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Alba Garrido-Trigo et al.
Nature communications, 14(1), 4506-4506 (2023-07-27)
Ulcerative colitis and Crohn's disease are chronic inflammatory intestinal diseases with perplexing heterogeneity in disease manifestation and response to treatment. While the molecular basis for this heterogeneity remains uncharacterized, single-cell technologies allow us to explore the transcriptional states within tissues
Laura L Swystun et al.
The Journal of clinical investigation, 128(9), 4057-4073 (2018-08-21)
Quantitative abnormalities of the von Willebrand factor-factor VIII (VWF-FVIII) complex associate with inherited bleeding or thrombotic disorders. Receptor-mediated interactions between plasma VWF-FVIII and phagocytic or immune cells can influence their hemostatic and immunogenic activities. Genetic association studies have demonstrated that
Jie Liu et al.
Chinese medical journal, 133(1), 49-60 (2020-01-11)
Pulmonary arterial hypertension (PH) is a progressive disease with limited therapeutic options, ultimately leading to right heart failure and death. Recent findings indicate the role of the Warburg effect (aerobic glycolysis) in the development of PH. However, the effect of
Silvia Snider et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 105(5), 1040-1053 (2016-03-10)
Traumatic spinal cord injury (SCI) is a damage to the spinal cord that results in loss or impaired motor and/or sensory function. SCI is a sudden and unexpected event characterized by high morbidity and mortality rate during both acute and
Fulvio D'Angelo et al.
Nature medicine, 25(1), 176-187 (2018-12-12)
Neurofibromatosis type 1 (NF1) is a common tumor predisposition syndrome in which glioma is one of the prevalent tumors. Gliomagenesis in NF1 results in a heterogeneous spectrum of low- to high-grade neoplasms occurring during the entire lifespan of patients. The
Antoine Louveau et al.
Nature, 523(7560), 337-341 (2015-06-02)
One of the characteristics of the central nervous system is the lack of a classical lymphatic drainage system. Although it is now accepted that the central nervous system undergoes constant immune surveillance that takes place within the meningeal compartment, the
Esraa Al Dujaily et al.
JNCI cancer spectrum, 4(2), pkz101-pkz101 (2020-03-20)
Statins have anticancer properties by acting as competitive inhibitors of the mevalonate pathway. They also have anti-inflammatory activity, but their role in suppressing inflammation in a cancer context has not been investigated to date. We have analyzed the relationship between
Netrin-1 is associated with macrophage infiltration and polarization in human epicardial adipose tissue in coronary artery disease
Gurses KM, et al.
Journal of Cardiology, 69(6) (2017)
Multiple Ets factors and interferon regulatory factor-4 modulate CD68 expression in a cell type-specific manner.
O'Reilly D
The Journal of Biological Chemistry, 278(24), 21909-21919 (2003)
Reza Bahramabadi et al.
Life sciences, 179, 73-79 (2017-05-04)
Previous studies approved the important roles of CD68, as scavenger receptors, in Alzheimer's disease (AD). The aim of this study was to evaluate the effect of treatment with anti-psychotic drugs and vitamin B12 on the expression levels of CD68 in
CD68/macrosialin: not just a histochemical marker.
Chistiakov DA
Laboratory Investigation; a Journal of Technical Methods and Pathology, 97(1), 4-13 (2017)
Simon M Jensen et al.
Frontiers in physiology, 11, 811-811 (2020-08-15)
The current model for repair of damaged tissue includes immune cells, mediating the progression from a pro-inflammatory to an anti-inflammatory environment. How this process changes with aging in human skeletal muscle under conditions of physiological exercise loading remains unclear. To
Stefan Reischl et al.
Digestive diseases (Basel, Switzerland), 38(5), 398-407 (2020-03-23)
Crohn's disease (CD) is characterized by relapsing intestinal inflammation. The anti-inflammatory protein annexin A1 (ANXA1) has been linked to inflammatory processes in the gut. To examine ANXA1 expression patterns in the inflamed intestine of patients with CD and associate ANXA1
Dapeng Li et al.
Cell, 184(16), 4203-4219 (2021-07-10)
SARS-CoV-2-neutralizing antibodies (NAbs) protect against COVID-19. A concern regarding SARS-CoV-2 antibodies is whether they mediate disease enhancement. Here, we isolated NAbs against the receptor-binding domain (RBD) or the N-terminal domain (NTD) of SARS-CoV-2 spike from individuals with acute or convalescent
Sofian Al Shboul et al.
Life science alliance, 4(12) (2021-10-15)
Better understanding of GBM signalling networks in-vivo would help develop more physiologically relevant ex vivo models to support therapeutic discovery. A "functional proteomics" screen was undertaken to measure the specific activity of a set of protein kinases in a two-step
Po Zhang et al.
Frontiers in immunology, 13, 824586-824586 (2022-04-05)
The development and progression of glioma are associated with the tumor immune microenvironment. Diffuse low-grade gliomas (LGGs) with higher immunosuppressive microenvironment tend to have a poorer prognosis. The study aimed to find a biological marker that can reflect the tumor
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