I110

应用筛选条件

关键词:'I110'

显示 1-30 共 408 条结果关于 "I110" 范围论文

Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.

Gang Yu et al.

Bioorganic & medicinal chemistry letters, 20(3), 896-902 (2010-01-05)

A novel class of phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore attached to its C-2, C-3 or C-4 position was designed for evaluation as anti-inflammatory (AI) agents. A number of compounds exhibited a combination of potent in vitro cyclooxygenase-2 (COX-2)

S- and C-nucleosidoquinazoline as new nucleoside analogs with potential analgesic and anti-inflammatory activity.

Abdel-Rahman B A El-Gazzar et al.

European journal of medicinal chemistry, 44(10), 4249-4258 (2009-06-23)

Thioglycosides and C-glycosides have received considerable attention, because they are widely employed as biological inhibitors, inducers and ligands for affinity chromatography of carbohydrate-processing enzymes and proteins. Moreover, they are promising candidates in synthetic carbohydrate chemistry as convenient and versatile glycosyl

The Effect of Cyclooxygenase Inhibition on Tendon-Bone Healing in an In Vitro Coculture Model.

Tim Schwarting et al.

Mediators of inflammation, 2015, 926369-926369 (2015-06-13)

The effects of cyclooxygenase (COX) inhibition following the reconstruction of the anterior cruciate ligament remain unclear. We examined the effects of selective COX-2 and nonselective COX inhibition on bone-tendon integration in an in vitro model. We measured the dose-dependent effects

Impact of active ingredients on the swelling properties of orally disintegrating tablets prepared by microwave treatment.

Syusuke Sano et al.

International journal of pharmaceutics, 468(1-2), 234-242 (2014-04-09)

The impact of different active pharmaceutical ingredients (APIs) loading on the properties of orally disintegrating tablets (ODTs) prepared according to our previously reported microwave (MW) treatment process was evaluated using famotidine (FAM), acetaminophen (AAP), and ibuprofen (IBU). None of the

Continuous Processing of Active Pharmaceutical Ingredients Suspensions via Dynamic Cross-Flow Filtration.

Johannes Gursch et al.

Journal of pharmaceutical sciences, 104(10), 3481-3489 (2015-07-07)

Over the last years, continuous manufacturing has created significant interest in the pharmaceutical industry. Continuous filtration at low flow rates and high solid loadings poses, however, a significant challenge. A commercially available, continuously operating, dynamic cross-flow filtration device (CFF) is

Synthesis and pharmacological evaluation of 1,3,4-oxadiazole bearing bis(heterocycle) derivatives as anti-inflammatory and analgesic agents.

B Jayashankar et al.

European journal of medicinal chemistry, 44(10), 3898-3902 (2009-05-09)

A series of novel ether-linked bis(heterocycle)s have been synthesized via [3+2]-cycloaddition reaction of nitrile oxide with allyl alcohol followed by intramolecular 1,3-diploar cycloaddition reaction of nitrile imine with carbonyl group. All the newly synthesized compounds were screened for their anti-inflammatory

Investigations on the viscoelastic performance of pressure sensitive adhesives in drug-in-adhesive type transdermal films.

Hans-Michael Wolff et al.

Pharmaceutical research, 31(8), 2186-2202 (2014-03-07)

We aimed to investigate the effect of solubility parameter and drug concentration on the rheological behaviour of drug-in-adhesive films intended for transdermal application. Films were prepared over a range of drug concentrations (5%, 10% and 20% w/w) using ibuprofen, benzoic

Single- and multiple-dose pharmacokinetics of a hydrocodone bitartrate extended-release tablet formulated with abuse-deterrence technology in healthy, naltrexone-blocked volunteers.

Mona Darwish et al.

Clinical therapeutics, 37(2), 390-401 (2014-12-30)

A hydrocodone extended-release (ER) formulation was developed to provide sustained pain relief with twice-daily dosing. Developed using the CIMA abuse-deterrence technology platform (CIMA Labs Inc, Brooklyn Park, Minnesota), this formulation also provides resistance against rapid release of hydrocodone when tablets

Considerations in the sterile manufacture of polymeric microneedle arrays.

Maelíosa T C McCrudden et al.

Drug delivery and translational research, 5(1), 3-14 (2015-03-20)

We describe, for the first time, considerations in the sterile manufacture of polymeric microneedle arrays. Microneedles (MN) made from dissolving polymeric matrices and loaded with the model drugs ovalbumin (OVA) and ibuprofen sodium and hydrogel-forming MN composed of "super-swelling" polymers

Clinical problem-solving. Unfolding the diagnosis.

