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Siddhartha Jaiswal et al.
Cell, 138(2), 271-285 (2009-07-28)
Macrophages clear pathogens and damaged or aged cells from the blood stream via phagocytosis. Cell-surface CD47 interacts with its receptor on macrophages, SIRPalpha, to inhibit phagocytosis of normal, healthy cells. We find that mobilizing cytokines and inflammatory stimuli cause CD47
Qing Lu et al.
American journal of respiratory cell and molecular biology, 57(6), 662-673 (2017-08-02)
Inhalation of acrolein, a highly reactive aldehyde, causes lung edema. The underlying mechanism is poorly understood and there is no effective treatment. In this study, we demonstrated that acrolein not only dose-dependently induced lung edema but also promoted LPS-induced acute
Ryusuke Yoshimi et al.
Journal of immunology (Baltimore, Md. : 1950), 182(12), 7527-7538 (2009-06-06)
The tripartite motif (TRIM) family member, TRIM21, is an E3 ubiquitin ligase for IFN regulatory factor (IRF)3 and IRF8 that functions in both innate and acquired immunity. It is also an autoantigen known as Ro52/SS-A. The function of TRIM21 in
Sebastian E Winter et al.
Infection and immunity, 77(5), 1904-1916 (2009-02-25)
Salmonella enterica serotype Typhimurium causes acute inflammatory diarrhea in humans. Flagella contribute to intestinal inflammation, but the mechanism remains unclear since most mutations abrogating pattern recognition of flagellin also prevent motility and reduce bacterial invasion. To determine the contribution of
Patty Zwollo et al.
Developmental and comparative immunology, 32(12), 1482-1496 (2008-07-12)
To date, the trout B-cell is poorly defined, as many essential molecular markers are not yet available for this species. In mammalian systems, the transcription factor Pax5, expressed from pre-B through plasmablast stages, provides an important marker for B-cell differentiation.
Janny C de Grauw et al.
Arthritis research & therapy, 11(2), R35-R35 (2009-03-11)
Inflammation is an important feature of many joint diseases, and levels of cartilage biomarkers measured in synovial fluid may be influenced by local inflammatory status. Little is known about the magnitude and time course of inflammation-induced changes in cartilage tissue
Eric Danilo Pauls Sotelo et al.
Veterinary sciences, 7(2) (2020-05-06)
Several studies in human and equine medicine have produced controversial results regarding the role of dimethylsulfoxide (DMSO) as a therapeutic agent. This study aimed to evaluate the effect of joint lavage with different DMSO concentrations on biomarkers of synovial fluid
Jiani Wang et al.
Scientific reports, 10(1), 12785-12785 (2020-08-01)
Elafin is an antimicrobial and anti-inflammatory protein. We hypothesize that elafin expression correlates with diabetes. Among non-diabetic and prediabetic groups, men have significantly higher serum elafin levels than women. Men with type 2 diabetes mellitus (T2DM) have significantly lower serum
Suhas G Kallapur et al.
American journal of respiratory and critical care medicine, 179(10), 955-961 (2009-02-24)
Chorioamnionitis frequently associates with preterm delivery and increased amniotic fluid IL-1, and causes fetal lung and systemic inflammation. However, chorioamnionitis is also associated with a paradoxical reduction in the incidence of surfactant deficiency-related respiratory distress syndrome in preterm infants. To
A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury.
Feng Qian et al.
The EMBO journal, 28(19), 2896-2907 (2009-08-22)
There are at least 11 mitogen-activated protein kinase (MAPK) phosphatases (MKPs) and only 3 major groups of MAPKs, raising the question of whether these phosphatases have non-redundant functions in vivo. Using a modified mouse model of local Shwartzman reaction, we
Lauren E Adams et al.
Antioxidants (Basel, Switzerland), 10(3) (2021-04-04)
Therapeutic hypothermia does not improve outcomes in neonatal hypoxia ischemia (HI) complicated by perinatal infection, due to well-described, pre-existing oxidative stress and neuroinflammation that shorten the therapeutic window. For effective neuroprotection post-injury, we must first define and then target CNS
Lina E Tze et al.
The Journal of experimental medicine, 208(1), 149-165 (2011-01-12)
Effective vaccine adjuvants must induce expression of major histocompatibility (MHC) class II proteins and the costimulatory molecule CD86 on dendritic cells (DCs). However, some adjuvants elicit production of cytokines resulting in adverse inflammatory consequences. Development of agents that selectively increase
Yan Su et al.
Frontiers in microbiology, 2, 154-154 (2011-08-04)
Genetically modified B cells are excellent tolerogenic antigen-presenting cells (APCs) in multiple models of autoimmunity. However, the mechanisms of action are still not completely understood. In our models, we generate antigen-specific tolerogenic B cells by transducing naïve or primed B
Sylvain Losdat et al.
PloS one, 6(7), e22221-e22221 (2011-07-19)
Mounting an immune response against pathogens incurs costs to organisms by its effects on important life-history traits, such as reproductive investment and survival. As shown recently, immune activation produces large amounts of reactive species and is suggested to induce oxidative
Ignacio M Larrayoz et al.
