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Adam D Pfefferle et al.
Disease models & mechanisms, 12(7) (2019-06-20)
The Wnt gene family encodes an evolutionarily conserved group of proteins that regulate cell growth, differentiation and stem cell self-renewal. Aberrant Wnt signaling in human breast tumors has been proposed as a driver of tumorigenesis, especially in the basal-like tumor
Hiroyuki Nagashima et al.
Immunity, 51(4), 682-695 (2019-07-30)
Innate lymphocytes maintain tissue homeostasis at mucosal barriers, with group 2 innate lymphoid cells (ILC2s) producing type 2 cytokines and controlling helminth infection. While the molecular understanding of ILC2 responses has advanced, the complexity of microenvironmental factors impacting ILC2s is
Tracking Endocytosis and Intracellular Trafficking of Epitope-tagged Syntaxin 3 by Antibody Feeding in Live, Polarized MDCK Cells.
Giovannone A J, et al.
Molecular Biology of the Cell (2017)
Caterina Nardella et al.
Science signaling, 2(55), ra2-ra2 (2009-01-30)
The mammalian target of rapamycin (mTOR) is a crucial effector in a complex signaling network commonly disrupted in cancer. mTOR exerts its multiple functions in the context of two different multiprotein complexes: mTOR complex 1 (mTORC1) and mTOR complex 2
Erika A Crane et al.
Bioorganic & medicinal chemistry, 27(12), 2508-2520 (2019-04-02)
To identify new potential therapeutic targets for neurodegenerative diseases, we initiated activity-based protein profiling studies with withanolide A (WitA), a known neuritogenic constituent of Withania somnifera root with unknown mechanism of action. Molecular probes were designed and synthesized, and led
F Buchholz et al.
Antimicrobial agents and chemotherapy, 54(1), 312-319 (2009-10-14)
Chip calorimetry is introduced as a new monitoring tool that provides real-time information about the physiological state of biofilms. Its potential for use for the study of the effects of antibiotics and other biocides was tested. Established Pseudomonas putida biofilms
Young Woo Eom et al.
Yonsei medical journal, 52(6), 999-1007 (2011-10-27)
This study examined a rapid isolation method decreasing the time and cost of the clinical application of adipose tissue-derived stem cells (ASCs). Aliquots (10 g) of the lipoaspirates were stored at 4°C without supplying oxygen or nutrients. At the indicated
Hyoungshin Park et al.
Journal of tissue engineering and regenerative medicine, 2(5), 279-287 (2008-05-31)
Electrical stimulation affects the deposition of extracellular matrices and cellular differentiation. Type I collagen is one of the most abundant extracellular matrix proteins; however, not much is known about the effects of electrical stimulation on collagen type I deposition in
Dermatophytes activate skin keratinocytes via MAPK signaling and induce immune responses.
Achterman R R, et al.
Infection and Immunity, IAI-02776 (2015)
Xin Wang et al.
The Journal of cell biology, 184(1), 143-158 (2009-01-14)
Ceramide transfer protein (CERT) functions in the transfer of ceramide from the endoplasmic reticulum (ER) to the Golgi. In this study, we show that CERT is an essential gene for mouse development and embryonic survival and, quite strikingly, is critical
Xiaozhen Liang et al.
PLoS pathogens, 7(9), e1002220-e1002220 (2011-09-21)
Human gammaherpesviruses are associated with the development of lymphoproliferative diseases and B cell lymphomas, particularly in immunosuppressed hosts. Understanding the molecular mechanisms by which human gammaherpesviruses cause disease is hampered by the lack of convenient small animal models to study
Jhih-Wei Hsu et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 142, 111487-111487 (2020-06-12)
Mono(2-ethylhexyl)phthalate (MEHP) promotes adipogenesis via PPARγ. PPARγ agonists, e.g., rosiglitazone (RSG), enhance adipocyte browning. However, scientific evidence regarding MEHP as a browning chemical is lacking. This study combined 3T3-L1 adipocytes and C57BL/6J mice to examine the potential roles of MEHP
Tamara J Nicolson et al.
Diabetes, 58(9), 2070-2083 (2009-06-23)
Zinc ions are essential for the formation of hexameric insulin and hormone crystallization. A nonsynonymous single nucleotide polymorphism rs13266634 in the SLC30A8 gene, encoding the secretory granule zinc transporter ZnT8, is associated with type 2 diabetes. We describe the effects
Seyed Javad Moghaddam et al.
