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关键词:'I2142'
显示 1-30 共 101 条结果 关于 "I2142" 范围 论文
Shi-Ying Cai et al.
Journal of hepatology, 74(3), 550-559 (2020-10-12)
The nuclear factor of activated T-cells (NFAT) plays an important role in immune responses by regulating the expression of inflammatory genes. However, it is not known whether NFAT plays any role in the bile acid (BA)-induced hepatic inflammatory response. Thus
Aida M Lopez-Guerrero et al.
Cellular signalling, 40, 44-52 (2017-09-04)
STIM1, the endoplasmic reticulum Ca
Katoh Shinsuke et al.
Journal of radiation research, 58(6), 809-815 (2017-11-07)
Chronic irradiation with low-dose-rate 137Cs-γ rays inhibits the differentiation of human neural progenitor cells and influences the expression of proteins associated with several cellular functions. We aimed to determine whether such chronic irradiation influences the expression of proteins associated with
Shradha Mawatwal et al.
Biochimica et biophysica acta, 1861(12), 3190-3200 (2017-09-25)
Phenotypic screening led to the identification of calcimycin as a potent inhibitor of Mycobacterium bovis BCG (M. bovis BCG) growth in vitro and in THP-1 cells. In the present study, we aim to decipher the mechanism of antimycobacterial activity of
Ju-Yeon Lee et al.
Bioorganic & medicinal chemistry letters, 19(21), 6053-6058 (2009-10-06)
Screening of library compounds has yielded pyrazolodiazepine derivatives with P2X7 receptor antagonist activity. To explore the structure-activity relationships (SAR) of these pyrazolodiazepines as human P2X7 receptor antagonists, derivatives were synthesized by substitutions at positions R2 and R3 of the pyrazolodiazepine
Ana B Ramos-Hryb et al.
Pharmacological reports : PR, 69(6), 1240-1246 (2017-11-13)
Ursolic acid has been shown to display antidepressant-like effects in mice through the modulation of monoaminergic systems. In this study, we sought to investigate the involvement of signaling pathways on the antidepressant-like effects of ursolic acid. Mice were treated orally
Beatriz Merino et al.
PloS one, 10(7), e0132884-e0132884 (2015-07-30)
This study evaluated the chronotropic and inotropic responses to glucagon in spontaneously beating isolated right atria of rat heart. For comparison, we also investigated the effects resulting from stimulating β-adrenoceptors with isoproterenol in this tissue. Isoproterenol increased both atrial frequency
Valery N Danilenko et al.
Journal of medicinal chemistry, 51(24), 7731-7736 (2008-12-05)
Aminomethylation of 9b,10-dihydro-1H-indolo[1,7:4,5,6]pyrrolo[3,4:2,3][1,4]diazepino-[1,7-a]indole-1,3(2H)-diones or 1H-indolo[1,7:4,5,6]pyrrolo[3,4:2,3][1,4]diazepino[1,7-a]indole-1,3(2H)-diones resulted in dialkylaminomethyl derivatives. Alkylation of the nitrogen atom of maleimide moiety of polyannelated diazepines with 1,3-dibromopropane and subsequent reaction with thiourea or its N-alkyl derivatives gave isothiourea-carrying compounds. The compounds containing isothiourea moiety were
Dobrin Draganov et al.
Scientific reports, 5, 16222-16222 (2015-11-11)
Overexpression of P2X7 receptors correlates with tumor growth and metastasis. Yet, release of ATP is associated with immunogenic cancer cell death as well as inflammatory responses caused by necrotic cell death at sites of trauma or ischemia-reperfusion injury. Using an
Yewei Liu et al.
American journal of physiology. Cell physiology, 303(3), C334-C347 (2012-06-01)
Reactive oxygen species (ROS) have been linked to oxidation and nuclear efflux of class IIa histone deacetylase 4 (HDAC4) in cardiac muscle. Here we use HDAC-GFP fusion proteins expressed in isolated adult mouse flexor digitorum brevis muscle fibers to study
Yangyang Yu et al.
International immunopharmacology, 49, 6-12 (2017-05-27)
Human LL-37 is an important class of cationic antimicrobial peptide (CAP) that is known to stimulate mast cell activation. While many studies have been conducted on LL-37, to date little is known about the functional receptors for LL-37-induced human mast
D Communi et al.
The Journal of biological chemistry, 274(21), 14734-14742 (1999-05-18)
D-myo-Inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) 3-kinase catalyzes the production of D-myo-inositol 1,3,4,5-tetrakisphosphate from the second messenger Ins (1,4,5)P3. Transient and okadaic acid-sensitive activation of Ins(1,4,5)P3 3-kinase by 8-10-fold is observed in homogenates prepared from rat cortical astrocytes after incubation with either carbachol
Kazutoshi Saito et al.
Toxicology in vitro : an international journal published in association with BIBRA, 40, 11-25 (2016-12-15)
To evaluate chemicals (e.g. lipophilic chemicals, pre/pro-haptens) that are difficult to correctly evaluate using in vitro skin sensitization tests (e.g. DPRA, KeratinoSens or h-CLAT), we developed a novel in vitro test termed "Epidermal Sensitization Assay: EpiSensA" that uses reconstructed human
Ivar S Stein et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(19), 3741-3750 (2020-04-24)
Structural plasticity of dendritic spines is a key component of the refinement of synaptic connections during learning. Recent studies highlight a novel role for the NMDA receptor (NMDAR), independent of ion flow, in driving spine shrinkage and LTD. Yet little
R J MacLeod et al.
The Journal of membrane biology, 172(1), 59-66 (1999-11-07)
To assess the activation of the charybdotoxin-insensitive K(+) channel responsible for Regulatory Volume Decrease (RVD) after substantial volume increases, we measured intracellular pH (pH(i)), intracellular calcium ([Ca(2+)](i)) and inhibitors of kinases and phosphoprotein phosphatases in guinea pig jejunal villus enterocytes
Stavroula Boubali et al.