Journal of hypertension, 27(12), 2365-2376 (2009-09-05)
Inhibition of angiotensin II receptor type 1 (AT1) reduces chronic inflammation associated with hypertension. We asked whether AT1 receptor inhibition would reduce the innate inflammatory response induced by bacterial lipopolysaccharide (LPS). We used unstimulated human circulating monocytes obtained from healthy
Sarah K Meadows et al.
PloS one, 3(4), e1912-e1912 (2008-04-03)
Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures. We have sought to determine the impact of several variables on the PB gene expression profile of an environmental
Pavlo Sakhatskyy et al.
American journal of physiology. Lung cellular and molecular physiology, 312(1), L56-L67 (2016-11-20)
Epidemiological studies indicate that cigarette smoking (CS) increases the risk and severity of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). The mechanism is not understood, at least in part because of lack of animal models that reproduce the key
Gillian D Pullinger et al.
Infection and immunity, 76(11), 5310-5321 (2008-09-17)
Salmonella enterica serovar Dublin is a host-restricted serovar associated with typhoidal disease in cattle. In contrast, the fowl-associated serovar S. enterica serovar Gallinarum is avirulent in calves, yet it invades ileal mucosa and induces enteritis at levels comparable to those
Katrina Ask et al.
Animals : an open access journal from MDPI, 10(11) (2020-11-25)
Equine orthopedic pain scales are targeted towards horses with moderate to severe orthopedic pain. Improved assessment of pain behavior and pain-related facial expressions at rest may refine orthopedic pain detection for mild lameness grades. Therefore, this study explored pain-related behaviors
J L Hayworth et al.
Clinical and experimental immunology, 157(1), 60-70 (2009-08-08)
Staphylococcal enterotoxin B (SEB) is a pyrogenic exotoxin and a potent superantigen which causes massive T cell activation and cytokine secretion, leading to profound immunosuppression and morbidity. The inhibition of SEB-induced responses is thus considered a goal in the management
Jen-Ruey Tang et al.
Journal of immunology (Baltimore, Md. : 1950), 190(6), 2913-2923 (2013-02-19)
Exposure to intrauterine inflammation impairs lung growth but paradoxically protects the neonatal pulmonary vasculature from hyperoxic injury. The mechanisms mediating these contradictory effects are unknown. The objective is to identify the role of NF-κB in mediating cytoprotective and proinflammatory responses
M Croes et al.
European cells & materials, 33, 211-226 (2017-03-08)
To explore the influence of inflammatory processes on bone formation, we applied a new in vivo screening model. Confined biological pockets were first created in rabbits as a response to implanted bone cement discs. These biomembrane pockets were subsequently used
Jan Mauer et al.
Nature immunology, 15(5), 423-430 (2014-04-01)
Obesity and resistance to insulin are closely associated with the development of low-grade inflammation. Interleukin 6 (IL-6) is linked to obesity-associated inflammation; however, its role in this context remains controversial. Here we found that mice with an inactivated gene encoding
Chong Liu et al.
World journal of gastroenterology, 15(46), 5843-5850 (2009-12-10)
To investigate the dysfunction of the immunological barrier of the intestinal mucosa during endotoxemia and to elucidate the potential mechanism of this dysfunction. Male Wistar rats were randomly distributed into two groups: control group and lipopolysaccharide (LPS) group. Endotoxemia was
Wilhelmina M G A C Groen et al.
International journal of molecular sciences, 21(22) (2020-11-19)
Gelatine methacryloyl (GelMA) hydrogels are widely used in studies aimed at cartilage regeneration. However, the endotoxin content of commercially available GelMAs and gelatines used in these studies is often overlooked, even though endotoxins may influence several cellular functions. Moreover, regulations
Jennifer M Monk et al.
International journal of environmental research and public health, 8(1), 117-135 (2011-02-15)
The tolerance model of acute (i.e., wasting) pre-pubescent protein and energy deficits proposes that the immune depression characteristic of these pathologies reflects an intact anti-inflammatory form of immune competence that reduces the risk of autoimmune reactions to catabolically released self
Olivia Sheppard et al.
Journal of neuroinflammation, 16(1), 106-106 (2019-05-20)
Systemic inflammation has been linked to synapse loss and cognitive decline in human patients and animal models. A role for microglial release of pro-inflammatory cytokines has been proposed based on in vivo and primary culture studies. However, mechanisms are hard
Xue-Qing Wu et al.
Reproduction (Cambridge, England), 141(2), 241-248 (2010-11-19)
Neonatal exposure to an immunological challenge (lipopolysaccharide, LPS) increases the activity of hypothalamo-pituitary-adrenal axis and sensitises the GNRH pulse generator to the inhibitory influence of stress in adult rats. We investigated the effects of neonatal exposure to LPS on various
Julien Vézilier et al.
Evolutionary applications, 6(3), 497-509 (2013-06-08)
Because of their role as vectors of diseases, the evolution of insecticide resistance in mosquitoes has been intensively investigated. Insecticide resistance is associated to a wide range of pleiotropic effects on several key life-history traits of mosquitoes such as longevity
Kenjiro Bandow et al.
Biochemical and biophysical research communications, 402(4), 755-761 (2010-11-03)
Osteoblasts express Toll like receptor (TLR) 4 and produce osteoclast-activating cytokines in response to the stimulation by lipopolysaccharide (LPS). It has recently been reported that LPS exerts an inhibitory effect on osteoblast differentiation into osteocytes. However, the molecular mechanisms of
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