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Makoto Mizunami et al.
PloS one, 9(9), e107442-e107442 (2014-09-13)
Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) is a key molecule in many systems of learning and memory in vertebrates, but roles of CaMKII in invertebrates have not been characterized in detail. We have suggested that serial activation of NO/cGMP signaling
Aram Ghalali et al.
Molecular cancer research : MCR, 15(6), 714-722 (2017-02-18)
Hepatocellular carcinoma (HCC) is rated as the fifth most common malignancy and third in cancer-related deaths worldwide. Statins, HMG-CoA reductase inhibitors, are potent cholesterol-lowering drugs, and recent epidemiologic evidence suggests that statins prevent aggressive HCC development. Previous experiments revealed that
Jean-Yves Tano et al.
Biochemical and biophysical research communications, 407(2), 432-437 (2011-03-19)
The phosphatidylinositol-3-kinase (PI3K)/AKT axis and the Nuclear Factor kappa B (NFκB) pathway play critical roles in macrophage survival. In cells other than macrophages proper operation of those two pathways requires Ca²(+) influx into the cell, but if that is the
Wei Wang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 28(2), 199-208 (2011-08-26)
4-AP, a voltage-gated potassium channel blocker, was identified to exert critical pro-apoptotic properties in various types of cancer cells. The present study aims to explore the effect of 4-AP on the apoptosis of human AML cells and the underlying mechanism.
Erik Schilling et al.
Innate immunity, 18(5), 738-744 (2012-03-02)
Nicotinamide phosphoribosyltransferase (NAMPT), an enzyme involved in NAD biosynthesis, has recently been identified as a novel mediator of innate immunity. In the present study, we report that treatment of LPS-primed monocytes with ATP greatly enhanced the secretion of NAMPT in
Rohan P Choraghe et al.
Journal of cell science, 133(5) (2020-01-23)
Dendritic cell-associated C-type lectin 1 (Dectin-1, also known as CLEC7A) is an innate immune pattern recognition receptor that recognizes β-glucan on the Candida albicans cell wall. Recognition of β-glucan by immune cells leads to phagocytosis, oxidative burst, cytokine and chemokine
Kaori Suzuki et al.
International journal of molecular medicine, 44(4), 1187-1196 (2019-08-01)
Cellular senescence is associated with the induction of a proinflammatory phenotype. Notably, senescent endothelial cells are detected at the sites of atherosclerotic lesions, suggesting the involvement of senescent endothelial cells in atherogenesis. Moreover, bacterial infection has been speculated to contribute
K Kanjanamekanant et al.
Journal of periodontal research, 48(2), 169-176 (2012-08-14)
Mechanical stress is an important factor in maintaining homeostasis of the periodontium. Interleukin-1beta (IL-1β) and adenosine triphosphate (ATP) are considered potent inflammatory mediators. In macrophages, ATP-activated P2X7 receptor is involved in IL-1β processing and release. Our previous works demonstrated mechanical
Hee Jung Kim et al.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 20(1), 101-109 (2016-01-26)
Reducing [Mg(2+)]o to 0.1 mM can evoke repetitive [Ca(2+)]i spikes and seizure activity, which induces neuronal cell death in a process called excitotoxicity. We examined the issue of whether cultured rat hippocampal neurons preconditioned by a brief exposure to 0.1
Safina Gadeock et al.
Biochimica et biophysica acta, 1798(11), 2058-2066 (2010-07-31)
The P2X7 receptor is an extracellular ATP-gated cation channel critical in inflammation and immunity, and can be up-regulated by IFN-γ and LPS. This study aimed to examine the effect of TGF-β1 on the up-regulation of P2X7 function and expression in
Abtar Mishra et al.
Biochimica et biophysica acta. General subjects, 1865(2), 129806-129806 (2020-12-01)
Host-directed therapy is considered a novel anti-tuberculosis strategy in tackling the tuberculosis burden through autophagy induction by various inducers to curtail the growth of intracellular Mycobacterium tuberculosis. In this study, we investigated the anti-tubercular role of soybean lectin, a lectin
Mirjam Schuchardt et al.
Scientific reports, 9(1), 3421-3421 (2019-03-06)
Serum amyloid A (SAA) is an uremic toxin and acute phase protein. It accumulates under inflammatory conditions associated with high cardiovascular morbidity and mortality in patients with sepsis or end-stage renal disease (ESRD). SAA is an apolipoprotein of the high-density
Asha Eapen et al.
The Journal of biological chemistry, 288(12), 8585-8595 (2013-01-31)
Dentin phosphophoryn (DPP) is a major noncollagenous protein in the dentin matrix. In this study, we demonstrate that pluripotent stem cells such as C3H10T1/2 and human bone marrow cells can be committed to the osteogenic lineage by DPP. Treatment with
Suzanna Salzer et al.
Journal of dermatological science, 76(3), 173-179 (2014-10-13)
In patients with rosacea, environmental stressors, especially UVB radiation, trigger disease flares that are characterized by inflammation and vascular hyperactivity. An altered innate immune detection and response system, modulated to a large extent by the aberrant production and processing of
Helen J Bradley et al.
British journal of pharmacology, 164(2b), 743-754 (2011-04-05)
The human P2X7 (hP2X7) receptor exhibits striking pharmacological differences from its rodent counterparts, particularly in terms of its antagonist profile. Here, we characterized the functional and pharmacological properties of the rhesus macaque monkey P2X7 (rmP2X7) receptor in comparison with the
Naoto Fukuno et al.
