L4250

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The functional interplay between the t(9;22)-associated fusion proteins BCR/ABL and ABL/BCR in Philadelphia chromosome-positive acute lymphatic leukemia.

Anahita Rafiei et al.

PLoS genetics, 11(4), e1005144-e1005144 (2015-04-29)

The hallmark of Philadelphia chromosome positive (Ph(+)) leukemia is the BCR/ABL kinase, which is successfully targeted by selective ATP competitors. However, inhibition of BCR/ABL alone is unable to eradicate Ph(+) leukemia. The t(9;22) is a reciprocal translocation which encodes not

Topical surfactant-induced pruritus: involvement of histamine released from epidermal keratinocytes.

Yoshihiro Inami et al.

The Journal of pharmacology and experimental therapeutics, 344(2), 459-466 (2012-12-12)

Surfactants, an important component of cleansers, often cause itch in humans. Topical application of sodium laurate and N-lauroylsarcosine sodium salt to the skin of mice immediately (for 1-1.5 hours) increased scratching, and the former increased scratching again between 2 and

Crosslinked self-assemblies of lipoid acid-substituted low molecular weight (1800 Da) polyethylenimine as reductive-sensitive non-viral gene vectors.

Xiaojiao Chen et al.

Nanotechnology, 23(41), 415602-415602 (2012-09-27)

In this study, amphiphilic polyethylenimine-graft-thioctic acid (PEI-TA) and polyethylenimine-graft-lauric acid (PEI-LA) were synthesized. Both PEI-TA and PEI-LA could self-assemble into micelles. Due to the existence of disulfide-linked rings at the end of hydrophobic moieties, PEI-TA could form stable micelles with

LASP1 is a novel BCR-ABL substrate and a phosphorylation-dependent binding partner of CRKL in chronic myeloid leukemia.

Jochen J Frietsch et al.

Oncotarget, 5(14), 5257-5271 (2014-06-11)

Chronic myeloid leukemia (CML) is characterized by a genomic translocation generating a permanently active BCR-ABL oncogene with a complex pattern of atypically tyrosine-phosphorylated proteins that drive the malignant phenotype of CML. Recently, the LIM and SH3 domain protein 1 (LASP1)

Hyperdiploidy associated with T315I mutation in BCR-ABL kinase domain in an accelerated phase-chronic myeloid leukemia case.

Walid Al-Achkar et al.

Molecular cytogenetics, 7(1), 89-89 (2015-01-27)

Chronic myeloid leukemia (CML) is genetically characterized by the occurrence of a reciprocal translocation t(9;22)(q34;q11), resulting in a BCR/ABL gene fusion on the derivative chromosome 22, i.e. the Philadelphia (Ph) chromosome. During CML progression 60-80% of the cases acquire additional

Metabolite Fingerprinting of Eugenia jambolana Fruit Pulp Extracts using NMR, HPLC-PDA-MS, GC-MS, MALDI-TOF-MS and ESI-MS/MS Spectrometry.

Ram Jee Sharma et al.

Natural product communications, 10(6), 969-976 (2015-07-23)

Eugenia jambolana, commonly known as 'jamun' or Indian blackberry, is an important source of bioactive compounds. All parts of the plant like stem bark, leaves, flower, fruit pulp and seeds are traditionally used for many diseases. Metabolite profiling in medicinally

Antimicrobial activity of saturated fatty acids and fatty amines against methicillin-resistant Staphylococcus aureus.

Takashi Kitahara et al.

Biological & pharmaceutical bulletin, 27(9), 1321-1326 (2004-09-02)

The objective of this study was to investigate the antimicrobial activities of saturated fatty acids and fatty amines against methicillin-resistant Staphylococcus aureus (MRSA). The antimicrobial activity of saturated fatty acids and fatty amines was determined by oxygen meters with multi-channels

Thyroid hormone responsive protein Spot14 enhances catalysis of fatty acid synthase in lactating mammary epithelium.

Michael C Rudolph et al.

Journal of lipid research, 55(6), 1052-1065 (2014-04-29)

Thyroid hormone responsive protein Spot 14 has been consistently associated with de novo fatty acid synthesis activity in multiple tissues, including the lactating mammary gland, which synthesizes large quantities of medium chain fatty acids (MCFAs) exclusively via FASN. However, the

Micellar catalytic effect as a factor of lipase activity regulation.

L R Bogdanova et al.

Doklady. Biochemistry and biophysics, 446, 238-241 (2012-11-08)

Phase 1/2 study of nilotinib prophylaxis after allogeneic stem cell transplantation in patients with advanced chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia.

Avichai Shimoni et al.

