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Yuki Ikeda et al.
International journal of molecular sciences, 22(11) (2021-06-03)
Insulin-like growth factor 1 receptor (IGF1R), a receptor-type tyrosine kinase, transduces signals related to cell proliferation, survival, and differentiation. We recently reported that OSI-906, an IGF1R inhibitor, in combination with the Aurora B inhibitor ZM447439 suppresses cell proliferation. However, the
Yu Shi et al.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 163(1), 43-50 (2012-05-15)
Androgens play a crucial role in sex differentiation, sexual maturation, and spermatogenesis in vertebrates. The action of androgens is mediated via androgen receptors (ARs). The present study reports the cloning of the cDNA sequence of the ar in the orange-spotted
Anne S Mortensen et al.
Chemosphere, 83(8), 1035-1044 (2011-03-01)
In the present study, groups of juvenile Atlantic salmon (Salmo salar) were fed gelatine capsules containing fish-food spiked with PFOA or PFOS (0.2 mg kg(-1) fish) and solvent (methanol). The capsules were given at days 0, 3 and 6. Blood
Right-sided vascular lesions: challenge.
Jennifer G Powers et al.
The American Journal of dermatopathology, 34(8), 833-833 (2011-10-20)
C Gómez et al.
Steroids, 78(1), 44-52 (2012-11-07)
Methyltestosterone (MT) is one of the most frequently detected anabolic androgenic steroids in doping control analysis. MT misuse is commonly detected by the identification of its two main metabolites excreted as glucuronide conjugates, 17α-methyl-5α-androstan-3α,17β-diol and 17α-methyl-5β-androstan-3α,17β-diol. The detection of these
Atul K Singh
General and comparative endocrinology, 181, 146-155 (2012-10-16)
Of the techniques available to mass-produce a sterile or monosex population, the hormonal induction of sex reversal is the most widely practiced. This paper presents the synthesis of works done on sex reversal using 17α methyltestosterone (17αMT), 17β estradiol, non-steroidal
Qinren Cai et al.
Se pu = Chinese journal of chromatography, 29(8), 712-717 (2011-12-02)
A method was developed for the simultaneous determination and identification of 12 steroid hormone residues in pig tissues, including stanolone, aldosterone, boldenone, danazol, metandienone, methyltestosterone, nadrolone, norethindrone, progesterone, stanozolol, testosterone and testosterone propionate, using liquid chromatography-tandem triple-quadrupole linear ion trap
Natacha S Hogan et al.
Environmental toxicology and chemistry, 31(6), 1391-1395 (2012-04-20)
Previous research demonstrated that exposure to exogenous androgens and effluents with androgenic activity can induce spiggin mRNA production in the kidney of the three-spined stickleback (Gasterosteus aculeatus). In the present study, we determine whether a short-term exposure to a known
K S Schmidt et al.
Analytica chimica acta, 717, 85-91 (2012-02-07)
Within the framework of the German National Residue Control Plan a specific number of samples of animal origin have to be analysed for natural and synthetic steroids each year. As a measure of external quality control of the methods applied
Kande Amarasinghe et al.
Journal of agricultural and food chemistry, 60(20), 5084-5088 (2012-05-03)
This paper describes the development of a fast method to screen and confirm methyltestosterone 17-O-glucuronide (MT-glu) in tilapia bile. The method consists of solid-phase extraction (SPE) followed by high-performance liquid chromatography-mass spectrometry. The system used was an Agilent 6530 Q-TOF
Yuqian Han et al.
Food chemistry, 135(4), 2988-2993 (2012-09-18)
A simple, rapid and sensitive method was developed for determination of 17α-methyltestosterone in aquatic products by extraction with subcritical 1,1,1,2-tetrafluoroethane (R134a) extraction and high performance liquid chromatography (HPLC). Response surface methodology (RSM) was adopted to optimise extraction pressure, temperature and
Eric H Phillips et al.
Clinical therapeutics, 25(12), 3027-3043 (2004-01-30)
The use of hormone-replacement therapy (HRT) to treat menopausal symptoms has been influenced over the years by various safety concerns. These concerns include endometrial cancer, breast cancer, and cardiovascular disease, and have altered how HRT is prescribed. Evaluating postmarketing surveillance
J G Oberlander et al.
Neuroscience, 226, 397-410 (2012-09-20)
Anabolic androgenic steroids (AAS), synthetic testosterone derivatives that are used for ergogenic purposes, alter neurotransmission and behaviors mediated by GABA(A) receptors. Some of these effects may reflect direct and rapid action of these synthetic steroids at the receptor. The ability
Daniela Stange et al.
Ecotoxicology and environmental safety, 75(1), 94-101 (2011-09-29)
Molluscs are raising attention as ecotoxicological test organisms due to their high diversity and ecological importance. The ovoviviparous prosobranch gastropod Potamopyrgus antipodarum (freshwater mudsnail) responds very sensitively to xenobiotics and has therefore been proposed as OECD standard test organism. Endocrine
Syed Ghulam Musharraf et al.
Steroids, 78(2), 171-181 (2012-11-20)
Electrospray ionization tandem mass spectrometry (ESI-MS/MS) was used to investigate the effect of different substitutions introduced during metabolism on fragmentation patterns of four anabolic steroids including methyltestosterone, methandrostenolone, cis-androsterone and adrenosterone, along with their metabolites. Collision-induced dissociation (CID) analysis was
How does an anabolic/androgenic steroid get banned from sport competition?
