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Ding Zhang et al.
Clinical and translational medicine, 10(8), e231-e231 (2020-12-31)
Acute lung injury is a serious form and major cause of patient death and still needs efficient therapies. The present study evidenced that co-transplantation of mesenchymal stem cells (MSCs) and telocytes (TCs) improved the severity of experimental lung tissue inflammation
Bingji Jin et al.
Experimental animals, 67(3), 337-347 (2018-03-13)
The epithelial sodium channel (ENaC) and mitogen-activated protein kinase (MAPK) pathway have been reported to be associated with the progression of acute lung injury (ALI). Oxymatrine (OMT) alone or combined with other drugs can ameliorate paraquat- or oleic acid-induced lung
Thomas F Bishop et al.
iScience, 24(11), 103281-103281 (2021-11-13)
Tadpoles of the frog Xenopus laevis can regenerate tails except for a short "refractory" period in which they heal rather than regenerate. Rapid and sustained production of ROS by NADPH oxidase (Nox) is critical for regeneration. Here, we show that
Prunelle Waldman et al.
Environmental science & technology, 51(23), 13633-13640 (2017-11-09)
Although the interaction between phages and bacteria has already been well described, it only recently emerged that human viruses also interact with bacteria in the mammalian gut. We studied whether this interaction could occur in tap water and thus confer
Fun Man Fung et al.
Scientific reports, 7(1), 10774-10774 (2017-09-09)
This study focuses on one of the key environmental threats, endotoxins, also known as lipopolysaccharides (LPS). A capillary electrophoresis method in combination with laser induced fluorescence (LIF) detection was developed for the analysis of endotoxins from 16 different bacterial strains.
Tingting Cheng et al.
Experimental cell research, 395(1), 112155-112155 (2020-07-01)
Acute respiratory distress syndrome (ARDS) is an organ failure syndrome caused by overactivation of the immune system. Mesenchymal stem cells (MSCs) have been found to be effective in ARDS therapy due to their excellent immunomodulatory abilities; however, people are concerned
Young Ok Kim et al.
Molecules and cells, 32(4), 359-365 (2011-09-10)
Respiratory tract exposure to viruses, air pollutants, or bacterial pathogens can lead to pulmonary diseases. The molecular mechanism of mucous overproduction increased by these pathogens provides the knowledge for developing new therapeutic strategies. There is established in vitro data demonstrating
Y Wannemuehler et al.
Journal of clinical microbiology, 27(12), 2881-2883 (1989-12-01)
A monoclonal antibody to the lipopolysaccharide of Moraxella bovis is described. In an indirect fluorescent-antibody test, this monoclonal antibody reacted with 39 of 39 strains of M. bovis tested and did not react with 26 nonfermenting gram-negative coccobacilli other than
Eveline Hoefkens et al.
Autophagy, 9(12), 2046-2055 (2013-11-20)
Genome-wide association studies have identified several genes implicated in autophagy (ATG16L1, IRGM, ULK1, LRRK2, and MTMR3), intracellular bacterial sensing (NOD2), and endoplasmic reticulum (ER) stress (XBP1 and ORMDL3) to be associated with Crohn disease (CD). We studied the known CD-associated
David Santiago-Algarra et al.
Nature communications, 12(1), 6660-6660 (2021-11-20)
Gene expression is controlled by the involvement of gene-proximal (promoters) and distal (enhancers) regulatory elements. Our previous results demonstrated that a subset of gene promoters, termed Epromoters, work as bona fide enhancers and regulate distal gene expression. Here, we hypothesized
Moonchul Park et al.
Advanced healthcare materials, 9(16), e2000658-e2000658 (2020-07-03)
Peri-implant disease is an inflammatory condition affecting the soft and hard tissues surrounding a dental implant. However, current preventative methods are insufficient due to the limited bioactivity on the dental implant and poor patient compliance. Recently, photo-biomodulation (PBM) therapy that
Maya Sangesland et al.
Cell reports, 32(8), 108065-108065 (2020-08-28)
B cell receptors (BCRs) display a combination of variable (V)-gene-encoded complementarity determining regions (CDRs) and adaptive/hypervariable CDR3 loops to engage antigens. It has long been proposed that the former tune for recognition of pathogens or groups of pathogens. To experimentally
Alekh Paranjapye et al.
The Journal of biological chemistry, 297(2), 100932-100932 (2021-07-05)
A complex network of transcription factors regulates genes involved in establishing and maintaining key biological properties of the human airway epithelium. However, detailed knowledge of the contributing factors is incomplete. Here we characterize the role of Krüppel-like factor 5 (KLF5)
Jing Zhang et al.
Immunology and cell biology, 87(2), 141-148 (2008-10-22)
In the present study we tested the responsiveness of human corneal epithelial cells (HCECs) and corneal fibroblasts to lipopolysaccharide (LPS), a Toll-like receptor (TLR) 4 ligand. Purified Pseudomonas aeruginosa LPS was used to stimulate telomerase-immortalized HCECs (HUCL) and stromal fibroblast
Samir Gautam et al.
American journal of physiology. Lung cellular and molecular physiology, 319(4), L661-L669 (2020-08-14)
The past two decades have witnessed a resurgence in neutrophil research, inspired in part by the discovery of neutrophil extracellular traps (NETs) and their myriad roles in health and disease. Within the lung, dysregulation of neutrophils and NETosis have been
Jian Lou et al.
