H9377

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Bidirectional communication between oocytes and ovarian follicular somatic cells is required for meiotic arrest of mammalian oocytes.

Karen Wigglesworth et al.

Proceedings of the National Academy of Sciences of the United States of America, 110(39), E3723-E3729 (2013-08-28)

Coordinated regulation of oocyte and ovarian follicular development is essential for fertility. In particular, the progression of meiosis, a germ cell-specific cell division that reduces the number of chromosomes from diploid to haploid, must be arrested until just before ovulation.

Global Metabolomic Identification of Long-Term Dose-Dependent Urinary Biomarkers in Nonhuman Primates Exposed to Ionizing Radiation.

Evan L Pannkuk et al.

Radiation research, 184(2), 121-133 (2015-08-01)

Due to concerns surrounding potential large-scale radiological events, there is a need to determine robust radiation signatures for the rapid identification of exposed individuals, which can then be used to guide the development of compact field deployable instruments to assess

Monitoring PfMDR1 transport in Plasmodium falciparum.

Sarah J Reiling et al.

Malaria journal, 14, 270-270 (2015-07-15)

The Plasmodium falciparum multidrug resistance 1 transporter, PfMDR1, contains five amino acid polymorphisms that are suggested to be involved in altered drug transport from the parasite's cytosol into the digestive vacuole (DV). Transport of a substrate into another intracellular compartment

Reduced parasite motility and micronemal protein secretion by a p38 MAPK inhibitor leads to a severe impairment of cell invasion by the apicomplexan parasite Eimeria tenella.

Françoise I Bussière et al.

PloS one, 10(2), e0116509-e0116509 (2015-02-18)

E. tenella infection is associated with a severe intestinal disease leading to high economic losses in poultry industry. Mitogen activated protein kinases (MAPKs) are implicated in early response to infection and are divided in three pathways: p38, extracellular signal-regulated protein

Validation of endogenous control reference genes for normalizing gene expression studies in endometrial carcinoma.

Thangesweran Ayakannu et al.

Molecular human reproduction, 21(9), 723-735 (2015-07-01)

Real-time quantitative RT-PCR (qRT-PCR) is a powerful technique used for the relative quantification of target genes, using reference (housekeeping) genes for normalization to ensure the generation of accurate and robust data. A systematic examination of the suitability of endogenous reference

Dereplication of known nucleobase and nucleoside compounds in natural product extracts by capillary electrophoresis-high resolution mass spectrometry.

Junhui Chen et al.

Molecules (Basel, Switzerland), 20(4), 5423-5437 (2015-03-31)

Nucleobase and nucleoside compounds exist widely in various organisms. An often occurring problem in the discovery of new bioactive compounds from natural products is reisolation of known nucleobase and nucleoside compounds. To resolve this problem, a capillary electrophoresis-high resolution mass

Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds.

Diana Ortiz et al.

PloS one, 10(4), e0123598-e0123598 (2015-04-22)

Development of resistance against current antimalarial drugs necessitates the search for novel drugs that interact with different targets and have distinct mechanisms of action. Malaria parasites depend upon high levels of glucose uptake followed by inefficient metabolic utilization via the

Effects of Two Different Rhodiola rosea Extracts on Primary Human Visceral Adipocytes.

Elena Pomari et al.

Molecules (Basel, Switzerland), 20(5), 8409-8428 (2015-05-15)

Rhodiola rosea (Rro) has been reported to have various pharmacological properties, including anti-fatigue, anti-stress and anti-inflammatory activity. It is also known to improve glucose and lipid metabolism, but the effects of Rhodiola rosea on adipocyte differentiation and metabolism are not

Imaging-based high-throughput screening assay to identify new molecules with transmission-blocking potential against Plasmodium falciparum female gamete formation.

Celia Miguel-Blanco et al.

Antimicrobial agents and chemotherapy, 59(6), 3298-3305 (2015-03-25)

In response to a call for the global eradication of malaria, drug discovery has recently been extended to identify compounds that prevent the onward transmission of the parasite, which is mediated by Plasmodium falciparum stage V gametocytes. Lately, metabolic activity

Epigenetic regulation of uterine biology by transcription factor KLF11 via posttranslational histone deacetylation of cytochrome p450 metabolic enzymes.

Ye Zheng et al.

Endocrinology, 155(11), 4507-4520 (2014-07-31)

Endocrine regulation of uterine biology is critical for embryo receptivity and human reproduction. Uterine endometrium depends on extrinsic sex steroid input and hence likely has mechanisms that enable adaptation to hormonal variation. Emerging evidence suggests that sex steroid bioavailability in

Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance.

