L8662

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Trace-level determination of sweeteners in sewage sludge using selective pressurized liquid extraction and liquid chromatography-tandem mass spectrometry.

Paula Arbeláez et al.

Journal of chromatography. A, 1408, 15-21 (2015-07-23)

The occurrence of sweeteners in the environment has become a matter of concern due to the possibility of adverse effects on human health and wildlife species. One of the routes by which sweeteners enter the environment is through sewage sludge.

Cytotoxicity testing of silver-containing burn treatments using primary and immortal skin cells.

Benjawan Boonkaew et al.

Burns : journal of the International Society for Burn Injuries, 40(8), 1562-1569 (2014-04-29)

A novel burn wound hydrogel dressing has been previously developed which is composed of 2-acrylamido-2-methylpropane sulfonic acid sodium salt with silver nanoparticles (silver AMPS). This study compared the cytotoxicity of this dressing to the commercially available silver products; Acticoat™, PolyMem

Nitric Oxide Plays a Central Role in Water Stress-Induced Tanshinone Production in Salvia miltiorrhiza Hairy Roots.

Xuhong Du et al.

Molecules (Basel, Switzerland), 20(5), 7574-7585 (2015-04-29)

Nitric oxide (NO), a well-known signaling molecule plays an important role in abiotic and biotic stress-induced production of plant secondary metabolites. In this study, roles of NO in water stress-induced tanshinone production in Salvia miltiorrhiza hairy roots were investigated. The

Preparation of pellets with controlled release of glucose as prevention of hypoglycaemia in paediatric patients.

Aleš Franc et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 75, 72-80 (2015-03-26)

Hypoglycaemic episodes represent serious and frequent complications of type 1 and 2 diabetes. Theoretically, the risk of hypoglycaemic states can be affected by a dosage form based on a food supplement containing a delayed release formulation of glucose. The release

Protein classification and distribution in osteoarthritic human synovial tissue by matrix-assisted laser desorption ionization mass spectrometry imaging.

Berta Cillero-Pastor et al.

Analytical and bioanalytical chemistry, 407(8), 2213-2222 (2014-12-17)

The remodeling of the synovial membrane, which normally lubricates the joints by producing synovial fluid, is one of the most characteristic events in the pathology of osteoarthritis (OA). The heterogeneity and spatial distribution of proteins in the synovial membrane are

Small-sized polymeric micelles incorporating docetaxel suppress distant metastases in the clinically-relevant 4T1 mouse breast cancer model.

Yunfei Li et al.

BMC cancer, 14, 329-329 (2014-06-03)

The small size of ultra-small nanoparticles makes them suitable for lymphatic delivery, and many recent studies have examined their role in anti-metastasis therapy. However, the anti-metastatic efficacy of small-sized nanocarriers loaded with taxanes such as docetaxel has not yet been

Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity.

Gesche Willjes et al.

Biochemistry, 52(22), 3930-3938 (2013-05-08)

Botulinum neurotoxins (BoNTs) block neurotransmitter release by proteolyzing SNARE proteins in peripheral nerve terminals. Entry into neurons occurs subsequent to interaction with gangliosides and a synaptic vesicle protein. Isoforms I and II of synaptotagmin were shown to act as protein

Efficient differentiation of stem cells encapsulated in a cytocompatible phospholipid polymer hydrogel with tunable physical properties.

Haruka Oda et al.

Biomaterials, 56, 86-91 (2015-05-03)

A large number of lineage-committed progenitor cells are required for advanced regenerative medicine based on cell engineering. Due to their ability to differentiate into multiple cells lines, multipotent stem cells have emerged as a vital source for generating transplantable cells

Metal-carbon fiber composite femoral stems in hip replacements: a randomized controlled parallel-group study with mean ten-year follow-up.

D B Bennett et al.

The Journal of bone and joint surgery. American volume, 96(24), 2062-2069 (2014-12-19)

Attempts to improve proximal load transfer and minimize stress shielding have included reducing the stiffness of femoral stems and using alternative stem materials, including carbon fiber composites. An uncemented implant (SR71) composed of a carbon-fiber-composite distal section and a porous-coated

Acute Iron Deprivation Reprograms Human Macrophage Metabolism and Reduces Inflammation In Vivo.

Marie Pereira et al.

Cell reports, 28(2), 498-511 (2019-07-11)

Iron is an essential metal that fine-tunes the innate immune response by regulating macrophage function, but an integrative view of transcriptional and metabolic responses to iron perturbation in macrophages is lacking. Here, we induced acute iron chelation in primary human

A generic approach to engineer antibody pH-switches using combinatorial histidine scanning libraries and yeast display.

