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L2880
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E V Sokolova et al.
Carbohydrate polymers, 254, 117251-117251 (2020-12-29)
The research described here presents data on the effect of galactans of red algae, carrageenans (λ/μ/ν-, κ-, κ/β-, and ι/κ-types), and agar on complement system activation in normal human serum. The experiments were based on well surfaces coated with triggering
Zeinab Zarei Behjani et al.
Journal of cellular physiology, 234(8), 13942-13950 (2019-01-10)
Sepsis and related disorders, especially acute lung injury (ALI), are the most challenging life-threatening diseases in the hospital intensive care unit. Complex pathophysiology, unbalanced immune condition, and high rate of mortality complicate the treatment of sepsis. Recently, cell therapy has
Chuanzong Qi et al.
International immunopharmacology, 87, 106812-106812 (2020-07-25)
Organic cation transporter 1/2 (OCTN1/2) play important roles in the transport of drugs related to pulmonary inflammatory diseases. Nevertheless, the involvement of inflammation induced by cigarette smoke extract (CSE) combined with lipopolysaccharide (LPS) in the regulation of OCTN1/2 is not
Margaret T Armstrong et al.
PloS one, 8(11), e80192-e80192 (2013-11-28)
In vertebrates and arthropods, blood clotting involves the establishment of a plug of aggregated thrombocytes (the cellular clot) and an extracellular fibrillar clot formed by the polymerization of the structural protein of the clot, which is fibrin in mammals, plasma
Mariana de Castro Silva et al.
Reproduction (Cambridge, England), 160(4), 627-638 (2020-08-26)
A non-reversible state of epithelial to mesenchymal transition (EMT) at term accumulates proinflammatory mesenchymal cells and predisposes fetal membrane to weakening prior to delivery at term. We investigated the induction of EMT in amnion epithelial cells (AEC) in response to
Chong Liu et al.
World journal of gastroenterology, 15(46), 5843-5850 (2009-12-10)
To investigate the dysfunction of the immunological barrier of the intestinal mucosa during endotoxemia and to elucidate the potential mechanism of this dysfunction. Male Wistar rats were randomly distributed into two groups: control group and lipopolysaccharide (LPS) group. Endotoxemia was
Fang Han et al.
Fish & shellfish immunology, 91, 148-158 (2019-05-15)
The Rho family GTPase Rac1 acts as a molecular switch for signal transduction to regulate various cellular functions. Here, a Rac1 homolog (LcRac1) was identified in large yellow croaker (Larimichthys crocea), one of the most economically important marine fishes. The
Binglun Zhang et al.
Experimental and therapeutic medicine, 14(3), 2194-2200 (2017-10-01)
In the present study, two different rat models of sepsis, cecal ligation and puncture (CLP), and lipopolysaccharide (LPS), were established. Changes in autophagy in both models were compared using transmission electron microscopy (TEM), immunohistochemistry, western blotting, and quantitative polymerase chain
Stephanie G Dakin et al.
Science translational medicine, 7(311), 311ra173-311ra173 (2015-10-30)
Improved understanding of the role of inflammation in tendon disease is required to facilitate therapeutic target discovery. We studied supraspinatus tendons from patients experiencing pain before and after surgical subacromial decompression treatment. Tendons were classified as having early, intermediate, or
Samra Sardar et al.
Arthritis research & therapy, 21(1), 16-16 (2019-01-12)
Development of autoimmune diseases is the result of a complex interplay between hereditary and environmental factors, with multiple genes contributing to the pathogenesis in human disease and in experimental models for disease. The T-box protein 3 is a transcriptional repressor
Amy G Brown et al.
PloS one, 12(10), e0186656-e0186656 (2017-10-20)
Exposure to prenatal inflammation is associated with diverse adverse neurobehavioral outcomes in exposed offspring. The mechanism by which inflammation negatively impacts the developing brain is poorly understood. Metabolomic profiling provides an opportunity to identify specific metabolites, and novel pathways, which
Frank M Davis et al.
Journal of immunology (Baltimore, Md. : 1950), 204(9), 2503-2513 (2020-03-25)
Macrophages are critical for the initiation and resolution of the inflammatory phase of wound healing. In diabetes, macrophages display a prolonged inflammatory phenotype preventing tissue repair. TLRs, particularly TLR4, have been shown to regulate myeloid-mediated inflammation in wounds. We examined
Shaohong Fang et al.
Cell death & disease, 12(1), 88-88 (2021-01-20)
Inducing autophagy and inhibiting apoptosis may provide a therapeutic treatment for atherosclerosis (AS). For the treatment of progressive AS, arsenic trioxide (ATO) has been used to coat vascular stents. However, the effect of ATO on autophagy of macrophages is still
Sachiko Tanaka et al.
Journal of neuroinflammation, 10, 143-143 (2013-12-03)
Parkinson's disease (PD) is an age-related progressive neurodegenerative disorder caused by selective loss of dopaminergic neurons from the substantia nigra (SN) to the striatum. The initial factor that triggers neurodegeneration is unknown; however, inflammation has been demonstrated to be significantly
Sabine Vettorazzi et al.
Nature communications, 6, 7796-7796 (2015-07-18)
Acute lung injury (ALI) is a severe inflammatory disease for which no specific treatment exists. As glucocorticoids have potent immunosuppressive effects, their application in ALI is currently being tested in clinical trials. However, the benefits of this type of regimen
Magdalena Maciuszek et al.