Alan D Rogol
Endocrinology, 152(12), 4473-4474 (2011-11-26)
Marco A Liñán-Cabello et al.
Revista de biologia tropical, 61(1), 203-212 (2013-07-31)
Little is known about the effects of the interaction of growth hormone (GH) with 17 alpha-methyltestosterone (17-MT) during fish growth. We evaluated this in the present study to assess the effect on fish growth. Fish in two batches of juvenile
Chang-Beom Park et al.
Ecotoxicology (London, England), 22(7), 1145-1154 (2013-07-11)
To elucidate the action mechanism of environmental androgenic chemicals on fish reproductive activity by transient stimulation in heavily polluted areas, individuals of the hermaphrodite fish Kryptolebias marmoratus were injected once with six concentrations of methyltestosterone (MT) (0.1, 1, 5, 10
Supreeda Homklin et al.
Chemosphere, 82(10), 1401-1407 (2011-01-05)
17α-Methyltestosterone (MT), an anabolic androgenic steroid, is used widely in inducing an all male population in aquaculture farming of fish, such as Nile tilapia (Oreochromis niloticus). Current understanding of the occurrence and fate of MT in the sediments and the
Maria K Parr et al.
Endocrinology, 152(12), 4718-4728 (2011-10-13)
Various products containing rarely characterized anabolic steroids are nowadays marketed as dietary supplements. Herein, the designer steroid methyl-1-testosterone (M1T) (17β-hydroxy-17α-methyl-5α-androst-1-en-3-one) was identified, and its biological activity, potential adverse effects, and metabolism were investigated. The affinity of M1T toward the androgen
Carlos A A Penatti et al.
Neuropharmacology, 61(4), 653-664 (2011-06-08)
Disruption of reproductive function is a hallmark of abuse of anabolic androgenic steroids (AAS) in female subjects. To understand the central actions of AAS, patch clamp recordings were made in estrous, diestrous and AAS-treated mice from gonadotropin releasing hormone (GnRH)
Nonglak Phumyu et al.
General and comparative endocrinology, 177(2), 278-292 (2012-04-07)
The influence of 17α-methyltestosterone (MT) on growth responses, biological parameters and the expression of genes involved in the GH-IGF pathway of the hypothalamic-pituitary-liver-gonadal axis were investigated in female, male, and sex-reversed Nile tilapia to evaluate the relationship between sex and
R Krysiak et al.
Acta clinica Belgica, 68(1), 65-67 (2013-05-01)
In this paper we report different effects of methyltestosterone administration on thyroid function in two twin brothers, one of whom suffered from hypothyroidism, while the other was apparently healthy. Methyltestosterone, which is a non-aromatisable androgen, resulted in a marked reduction
Wenbo Jiang et al.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 160(4), 187-193 (2011-09-06)
Gobiocypris rarus is an emerging fish model for aquatic toxicology in China as it is sensitive to environmental hormone disruptors. Exogenous sex steroids can affect sex differentiation and the expression of sex-related genes. Foxl2, a member of forkhead-box transcription factor
R P Júnior et al.
Homeopathy : the journal of the Faculty of Homeopathy, 101(3), 154-158 (2012-07-24)
Nile tilapia (Oreochromis niloticus), are widely used in fish farming, hormonal treatments are used to increase productivity. Studies of the characteristics of the fiber types are important in species that have well developed muscle mass, such as Nile tilapia. A
Supreeda Homklin et al.
Journal of hazardous materials, 221-222, 35-44 (2012-05-01)
17α-Methyltestosterone (MT), a synthetic anabolic androgenic steroid, is widely used in aquafarming for the production of an all male fish population such as Nile tilapia. This study isolated, identified and characterized MT-degrading bacteria in the sediment and water from a
Michael J Hemmer et al.
Aquatic toxicology (Amsterdam, Netherlands), 103(1-2), 71-78 (2011-03-12)
Protein expression changes can be used for detection of biomarkers that can be applied diagnostically to screen chemicals for endocrine modifying activity. In this study, surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) coupled with a short term fish assay
Xuesong Hu et al.
Molecular reproduction and development, 78(6), 376-390 (2011-05-14)
It is known that the hypothalamic-pituitary-gonadal axis participates in the sex change of hermaphrodite teleosts, and gonadal steroid hormones mediate this physiological process. The secretion of gonadal steroids is directly regulated by signaling pathways involving gonadotropins (GtHs) and gonadotropin receptors
Lee D Wilson et al.
Journal of agromedicine, 15(2), 105-116 (2010-04-22)
Polymeric sorbent materials that incorporate beta-cyclodextrin (CD) have been prepared and their sorption behavior toward two model agrochemical contaminant compounds, p-nitrophenol (PNP) and methyl chloride examined. The sorption of PNP was studied in aqueous solution using ultraviolet-visible (UV-Vis) spectroscopy, whereas
Daniel P Roberts et al.
AMB Express, 11(1), 10-10 (2021-01-08)
Ethanol extract of cell mass of Serratia marcescens strain N4-5, when applied as a treatment to cucumber seed, has been shown to provide control of the oomycete soil-borne plant pathogen Pythium ultimum equivalent to that provided by a seed-treatment chemical
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