HPA000980

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关键词:'HPA000980'

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Vascular Adhesion Protein-1 (VAP-1) as Predictor of Radiographic Severity in Symptomatic Knee Osteoarthritis in the New York University Cohort.

Eirini Bournazou et al.

International journal of molecular sciences, 20(11) (2019-05-31)

To investigate the expression of vascular adhesion protein-1 (VAP-1) in joint tissues and serum in symptomatic knee osteoarthritis (SKOA) patients and examine whether VAP-1 levels predict increased risk of disease severity in a cross-sectional study. Baseline VAP-1 expression and soluble

Serum vascular adhesion protein-1 predicts all-cause mortality and cancer-related mortality in subjects with colorectal cancer.

Yu-I Li et al.

Clinica chimica acta; international journal of clinical chemistry, 428, 51-56 (2013-11-12)

Vascular adhesion protein-1 (VAP-1) participates in inflammation and catalyzes the breakdown of amines to produce aldehyde, hydrogen peroxide, and ammonia. Serum VAP-1 can predict cancer mortality, including colorectal cancer (CRC) mortality, in type 2 diabetic subjects. However, it remains unknown

Evaluation of serum and tissue levels of VAP-1 in colorectal cancer.

Stephen T Ward et al.

BMC cancer, 16, 154-154 (2016-02-26)

The endothelial adhesion molecule, vascular adhesion protein-1 (VAP-1, AOC3) promotes lymphocyte recruitment to tumours, although the contribution that VAP-1 makes to lymphocyte recruitment in human colorectal cancer (CRC) is unknown. VAP-1 exists in circulating soluble form (sVAP-1). A previous study

Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis.

Chris J Weston et al.

The Journal of clinical investigation, 125(2), 501-520 (2015-01-07)

Nonalcoholic fatty liver disease (NAFLD) encompasses a range of manifestations, including steatosis and cirrhosis. Progressive disease is characterized by hepatic leukocyte accumulation in the form of steatohepatitis. The adhesion molecule vascular adhesion protein-1 (VAP-1) is a membrane-bound amine oxidase that

NG2/CSPG4, CD146/MCAM and VAP1/AOC3 are regulated by myocardin-related transcription factors in smooth muscle cells.

Catarina Rippe et al.

Scientific reports, 11(1), 5955-5955 (2021-03-18)

The present work addressed the hypothesis that NG2/CSPG4, CD146/MCAM, and VAP1/AOC3 are target genes of myocardin-related transcription factors (MRTFs: myocardin/MYOCD, MRTF-A/MKL1, MRTF-B/MKL2) and serum response factor (SRF). Using a bioinformatics approach, we found that CSPG4, MCAM, and AOC3 correlate with

Tripartite factors leading to molecular divergence between human and murine smooth muscle.

Soo Jung Lee et al.

PloS one, 15(1), e0227672-e0227672 (2020-01-17)

A large number of pre-clinical and developmental investigations involve experimental vertebrate animals, of which mice have emerged as a favored organism. Recognition of the differences between humans and mice is essential for assessment of the relevance of animal studies to

Exometabolomic Analysis of Decidualizing Human Endometrial Stromal and Perivascular Cells.

Sarah L Harden et al.

Frontiers in cell and developmental biology, 9, 626619-626619 (2021-02-16)

Differentiation of endometrial fibroblasts into specialized decidual cells controls embryo implantation and transforms the cycling endometrium into a semi-permanent, immune-protective matrix that accommodates the placenta throughout pregnancy. This process starts during the midluteal phase of the menstrual cycle with decidual

Cloning of vascular adhesion protein 1 reveals a novel multifunctional adhesion molecule.

D J Smith et al.

The Journal of experimental medicine, 188(1), 17-27 (1998-07-07)

Vascular adhesion protein 1 (VAP-1) is a human endothelial sialoglycoprotein whose cell surface expression is induced under inflammatory conditions. It has been shown previously to participate in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular

Vascular adhesion protein-1, a novel molecule, in kidney and heart allograft recipients.

E Koc-Zorawska et al.

Transplantation proceedings, 45(5), 2009-2012 (2013-06-19)

VAP-1 (vascular adhesion protein-1) is a copper-containing SSAO (semicarbazide-sensitive amine oxidase) secreted by vascular smooth muscle cells, adipocytes, and endothelial cells. Elevation of SSAO activity is observed in atherosclerosis, diabetes mellitus, and obesity. The aim of the study was to

VAP-1 in peritoneally dialyzed patients.

Ewa Koc-Zorawska et al.

Postepy higieny i medycyny doswiadczalnej (Online), 67, 1340-1344 (2014-01-01)

VAP-1 (vascular adhesion protein-1) possesses semicarbazide-sensitive amine oxidase (SSAO) activity. It has also been found that serum VAP-1 was elevated in acute and chronic hyperglycemia and in patients with diabetes as well as in chronic kidney disease. Renalase, with possible

Involvement of SSAO/VAP-1 in oxygen-glucose deprivation-mediated damage using the endothelial hSSAO/VAP-1-expressing cells as experimental model of cerebral ischemia.

Ping Sun et al.

Cerebrovascular diseases (Basel, Switzerland), 37(3), 171-180 (2014-02-08)

In the acute phase of ischemic stroke, endothelial cells are activated and induce the expression of adhesion molecules. Vascular adhesion protein 1 (VAP-1) is a proinflammatory protein that mediates leukocyte recruitment through its semicarbazide-sensitive amine oxidase (SSAO) activity (EC 1.4.3.21).

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