Christian Schröter et al.

mAbs, 7(1), 138-151 (2014-12-20)

There is growing interest in the fast and robust engineering of protein pH-sensitivity that aims to reduce binding at acidic pH, compared to neutral pH. Here, we describe a novel strategy for the incorporation of pH-sensitive antigen binding functions into

A central role for intermolecular dityrosine cross-linking of fibrinogen in high molecular weight advanced oxidation protein product (AOPP) formation.

Graziano Colombo et al.

Biochimica et biophysica acta, 1850(1), 1-12 (2014-10-05)

Advanced oxidation protein products (AOPPs) are dityrosine cross-linked and carbonyl-containing protein products formed by the reaction of plasma proteins with chlorinated oxidants, such as hypochlorous acid (HOCl). Most studies consider human serum albumin (HSA) as the main protein responsible for

Graphene-derivatized silica as an efficient solid-phase extraction sorbent for pre-concentration of fluoroquinolones from water followed by liquid-chromatography fluorescence detection.

Andrea Speltini et al.

Journal of chromatography. A, 1379, 9-15 (2015-01-07)

This work presents a novel analytical method based on graphene for the determination of five widely used fluoroquinolones (FQs) in aqueous matrices. The procedure entails solid-phase extraction (SPE) on graphene-derivatized silica (200mg), followed by liquid chromatography with fluorescence detection. Monolayer

Understanding nanocellulose chirality and structure-properties relationship at the single fibril level.

Ivan Usov et al.

Nature communications, 6, 7564-7564 (2015-06-26)

Nanocellulose fibrils are ubiquitous in nature and nanotechnologies but their mesoscopic structural assembly is not yet fully understood. Here we study the structural features of rod-like cellulose nanoparticles on a single particle level, by applying statistical polymer physics concepts on

TLC-Direct Bioautography as a Bioassay Guided Method for Investigation of Antibacterial Compounds in Hypericum perforatum L.

Wioleta Jesionek et al.

Journal of AOAC International, 98(4), 1013-1020 (2015-08-14)

Fast high-throughput TLC-direct bioautography (DB) is an effect-directed analysis method that enables searching for biologically active (e.g., antimicrobial) substances in complex mixtures like plant extracts. The principle of the method is that separation and detection of biological properties of given

Stepwise assembly of a cross-linked free-standing nanoparticle sheet with controllable shape.

Hui Zhang et al.

Nanoscale, 7(25), 11033-11039 (2015-06-09)

In this paper, we report a free-standing thin lamella consisting of nanoparticles with controllable shape. A self-assembly technique is utilized to obtain this sheet in a step by step fashion with nanoparticles and polymer single crystals as the basic building

A possible role of endogenous central corticotrophin releasing factor in lipopolysaccharide induced thymic involution and cell apoptosis: effect of peripheral injection of corticotrophin releasing factor.

Meenal P Ullewar et al.

Journal of neuroimmunology, 280, 58-65 (2015-03-17)

The aim of the study was to investigate the role of endogenous peripheral and central corticotrophin-releasing factor (CRF) following lipopolysaccharide (LPS) challenge on thymic involution and apoptosis. Administration of LPS (100 μg/mouse, ip) led to thymic involution, to a decrease

Alpha-Linolenic Acid-Induced Increase in Neurogenesis is a Key Factor in the Improvement in the Passive Avoidance Task After Soman Exposure.

Tetsade C B Piermartiri et al.

Neuromolecular medicine, 17(3), 251-269 (2015-04-30)

Exposure to organophosphorous (OP) nerve agents such as soman inhibits the critical enzyme acetylcholinesterase (AChE) leading to excessive acetylcholine accumulation in synapses, resulting in cholinergic crisis, status epilepticus and brain damage in survivors. The hippocampus is profoundly damaged after soman

Renal ApoA-1 amyloidosis with Glu34Lys mutation and intra-amyloid lipid accumulation.

Nicole K Andeen et al.

Journal of the American Society of Nephrology : JASN, 25(12), 2703-2705 (2014-06-14)

Apolipoprotein A-1 (ApoA-1) amyloidosis occurs as a nonhereditary condition in atherosclerotic plaques, but it can also manifest as a hereditary disorder caused by mutations of the APOA1 gene. Hereditary ApoA-1 amyloidosis presents with diverse organ involvement based on the position

Improved antifungal activity of amphotericin B-loaded TPGS-b-(PCL-ran-PGA) nanoparticles.

Xiaolong Tang et al.

International journal of clinical and experimental medicine, 8(4), 5150-5162 (2015-07-02)

To develop amphotericin B-loaded biodegradable TPGS-b-(PCL-ran-PGA) nanoparticles (PLGA-TPGS-AMB NPs) for fungal infection treatment, PLGA-TPGS NPs and PLGA NPs were synthesized by a modified double emulsion method and characterized in terms of size and size distribution, morphology and zeta potential. Drug

A lysine-rich membrane-associated PHISTb protein involved in alteration of the cytoadhesive properties of Plasmodium falciparum-infected red blood cells.