Cancer, 121(6), 863-871 (2014-11-13)

Allogeneic stem cell transplantation (SCT) remains the standard treatment for advanced chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL). Relapsed disease is the major cause of treatment failure, especially when SCT is given in the setting

Therapeutic envelope vaccination in combination with antiretroviral therapy temporarily rescues SIV-specific CD4⁺ T-cell-dependent natural killer cell effector responses in chronically infected rhesus macaques.

Diego A Vargas-Inchaustegui et al.

Immunology, 145(2), 288-299 (2015-01-30)

Natural killer (NK) cells are essential components of the immune system, and due to their rapid response potential, can have a great impact during early anti-viral immune responses. We have previously shown that interleukin-2-dependent NK and CD4(+) T-cell co-operative immune

Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes.

P K Powell et al.

Archives of biochemistry and biophysics, 335(1), 219-226 (1996-11-01)

Human liver microsomes are capable of oxidizing lauric acid (laurate), a model medium-chain fatty acid, at both the omega- and omega-1 positions to form 12- and 11-hydroxylaurate, respectively. These laurate hydroxylation reactions are apparently catalyzed by distinct P450 enzymes. While

Magnetic Biocomposites for Remote Melting.

Mengbo Zhou et al.

Biomacromolecules, 16(8), 2308-2315 (2015-07-03)

A new approach toward the fabrication of biocompatible composites suitable for remote melting is presented. It is shown that magnetite nanoparticles (MNP) can be embedded into a matrix of biocompatible thermoplastic dextran esters. For that purpose, fatty acid esters of

Human skin permeability enhancement by lauric acid under equilibrium aqueous conditions.

S W Smith et al.

Journal of pharmaceutical sciences, 84(5), 551-556 (1995-05-01)

An in vitro method was developed to investigate the enhancement of hydrocortisone transport across human stratum corneum (SC) by a model enhancer, lauric acid, in aqueous solutions under equilibrium conditions with respect to the enhancer. In contrast to classical (i.e.

Non-animal photosafety screening for complex cosmetic ingredients with photochemical and photobiochemical assessment tools.

Hayato Nishida et al.

Regulatory toxicology and pharmacology : RTP, 72(3), 578-585 (2015-06-07)

Previously, a non-animal screening approach was proposed for evaluating photosafety of cosmetic ingredients by means of in vitro photochemical and photobiochemical assays; however, complex cosmetic ingredients, such as plant extracts and polymers, could not be evaluated because their molecular weight

Improved performance of dye-sensitized solar cells using dual-function TiO(2) nanowire photoelectrode.

Zico Alaia Akbar et al.

Optics express, 23(19), A1280-A1287 (2015-09-26)

A unique, hierarchically structured, aggregated TiO(2) nanowire (A-TiO(2)-nw) is prepared by solvothermal synthesis and used as a dual-functioning photoelectrode in dye-sensitized solar cells (DSSCs). The A-TiO(2)-nw shows improved light scattering compared to conventional TiO(2) nanoparticles (TiO(2)-np) and dramatically enhanced dye

Characteristics of sugar surfactants in stabilizing proteins during freeze-thawing and freeze-drying.

Koreyoshi Imamura et al.

Journal of pharmaceutical sciences, 103(6), 1628-1637 (2014-05-07)

Sugar surfactants with different alkyl chain lengths and sugar head groups were compared for their protein-stabilizing effect during freeze-thawing and freeze-drying. Six enzymes, different in terms of tolerance against inactivation because of freeze-thawing and freeze-drying, were used as model proteins.

Efficacy of the polo-like kinase inhibitor rigosertib, alone or in combination with Abelson tyrosine kinase inhibitors, against break point cluster region-c-Abelson-positive leukemia cells.

Seiichi Okabe et al.

Oncotarget, 6(24), 20231-20240 (2015-05-27)

The potency of Abelson (ABL) tyrosine kinase inhibitors (TKIs) against chronic myeloid leukemia (CML) has been demonstrated. However, ABL TKI resistance can develop. In this study, we investigated the efficacy of a combination therapy including rigosertib (ON 01910.Na), a polo-like

Basal Lamina Mimetic Nanofibrous Peptide Networks for Skeletal Myogenesis.

I Ceren Yasa et al.

Scientific reports, 5, 16460-16460 (2015-11-12)

Extracellular matrix (ECM) is crucial for the coordination and regulation of cell adhesion, recruitment, differentiation and death. Therefore, equilibrium between cell-cell and cell-matrix interactions and matrix-associated signals are important for the normal functioning of cells, as well as for regeneration.

The effect of aliphatic carboxylic acids on olfaction-based host-seeking of the malaria mosquito Anopheles gambiae sensu stricto.

Renate C Smallegange et al.

Journal of chemical ecology, 35(8), 933-943 (2009-07-25)

The role of aliphatic carboxylic acids in host-seeking response of the malaria mosquito Anopheles gambiae sensu stricto was examined both in a dual-choice olfactometer and with indoor traps. A basic attractive blend of ammonia + lactic acid served as internal

How relevant are assembled equilibrium samples in understanding structure formation during lipid digestion?