Gadi Lalazar et al.

The New England journal of medicine, 370(14), 1344-1348 (2014-04-04)

Characterization of large surface area polymer monoliths and their utility for rapid, selective solid phase extraction for improved sample clean up.

Esme Candish et al.

Journal of chromatography. A, 1410, 9-18 (2015-08-04)

While polymer monoliths are widely described for solid phase extraction (SPE), appropriate characterization is rarely provided to unravel the links between physical characteristics and observed advantages and disadvantages. Two known approaches to fabricate large surface area polymer monoliths with a

Acetaminophen and Ibuprofen overdosage.

Jennifer Argentieri et al.

Pediatrics in review, 33(4), 188-189 (2012-04-05)

The advantages and limitations of the analgesics available for control of postoperative pain after a dental procedure.

Jasmin Davey

SAAD digest, 29, 70-81 (2013-04-02)

Monitoring and removal of residual phthalate esters and pharmaceuticals in the drinking water of Kaohsiung City, Taiwan.

Gordon C C Yang et al.

Journal of hazardous materials, 277, 53-61 (2014-04-08)

This study monitored the occurrence and removal efficiencies of 8 phthalate esters (PAEs) and 13 pharmaceuticals present in the drinking water of Kaohsiung City, Taiwan. The simultaneous electrocoagulation and electrofiltration (EC/EF) process was used to remove the contaminants. To this

Adoption of polymeric micelles to enhance the oral bioavailability of dexibuprofen: formulation, in-vitro evaluation and in-vivo pharmacokinetic study in healthy human volunteers.

Ghada Abdelbary et al.

Pharmaceutical development and technology, 19(6), 717-727 (2013-08-14)

This work aimed to incorporate Dexibuprofen (DXI), the pharmacologically active and more potent form of ibuprofen, into polymeric micelles based tablets with enhanced oral bioavailability. Thin film hydration technique was employed to prepare DXI polymeric micelles using Pluronic® F127 and/or

Synthesis and pharmacological evaluation of 2(3H)-furanones and 2(3H)-pyrrolones, combining analgesic and anti-inflammatory properties with reduced gastrointestinal toxicity and lipid peroxidation.

M M Alam et al.

European journal of medicinal chemistry, 44(6), 2636-2642 (2008-12-09)

A series of 3-arylidene-5-(4-chloro-phenyl)-2(3H)-furanones (2-13) and their nitrogen analogues 1-benzylpyrrolones (14-18) were synthesized. The compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation actions. Some of the newly synthesized compounds showed good anti-inflammatory and analgesic activities with low

Use of in-die powder densification parameters in the implementation of process analytical technologies for tablet production on industrial scale.

Marco Cespi et al.

International journal of pharmaceutics, 477(1-2), 140-147 (2014-10-12)

The use of process analytical technologies (PAT) to ensure final product quality is by now a well established practice in pharmaceutical industry. To date, most of the efforts in this field have focused on development of analytical methods using spectroscopic

Electrochemical detection and degradation of ibuprofen from water on multi-walled carbon nanotubes-epoxy composite electrode.

Sorina Motoc et al.

Journal of environmental sciences (China), 25(4), 838-847 (2013-08-09)

This work describes the electrochemical behaviour of ibuprofen on two types of multi-walled carbon nanotubes based composite electrodes, i.e., multi-walled carbon nanotubes-epoxy (MWCNT) and silver-modified zeolite-multi-walled carbon nanotubes-epoxy (AgZMWCNT) composites electrodes. The composite electrodes were obtained using two-roll mill procedure.

Study of fluorescence interaction and conformational changes of bovine serum albumin with histamine H₁ -receptor--drug epinastine hydrochloride by spectroscopic and time-resolved fluorescence methods.

Girish G Ariga et al.

Biopolymers, 103(11), 646-657 (2015-07-29)

The fluorescence, ultraviolet (UV) absorption, time resolved techniques, circular dichroism (CD), and infrared spectral methods were explored as tools to investigate the interaction between histamine H1 drug, epinastine hydrochloride (EPN), and bovine serum albumin (BSA) under simulated physiological conditions. The

Molecular insight into affinities of drugs and their metabolites to lipid bilayers.

Markéta Paloncýová et al.

The journal of physical chemistry. B, 117(8), 2403-2410 (2013-02-08)

The penetration properties of drug-like molecules on human cell membranes are crucial for understanding the metabolism of xenobiotics and overall drug distribution in the human body. Here, we analyze partitioning of substrates of cytochrome P450s (caffeine, chlorzoxazone, coumarin, ibuprofen, and

Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents.