Michael Murphy et al.

The Journal of biological chemistry, 290(31), 19218-19232 (2015-06-18)

Endotoxin tolerance reprograms Toll-like receptor (TLR) 4-mediated macrophage responses by attenuating induction of proinflammatory cytokines while retaining expression of anti-inflammatory and antimicrobial mediators. We previously demonstrated deficient TLR4-induced activation of IL-1 receptor-associated kinase (IRAK) 4, IRAK1, and TANK-binding kinase (TBK)

Exposure of neonatal rats to alcohol has differential effects on neuroinflammation and neuronal survival in the cerebellum and hippocampus.

Lauren A Topper et al.

Journal of neuroinflammation, 12, 160-160 (2015-09-05)

Fetal alcohol exposure is a leading cause of preventable birth defects, yet drinking during pregnancy remains prevalent worldwide. Studies suggest that activation of the neuroimmune system plays a role in the effects of alcohol exposure during the rodent equivalent to

Enhancing malaria diagnosis through microfluidic cell enrichment and magnetic resonance relaxometry detection.

Tian Fook Kong et al.

Scientific reports, 5, 11425-11425 (2015-06-18)

Despite significant advancements over the years, there remains an urgent need for low cost diagnostic approaches that allow for rapid, reliable and sensitive detection of malaria parasites in clinical samples. Our previous work has shown that magnetic resonance relaxometry (MRR)

DBZ regulates cortical cell positioning and neurite development by sustaining the anterograde transport of Lis1 and DISC1 through control of Ndel1 dual-phosphorylation.

Masayuki Okamoto et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(7), 2942-2958 (2015-02-24)

Cell positioning and neuronal network formation are crucial for proper brain function. Disrupted-in-Schizophrenia 1 (DISC1) is anterogradely transported to the neurite tips, together with Lis1, and functions in neurite extension via suppression of GSK3β activity. Then, transported Lis1 is retrogradely

Folic acid facilitates in vitro maturation of mouse and Xenopus laevis oocytes.

Xiaoli Huang et al.

The British journal of nutrition, 109(8), 1389-1395 (2012-08-31)

The water-soluble B vitamins, folate and folic acid, play an important role in reproductive health, but little is known about the effects of folic acid on infertility. The present study tested the hypothesis that folic acid affects oocyte maturation, a

Assessing embryo quality by combining non-invasive markers: early time-lapse parameters reflect gene expression in associated cumulus cells.

Elizabeth R Hammond et al.

Human reproduction (Oxford, England), 30(8), 1850-1860 (2015-06-05)

Are there associations between early time-lapse parameters, expression of candidate embryo viability genes in cumulus cells and embryo quality on Day 5? Early time-lapse parameters correlate to the expression levels of candidate embryo viability genes in cumulus cells but a

Fe(III) mineral reduction followed by partial dissolution and reactive oxygen species generation during 2,4,6-trinitrotoluene transformation by the aerobic yeast Yarrowia lipolytica.

Ayrat M Ziganshin et al.

AMB Express, 5, 8-8 (2015-04-09)

Understanding the factors that influence pollutant transformation in the presence of ferric (oxyhydr)oxides is crucial to the efficient application of different remediation strategies. In this study we determined the effect of goethite, hematite, magnetite and ferrihydrite on the transformation of

The neuroprotective properties of the superoxide dismutase mimetic tempol correlate with its ability to reduce pathological glutamate release in a rodent model of stroke.

Preeti Dohare et al.

Free radical biology & medicine, 77, 168-182 (2014-09-17)

The contribution of oxidative stress to ischemic brain damage is well established. Nevertheless, for unknown reasons, several clinically tested antioxidant therapies have failed to show benefits in human stroke. Based on our previous in vitro work, we hypothesized that the

Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands.

Ibtissam Talhaoui et al.

Nucleic acids research, 42(10), 6300-6313 (2014-04-03)

The human thymine-DNA glycosylase (TDG) initiates the base excision repair (BER) pathway to remove spontaneous and induced DNA base damage. It was first biochemically characterized for its ability to remove T mispaired with G in CpG context. TDG is involved

Tyrosine kinase inhibitors: New class of antimalarials on the horizon?

Vrushali Pathak et al.

Blood cells, molecules & diseases, 55(2), 119-126 (2015-07-05)

Development of the antimalarial drug resistant strains has currently become a major public health challenge. There is an urgent need to develop new antimalarial drugs. Tyrosine kinase inhibitors (TKIs) are receiving increasing attention as anticancer therapy. It has revolutionarised the

Compartment-specific modulation of GABAergic synaptic transmission by TRPV1 channels in the dentate gyrus.