Acta pharmacologica Sinica, 40(6), 769-780 (2018-11-18)
Tissue factor (TF)-dependent coagulation contributes to lung inflammation and the pathogenesis of acute lung injury (ALI). In this study, we explored the roles of targeted endothelial anticoagulation in ALI using two strains of transgenic mice expressing either a membrane-tethered human
Iga Kucharska et al.
Biochemistry, 55(36), 5061-5072 (2016-08-18)
Pseudomonas aeruginosa is an opportunistic human pathogen causing pneumonias that are particularly severe in cystic fibrosis and immunocompromised patients. The outer membrane (OM) of P. aeruginosa is much less permeable to nutrients and other chemical compounds than that of Escherichia
Akiko Chiba et al.
Molecular cancer research : MCR, 18(1), 130-139 (2019-10-20)
Breast tumors have their own specific microbiota, distinct from normal mammary gland tissue. Patients with breast cancer that present with locally advanced disease often undergo neoadjuvant chemotherapy to reduce tumor size prior to surgery to allow breast conservation or limit
Davide Vallese et al.
Respiration; international review of thoracic diseases, 89(4), 329-342 (2015-03-21)
The role of mitogen-activated protein kinases (MAPK) in regulating the inflammatory response in the airways of patients with chronic obstructive pulmonary disease (COPD) and asthmatic patients is unclear. To investigate the expression of activated MAPK in lungs of COPD patients
Matthew Stephens et al.
Gut microbes, 11(3), 421-432 (2019-06-18)
Patients presenting with Inflammatory bowel disease have been shown to exhibit an altered microbiome in both Crohn's disease and Ulcerative colitis. This shift in the microbial content led us to question whether several of these microbes are important in inflammatory
J Moraleda-Prados et al.
Developmental and comparative immunology, 114, 103848-103848 (2020-09-06)
Infections are able to trigger epigenetic modifications; however, epigenetic-mediating infections in the immune system in fish is currently unavailable. Within this purpose, zebrafish were immune-stimulated with three lipopolysaccharides (LPS) during sex differentiation. Methylation patterns of three immune genes were studied
Per-Ola Onnervik et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 59(10), 817-825 (2010-04-14)
The aim was to create pathological changes in mice relevant to human smoke exposure that can be used to further understand the mechanisms and pathology of smoke-induced inflammatory disease. Mice were exposed to tobacco smoke or lipopolysaccharide (LPS) to generate
Chiara Falciani et al.
PloS one, 7(10), e46259-e46259 (2012-10-12)
The branched M33 antimicrobial peptide was previously shown to be very active against Gram-negative bacterial pathogens, including multidrug-resistant strains. In an attempt to produce back-up molecules, we synthesized an M33 peptide isomer consisting of D-aminoacids (M33-D). This isomeric version showed
John M Veranth et al.
Toxicological sciences : an official journal of the Society of Toxicology, 82(1), 88-96 (2004-08-18)
Cultured human lung epithelial cells (BEAS-2B) were treated in vitro with PM(2.5)-enriched particles of soil-derived mineral dust from nine sites in the western United States. The particle samples simulate windblown dust and vehicle-generated emissions from unpaved roads. Five of the
Yong-Jae Kim et al.
Infection and immunity, 82(8), 3252-3260 (2014-05-29)
Inflammatory responses are a first line of host defense against a range of invading pathogens, consisting of the release of proinflammatory cytokines followed by attraction of polymorphonuclear neutrophils (PMNs) to the site of inflammation. Among the many virulence factors that
Tsang-Hsiung Lin et al.
Frontiers in immunology, 7, 440-440 (2016-11-09)
Epidemiological studies based on the "hygiene hypothesis" declare that the level of childhood exposure to environmental microbial products is inversely related to the incidence of allergic diseases in later life. Multiple types of immune cell-mediated immune regulation networks support the
Chia-Hsin Liu et al.
Cancer research, 81(1), 144-157 (2020-10-31)
Chronic obstructive pulmonary disease (COPD) is an inflammatory disease that is associated with increased risk of lung cancer. Pseudomonas aeruginosa (PA) infections are frequent in patients with COPD, which increase lung inflammation and acute exacerbations. However, the influences of PA-induced
Omar Qazi et al.
Faraday discussions, 149, 23-36 (2011-03-18)
Rapid detection of the category B biothreat agents Burkholderia pseudomallei and Burkholderia mallei in acute infections is critical to ensure that appropriate treatment is administered quickly to reduce an otherwise high probability of mortality (ca. 40% for B. pseudomallei). We
Xuezhi Zhang et al.
Nature communications, 7, 10938-10938 (2016-03-02)
Extracellular traps (ETs) from neutrophils are reticulated nets of DNA decorated with anti-microbial granules, and are capable of trapping and killing extracellular pathogens. Various phagocytes of mammals and invertebrates produce ETs, however, the evolutionary history of this DNA-based host defence
Peggy S Lai et al.
American journal of respiratory cell and molecular biology, 47(2), 209-217 (2012-04-21)
Little is known about the mechanisms of persistent airflow obstruction that result from chronic occupational endotoxin exposure. We sought to analyze the inflammatory response underlying persistent airflow obstruction as a result of chronic occupational endotoxin exposure. We developed a murine
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