induced CD28(-) memory CD8 T
Isaak Quast et al.
The Journal of clinical investigation, 125(11), 4160-4170 (2015-10-06)
IgG molecules exert both pro- and antiinflammatory effector functions based on the composition of the fragment crystallizable (Fc) domain glycan. Sialylated IgG Fc domains have antiinflammatory properties that are attributed to their ability to increase the activation threshold of innate
Hayato Hosoi et al.
European journal of immunology, 44(6), 1747-1758 (2014-04-12)
T cells express multiple integrin molecules. The significance of signaling through these molecules on acquisition of T-cell effector functions and memory formation capacity remains largely unknown. Moreover, the impact of stimulation through these signals on the generation of T cells
Dhifaf Sarhan et al.
European journal of immunology, 45(6), 1783-1793 (2015-03-17)
Dendritic cell (DC) vaccines induce T-cell responses in cancer patients. However, there is a paucity of data regarding the role of DC vaccines in shaping natural killer (NK) cell responses. Here, we observe that NK cells are less activated following
Kim C M Santegoets et al.
PloS one, 9(10), e110966-e110966 (2014-10-24)
In rheumatoid arthritis (RA) macrophages play a major role in amplifying synovial inflammation. Important activating signals are those induced by Toll-like receptor (TLR) ligands and by activated T cells. The balance between activating and inhibitory Fc gamma receptors (FcγRs) on
Janine Jahn et al.
Obesity (Silver Spring, Md.), 23(11), 2233-2241 (2015-09-24)
Natural killer (NK) cells are the first defense against malignant cells, and their functions are severely impaired in individuals with obesity. However, it is not known whether functions can be re-activated after weight loss. The alterations of NK cell functions
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