Andrés E Chávez et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(50), 16621-16629 (2014-12-17)

The transient receptor potential TRPV1 or vanilloid receptor is a nonselective ligand-gated channel highly expressed in primary sensory neurons where it mediates nociception. TRPV1 is also expressed in the brain where its activation depresses excitatory synaptic transmission. Whether TRPV1 also

Post-slaughter changes in ATP metabolites, reducing and phosphorylated sugars in chicken meat.

Michel Aliani et al.

Meat science, 94(1), 55-62 (2013-02-05)

The formation of ATP breakdown products in chicken M. pectoralis major post-slaughter is reported. The concentrations of metabolites were followed in chicken breast throughout the carcass processing post-slaughter and during chilled storage. The concentration of glucose remains similar throughout the

Oxidative stress modulates nucleobase transport in microvascular endothelial cells.

Derek B J Bone et al.

Microvascular research, 95, 68-75 (2014-07-01)

Purine nucleosides and nucleobases play key roles in the physiological response to vascular ischemia/reperfusion events. The intra- and extracellular concentrations of these compounds are controlled, in part, by equilibrative nucleoside transporter subtype 1 (ENT1; SLC29A1) and by equilibrative nucleobase transporter

Killer Ig-like receptor (KIR) genotype predicts the capacity of human KIR-positive CD56dim NK cells to respond to pathogen-associated signals.

Daniel S Korbel et al.

Journal of immunology (Baltimore, Md. : 1950), 182(10), 6426-6434 (2009-05-06)

IFN-gamma emanating from NK cells is an important component of innate defense against infection. In this study, we demonstrate that, following in vitro stimulation of human peripheral blood NK cells with a variety of microbial ligands, CD56(dim) as well as

Delamanid does not inhibit or induce cytochrome p450 enzymes in vitro.

Yoshihiko Shimokawa et al.

Biological & pharmaceutical bulletin, 37(11), 1727-1735 (2014-11-05)

Delamanid is a new drug for the treatment of multidrug-resistant tuberculosis. Individuals who are co-infected with human immunodeficiency virus and Mycobacterium tuberculosis may require treatment with a number of medications that might interact significantly with the CYP enzyme system as

A New Set of Chemical Starting Points with Plasmodium falciparum Transmission-Blocking Potential for Antimalarial Drug Discovery.

Maria Jesus Almela et al.

PloS one, 10(8), e0135139-e0135139 (2015-09-01)

The discovery of new antimalarials with transmission blocking activity remains a key issue in efforts to control malaria and eventually eradicate the disease. Recently, high-throughput screening (HTS) assays have been successfully applied to Plasmodium falciparum asexual stages to screen millions

AUF1 p45 promotes West Nile virus replication by an RNA chaperone activity that supports cyclization of the viral genome.

Susann Friedrich et al.

Journal of virology, 88(19), 11586-11599 (2014-08-01)

A central aspect of current virology is to define the function of cellular proteins (host factors) that support the viral multiplication process. This study aimed at characterizing cellular proteins that assist the RNA replication process of the prevalent human pathogen

Biotinylated probes of artemisinin with labeling affinity toward Trypanosoma brucei brucei target proteins.

Benetode Konziase

Analytical biochemistry, 482, 25-31 (2015-04-29)

We studied the target proteins of artemisinin in Trypanosoma brucei brucei using the affinity-labeling method. We designed and synthesized four biotinylated probes of artemisinin for use as molecular tools. Their in vitro trypanocidal activities (data not shown) proved that they

Lipopeptides are signaled by Toll-like receptor 1, 2 and 6 in endolysosomes.

Yuji Motoi et al.

International immunology, 26(10), 563-573 (2014-05-27)

Toll-like receptors (TLRs) recognize a variety of microbial products and induce defense responses. Pathogen sensing by TLRs occurs either on the cell surface or in endolysosomes. TLR-dependent responses are greatly influenced by the site of pathogen sensing. TLR heterodimers TLR1/TLR2

Characterization of a Large Panel of Rabbit Monoclonal Antibodies against HIV-1 gp120 and Isolation of Novel Neutralizing Antibodies against the V3 Loop.

Yali Qin et al.

PloS one, 10(6), e0128823-e0128823 (2015-06-04)

We recently reported the induction of potent, cross-clade neutralizing antibodies (nAbs) against Human Immunodeficiency Virus type-1 (HIV-1) in rabbits using gp120 based on an M-group consensus sequence. To better characterize these antibodies, 93 hybridomas were generated, which represent the largest

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