Fish physiology and biochemistry, 46(5), 1775-1794 (2020-06-11)
Inflammation is the evolutionary conserved immune response to harmful stimuli such as pathogens or damaged cells. This multistep process acts by removing injurious stimuli and initiating the healing process. Therefore, it must be tightly regulated by cytokines, chemokines, and enzymes
Monica Yabal et al.
Cell reports, 7(6), 1796-1808 (2014-06-03)
X-linked inhibitor of apoptosis protein (XIAP) has been identified as a potent regulator of innate immune responses, and loss-of-function mutations in XIAP cause the development of the X-linked lymphoproliferative syndrome type 2 (XLP-2) in humans. Using gene-targeted mice, we show
Fan Chen et al.
Bone research, 8, 10-10 (2020-03-07)
The inflammatory response is induced by the overexpression of inflammatory cytokines, mainly interleukin (IL)-1β, and is one of the main causes of intervertebral disc degeneration (IVDD). NLR pyrin domain containing 3 (NLRP3) inflammasome activation is an important source of IL-1β.
Dong-Ki Kim et al.
PloS one, 11(1), e0147553-e0147553 (2016-01-23)
TNF-α stimulated gene/protein 6 (TNFAIP6/TSG-6) is a multifunctional protein that has a number of potential therapeutic applications. Experiments and clinical trials with TSG-6, however, have been limited by the technical difficulties of producing the recombinant protein. We prepared stable clones
Yadav Adhikari et al.
Epilepsia open, 5(3), 386-396 (2020-09-12)
Sudden unexpected death in epilepsy (SUDEP) is the cause of premature death of 50% patients with chronic refractory epilepsy. Respiratory failure during seizures is regarded as an important mechanism of SUDEP. Previous studies have shown that abnormal serotonergic neurotransmission is
Irene Cimino et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(27) (2021-07-01)
An acute increase in the circulating concentration of glucocorticoid hormones is essential for the survival of severe somatic stresses. Circulating concentrations of GDF15, a hormone that acts in the brain to reduce food intake, are frequently elevated in stressful states.
Li Zhang et al.
International journal of molecular medicine, 35(4), 1003-1010 (2015-02-20)
Mesenchymal stem cells (MSCs) have been applied to cell-based therapy due to their multiple differentiation ability, the low expression of co-stimulatory molecules and immunosuppressive properties. Despite their immunomodulatory role, the issue of the survival and permanence of MSCs at the
Xin Li et al.
Life sciences, 261, 118314-118314 (2020-08-25)
Placental tissues from patients with preeclampsia (PE) and in the lipopolysaccharide (LPS)-induced PE-like model were used to investigate the implication of placental inflammation and apoptosis in PE. Whether the beneficial effects of nicotine are related to inhibition of placental inflammation
Bing Liu et al.
Environmental technology, 40(20), 2684-2694 (2018-03-08)
Municipal wastewater treatment plant (WWTP) effluent is increasingly used as reclaimed water and as water sources for downstream areas. Effluent dissolved organic nitrogen (DON) is considered to be the precursor to nitrogen disinfection by-products (N-DBPs). Here, we investigated DON removal
Hugo de Vries et al.
Microorganisms, 8(10) (2020-10-18)
Piglets are susceptible to infections in early life and around weaning due to rapid environmental and dietary changes. A compelling target to improve pig health in early life is diet, as it constitutes a pivotal determinant of gut microbial colonization
Jing-Yun Lin et al.
Developmental and comparative immunology, 52(2), 166-171 (2015-05-31)
Myeloid differentiation factor 88 (MyD88) is an adapter protein involved in the interleukin-1 receptor (IL-1R) and Toll-like receptor (TLR)-mediated activation of nuclear factor-kappaB (NF-κB). In this study, a full length cDNA of MyD88 was cloned from turbot, Scophthalmus maximus. It
Evangelos J Giamarellos-Bourboulis et al.
Cell, 183(2), 315-323 (2020-09-18)
BCG vaccination in children protects against heterologous infections and improves survival independently of tuberculosis prevention. The phase III ACTIVATE trial assessed whether BCG has similar effects in the elderly. In this double-blind, randomized trial, elderly patients (n = 198) received BCG
Yunan Mo et al.
Biochemical and biophysical research communications, 520(1), 171-178 (2019-10-05)
SS-31 is a kind of mitochondrion-targeted peptide. Recent studies indicated significant neuroprotective effects of SS-31. In this study, we investigated that SS-31 protected the murine cultured microglial cells (BV-2) against lipopolysaccharide (LPS)-induced inflammation and oxidative stress through stabilizing mitochondrial morphology.
Laura D Weinstock et al.
Frontiers in bioengineering and biotechnology, 8, 666-666 (2020-08-09)
Macrophage activity is a major component of the healthy response to infection and injury that consists of tightly regulated early pro-inflammatory activation followed by anti-inflammatory and regenerative activity. In numerous diseases, however, macrophage polarization becomes dysregulated and can not only
Stine Mandrup Andreassen et al.
BMC veterinary research, 11, 141-141 (2015-06-28)
Studies in humans have shown that haemostatic and inflammatory pathways both play important roles in the pathogenesis of joint disease. The aim of this study was to assess mRNA expression of haemostatic and inflammatory factors in cultured equine fibroblast-like synoviocytes
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