American journal of respiratory cell and molecular biology, 40(4), 443-453 (2008-10-18)
Lung cancer is the leading cause of cancer deaths in the United States. In addition to genetic abnormalities induced by cigarette smoke, several epidemiologic studies have found that smokers with chronic obstructive pulmonary disease (COPD), an inflammatory disease of the
Robin Tranchant et al.
Lung cancer (Amsterdam, Netherlands), 126, 15-24 (2018-12-12)
Malignant pleural mesothelioma (MPM) is an aggressive tumor with limited therapeutic options, requiring the development of efficient targeted therapies based on molecular phenotype of the tumor and to identify predictive biomarkers of the response. The effect of inhibitors was investigated
Karen Pauwelyn et al.
PloS one, 6(8), e23096-e23096 (2011-08-11)
Mouse embryonic stem cells (mESC) have been used to study lineage specification in vitro, including towards a hepatocyte-like fate, and such investigations guided lineage differentiation protocols for human (h)ESC. We recently described a four-step protocol to induce hepatocyte-like cells from
Rebecca R Achterman et al.
Infection and immunity, 83(4), 1705-1714 (2015-02-11)
Dermatophytes cause superficial and cutaneous fungal infections in immunocompetent hosts and invasive disease in immunocompromised hosts. However, the host mechanisms that regulate innate immune responses against these fungi are largely unknown. Here, we utilized commercially available epidermal tissues and primary
Chuan Yan et al.
Biochemical and biophysical research communications, 509(1), 175-181 (2018-12-26)
TGFB signaling pathway plays a key role on liver disease progression. In our previous study, we have demonstrated the oncogenic ability of Tgfb signaling pathway as a chronic induction of tgfb1a specifically in hepatocytes led to both hepatocellular carcinoma (HCC)
Denis Fourches et al.
Chemical research in toxicology, 23(1), 171-183 (2009-12-18)
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this
Ji-Yeon Jang et al.
Journal of biomedicine & biotechnology, 2011, 860652-860652 (2011-03-16)
Existing studies examining the control of mesenchymal stem cell (MSC) differentiation into desired cell types have used a variety of biochemical reagents such as growth factors despite possible side effects. Recently, the roles of biomimetic microphysical environments have drawn much
Xiao Cheng et al.
Redox biology, 40, 101863-101863 (2021-01-29)
Obesity-induced insulin resistance is a risk factor for diabetes and cardiovascular disease. However, the mechanisms underlying endothelial senescence in obesity, and how it impacts obesity-induced insulin resistance remain incompletely understood. In this study, transcriptome analysis revealed that the long non-coding
Dianjun Cao et al.
Archives of virology, 154(5), 755-763 (2009-04-04)
Using an immunocytochemical staining assay involving six different recombinant baculoviruses with each expressing one of the major bovine rotavirus VP7 (G6, G8 and G10) and VP4 (P6[1], P7[5] and P8[11]) serotypes, we analyzed IgG antibody responses to individual proteins in
Yoshiyuki Mochida et al.
Matrix biology : journal of the International Society for Matrix Biology, 28(1), 44-52 (2008-12-04)
Decorin (DCN) is one of the major matrix proteoglycans in bone. To investigate the role of DCN in matrix mineralization, the expression of DCN in MC3T3-E1 (MC) cell cultures and the phenotypes of MC-derived clones expressing higher (sense; S-DCN) or
Odile Mondesert et al.
PloS one, 10(7), e0134411-e0134411 (2015-08-01)
Monitoring the DNA-Damage Response (DDR) activated pathway in multicellular tumor spheroid models is an important challenge as these 3D models have demonstrated their major relevance in pharmacological evaluation. Herein we present DDR-Act-FP, a fluorescent biosensor that allows detection of DDR
Patrizia Pellegatti et al.
PloS one, 3(7), e2599-e2599 (2008-07-10)
There is growing awareness that tumour cells build up a "self-advantageous" microenvironment that reduces effectiveness of anti-tumour immune response. While many different immunosuppressive mechanisms are likely to come into play, recent evidence suggests that extracellular adenosine acting at A2A receptors
Coralie Apfeldorfer et al.
Diagnostic pathology, 3 Suppl 1, S16-S16 (2008-08-05)
Historically, histopathology evaluation is performed by a pathologist generating a qualitative assessment on thin tissue sections on glass slides. In the past decade, there has been a growing interest for tools able to reduce human subjectivity and improve workload. Whole
Monica A Serban et al.
Acta biomaterialia, 4(1), 67-75 (2007-11-06)
In vitro cell culture is a vital research tool for cell biology, pharmacology, toxicology, protein production, systems biology and drug discovery. Traditional culturing methods on plastic surfaces do not accurately represent the in vivo environment, and a paradigm shift from
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