Nicholas I Proellocks et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(7), 3103-3113 (2014-04-08)

The genomes of malaria parasites (Plasmodium spp.) contain a family of genes encoding proteins with a Plasmodium helical interspersed subtelomeric (PHIST) domain, most of which are predicted to be exported into the parasite-infected human red blood cell (iRBC). Here, using

Development of multifunctional lipid nanocapsules for the co-delivery of paclitaxel and CpG-ODN in the treatment of glioblastoma.

Giovanna Lollo et al.

International journal of pharmaceutics, 495(2), 972-980 (2015-10-03)

In this work, multifunctional lipid nanocapsules (M-LNC) were designed to combine the activity of the cytotoxic drug paclitaxel (PTX) with the immunostimulant CpG. This nanosystem, consisting of modified lipid nanocapsules coated with a cationic polymeric shell composed of chitosan (CS)

Therapeutic site selection is important for the successful development of collateral vessels.

Ayako Nishiyama et al.

Journal of vascular surgery, 62(1), 190-199 (2014-03-19)

Induction of collateral development to improve tissue perfusion is a promising approach for the treatment of arterial occlusive diseases. Several growth factors and cells have been reported to increase collateral circulation; however, the appropriate site for the delivery of these

Role of seaweed laminaran from Saccharina longicruris on matrix deposition during dermal tissue-engineered production.

Akram Ayoub et al.

International journal of biological macromolecules, 75, 13-20 (2015-01-21)

Our laboratory has developed a technique to reconstruct in vitro tissue from human cells using the self-assembly tissue-engineering method, which utilizes the ability of fibroblasts to deposit the matrix they secrete. The time necessary for tissue construction, several weeks, is

A Neutralizing Monoclonal IgG1 Antibody of Platelet-Activating Factor Acetylhydrolase SsE Protects Mice against Lethal Subcutaneous Group A Streptococcus Infection.

Mengyao Liu et al.

Infection and immunity, 83(7), 2796-2805 (2015-04-29)

Group A Streptococcus (GAS) can cause life-threatening invasive infections, including necrotizing fasciitis. There are no effective treatments for severe invasive GAS infections. The platelet-activating factor (PAF) acetylhydrolase SsE produced by GAS is required for invasive GAS to evade innate immune

Myogenic stem cell-laden hydrogel scaffold in wound healing of the disrupted external anal sphincter.

T Ignacio Montoya et al.

International urogynecology journal, 26(6), 893-904 (2015-02-04)

To evaluate the effect of myogenic stem cell-laden hydrogel scaffold on contractile function and histomorphology of the external anal sphincter (EAS) after transection without repair. Eighty female rats underwent anal sphincter transection without repair. After 2 weeks, animals were injected

Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.

Diana A Stolfa et al.

Journal of molecular biology, 426(20), 3442-3453 (2014-03-25)

Schistosomiasis, caused by the parasitic flatworm Schistosoma mansoni and related species, is a tropical disease that affects over 200 million people worldwide. A new approach for targeting eukaryotic parasites is to tackle their dynamic epigenetic machinery that is necessary for

Interaction of endothelial nitric oxide synthase with mitochondria regulates oxidative stress and function in fetal pulmonary artery endothelial cells.

Girija G Konduri et al.

American journal of physiology. Lung cellular and molecular physiology, 309(9), L1009-L1017 (2015-09-01)

An increase in oxygen tension at birth is one of the key signals that initiate pulmonary vasodilation in the fetal lung. We investigated the hypothesis that targeting endothelial nitric oxide synthase (eNOS) to the mitochondrial outer membrane regulates reactive oxygen

Impairment of type I but not type III IFN signaling by hepatitis C virus infection influences antiviral responses in primary human hepatocytes.

Jacques Friborg et al.

PloS one, 10(3), e0121734-e0121734 (2015-04-01)

Peginterferon lambda-1a (Lambda), a type III interferon (IFN), acts through a unique receptor complex with limited cellular expression outside the liver which may result in a differentiated tolerability profile compared to peginterferon alfa (alfa). In Phase 2b clinical studies, Lambda

Liquid culture production of microsclerotia and submerged conidia by Trichoderma harzianum active against damping-off disease caused by Rhizoctonia solani.

Nilce N Kobori et al.

Fungal biology, 119(4), 179-190 (2015-03-31)

Media and culturing protocols were identified that supported the formation of submerged conidia and microsclerotia (MS) by Trichoderma harzianum Rifai strain T-22 using liquid culture fermentation. Liquid media with a higher carbon concentration (36 g L(-1)) promoted MS formation at

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