Khurshid I Molvi et al.

European journal of medicinal chemistry, 42(8), 1049-1058 (2007-03-06)

A series of new tetrasubstituted thiophenes (4a-4i, 5a-5i and 6a-6f) have been synthesized as novel anti-inflammatory agents and were evaluated for their anti-inflammatory activity in carrageenin-induced rat hind paw oedema model at the doses of 10, 20 and 40mg/kg body

Effect of Beta-Asarone on Impairment of Spatial Working Memory and Apoptosis in the Hippocampus of Rats Exposed to Chronic Corticosterone Administration.

Bombi Lee et al.

Biomolecules & therapeutics, 23(6), 571-581 (2015-11-05)

β-asarone (BAS) is an active component of Acori graminei rhizoma, a traditional medicine used clinically in treating dementia and chronic stress in Korea. However, the cognitive effects of BAS and its mechanism of action have remained elusive. The purpose of

Cholesterol expels ibuprofen from the hydrophobic membrane core and stabilizes lamellar phases in lipid membranes containing ibuprofen.

Richard J Alsop et al.

Soft matter, 11(24), 4756-4767 (2015-04-29)

There is increasing evidence that common drugs, such as aspirin and ibuprofen, interact with lipid membranes. Ibuprofen is one of the most common over the counter drugs in the world, and is used for relief of pain and fever. It

Surgical suture assembled with polymeric drug-delivery sheet for sustained, local pain relief.

Ji Eun Lee et al.

Acta biomaterialia, 9(9), 8318-8327 (2013-06-19)

Surgical suture is a strand of biocompatible material designed for wound closure, and therefore can be a medical device potentially suitable for local drug delivery to treat pain at the surgical site. However, the preparation methods previously introduced for drug-delivery

Optimized mixed oils remarkably reduce the amount of surfactants in microemulsions without affecting oral bioavailability of ibuprofen by simultaneously enlarging microemulsion areas and enhancing drug solubility.

Yizhen Chen et al.

International journal of pharmaceutics, 487(1-2), 17-24 (2015-04-07)

The toxicity and irritation associated with high amounts of surfactants restrict the extensive utilization of microemulsions. To address these shortcomings, employing mixed oils to enlarge microemulsion areas therefore reducing surfactant contents is a promising strategy. However, what kinds of mixed

A low cytotoxic cationic metal-organic framework carrier for controllable drug release.

Quan Hu et al.

Journal of medicinal chemistry, 57(13), 5679-5685 (2014-06-13)

A positively charged porous drug carrier MOF-74-Fe(III) (1, MOF = metal-organic framework), which could not be directly synthesized using ferric salts, was prepared through the oxidation of the neutral crystal MOF-74-Fe(II). This cationic host material exhibits very low cytotoxicity upon

Predicting the dissolution behavior of pharmaceutical tablets with NIR chemical imaging.

Ketsia Yekpe et al.

International journal of pharmaceutics, 486(1-2), 242-251 (2015-04-04)

Near infrared chemical imaging (NIRCI) is a common analytical non-destructive technique for the analysis of pharmaceutical tablets. This powerful process analytical technology provides opportunity to chemically understand the sample, and also to determine spatial distribution and size of ingredients in

A diazen-1-ium-1,2-diolated nitric oxide donor ester prodrug of 3-(4-hydroxymethylphenyl)-4-(4-methanesulfonylphenyl)-5H-furan-2-one: synthesis, biological evaluation and nitric oxide release studies.

Khaled R A Abdellatif et al.

Bioorganic & medicinal chemistry letters, 21(13), 3951-3956 (2011-06-07)

A novel hybrid nitric oxide-releasing anti-inflammatory (AI) ester prodrug (NONO-coxib 14) wherein an O(2)-acetoxymethyl 1-(2-carboxypyrrolidin-1-yl)diazen-1-ium-1,2-diolate (O(2)-acetoxymethyl PROLI/NO) NO-donor moiety was covalently coupled to the CH(2)OH group of 3-(4-hydroxymethylphenyl)-4-(4-methylsulfonylphenyl)-5H-furan-2-one (12), was synthesized. The prodrug 14 released a low amount of NO

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Lourdes Santana et al.

Journal of medicinal chemistry, 51(21), 6740-6751 (2008-10-07)

The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared and assayed 33 coumarin derivatives

In reply to "ibuprofen for prevention of acute mountain sickness-is bigger really better?".

Jeffrey H Gertsch et al.

Wilderness & environmental medicine, 24(2), 178-179 (2013-06-04)

1/14