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immunoglobulin kappa variable 1/OR-2 (pseudogene)
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关键词:'immunoglobulin kappa variable 1/OR-2 (pseudogene)'
显示 1-22 共 22 条结果 关于 "immunoglobulin kappa variable 1/OR-2 (pseudogene)" 范围 论文
C Huber et al.
Nucleic acids research, 18(12), 3475-3478 (1990-06-25)
The VK gene segments that have been transposed from the kappa locus on the short arm of chromosome 2 at 2p11-12 to other chromosomal sites are called orphons. The 18 VK orphons sequenced up to now carry defects and are
Richard J N Allcock et al.
European journal of immunology, 33(2), 567-577 (2003-03-21)
We have characterized a cluster of single immunoglobulin variable (IgV) domain receptors centromeric of the major histocompatibility complex (MHC) on human chromosome 6. In addition to triggering receptor expressed on myeloid cells (TREM)-1 and TREM2, the cluster contains NKp44, a
E Lötscher et al.
Nature, 320(6061), 456-458 (1986-04-03)
The gene segments encoding the constant and variable regions of human immunoglobulin light chains of the kappa type (C kappa, V kappa) have been localized to chromosome 2. The distance between the C kappa and V kappa genes and the
T J Henderson et al.
Immunogenetics, 37(6), 426-436 (1993-01-01)
To examine genetic variation at immunoglobulin (Ig) multigene loci over short spans of evolutionary time, we have compared members of an Ig kappa chain variable (V kappa) region family from several mouse species. In this study, seven unique Igk-V24 family
M Pech et al.
Nucleic acids research, 12(24), 9229-9236 (1984-12-21)
The variable regions of immunoglobulins are encoded by multigene families which are rearranged during B-cell differentiation. These families were classified in groups and subgroups based on their amino acid sequences. Genes belonging to a distinct subgroup are believed to occur
B Straubinger et al.
Nucleic acids research, 15(22), 9567-9575 (1987-11-25)
Two gene segments coding for the variable region of human immunoglobulin light chains of the kappa type (VK genes, ref. 2) were found to have unusual structures. The two genes which are called A6 and A22 are located in duplicated
M Kawaichi et al.
The Journal of biological chemistry, 267(6), 4016-4022 (1992-02-25)
We have isolated a cDNA clone (RBP-2) for the protein (RBP-J kappa) which binds to immunoglobulin recombination signals with 23-base pair spacers (Matsunami, N., Hamaguchi, Y., Yamamoto, Y., Kuze, K., Kangawa, K., Matsuo, H., Kawaichi, M., and Honjo, T. (1989)
T J Vasicek et al.
The Journal of experimental medicine, 172(2), 609-620 (1990-08-01)
We determined the DNA sequence of two large regions of chromosome 22: 33.7 kb containing the C lambda complex; and 5.2 kb 5' of the functionally rearranged lambda gene from the human myeloma, U266. Analysis of these sequences reveals the
Fei Xiao et al.
Brain research, 1255, 180-189 (2008-12-27)
Proteomic analysis of cerebrospinal fluid (CSF) from patients with temporal lobe epilepsy (TLE) and controls was carried out using two-dimensional gel electrophoresis followed by liquid chromatography electrospray ionization tandem mass spectrometry. Five protein spots showed significant differential expression (p<0.05): vitamin
L Reininger et al.
Journal of immunology (Baltimore, Md. : 1950), 138(1), 316-323 (1987-01-01)
The variable (V) region sequences of six immunoglobulin M (IgM, kappa) monoclonal autoantibodies that recognize bromelinized isologous red blood cells, obtained by fusions of peritoneal cells from NZB or CBA/J nonimmunized mice with BALB/c myeloma cells, were determined by direct
S Eccles et al.
The New biologist, 2(9), 801-811 (1990-09-01)
In contrast to the mouse immunoglobulin heavy chain and kappa light chain genes, very little is known about the regulation of expression of the immunoglobulin lambda light chain locus. To identify elements responsible for lambda gene regulation we mapped DNaseI
Stephen Malin et al.