Biochemical and biophysical research communications, 408(2), 202-207 (2011-03-05)
Mechanical stress plays a key role in bone remodeling. Previous studies showed that loading of mechanical stretch induces a rapid Ca(2+) influx and subsequent activation of stress-activated protein kinase pathways in osteoblasts. However, the activation mechanism and its significance in
Aaron M Rozeboom et al.
Neurobiology of learning and memory, 125, 265-273 (2015-10-20)
Hebbian, or associative, forms of synaptic plasticity are considered the molecular basis of learning and memory. However, associative synaptic modifications, including long-term potentiation (LTP) and depression (LTD), can form positive feedback loops which must be constrained for neural networks to
Wen-Jing Qian et al.
Neuropharmacology, 124, 143-156 (2017-04-23)
Endocannabinoid signaling system is involved in regulating multiple neuronal functions in the central nervous system by activating G-protein coupled cannabinoid CB1 and CB2 receptors (CB1Rs and CB2Rs). Growing evidence has shown that CB1Rs and CB2Rs are extensively expressed in retinal
Luciana De Angelis et al.
Skeletal muscle, 5, 18-18 (2015-07-07)
The Y-box protein MSY3/Csda represses myogenin transcription in skeletal muscle by binding a highly conserved cis-acting DNA element located just upstream of the myogenin minimal promoter (myogHCE). It is not known how this MSY3 activity is controlled in skeletal muscle.
Yuan-Yuan Zhang et al.
Biochemical and biophysical research communications, 470(2), 368-374 (2016-01-19)
The sole and endogenous anti-microbial peptide LL-37 is a significant effector molecule in the innate host defense system. Apart from its broadly direct anti-microbial activity, the peptide also activates mast cell in respect of allergic diseases and inflammation. On the
Hendra Gunosewoyo et al.
Bioorganic & medicinal chemistry, 17(14), 4861-4865 (2009-06-23)
The purinergic P2X(7) receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some
So Yeon Jo et al.
Journal of ethnopharmacology, 200, 16-21 (2017-02-09)
As the seed of Zizyphus jujuba var. spinosa (Bunge) Hu ex H.F. Chow (Rhamnaceae) has been used to sleep disturbances in traditional Chinese and Korean medicine, many previous studies have focused on its sedative effect. Recently, we reported the neuroprotective
Shradha Mawatwal et al.
Cytokine, 111, 1-12 (2018-08-07)
Previously, we reported pivotal role of P2RX7 in augmenting autophagy in THP-1 cells upon Calcimycin treatment by modulating intracellular Calcium regulated ATP production but the role of immune modulators in Calcimycin induced autophagy is not known. In this study, we
Hiraku Kameda et al.
Endocrinology, 160(2), 276-291 (2018-12-12)
Because an acidic cellular microenvironment is engendered by inflammation and may determine cell differentiation, we elucidated the impact of acidic conditions on induction of proopiomelanocortin (POMC) expression. Here, we demonstrate mechanisms for proton sensitivity of CRH receptor 1 (CRHR1) signaling
Ga Eun Lee et al.
Bioorganic & medicinal chemistry letters, 19(3), 954-958 (2008-12-27)
Iminium quaternary protoberberine alkaloids (QPA) have been found to be novel P2X(7) antagonists. To assess their structure-activity relationships, these compounds were modified at their R(1) and R(2) groups and assayed for their ability to inhibit the 2'(3')-O-(4-benzoylbenzoyl)-ATP (BzATP)-induced uptake of
Regina Stark et al.
Science immunology, 3(30) (2018-12-16)
Tissue-resident memory T cells (TRM) are noncirculating immune cells that contribute to the first line of local defense against reinfections. Their location at hotspots of pathogen encounter frequently exposes TRM to tissue damage. This history of danger-signal exposure is an
Andrea Giannuzzo et al.
Molecular cancer, 14, 203-203 (2015-11-27)
Pancreatic ductal adenocarcinoma (PDAC) is presently one of the cancers with the worst survival rates and least effective treatments. Moreover, total deaths due to PDAC are predicted to increase in the next 15 years. Therefore, novel insights into basic mechanism
Benjamin Seelbinder et al.
Biophysical journal, 118(11), 2627-2640 (2020-05-15)
Mechanisms of cellular and nuclear mechanosensation are unclear, partially because of a lack of methods that can reveal dynamic processes. Here, we present a new concept for a low-cost, three-dimensionally printed device that enables high-magnification imaging of cells during stretch.
G Aleph Prieto et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(5), 1197-1212 (2016-12-18)
Long-term potentiation (LTP) is an activity-dependent and persistent increase in synaptic transmission. Currently available techniques to measure LTP are time-intensive and require highly specialized expertise and equipment, and thus are not well suited for screening of multiple candidate treatments, even
Ming Lu et al.
The Journal of endocrinology, 208(1), 31-39 (2010-10-27)
Intracellular calcium ([Ca(2+)](i)) is the most relevant modulator of parathyroid hormone (PTH) secretion. Uniquely, an increase in [Ca(2+)](i) results in an inhibition of PTH secretion, and it probably exerts its function via calcium-binding protein pathways. The ubiquitous calcium-binding proteins, calmodulin
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