Molecular immunology, 52(2), 51-60 (2012-05-15)
Calcium (Ca2+) plays an essential role in lymphocyte activation and differentiation by affecting signaling pathways leading to cytokine production. Among the enzymes responding to calcium increase, Ca2+/calmodulin-dependent protein kinase II (CaMKII) has been involved in anergy with a still poorly
Flavia D Toledo et al.
Archives of toxicology, 88(9), 1695-1709 (2014-03-13)
Oxidative stress (OS) is a common event in most hepatopathies, leading to mitochondrial permeability transition pore (MPTP) formation and further exacerbation of both OS from mitochondrial origin and cell death. Intracellular Ca²⁺ increase plays a permissive role in these events
Jian Peng et al.
International journal of molecular sciences, 20(18) (2019-09-11)
Social learning plays important roles in gaining new foraging skills and food preferences. However, the potential role and molecular mechanism of social learning in acquiring new feeding habits is less clear in fish. In the present study, we examined the
Ashok Kumar et al.
Aging, 11(14), 5140-5157 (2019-07-25)
We examined the contribution of N-methyl-D-aspartate receptor (NMDAR) subunits in the redox-mediated decline in NMDAR function during aging. GluN2A and GluN2B selective antagonists decreased peak NMDAR currents to a similar extent in young and aged animals, indicating that a shift
Srabani Mitra et al.
Purinergic signalling, 15(1), 119-123 (2018-12-14)
The pro-inflammatory cytokine IL-1β is a secreted protein that is cleaved by caspase-1 during inflammasome activation upon recognition of internal and external insults to cells. Purinergic receptor P2X7 has been described to be involved in the release pathway of bioactive
Chiung-Chun Huang et al.
The international journal of neuropsychopharmacology, 17(8), 1233-1242 (2014-02-22)
The intercalated cell masses (ITCs) of the amygdala are clusters of GABAergic interneurons that surround the basolateral complex of the amygdala. ITCs have been increasingly implicated in the acquisition and extinction of conditioned fear responses, but the underlying cellular mechanisms
Irma E Cisneros et al.
Frontiers in neurology, 11, 593146-593146 (2020-12-17)
Methamphetamine (METH) use, referred to as methamphetamine use disorder (MUD), results in neurocognitive decline, a characteristic shared with HIV-associated neurocognitive disorders (HAND). MUD exacerbates HAND partly through glutamate dysregulation. Astrocyte excitatory amino acid transporter (EAAT)-2 is responsible for >90% of
Ang Li et al.
American journal of physiology. Cell physiology, 299(6), C1308-C1317 (2010-10-12)
ATP release by nonpigmented (NPE) and pigmented (PE) ciliary epithelial cells is the enabling step in purinergic regulation of aqueous humor formation, but the release pathways are unknown. We measured ATP release from primary cultures of bovine mixed NPE and
Christina B Wölwer et al.
PloS one, 11(1), e0146201-e0146201 (2016-01-06)
Although erythroid enucleation, the property of erythroblasts to expel their nucleus, has been known for 7ore than a century, surprisingly little is known regarding the molecular mechanisms governing this unique developmental process. Here we show that similar to cytokinesis, nuclear
Delong Jiao et al.
Scientific reports, 7(1), 1848-1848 (2017-05-14)
The role of antimicrobial peptide LL-37 in asthma exacerbation is unclear. Microbial infection, which is the most common inducer of asthma exacerbation, is accompanied by elevated LL-37. The present study found that co-culture of eosinophils and bronchial epithelial cell line
Bruno de Araújo Herculano et al.
Behavioural brain research, 219(1), 92-97 (2010-12-28)
Preconditioning by N-methyl-d-aspartate (NMDA) may be promoted in vivo by the administration of a sub-convulsing dose of NMDA, with a neuroprotective effect against seizures and neuronal death induced by the infusion of quinolinic acid (QA) in mice. This study aimed
P O Bogatcheva et al.
Bulletin of experimental biology and medicine, 154(3), 316-319 (2013-03-14)
Calmodulin inhibitor W-7 did not cause changes in the quantal content of postsynaptic end-plate potentials (EPP) in newly formed synapses, but prevented facilitation of acetylcholine secretion induced by L-type Ca(2+)channels blocker nitrendipine. CaMKII inhibitor KN-62 produced similar effect and suppressed
Activation of inflammasome by attenuated Salmonella typhimurium in bacteria-mediated cancer therapy.
Thuy Xuan Phan et al.
Microbiology and immunology, 59(11), 664-675 (2015-10-27)
Escherichia coli and attenuated Salmonella both naturally accumulate in a tumor mass, yet have distinct therapeutic efficacy: the E. coli K-12 strain (MG1655) cannot induce as significant a tumor suppression as attenuated Salmonella typhimurium, despite similar levels of accumulation in
Satoshi Fujii et al.
Learning & memory (Cold Spring Harbor, N.Y.), 27(2), 52-66 (2020-01-18)
In CA1 neurons of guinea pig hippocampal slices, long-term potentiation (LTP) was induced in field excitatory postsynaptic potentials (EPSPs) or population spikes (PSs) by the delivery of high-frequency stimulation (HFS, 100 pulses at 100 Hz) to CA1 synapses, and was
Jing Wang et al.
Neuroscience letters, 653, 64-70 (2017-05-22)
Addictive substances mediate positive and negative states promoting compulsive drug use. However, substrates for aversive effects of drugs are not fully understood. We found that inactivation of the lateral habenula (LHb) by microinjection of tetrodotoxin (TTX) abolished naloxone-precipitated conditioned place
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