Nature immunology, 11(2), 171-179 (2009-12-01)
STAT5 and interleukin 7 (IL-7) signaling are thought to control B lymphopoiesis by regulating the expression of key transcription factors and by activating variable (V(H)) gene segments at the immunoglobulin heavy-chain (Igh) locus. Using conditional mutagenesis to delete the gene
R T Boyd et al.
Proceedings of the National Academy of Sciences of the United States of America, 83(23), 9134-9138 (1986-12-01)
Two phenotypic markers of mouse immunoglobulin kappa light chains, the IB-peptide marker and the Ef1a isoelectric focusing marker, are expressed by the C58/J, AKR/J, RF/J, and PL/J strains (called expressor strains) but not by BALB/c and most inbred strains. Expression
P Sanchez et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(24), 9185-9188 (1987-12-01)
Recently, we reported evidence for the existence of an immunoglobulin lambda light chain (lambda x) whose variable region differs from those encoded by the known V lambda gene segments V lambda 1 and V lambda 2. Expression of lambda x
Luis Requena et al.
Archives of dermatology, 139(4), 475-486 (2003-04-23)
Specific cutaneous involvement in patients with multiple myeloma (MM) is very uncommon. It usually occurs in late stages of MM as a reflection of increased tumor cell burden. We studied 8 patients with cutaneous involvement of MM without underlying bony
T J Henderson et al.
Immunogenetics, 37(6), 415-425 (1993-01-01)
We have examined the same kappa chain variable (V kappa) region family in several mouse species in order to observe short-term, incremental change at immunoglobulin (Ig) multigene loci. In the present study, the Igk-V24 family has been characterized in a
K P Lam et al.
The Journal of experimental medicine, 190(4), 471-477 (1999-08-17)
Mice expressing the immunoglobulin (Ig) heavy (H) chain variable (V) region from a rearranged V(H)12 gene inserted into the IgH locus generate predominantly B-1 cells, whereas expression of two other V(H) region transgenes (V(H)B1-8 and V(H)glD42) leads to the almost
S Weiss et al.
The EMBO journal, 6(4), 927-932 (1987-04-01)
Somatic point mutations are usually found in the coding and flanking regions of functionally and aberrantly rearranged immunoglobulin variable region gene segments. Mutations in the unrearranged V gene segments of myelomas or hybridomas have not been described so far. We
P D Ponath et al.
Immunogenetics, 29(4), 249-257 (1989-01-01)
The mouse Igk-VSer gene encodes an immunoglobulin kappa light chain variable region which gives rise to two phenotypic polymorphisms of mouse kappa chains. The nucleotide sequences of coding and flanking regions of the Igk-VSerc and Igk-VSerd alleles found in recently
H Schwarzenbach et al.
The Journal of biological chemistry, 270(2), 898-907 (1995-01-13)
The B cell-specific expression of immunoglobulin (Ig) genes is controlled by the concerted action of variable (V) region promoters and intronic or 3' enhancers, all of which are active in a lymphoid-specific manner. A crucial highly conserved element of the
Johnson Chia-Shen Yang et al.
Journal of biomedical science, 22, 40-40 (2015-06-11)
The NF-κB signaling pathway plays a role in local and remote tissue damage following ischemia-reperfusion (I/R) injury to skeletal muscles. Evidence suggests that exosomes can act as intercellular communicators by transporting active proteins to remote cells and may play a
L R Gottschalk et al.
Molecular and cellular biology, 10(10), 5486-5495 (1990-10-01)
A transcriptional enhancer has been mapped to a region 5.5 kilobases 3' of the C beta 2 gene in the human T-cell receptor (TCR) beta-chain locus. Transient transfections allowed localization of enhancer activity to a 480-base-pair HincII-XbaI restriction enzyme fragment.
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