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关键词:'HPA008763'
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Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay
Nguyen A D, et al.
Proceedings of the National Academy of Sciences of the USA, 115(12), E2849-E2858 (2018)
Swetha Mohan et al.
Molecular neurodegeneration, 16(1), 51-51 (2021-08-05)
Progranulin loss-of-function mutations are linked to frontotemporal lobar degeneration with TDP-43 positive inclusions (FTLD-TDP-Pgrn). Progranulin (PGRN) is an intracellular and secreted pro-protein that is proteolytically cleaved into individual granulin peptides, which are increasingly thought to contribute to FTLD-TDP-Pgrn disease pathophysiology.
Martin J Edelman et al.
Human pathology, 45(9), 1893-1899 (2014-07-19)
GP88 (progranulin) is a growth and survival factor implicated in tumorigenesis and drug resistance. Previous studies showed that GP88 was expressed in breast cancer tissue in inverse correlation with survival. This study evaluates GP88 tissue expression in localized/locally advanced lung
Yuko Tanaka et al.
Endocrine journal, 61(12), 1191-1196 (2014-09-19)
Progranulin (PRGN) was recently identified as one of the adipokines involved in the development of insulin resistance. Thus, the aim of this study was to explore the importance of PRGN as a novel marker for metabolic diseases in Japanese. A
Skylar E Davis et al.
The Journal of biological chemistry, 297(3), 100993-100993 (2021-07-24)
Loss-of-function mutations in progranulin (GRN) are a major genetic cause of frontotemporal dementia (FTD), possibly due to loss of progranulin's neurotrophic and anti-inflammatory effects. Progranulin promotes neuronal growth and protects against excitotoxicity and other forms of injury. It is unclear
Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice
Elkabets M, et al.
The Journal of Clinical Investigation, 121(2), 784-799 (2011)
Christopher J Holler et al.
eNeuro, 4(4) (2017-08-23)
Homozygous or heterozygous mutations in the GRN gene, encoding progranulin (PGRN), cause neuronal ceroid lipofuscinosis (NCL) or frontotemporal dementia (FTD), respectively. NCL and FTD are characterized by lysosome dysfunction and neurodegeneration, indicating PGRN is important for lysosome homeostasis in the
Songkiad Upontain et al.
Asian Pacific journal of cancer prevention : APJCP, 19(9), 2437-2445 (2018-09-27)
The secreted growth factor granulin (GRN) is upregulated during diverse epithelial cancers. GRN stimulates cell growth and development while inhibiting apoptosis. Orthologues of vertebrate granulins evolved in other animals including the liver fluke Opisthorchis viverrini. Curiously, liver fluke granulin, termed
Andrew D Nguyen et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(12), E2849-E2858 (2018-03-08)
Frontotemporal dementia (FTD) is the most common neurodegenerative disorder in individuals under age 60 and has no treatment or cure. Because many cases of FTD result from GRN nonsense mutations, an animal model for this type of mutation is highly
Malene Overby et al.
The Journal of biological chemistry, 299(12), 105446-105446 (2023-11-11)
Increasing evidence suggests that aberrant regulation of sortilin ectodomain shedding can contribute to amyloid-β pathology and frontotemporal dementia, although the mechanism by which this occurs has not been elucidated. Here, we probed for novel binding partners of sortilin using multiple
Jonathan Frew et al.
Molecular neurodegeneration, 15(1), 21-21 (2020-03-18)
Frontotemporal lobar degeneration (FTLD) is a devastating and progressive disorder, and a common cause of early onset dementia. Progranulin (PGRN) haploinsufficiency due to autosomal dominant mutations in the progranulin gene (GRN) is an important cause of FTLD (FTLD-GRN), and nearly
Granulin Expression in Hamsters during Opisthorchis viverrini Infection-Induced Cholangiocarcinogenesis
Upontain S, et al.
Asian Pacific Journal of Cancer Prevention, 19(9), 2437-2437 (2018)
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