Stephanie Phan et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 96, 117-124 (2015-07-28)

Lipid-based formulations are gaining interest for use as drug delivery systems for poorly water-soluble drug compounds. During digestion, the lipolysis products self-assemble with endogenous surfactants in the gastrointestinal tract to form colloidal structures, enabling enhanced drug solubilisation. Although earlier studies

Expression of Tight Junction Components in Hepatocyte-Like Cells Differentiated from Human Embryonic Stem Cells.

Boglárka Erdélyi-Belle et al.

Pathology oncology research : POR, 21(4), 1059-1070 (2015-04-08)

Human embryonic stem cells can be differentiated in vitro into a wide variety of progeny cells by addition of different morphogens and growth factors. Our aim was to monitor the expression pattern of tight junction (TJ) components and various cellular

A model to predict the ATP equivalents of macronutrients absorbed from food.

Leah Coles et al.

Food & function, 4(3), 432-442 (2012-12-13)

Calculating the physiologically available energy of food at the cellular level (ATP), based on known stoichiometric relationships and predicted nutrient uptake from the human digestive tract may be more accurate than using currently available factorial or empirical models for estimating

MRD assessed by WT1 and NPM1 transcript levels identifies distinct outcomes in AML patients and is influenced by gemtuzumab ozogamicin.

Juliette Lambert et al.

Oncotarget, 5(15), 6280-6288 (2014-07-16)

We analysed the prognostic significance of minimal residual disease (MRD) level in adult patients with acute myeloid leukemia (AML) treated in the randomized gemtuzumab ozogamicin (GO) ALFA-0701 trial. Levels of WT1 and NPM1 gene transcripts were assessed using cDNA-based real-time

Comparison of nitroethane, 2-nitro-1-propanol, lauric acid, Lauricidin® and the Hawaiian marine algae, Chaetoceros, for potential broad-spectrum control of anaerobically grown lactic acid bacteria.

Aleksandar K Božic et al.

Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 47(4), 269-274 (2012-03-21)

The gastrointestinal tract of bovines often contains bacteria that contribute to disorders of the rumen, and may also contain foodborne or opportunistic human pathogens as well as bacteria capable of causing mastitis in cows. Thus there is a need to

Can tonsillectomy modify the innate and adaptive immunity pathways involved in IgA nephropathy?

Luca Vergano et al.

Journal of nephrology, 28(1), 51-58 (2014-04-24)

The benefits of tonsillectomy in IgA nephropathy (IgAN) are still debated. Tonsillectomy may remove pathogen sources and reduce the mucosal associated lymphoid tissue (MALT), limiting degalactosylated IgA1 (deGal-IgA1) production, which is considered to be the initiating pathogenetic event leading to

Alveolar bone loss is associated with circulating anti-citrullinated protein antibody (ACPA) in patients with rheumatoid arthritis.

Shawneen M Gonzalez et al.

Journal of periodontology, 86(2), 222-231 (2014-10-10)

This study examines: 1) alveolar bone loss (ABL), a hallmark of periodontitis, in anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA) patients versus control patients with osteoarthritis (OA); and 2) the association of ABL with RA disease activity and ACPA concentrations

Effects of synthetic alkamides on Arabidopsis fatty acid amide hydrolase activity and plant development.

Lionel Faure et al.

Phytochemistry, 110, 58-71 (2014-12-11)

Alkamides and N-acylethanolamines (NAEs) are bioactive, amide-linked lipids that influence plant development. Alkamides are restricted to several families of higher plants and some fungi, whereas NAEs are widespread signaling molecules in both plants and animals. Fatty acid amide hydrolase (FAAH)

Ferrofluid of magnetic clay and menthol based deep eutectic solvent: Application in directly suspended droplet microextraction for enrichment of some emerging contaminant explosives in water and soil samples.

Ali Reza Zarei et al.

Journal of chromatography. A, 1553, 32-42 (2018-04-21)

In this work, for the first time, ferrofluid of magnetic montmorillonite nanoclay and deep eutectic solvent was prepared and coupled with directly suspended droplet microextraction. Incorporation of ferrofluid in a miniaturized sample preparation technique resulted in achieving high extraction efficiency

Development of drug-in-adhesive patch formulations for transdermal delivery of fluoxetine: In vitro and in vivo evaluations.

Eunjae Jung et al.

International journal of pharmaceutics, 487(1-2), 49-55 (2015-04-12)

The aim of this study was to develop drug-in adhesive (DIA) patch formulations for the transdermal delivery of fluoxetine (FX). The DIA patch formulations containing FX were prepared and optimized with various pressure sensitive adhesives, drug contents and enhancers. Among

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